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Food Science and Human Wellness 2020, 9(4): 338-345 https://doi.org/10.1016/j.fshw.2020.05.008
Research Article | Open Access | Issue | Published: 03 June 2020

Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice

Show Author's Information Xin Liua,  Chenmin Jianga,  Yong Chena,  Fangxiong Shib,  Chaoqiang Laic,  Lirong Shena( )
Department of Food Science and Nutrition, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, China
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
USDA ARS, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111, United States

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Action mechanism, Major royal jelly proteins, Immature female mice, Puberty onset, Follicular development
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Liu X, Jiang C, Chen Y, et al. Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice. Food Science and Human Wellness, 2020, 9(4): 338-345. https://doi.org/10.1016/j.fshw.2020.05.008
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Abstract Full text About this article

The major royal jelly proteins (MRJPs) are the central constituents responsible for the specific activities of royal jelly. Here MRJPs via oral administration daily for 45 consecutive days were evaluated the effects on the reproductive parameters in immature female mice (FM). Neonatal FM were divided into four groups fed MRJPs with doses of 0, 125, 250 and 500mg/kg/body weight (M125, M250 and M500). The results in M125, M250 and M500 showed that the times of estrus were accelerated by 10.7%, 15.5% and 10.7%, the secondary follicles number were increased by 50.7%, 78.8% and 38.6%, the Graafian follicles were increased by 600.0% and 774.0% and 150.0%, respectively. M500 induced multi-oocyte follicles. The serum estradiol levels of the three groups were increased by 47.1%, 64.9% and 31.1%, the action of MRJPs raising hormone secretion level is mainly via upregulating expression of ERβ gene. Antioxidant parameters of ovarian tissue showed that the malondialdehyde levels in M125 and M250 were decreased, the superoxide dismutase activities and glutathione peroxidase activities in M125 and M250 were increased. In conclusion, MRJPs may accelerate onset of puberty and promote follicular development in FM. Our findings would facilitate better understanding of the benefit effect of MRJPs as the key ingredient in royal jelly on promoting fertility performance.


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About this article

Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice

Show Author's information Xin Liua, Chenmin Jianga, Yong Chena, Fangxiong Shib, Chaoqiang Laic, Lirong Shena( )
Department of Food Science and Nutrition, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, China
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
USDA ARS, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111, United States

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

The major royal jelly proteins (MRJPs) are the central constituents responsible for the specific activities of royal jelly. Here MRJPs via oral administration daily for 45 consecutive days were evaluated the effects on the reproductive parameters in immature female mice (FM). Neonatal FM were divided into four groups fed MRJPs with doses of 0, 125, 250 and 500mg/kg/body weight (M125, M250 and M500). The results in M125, M250 and M500 showed that the times of estrus were accelerated by 10.7%, 15.5% and 10.7%, the secondary follicles number were increased by 50.7%, 78.8% and 38.6%, the Graafian follicles were increased by 600.0% and 774.0% and 150.0%, respectively. M500 induced multi-oocyte follicles. The serum estradiol levels of the three groups were increased by 47.1%, 64.9% and 31.1%, the action of MRJPs raising hormone secretion level is mainly via upregulating expression of ERβ gene. Antioxidant parameters of ovarian tissue showed that the malondialdehyde levels in M125 and M250 were decreased, the superoxide dismutase activities and glutathione peroxidase activities in M125 and M250 were increased. In conclusion, MRJPs may accelerate onset of puberty and promote follicular development in FM. Our findings would facilitate better understanding of the benefit effect of MRJPs as the key ingredient in royal jelly on promoting fertility performance.

Keywords: Action mechanism, Major royal jelly proteins, Immature female mice, Puberty onset, Follicular development

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Publication history

Received: 12 February 2020
Revised: 18 April 2020
Accepted: 27 May 2020
Published: 03 June 2020
Issue date: December 2020

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© 2020 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

Acknowledgements

The authors are grateful to Dr. Quanwei Wei from Nanjing Agricultural University, Nanjing, China for his technical assistance. This work was supported by the National Natural Science Foundation of China (no. 31271848)

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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