Antioxidant and <i>α</i>-glucosidase inhibitiory activity of <i>Cercis chinensis</i> flowers

Juanjuan Zhang; Li Zhou; Lili Cui; Zhenhua Liu; Jinfeng Wei; Wenyi Kang

doi:10.1016/j.fshw.2020.04.003

Food Science and Human Wellness 2020, 9(4): 313-319 https://doi.org/10.1016/j.fshw.2020.04.003

Research Article | Issue | Published: 23 April 2020

Antioxidant and α-glucosidase inhibitiory activity of Cercis chinensis flowers

Show Author's Information Hide Author's Information Juanjuan Zhang^{^a^,^d^,¹}, Li Zhou^{^a^,^b^,^c^,¹}, Lili Cui^{^a^,^b^,^c}, Zhenhua Liu^{^a^,^c}, Jinfeng Wei^{^a^,^b^,^c^,^e}(

), Wenyi Kang^{^a^,^b^,^c}(

)

National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng, 475004, China

Kaifeng Key Laboratory of Functional Components in Health Food, Kaifeng, 475004, China

Joint International Research Laboratory of Food & Medicine Resource Function, Henan Province, Kaifeng, 475004, China

Zhengzhou City Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou, 450063, China

Minsheng College, Henan University, Kaifeng, Henan, 475004, China

1 These authors contributed equally to this work. Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Keywords:

α-glucosidase, Antioxidative activity, Cercis chinensis bunge, Chemical component

Cite this article:

Zhang J, Zhou L, Cui L, et al. Antioxidant and α-glucosidase inhibitiory activity of Cercis chinensis flowers. Food Science and Human Wellness, 2020, 9(4): 313-319. https://doi.org/10.1016/j.fshw.2020.04.003

Download citation

EndNote(RIS)

BibTeX

453

Views

Downloads

Citations

Crossref

N/A

WoS

Scopus

CSCD

Abstract Full text About this article

Abstract

Antioxidant and α-glucosidase inhibitiory active compounds of Cercis chinensis flowers were investigated with bio-assay guiding method. Ethyl acetate fraction (CLEa) and n-butanol fraction (CLBu) exhibited antioxidant and α-glucosidase inhibitiory activity in vitro, and the corresponding active fractions, EaFr.3, EaFr.5 and BuFr.1, exhibited higher antioxidant and α-glucosidase inhibitiory activity than those of other fractions. Eight compounds, ethyl gallate (1), stearic acid (2), docosanoic acid (3), 5α-stigmast-9(11)-en-3β-ol (4), kaempferol-3-O-α-rhamnopyranoside (5), vanillic acid (6), fisetin (7), and β-sitosterol (8), were isolated and identified from CLEa and CLBu. Ethyl gallate shown the highest antioxidant activity by scavenging DPPH radical and reducing ferric compared. Docosanoic acid and vanillic acid shown stronger α-glucosidase inhibitory activity than that of acarbose.

Full text

Abstract

Full text

Outline

About this article

Antioxidant and α-glucosidase inhibitiory activity of Cercis chinensis flowers

Show Author's information Hide Author's Information Juanjuan Zhang^{^a^,^d^,¹}, Li Zhou^{^a^,^b^,^c^,¹}, Lili Cui^{^a^,^b^,^c}, Zhenhua Liu^{^a^,^c}, Jinfeng Wei^{^a^,^b^,^c^,^e}(

), Wenyi Kang^{^a^,^b^,^c}(

)

National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng, 475004, China

Kaifeng Key Laboratory of Functional Components in Health Food, Kaifeng, 475004, China

Joint International Research Laboratory of Food & Medicine Resource Function, Henan Province, Kaifeng, 475004, China

Zhengzhou City Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou, 450063, China

Minsheng College, Henan University, Kaifeng, Henan, 475004, China

1 These authors contributed equally to this work. Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Abstract

Keywords: α-glucosidase, Antioxidative activity, Cercis chinensis bunge, Chemical component

References(34)

[1]

Chinese Academy of Sciences, China Flora Editorial Board, Flora of China, Science Press, Beijing, 1988.

[2]

Q. Wei, Q. Gui, Z. Qiu, et al., Microwave-assisted extraction and antioxidant activities in vitro of polysaccharides from Cercis chinensis Bunge flowers, Food Sci. 36 (2015) 39–44.

Google Scholar

[3]

X.M. Ma, P.F. Hu, L. Fang, et al., Study on antioxidant activity of essential oil from Cercis chinensis flowers in vitro, Food Res. Develop. 36 (2015) 5–7.

