Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R
Editors-in-Chief: Ailong Huang, Tong-Chuan He
Open Access
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Volume 10
Issue 2, March 2023
pp.301-637 50 articles
LETTER
Open Access Letter
Akt3 promotes cancer stemness in triple-negative breast cancer through YB1-Snail/Slug signaling axis
https://doi.org/10.1016/j.gendis.2022.08.006
Published: 01 September 2022
2023, 10 (2): 301-306
Downloads: 3 | Views: 107 | PDF (982.5 KB)
RESEARCH HIGHLIGHTS
Open Access Research Highlight
Glutamine-released ammonia acts as an unprecedented signaling molecule activating lipid production
https://doi.org/10.1016/j.gendis.2022.07.017
Published: 12 August 2022
2023, 10 (2): 307-309
Downloads: 1 | Views: 91 | PDF (472.1 KB)
Open Access Research Highlight
Engineered nucleus-free mesenchymal stem cells (MSCs) for the targeted delivery of therapeutics to disease site
https://doi.org/10.1016/j.gendis.2022.09.001
Published: 14 September 2022
2023, 10 (2): 310-312
Downloads: 3 | Views: 131 | PDF (461 KB)
RAPID COMMUNICATIONS
Open Access Rapid Communication
Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe
https://doi.org/10.1016/j.gendis.2022.02.004
Published: 17 March 2022
2023, 10 (2): 313-316
Downloads: 3 | Views: 111 | PDF (866.6 KB)
Open Access Rapid Communication
LncRNA-AP006284.1 promotes prostate cancer cell growth and motility by forming RNA-DNA triplexes and recruiting GNL3/SFPQ complex to facilitate RASSF7 transcription
https://doi.org/10.1016/j.gendis.2022.04.005
Published: 26 April 2022
2023, 10 (2): 317-320
Downloads: 2 | Views: 100 | PDF (797.7 KB)
Open Access Rapid Communication
Lipid catabolism and mitochondrial uncoupling are stimulated in brown adipose tissue of amyotrophic lateral sclerosis mouse models
https://doi.org/10.1016/j.gendis.2022.04.006
Published: 27 April 2022
2023, 10 (2): 321-324
Downloads: 3 | Views: 149 | PDF (794.2 KB)
Open Access Rapid Communication
Microtubule actin crosslinking factor 1 functions as a novel therapeutic target in lung metastasis of osteosarcoma
https://doi.org/10.1016/j.gendis.2022.03.012
Published: 15 April 2022
2023, 10 (2): 325-328
Downloads: 3 | Views: 131 | PDF (1 MB)
Open Access Rapid Communication
Loss of the emei tumor suppressor promotes tumorigenesis via the JNK and Hippo pathway
https://doi.org/10.1016/j.gendis.2022.02.020
Published: 01 April 2022
2023, 10 (2): 329-331
Downloads: 2 | Views: 122 | PDF (1.2 MB)
Open Access Rapid Communication
Crotonylation of PRKACA enhances PKA activity and promotes colorectal cancer development via the PKA-FAK-AKT pathway
https://doi.org/10.1016/j.gendis.2022.02.018
Published: 31 March 2022
2023, 10 (2): 332-335
Downloads: 2 | Views: 130 | PDF (1 MB)
Open Access Rapid Communication
SETD2 mediates immunotherapy and radiotherapy efficacy via regulating DNA damage responses and genomic stability in lung adenocarcinoma
https://doi.org/10.1016/j.gendis.2022.02.016
Published: 28 March 2022
2023, 10 (2): 336-339
Downloads: 1 | Views: 93 | PDF (1.2 MB)
Open Access Rapid Communication
A network based efficient drug repurposing strategy for targeting diabesity
https://doi.org/10.1016/j.gendis.2022.02.015
Published: 28 March 2022
2023, 10 (2): 340-343
Downloads: 1 | Views: 113 | PDF (1.3 MB)
Open Access Rapid Communication
MyD88 in macrophages protects against colitis via inhibiting the activation of NLRP3 inflammasome in epithelial cells
