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Journal of Neurorestoratology 2023, 11(1): 100040 https://doi.org/10.1016/j.jnrt.2022.100040
Review | Open Access | Issue | Published: 17 December 2022

Roles of Eph/ephrin signaling pathway in repair and regeneration for ischemic cerebrovascular and cardiovascular diseases

Show Author's Information Songyang Zhenga,  Fangling Suna,  Xin Tiana,  Zixin Zhua,  Yufeng Wanga,  Wenrong Zhenga,  Tingting Liua( ),  Wen Wanga,b( )
Department of Experimental Animal Center, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
Beijing Institute for Brain Disorders, Beijing 100069, China
Keywords:
Regeneration, Cardiovascular disease, Cerebrovascular disease, Repair, Eph/ephrin
Cite this article:
Zheng S, Sun F, Tian X, et al. Roles of Eph/ephrin signaling pathway in repair and regeneration for ischemic cerebrovascular and cardiovascular diseases. Journal of Neurorestoratology, 2023, 11(1): 100040. https://doi.org/10.1016/j.jnrt.2022.100040
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Abstract Full text About this article

Ischemic cerebrovascular and cardiovascular diseases in brain and heart tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension, etc. Have been increasing in morbidity and mortality in the middle-aged and elderly population over several years. In recent years, the Eph/ephrin signaling pathway has been found to have a major role in the processes of neurogenesis, synaptic plasticity, and angiogenesis, which is likely a key pathway in the modulation of neurological and cardiac functions. Therefore, an in-depth understanding of the role of the Eph/Ephrin signaling pathway in pathophysiological processes will be the emphasis of future research. In ischemic cardiovascular and cerebrovascular diseases, in particular, the development of effective treatment to modulate the Eph/Ephrin signaling pathway to promote neural and vascular repair and regeneration is of great clinical significance and social value. In this study, the role of the Eph/ephrin signaling pathway in ischemic cerebrovascular and cardiovascular diseases is reviewed.


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About this article

Roles of Eph/ephrin signaling pathway in repair and regeneration for ischemic cerebrovascular and cardiovascular diseases

Show Author's information Songyang Zhenga, Fangling Suna, Xin Tiana, Zixin Zhua, Yufeng Wanga, Wenrong Zhenga, Tingting Liua( ), Wen Wanga,b( )
Department of Experimental Animal Center, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
Beijing Institute for Brain Disorders, Beijing 100069, China

Abstract

Ischemic cerebrovascular and cardiovascular diseases in brain and heart tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension, etc. Have been increasing in morbidity and mortality in the middle-aged and elderly population over several years. In recent years, the Eph/ephrin signaling pathway has been found to have a major role in the processes of neurogenesis, synaptic plasticity, and angiogenesis, which is likely a key pathway in the modulation of neurological and cardiac functions. Therefore, an in-depth understanding of the role of the Eph/Ephrin signaling pathway in pathophysiological processes will be the emphasis of future research. In ischemic cardiovascular and cerebrovascular diseases, in particular, the development of effective treatment to modulate the Eph/Ephrin signaling pathway to promote neural and vascular repair and regeneration is of great clinical significance and social value. In this study, the role of the Eph/ephrin signaling pathway in ischemic cerebrovascular and cardiovascular diseases is reviewed.

Keywords: Regeneration, Cardiovascular disease, Cerebrovascular disease, Repair, Eph/ephrin

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Received: 29 August 2022
Revised: 02 December 2022
Accepted: 06 December 2022
Published: 17 December 2022
Issue date: March 2023

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© 2022 The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press.

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