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13 March 2020
Photoacoustic viscoelasticity imaging for the detection of acute hepatitis: a feasibility study
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Biomechanical assessments are essential for the understanding of physiological states and the characterization of certain tissue pathologies such as liver cirrhosis. In this work, we showed by the photoacoustic viscoelasticity (PAVE) imaging that obvious mechanical change was also observed in the development of the acute hepatitis owing to the hepatocyte enlargement and intracellular fluid increment, indicating that the PAVE technique can be developed as a supplementary method for detecting acute hepatitis in future. The feasibility of the PAVE imaging is validated by a group of agar phantoms. Furthermore, acute hepatitis pathological animal models were established and imaged ex vivo and in situ by the PAVE technique to demonstrate its capability for the mechanical characterization of acute hepatitis, and the imaging results were consistent with pathological results. The feasibility study of detecting acute hepatitis by the PAVE technique proved that this method has potential to be developed as a clinical biomechanical imaging method to supplement current clinical strategy for liver disease detection.
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Photoacoustic viscoelasticity imaging for the detection of acute hepatitis: a feasibility study
)
Abstract
Biomechanical assessments are essential for the understanding of physiological states and the characterization of certain tissue pathologies such as liver cirrhosis. In this work, we showed by the photoacoustic viscoelasticity (PAVE) imaging that obvious mechanical change was also observed in the development of the acute hepatitis owing to the hepatocyte enlargement and intracellular fluid increment, indicating that the PAVE technique can be developed as a supplementary method for detecting acute hepatitis in future. The feasibility of the PAVE imaging is validated by a group of agar phantoms. Furthermore, acute hepatitis pathological animal models were established and imaged ex vivo and in situ by the PAVE technique to demonstrate its capability for the mechanical characterization of acute hepatitis, and the imaging results were consistent with pathological results. The feasibility study of detecting acute hepatitis by the PAVE technique proved that this method has potential to be developed as a clinical biomechanical imaging method to supplement current clinical strategy for liver disease detection.
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Acknowledgements
This research was supported by the National Natural Science Foundation of China (61627827, 61331001, 91539127), the Science and Technology Planning Project of Guangdong Province, China (2015B020233016, 2014B020215003, 2014A020215031), the Postdoctoral Innovative Talent Support Program of China (BX201700084), and the Distinguished Young Teacher Project in Higher Education of Guangdong, China (YQ2015049). We thank the Third Affiliated Hospital of Sun Yat-Sen University for providing the results of shear wave elastography.
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