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Commentary | Open Access

Interplay among oncogenic pathways governs hepatobiliary lineage decisions in liver cancer

Yonglong Pana,b, Xiaoping Chena,c, Ze-yang Dinga( )
Division of Hepato-Pancreato-Biliary Surgery, Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China
Key Laboratory of Molecular Biophysics, Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Key Laboratory of Organ Transplantation, Ministry of Education, National Health Commission, Chinese Academy of Medical Sciences, Wuhan 430030, China
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Keywords

Liver cancerRat sarcoma viral oncogene homolog (RAS)AktLineage conversionPlasticity

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iLIVER
Volume 5 Issue 2,
June 2026
DOI: 10.1016/j.iliver.2026.100241

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Cite this article:
Pan Y, Chen X, Ding Z-y. Interplay among oncogenic pathways governs hepatobiliary lineage decisions in liver cancer. iLIVER, 2026, 5(2). https://doi.org/10.1016/j.iliver.2026.100241

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Received: 05 February 2026
Revised: 11 April 2026
Accepted: 27 April 2026
Published: 06 May 2026
© 2026 The Authors. Tsinghua University Press.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).