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Food Science and Human Wellness 2021, 10(2): 119-130 https://doi.org/10.1016/j.fshw.2021.02.016
Review Article | Open Access | Issue | Published: 22 March 2021

Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review

Show Author's Information Wen Zenga,  Dong Hea,  Yifan Xinga,  Junyu Liua,  Nan Sua,  Chong Zhanga,b,  Yi Wanga( ),  Xinhui Xinga,b,c( )
MOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
Centre for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China
Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China

Peer review under responsibility of KeAi Communications Co., Ltd

Keywords:
Ulcerative colitis, Gut microbiome, Dietary intake, Metabolite, Homeostasis
Cite this article:
Zeng W, He D, Xing Y, et al. Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review. Food Science and Human Wellness, 2021, 10(2): 119-130. https://doi.org/10.1016/j.fshw.2021.02.016
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Abstract Full text About this article

Ulcerative colitis (UC) is a chronic systematic inflammation disorder with increasing incidence, unknown pathogenesis, limited drug treatment, and abundant medical expenses. Dietary intake, as a daily indispensable environment factor, is closely related to UC pathogenesis and prevention. The underlying interactions between dietary intake and UC progression are implicated with the modulation of gut microbiome as well as microbial metabolites, suggesting the complex and systematic characteristics of UC. However, the triangular relationships with dietary intake, gut microbiota homeostasis, and UC have not been well summarized so far. Here we review the recent studies of dietary intake on the regulation of gut microbiome homeostasis as well as modulation of UC progression. These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites, which contribute to gut microbiome homeostasis through multiple manipulations including immune modulation, inflammation restriction as well as epithelial barrier maintenance, thus finally determine the fate of UC progression and give implications for functional food development for prevention and treatment of UC patients.


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About this article

Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review

Show Author's information Wen Zenga, Dong Hea, Yifan Xinga, Junyu Liua, Nan Sua, Chong Zhanga,b, Yi Wanga( ), Xinhui Xinga,b,c( )
MOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
Centre for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China
Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China

Peer review under responsibility of KeAi Communications Co., Ltd

Abstract

Ulcerative colitis (UC) is a chronic systematic inflammation disorder with increasing incidence, unknown pathogenesis, limited drug treatment, and abundant medical expenses. Dietary intake, as a daily indispensable environment factor, is closely related to UC pathogenesis and prevention. The underlying interactions between dietary intake and UC progression are implicated with the modulation of gut microbiome as well as microbial metabolites, suggesting the complex and systematic characteristics of UC. However, the triangular relationships with dietary intake, gut microbiota homeostasis, and UC have not been well summarized so far. Here we review the recent studies of dietary intake on the regulation of gut microbiome homeostasis as well as modulation of UC progression. These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites, which contribute to gut microbiome homeostasis through multiple manipulations including immune modulation, inflammation restriction as well as epithelial barrier maintenance, thus finally determine the fate of UC progression and give implications for functional food development for prevention and treatment of UC patients.

Keywords: Ulcerative colitis, Gut microbiome, Dietary intake, Metabolite, Homeostasis

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Received: 04 January 2020
Revised: 24 March 2020
Accepted: 23 June 2020
Published: 22 March 2021
Issue date: March 2021

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© 2021 Beijing Academy of Food Sciences.

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Acknowledgements

This work was supported by the National Key Research and Development Plan, China (2016YFD0400203-4).

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