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iLIVER 2023, 2(2): 116-121 https://doi.org/10.1016/j.iliver.2023.05.003
Review | Open Access | Issue | Published: 23 May 2023

Hepatic allograft rejection after liver transplantation: Clinicopathological debates!

Show Author's Information Nourhan Badwei( )
Tropical Medicine, Gastroenterology and Hepatology, Hepatoma Group, Faculty of Medicine, Ain Shams University, Cairo 11588, Egypt
Keywords:
Liver transplantation, Graft rejection, Diagnostic debates
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Badwei N. Hepatic allograft rejection after liver transplantation: Clinicopathological debates!. iLIVER, 2023, 2(2): 116-121. https://doi.org/10.1016/j.iliver.2023.05.003
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Abstract Full text About this article

Liver transplantation (LT) represents a life-saving surgical procedure and is considered the current standard of care for the majority of patients having end-stage liver disease. As known, significant progress in organ preservation techniques, perioperative care, and strict immunosuppression protocols are associated with favorable patient/graft survival post-LT. Hence, proper evaluation of liver allograft-related complications among survivors has paid great attention, particularly the rejection sequel after LT. It is a seriously underestimated cause of allograft injury, which pushes researchers for understanding the exact pathogenesis of different types and proper time diagnosis for better management of such complications. However, it still represents a challenge because of the complexities related to diagnosis and histopathology. Hence, increasing clinical awareness with earlier diagnosis of post-LT rejection is essential through stimulating further studies. Therefore, our review will focus on the clinicopathological debates regarding liver allograft loss after transplantation.


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About this article

Hepatic allograft rejection after liver transplantation: Clinicopathological debates!

Show Author's information Nourhan Badwei( )
Tropical Medicine, Gastroenterology and Hepatology, Hepatoma Group, Faculty of Medicine, Ain Shams University, Cairo 11588, Egypt

Abstract

Liver transplantation (LT) represents a life-saving surgical procedure and is considered the current standard of care for the majority of patients having end-stage liver disease. As known, significant progress in organ preservation techniques, perioperative care, and strict immunosuppression protocols are associated with favorable patient/graft survival post-LT. Hence, proper evaluation of liver allograft-related complications among survivors has paid great attention, particularly the rejection sequel after LT. It is a seriously underestimated cause of allograft injury, which pushes researchers for understanding the exact pathogenesis of different types and proper time diagnosis for better management of such complications. However, it still represents a challenge because of the complexities related to diagnosis and histopathology. Hence, increasing clinical awareness with earlier diagnosis of post-LT rejection is essential through stimulating further studies. Therefore, our review will focus on the clinicopathological debates regarding liver allograft loss after transplantation.

Keywords: Liver transplantation, Graft rejection, Diagnostic debates

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Publication history
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Publication history

Received: 12 February 2023
Revised: 11 May 2023
Accepted: 14 May 2023
Published: 23 May 2023
Issue date: June 2023

Copyright

© 2023 The Author(s). Tsinghua University Press.

Acknowledgements

Special Thanks to ASCOT Centre Staff members at Ain shams university, Cairo Egypt for giving me the opportunity to be trained there, their insights and knowledge into liver transplantation steered me. And to my parents (D. Lobna and D. Badwei), who set me off on the road to this career a long time ago.

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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