Omics insights into ocean health: Molecular adaptations and ecosystem resilience under climate stress

Despite extensive research documenting the impacts of climate change on marine ecosystems, the molecular mechanisms driving organismal and ecosystem resilience to ocean warming, acidification, and deoxygenation remain insufficiently understood. This review addresses this knowledge gap by synthesizing recent advances in omics technologies―including genomics, transcriptomics, proteomics, metabolomics, and epigenomics―that illuminate adaptive genetic, metabolic, and epigenetic processes in marine organisms. These approaches help identify climate-tolerant genetic variants, uncover metabolic pathways for stress mitigation, and reveal epigenetic modifications enabling rapid adaptation. Together, such insights are transforming biodiversity monitoring, predictive ecosystem modeling, and the evidence-based design of climate-resilient marine protected areas (MPAs) grounded in genomic and functional diversity. Studies on marine microbial communities further provide promising avenues for blue carbon ecosystem enhancement and climate mitigation. Integrating omics findings into global governance frameworks, including the United Nations Convention on the Law of the Sea (UNCLOS) and International Maritime Organization (IMO), strengthens adaptive fisheries management, spatial planning, and climate-resilient policy. Key challenges for multi-omics integration are discussed alongside innovative solutions, such as integrative analytical approaches and the adoption of standardized molecular indicators. By bridging molecular science, policy, and management, this review outlines how interdisciplinary collaboration can advance adaptive and sustainable stewardship of the ocean in an era of unprecedented environmental change.