Google Scholar

[4]

X.Q. Sun, Study on scavenging free radical of total flavonoids of Cercis chinensis Bunge, Food Res. Develop. 36 (2015) 70–74.

Google Scholar

[5]

L.H. Mu, J.B. Li, J.Z. Yang, et al., New dibenz [b, f]oxepins from Cercis chinensis bunge, J. Asian Nat. Prod. Res. 9 (2007) 649–653, http://dx.doi.org/10.1080/10286020600979860.

DOI Google Scholar

[6]

M.J. Shi, N. He, W.J. Li, et al., Simultaneous determination of myricetrin, quercitrin and afzelin in leaves of Cercis chinensis by a fast and effective method of ionic liquid microextraction coupled with HPLC, Chem. Cent. J. 12 (2018) 1–9, http://dx.doi.org/10.1186/s13065-018-0391-8.

DOI Google Scholar

[7]

J.T. Wang, Antioxidant activity and antioxidant activity in vivo of red pigment from flowers of Cercis chinensis Bge, Food Sci. Technol. 36 (2011) 238–241.

Google Scholar

[8]

J.C. Liu, C.L. Zhang, Z.Z. Lv, et al., Extraction of total phenolics and flavanoids from peach blossoms and their antioxidant activity, J Food Safety Quality 4 (2013) 1750–1755.

Google Scholar

[9]

H.L. Sun, N. He, M.J. Shi, et al., Study on spectrum-effect relationship of inhibitory effects of the extract of Cercis chinensis leaves on the activity of tyrosinase, China Pharm. 29 (2018) 3340–3343.

Google Scholar

[10]

Y. Zhang, T.D. Li, Y.F. Gao, et al., Anti-inflammatory, analgesic, anti-hypoxia and anti-fatigue effect of Cercis chinensis leaf on model mice, China Pharm. 20 (2009) 2817–2818.

Google Scholar

[11]

J.T. Wang, G.Q. Wu, M.Y. Yang, Study of red pigment from flowers of Cercis chinensis Bge on blood glucose and serum lipid levels in model rats, Sci. Technol. Food Ind. 34 (2013) 330–337.

DOI Google Scholar

[12]

W.X. Hao, M. Wang, M.X. Lv, The inhibitory effects of Yixing Black Tea extracts on α-glucosidase, J. Food Biochem. 41 (2017) 1–6, http://dx.doi.org/10.1111/jfbc.12269.

DOI Google Scholar

[13]

J. Wei, G. Zhang, X. Zhang, et al., Polyphenols from Sorbus aucuparia ameliorate insulin resistance and metabolic disorders in diabetic mice, Curr. Top. Nutraceut. Res. 14 (2016) 227–233.

Google Scholar

[14]

S. Cadenas, ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection, Free Radical Biol, Med. 117 (2018) 76–89, http://dx.doi.org/10.1016/j.freeradbiomed.2018.01.024.

DOI Google Scholar

[15]

C.D. Ochoa, R.F. Wu, L.S. Terada, ROS signaling and ER stress in cardiovascular disease, Mol. Aspects Med. 63 (2018) 18–29, http://dx.doi.org/10.1016/j.mam.2018.03.002.

DOI Google Scholar

[16]

B.P. Xu, M. Yao, Z.J. Li, et al., Neurological recovery and antioxidant effects of resveratrol in rats with spinal cord injury: a meta-analysis, Neural Regen. Res. 15 (2020) 482–490, http://dx.doi.org/10.4103/1673-5374.266064.

DOI Google Scholar

[17]

B.Y. Aju, R. Rajalakshmi, S. Mini, Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats, Heliyon 5 (2019), e02935, http://dx.doi.org/10.1016/j.heliyon.2019.e02935.

DOI Google Scholar

[18]

X.C. Guo, Z.J. Zhang, Z.Y. Xia, et al., Content determination of four triterpenes in Caragana sinica by HPLC and α-glucosidase activity assay in vitro, Chin. Pharm. J. 52 (2017) 488–493, http://dx.doi.org/10.11669/cpj.2017.06.013.

DOI Google Scholar

[19]

Q.F. Guo, L. Chen, Z.H. Yin, et al., Secondary metabolites and α-glucosidase inhibitory activities of Chaetomium globosum H6, Mycosystema 38 (2019) 134–144, http://dx.doi.org/10.13346/j.mycosystema.180155.