https://doi.org/10.1016/j.gendis.2022.04.021
Published: 18 May 2022
2023, 10 (2): 344-347
Downloads: 1 | Views: 90 | PDF (943 KB)
Open Access Rapid Communication
β-Arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity
https://doi.org/10.1016/j.gendis.2022.04.017
Published: 17 May 2022
2023, 10 (2): 348-351
Downloads: 2 | Views: 106 | PDF (1.1 MB)
Open Access Rapid Communication
OXCT1 regulates NF-κB signaling pathway through β-hydroxybutyrate-mediated ketone body homeostasis in lung cancer
https://doi.org/10.1016/j.gendis.2022.04.020
Published: 11 May 2022
2023, 10 (2): 352-355
Downloads: 3 | Views: 132 | PDF (951.5 KB)
Open Access Rapid Communication
CTGF/CCN2 promotes the proliferation of human osteosarcoma cells via cross-talking with the stromal CXCL12/CXCR4-AKT-αvβ3 signaling axis in tumor microenvironment
https://doi.org/10.1016/j.gendis.2022.04.016
Published: 06 May 2022
2023, 10 (2): 356-358
Downloads: 2 | Views: 108 | PDF (694.8 KB)
Open Access Rapid Communication
Single-cell analysis reveals the lncRNA-MEG3/miRNA-133a-3p/PRRT2 axis regulates skeletal muscle regeneration and myogenesis
https://doi.org/10.1016/j.gendis.2022.04.012
Published: 05 May 2022
2023, 10 (2): 359-362
Downloads: 1 | Views: 98 | PDF (1,016.9 KB)
Open Access Rapid Communication
The landscape of UBE2S in hepatocellular carcinoma: Prognostic significance, immuno-oncology feature and drug response
https://doi.org/10.1016/j.gendis.2022.04.010
Published: 30 April 2022
2023, 10 (2): 363-365
Downloads: 5 | Views: 148 | PDF (810.9 KB)
Open Access Rapid Communication
BAF45D regulates spinal cord neural stem/progenitor cell fate through the SMAD-PAX6 axis
https://doi.org/10.1016/j.gendis.2022.05.007
Published: 20 May 2022
2023, 10 (2): 366-369
Downloads: 4 | Views: 100 | PDF (798.6 KB)
Open Access Rapid Communication
Circular RNA circEIF3C promotes intrahepatic cholangiocarcinoma progression and immune evasion via the miR-34a-5p/B7–H4 axis
https://doi.org/10.1016/j.gendis.2022.05.005
Published: 19 May 2022
2023, 10 (2): 370-372
Downloads: 1 | Views: 120 | PDF (819.6 KB)
Open Access Rapid Communication
Coding variants of the interleukin-11 receptor with reduced protein maturation show protease-dependent trans-signaling and transduce normal STAT3 signaling
https://doi.org/10.1016/j.gendis.2022.05.001
Published: 16 May 2022
2023, 10 (2): 373-376
Downloads: 1 | Views: 95 | PDF (690 KB)
Open Access Rapid Communication
An integrated genome-wide analysis identifies HUR/ELAVL1 as a positive regulator of osteogenesis through enhancing the β-catenin signaling activity
https://doi.org/10.1016/j.gendis.2022.04.022
Published: 13 May 2022
2023, 10 (2): 377-380
Downloads: 3 | Views: 125 | PDF (1.3 MB)
Open Access Rapid Communication
Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility
https://doi.org/10.1016/j.gendis.2022.04.023
Published: 13 May 2022
2023, 10 (2): 381-384
Downloads: 2 | Views: 82 | PDF (1.4 MB)
Open Access Rapid Communication
Coronaviruses RNA interacts with host miR-500a-5p and miR-501-5p to regulate multiple pathways
https://doi.org/10.1016/j.gendis.2022.07.008
Published: 06 August 2022
2023, 10 (2): 385-388
Downloads: 1 | Views: 120 | PDF (1.3 MB)
Open Access Rapid Communication
Crystal structure of RNA helicase from Saint Louis encephalitis virus and discovery of its inhibitors
https://doi.org/10.1016/j.gendis.2022.07.001
