Crotonylation of PRKACA enhances PKA activity and promotes colorectal cancer development via the PKA-FAK-AKT pathway

Jia-Yi Hou; Li-Juan Gao; Jing Shen; Lan Zhou; Jian-Yun Shi; Teng Sun; Shu-Lan Hao; De-Ping Wang; Ji-Min Cao

doi:10.1016/j.gendis.2022.02.018

Genes & Diseases 2023, 10(2): 332-335 https://doi.org/10.1016/j.gendis.2022.02.018

Rapid Communication |

Open Access | Issue | Published: 31 March 2022

Crotonylation of PRKACA enhances PKA activity and promotes colorectal cancer development via the PKA-FAK-AKT pathway

Show Author's Information Hide Author's Information Jia-Yi Hou^{^a^,^b^,}, Li-Juan Gao^{^a}, Jing Shen^{^a}, Lan Zhou^{^a}, Jian-Yun Shi^{^a}, Teng Sun^{^a}, Shu-Lan Hao^{^c}, De-Ping Wang^{^a}(

), Ji-Min Cao^{^a}(

)

Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, and the Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China

Department of Clinical Laboratory, Shanxi Provincial Academy of Traditional Chinese Medicine, Taiyuan, Shanxi 030012, China

Oncology Department, Shanxi Provincial Academy of Traditional Chinese Medicine, Taiyuan, Shanxi 030012, China

Peer review under responsibility of Chongqing Medical University.

Cite this article:

Hou J-Y, Gao L-J, Shen J, et al. Crotonylation of PRKACA enhances PKA activity and promotes colorectal cancer development via the PKA-FAK-AKT pathway. Genes & Diseases, 2023, 10(2): 332-335. https://doi.org/10.1016/j.gendis.2022.02.018