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Ischemic cerebrovascular and cardiovascular diseases in brain and heart tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension, etc. Have been increasing in morbidity and mortality in the middle-aged and elderly population over several years. In recent years, the Eph/ephrin signaling pathway has been found to have a major role in the processes of neurogenesis, synaptic plasticity, and angiogenesis, which is likely a key pathway in the modulation of neurological and cardiac functions. Therefore, an in-depth understanding of the role of the Eph/Ephrin signaling pathway in pathophysiological processes will be the emphasis of future research. In ischemic cardiovascular and cerebrovascular diseases, in particular, the development of effective treatment to modulate the Eph/Ephrin signaling pathway to promote neural and vascular repair and regeneration is of great clinical significance and social value. In this study, the role of the Eph/ephrin signaling pathway in ischemic cerebrovascular and cardiovascular diseases is reviewed.

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Publication history

Received: 29 August 2022
Revised: 02 December 2022
Accepted: 06 December 2022
Published: 17 December 2022
Issue date: March 2023

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© 2022 The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press.

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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