Published: 31 July 2022
2023, 10 (2): 389-392
Downloads: 3 | Views: 113 | PDF (1.2 MB)
Open Access Rapid Communication
Transcriptomic analysis identifies a pan-cancer association of IL27 expression with cancer prognosis and immune microenvironment
https://doi.org/10.1016/j.gendis.2022.08.016
Published: 16 September 2022
2023, 10 (2): 393-395
Downloads: 1 | Views: 110 | PDF (1.1 MB)
Open Access Rapid Communication
A focused transcriptomic analysis of the TP53-regulated genes identifies the GPI-anchored molecule-like protein (GML) as a favorable prognostic predictor of lung cancer
https://doi.org/10.1016/j.gendis.2022.08.022
Published: 11 October 2022
2023, 10 (2): 396-398
Downloads: 2 | Views: 93 | PDF (493.7 KB)
Open Access Rapid Communication
Stabilization of MYC G-quadruplex DNA by ruthenium (Ⅱ) complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation
https://doi.org/10.1016/j.gendis.2022.08.019
Published: 07 September 2022
2023, 10 (2): 399-402
Downloads: 3 | Views: 120 | PDF (1.2 MB)
REVIEW ARTICLES
Open Access Review Article
Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead
https://doi.org/10.1016/j.gendis.2021.08.011
Published: 28 September 2021
2023, 10 (2): 403-414
Downloads: 4 | Views: 174 | PDF (2.4 MB)
Open Access Review Article
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology
https://doi.org/10.1016/j.gendis.2021.08.012
Published: 23 October 2021
2023, 10 (2): 415-429
Downloads: 2 | Views: 135 | PDF (1.7 MB)
Open Access Review Article
Oncolytic viruses: A novel treatment strategy for breast cancer
https://doi.org/10.1016/j.gendis.2021.11.011
Published: 16 December 2021
2023, 10 (2): 430-446
Downloads: 5 | Views: 152 | PDF (1.3 MB)
Open Access Review Article
The role of autophagy in regulating metabolism in the tumor microenvironment
https://doi.org/10.1016/j.gendis.2021.10.010
Published: 03 December 2021
2023, 10 (2): 447-456
Downloads: 1 | Views: 136 | PDF (1.6 MB)
Open Access Review Article
Sterol carrier protein 2: A promising target in the pathogenesis of atherosclerosis
https://doi.org/10.1016/j.gendis.2021.12.007
Published: 10 January 2022
2023, 10 (2): 457-467
Downloads: 2 | Views: 131 | PDF (1.1 MB)
Open Access Review Article
The recent advances and future perspectives of genetic compensation studies in the zebrafish model
https://doi.org/10.1016/j.gendis.2021.12.003
Published: 05 January 2022
2023, 10 (2): 468-479
Downloads: 1 | Views: 141 | PDF (1 MB)
Open Access Review Article
Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis
https://doi.org/10.1016/j.gendis.2021.12.006
Published: 06 January 2022
2023, 10 (2): 480-494
Downloads: 1 | Views: 124 | PDF (1.7 MB)
Open Access Review Article
The role of regulators of RNA m6A methylation in lung cancer
https://doi.org/10.1016/j.gendis.2021.12.017
Published: 29 January 2022
2023, 10 (2): 495-504
Downloads: 4 | Views: 134 | PDF (646.4 KB)
Open Access Review Article
The essential role of N6-methyladenosine RNA methylation in complex eye diseases
https://doi.org/10.1016/j.gendis.2022.05.008
Published: 26 May 2022
2023, 10 (2): 505-520
Downloads: 1 | Views: 131 | PDF (2 MB)
FULL LENGTH ARTICLES
Open Access Full Length Article
Phase Ⅰ trial of human umbilical cord-derived mesenchymal stem cells for treatment of severe bronchopulmonary dysplasia
https://doi.org/10.1016/j.gendis.2022.02.001
Published: 22 February 2022
2023, 10 (2): 521-530
