Review Article
Open Access
Issue
Published:
11 February 2023
Open Access
Issue
Published:
11 February 2023
Surface-functionalized design of blood-contacting biomaterials for preventing coagulation and promoting hemostasis
Cite this article:
WANG Y, ZHAI W, CHENG S, et al.
Surface-functionalized design of blood-contacting biomaterials for preventing coagulation and promoting hemostasis.
Friction,
2023, 11(8): 1371-1394.
https://doi.org/10.1007/s40544-022-0710-x
Download citation
569
Views
32
Downloads
Citations
68
Crossref
80
WoS
84
Scopus
0
CSCD
The anticoagulation and hemostatic properties of blood-contacting materials are opposite lines of research, but their realization mechanisms are inspired by each other. Contact between blood and implantable biomaterials is a classic problem in tribological research, as both antithrombotic and hemostatic materials are closely associated with this problem. Thrombus formation on the surfaces of blood-contacting biomedical devices can detrimentally affect their performance and patient life, so specific surface functionalization is required. Currently, intensive research has focused on the development of super-lubricated or super-hydrophobic coatings, as well as coatings that deliver antithrombotic drugs. In addition, hemostatic biomaterials with porous structures, biochemical substances, and strongly adhesive hydrogels can be used to achieve rapid and effective hemostasis via physical or biochemical mechanisms. This article reviews methods of preparing anticoagulant coatings on material surfaces and the current status of rapid hemostatic materials. It also summarizes fundamental concepts for the design and synthesis of anticoagulant and hemostatic materials by discussing thrombosis and hemostasis mechanisms in biomedical devices and normal organisms. Because there are relatively few reports reviewing the progress in surface-functionalized design for anticoagulation and hemostasis, it is anticipated that this review can provide a useful summary of the applications of both bio-adhesion and bio-lubrication techniques in the field of biomedical engineering.
menu
Abstract
Full text
Outline
About this article
Surface-functionalized design of blood-contacting biomaterials for preventing coagulation and promoting hemostasis
Abstract
The anticoagulation and hemostatic properties of blood-contacting materials are opposite lines of research, but their realization mechanisms are inspired by each other. Contact between blood and implantable biomaterials is a classic problem in tribological research, as both antithrombotic and hemostatic materials are closely associated with this problem. Thrombus formation on the surfaces of blood-contacting biomedical devices can detrimentally affect their performance and patient life, so specific surface functionalization is required. Currently, intensive research has focused on the development of super-lubricated or super-hydrophobic coatings, as well as coatings that deliver antithrombotic drugs. In addition, hemostatic biomaterials with porous structures, biochemical substances, and strongly adhesive hydrogels can be used to achieve rapid and effective hemostasis via physical or biochemical mechanisms. This article reviews methods of preparing anticoagulant coatings on material surfaces and the current status of rapid hemostatic materials. It also summarizes fundamental concepts for the design and synthesis of anticoagulant and hemostatic materials by discussing thrombosis and hemostasis mechanisms in biomedical devices and normal organisms. Because there are relatively few reports reviewing the progress in surface-functionalized design for anticoagulation and hemostasis, it is anticipated that this review can provide a useful summary of the applications of both bio-adhesion and bio-lubrication techniques in the field of biomedical engineering.
Keywords:
lubrication, hydrogel, hemostasis, anticoagulation, fibrous membrane
References(148)
[1]
Chen L, Qian L. Role of interfacial water in adhesion, friction, and wear—A critical review. Friction 9: 1–28 (2021)
[2]
Zhang Z, Yin N, Chen S, Liu C. Tribo-informatics: Concept, architecture, and case study. Friction 9: 642–655 (2021)
[3]
Jin Z M, Zheng J, Li W, Zhou Z R. Tribology of medical devices. Biosurf Biotribology 2: 173–192 (2016)
[4]
Neubauer K, Zieger B. Endothelial cells and coagulation. Cell Tissue Res 387: 391–398 (2022)
[5]
Gegenschatz-Schmid K, Buzzi S, Grossmann J, Roschitzki B, Urbanet R, Heuberger R, Glück D, Zucker A, Ehrbar M. Reduced thrombogenicity of surface-treated Nitinol implants steered by altered protein adsorption. Acta Biomater 137: 331–345 (2022)
[6]
Labarrere C A, Dabiri A E, Kassab G S. Thrombogenic and inflammatory reactions to biomaterials in medical devices. Front Bioeng Biotechnol 8: 123 (2020)
[7]
Yu P, Zhong W. Hemostatic materials in wound care. Burns & Trauma 9: tkab019 (2021)