DOI Google Scholar

[20]

X.D. Zhu, X. Zhang, H.Y. Wang, et al., Antioxidant activity of Smilax glabra Roxb. Leave and seed in vitro, Nat. Prod. Res. Dev. 28 (2016) 1816–1821.

Google Scholar

[21]

J.M. Wang, Y. Chen, C.C. Lu, et al., Spectrum-effect relationship of antioxidant activity of wine fried Ligustrum lucidum fructus, Chin. Pharm. J. 51 (2016) 1907–1912.

Google Scholar

[22]

W.Y. Kang, J.M. Wang, In vitro antioxidant properties and in vivo lowering blood lipid of Forsythia suspense leaves, Med. Chem. Res. 19 (2010) 617–628, http://dx.doi.org/10.1007/s00044-009-9217-5.

DOI Google Scholar

[23]

J.M. Wang, Y. Chen, C.Q. Li, et al., Spectrum-effect relation of antioxidant activity of Flos Carthami based on DPPH, ABTS and FRAP assay, Chin. Pharm. J. 52 (2017) 825–831.

Google Scholar

[24]

C.Q. Li, Y. Chen, R.Y. Zhu, et al., Spectrum-effect relationship in antioxidant activity of Ligustri Lucidi Fructus based on DPPH, ABTS and FRAP assays, China J. Chin. Mater. Med. 41 (2016) 1670–1677, http://dx.doi.org/10.4268/cjcmm20160917.

DOI Google Scholar

[25]

B. Bi, C.L. Niu, J.S. Bao, et al., Studies on chemical constituents from Potentilla discolor, J. Jilin agric. Univ. 32 (2010) 425–427.

Google Scholar

[26]

M. Zhang, M. Chen, H.Q. Zhang, et al., Studies on the chemical constituents of the root bark of Morus alba L, Nat. Prod. Res. Dev. 22 (2010) 416–418.

Google Scholar

[27]

H.L. Wang, X. Li, J.W. Chen, Study on chemical constituents of medicinal herb Polygala japonica from Polygalaceae, J. Nanjing TCM Univ. 27 (2011) 470–473.

Google Scholar

[28]

S.H. Liu, Y.L. Wang, J.F. Bai, et al., Chemical constituents from ficus tsiangii and their PTP1B inhibitory effects, Nat. Prod. Res. Dev. 28 (2016) 1741–1746.

Google Scholar

[29]

H.S. Wang, H.F. Dai, P. Wang, et al., Chemical constituents from litters of Casuarina equisetifolia and their biological activity, Nat. Prod. Res. Dev. 30 (390-395) (2018) 533.

Google Scholar

[30]

Y.C. Zhang, B. Zhang, X.P. Li, et al., Chemical constitutes from flesh of Trichosanthes kirilowii, Chin. Tradit. Herbal Drugs 50 (2019) 3284–3290.

Google Scholar

[31]

S.Y. Kang, J.Y. Kang, M.J. Oh, Antiviral activities of flavonoids isolated from the bark of rhus verniciflua stokes against fish pathogenic viruses in vitro, J. Microbiology 50 (2012) 293–300, http://dx.doi.org/10.1007/s12275-012-2068-7.

DOI Google Scholar

[32]

M. Bhat, S.S. Zinjarde, S.Y. Bhargava, et al., Antidiabetic Indian plants: a good source of potent amylase inhibitors, Evid. Complement. Alternat. Med. (2011), http://dx.doi.org/10.1093/ecam/nen040, 810207-810207.

[33]

D.A. Kuntz, C.A. Tarling, S.G. Withers, et al., Structural analysis of golgi α-mannosidase Ⅱ inhibitors identified from a focused glycosidase inhibitor screen, Biochem. 47 (2008) 10058–10068, http://dx.doi.org/10.1021/bi8010785.

DOI Google Scholar

[34]

Z.H. Yin, W. Zhang, F.J. Feng, et al., α-Glucosidase inhibitors isolated from medicinal plants, Food Sci. Hum. Wellness 3 (2014) 3–4, http://dx.doi.org/10.1016/j.fshw.2014.11.003.

DOI Google Scholar

About this article

Publication history

Acknowledgements

Publication history

Received: 17 December 2019

Revised: 16 January 2020

Accepted: 03 April 2020

Published: 23 April 2020

Issue date: December 2020

Copyright

Acknowledgements

This work was supported by Key Project in Science and Technology Agency of Henan Province (192102110112, 192102110214 and 182102410083); Innovation Training Program for College Students (201910475107 and MSCXSY2019036).