Downloads: 1 | Views: 132 | PDF (2 MB)
Open Access Full Length Article
LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy
https://doi.org/10.1016/j.gendis.2021.11.004
Published: 24 November 2021
2023, 10 (2): 531-541
Downloads: 3 | Views: 150 | PDF (3.8 MB)
Open Access Full Length Article
Metformin ameliorates HMGB1-mediated oxidative stress through mTOR pathway in experimental periodontitis
https://doi.org/10.1016/j.gendis.2021.06.003
Published: 30 June 2021
2023, 10 (2): 542-553
Downloads: 2 | Views: 150 | PDF (2.7 MB)
Open Access Full Length Article
N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis
https://doi.org/10.1016/j.gendis.2022.02.014
Published: 26 March 2022
2023, 10 (2): 554-567
Downloads: 1 | Views: 118 | PDF (3.1 MB)
Open Access Full Length Article
Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer
https://doi.org/10.1016/j.gendis.2021.12.019
Published: 09 February 2022
2023, 10 (2): 568-582
Downloads: 1 | Views: 112 | PDF (5.3 MB)
Open Access Full Length Article
Cathepsin K contributed to disturbed flow-induced atherosclerosis is dependent on integrin-actin cytoskeleton–NF–κB pathway
https://doi.org/10.1016/j.gendis.2022.03.020
Published: 25 April 2022
2023, 10 (2): 583-595
Downloads: 1 | Views: 148 | PDF (5.2 MB)
Open Access Full Length Article
A novel coumarin derivative DBH2 inhibits proliferation and induces apoptosis of chronic myeloid leukemia cells
https://doi.org/10.1016/j.gendis.2022.08.021
Published: 08 September 2022
2023, 10 (2): 596-607
Downloads: 1 | Views: 104 | PDF (3.2 MB)
Open Access Full Length Article
Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/overweight
https://doi.org/10.1016/j.gendis.2022.10.023
Published: 29 November 2022
2023, 10 (2): 608-617
Downloads: 1 | Views: 127 | PDF (3 MB)
Erratums
Open Access Erratum
Corrigendum to ‘Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)’ [Genes Dis 8 (2021) 814-826]
https://doi.org/10.1016/j.gendis.2023.02.001
Published: 28 February 2023
2023, 10 (2): 618-619
Downloads: 1 | Views: 117 | PDF (595.1 KB)
Open Access Erratum
Corrigendum to ‘Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways’ [Genes & Diseases 9 (2022) 466–478]
https://doi.org/10.1016/j.gendis.2023.02.002
Published: 28 February 2023
2023, 10 (2): 620-623
Downloads: 2 | Views: 138 | PDF (1.9 MB)
Open Access Erratum
Corrigendum to “Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs)” [Genes & Diseases 4 (2017) 229–239]
https://doi.org/10.1016/j.gendis.2023.02.003
Published: 28 February 2023
2023, 10 (2): 624-626
Downloads: 3 | Views: 152 | PDF (788.6 KB)
Open Access Erratum
Corrigendum to “The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs” [Genes & Diseases 5 (2018) 62–74]
https://doi.org/10.1016/j.gendis.2023.02.004
Published: 26 February 2023
2023, 10 (2): 627-629
Downloads: 1 | Views: 101 | PDF (598 KB)
Open Access Erratum
Corrigendum to “Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes (imPODs)” [Genes & Diseases 5 (2018) 137–149]
https://doi.org/10.1016/j.gendis.2023.02.005
Published: 24 February 2023
2023, 10 (2): 630-631
Downloads: 2 | Views: 110 | PDF (649.9 KB)
Open Access Erratum
Corrigendum to “Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference” [Genes & Diseases 5(2018):172–184]
https://doi.org/10.1016/j.gendis.2023.03.001
Published: 23 March 2023
2023, 10 (2): 632-637
Downloads: 2 | Views: 101 | PDF (3.2 MB)