[8]
Hu X, Chen H, Li J, Meng K, Wang Y, Li Y. A microfluidic bleeding model to investigate the effects of blood flow shear on microvascular hemostasis. Friction 10: 128–141 (2022)
[9]
Yang X, Liu W, Li N, Wang M, Liang B, Ullah I, Luis Neve A, Feng Y, Chen H, Shi C. Design and development of polysaccharide hemostatic materials and their hemostatic mechanism. Biomater Sci 5: 2357–2368 (2017)
[10]
Jaffer I H, Weitz J I. The blood compatibility challenge. Part 1: Blood-contacting medical devices: The scope of the problem. Acta Biomater 94: 2–10 (2019)
[11]
Hong Z, Yu X, Jiang H, Xue M, Peng S, Luo Y, Yin Z, Xie C. Influence of surface morphology and surface free energy on the anticoagulant properties of nanocone-shaped ZnO films. J Appl Polym Sci 139: 52005 (2022)
[12]
Liu K, Zhang F, Wei Y, Hu Q, Luo Q, Chen C, Wang J, Yang L, Luo R, Wang Y. Dressing blood-contacting materials by a stable hydrogel coating with embedded antimicrobial peptides for robust antibacterial and antithrombus properties. ACS Appl Mater Interfaces 13: 38947–38958 (2021)
[13]
Táborská J, Riedelová Z, Brynda E, Májek P, Riedel T. Endothelialization of an ePTFE vessel prosthesis modified with an antithrombogenic fibrin/heparin coating enriched with bound growth factors. RSC Adv 11: 5903–5913 (2021)
[14]
Yang X, Chen M, Li P, Ji Z, Wang M, Feng Y, Shi C. Fabricating poly(vinyl alcohol)/gelatin composite sponges with high absorbency and water-triggered expansion for noncompressible hemorrhage and wound healing. J Mater Chem B 9: 1568–1582 (2021)
[15]
Shin J, Cha B, Park J-S, Ko W, Kwon K S, Lee J-W, Kim H K, Shin Y W. Efficacy of a novel hemostatic adhesive powder in patients with upper gastrointestinal tumor bleeding. BMC Gastroenterol 21: 40 (2021)
[16]
Singh G, Nayal A, Malhotra S, Koul V. Dual functionalized chitosan based composite hydrogel for haemostatic efficacy and adhesive property. Carbohydr Polym 247: 116757 (2020)
[17]
García-Villén F, Souza M S I, de Melo Barbosa R, Borrego-Sánchez A, Sánchez-Espejo R, Ojeda-Riascos S, Iborra V C. Natural inorganic ingredients in wound healing. Curr Pharm Des 26: 621–641 (2020)
[18]
Shi Z, Lan G, Hu E, Lu F, Qian P, Liu J, Dai F, Xie R. Puff pastry-like chitosan/konjac glucomannan matrix with thrombin-occupied microporous starch particles as a composite for hemostasis. Carbohydr Polym 232: 115814 (2020)
[19]
Singh R, Shitiz K, Singh A. Chitin and chitosan: biopolymers for wound management. Int Wound J 14: 1276–1289 (2017)
[20]
Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico T J, Ridger V, Roddie H, Evans P C. Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nat Rev Cardiol 17: 52–63 (2020)
[21]
Givens C, Tzima E. Endothelial mechanosignaling: does one sensor fit all? Antioxid Redox Signal 25: 373–388 (2016)
[22]
Chen Y M, Kurokawa T, Tominaga T, Yasuda K, Osada Y, Gong J P, Yamamoto K, Ando J. Study on the sliding friction of endothelial cells cultured on hydrogel and the role of glycocalyx on friction reduction. Adv Eng Mater 12: 628–636 (2010)
[23]
Lin C, Kaper H J, Li W, Splinter R, Sharma P K. Role of endothelial glycocalyx in sliding friction at the catheter-blood vessel interface. Sci Rep 10: 11855 (2020)
[24]
Kenry, Loh K P, Lim C T. Molecular hemocompatibility of graphene oxide and its implication for antithrombotic applications. Small 11: 5105–5117 (2015)
[25]
Li L, Yang L, Liao Y, Yu H, Liang Z, Zhang B, Lan X, Luo R, Wang Y. Superhydrophilic versus normal polydopamine coating: A superior and robust platform for synergistic antibacterial and antithrombotic properties. Chem Eng J 402: 126196 (2020)
[26]
Thomas G, Andrew L F, Alan D M. Platelet physiology. Semin Thromb Hemostasis 42: 191–204 (2016)
[27]
Devine R, Singha P, Handa H. Versatile biomimetic medical device surface: Hydrophobin coated, nitric oxide-releasing polymer for antimicrobial and hemocompatible applications. Biomater Sci 7: 3438–3449 (2019)
[28]
Jaffer I H, Fredenburgh J C, Hirsh J, Weitz J I. Medical device-induced thrombosis: What causes it and how can we prevent it? J Thromb Haemostasis 13: S72–S81 (2015)
[29]
Schmaier A H. Physiologic activity of the contact activation system. Thromb Res 133: S41–S44 (2014)
[30]
Drozd N N, Lunkov A P, Shagdarova B T, Zhuikova Y V, Il'ina A V, Varlamov V P. Chitosan/heparin layer-by-layer coatings for improving thromboresistance of polyurethane. Surf Interfaces 28: 101674 (2022)
[31]
Julie Brogaard L, Anne-Mette H. Thrombin: A pivotal player in hemostasis and beyond. Semin Thromb Hemost 47: 759–774 (2021)
[32]
Cardenas J C. Thrombin generation following severe trauma: mechanisms, modulators, and implications for hemostasis and thrombosis. Shock 56: 682–690 (2021)
[33]
Lasne D, Jude B, Susen S. From normal to pathological hemostasis. Can J Anesth 53: S2–S11 (2006)
[34]
Wang Y, Cheng L, Wen S, Zhou S, Wang Z, Deng L, Mao H-Q, Cui W, Zhang H. Ice-inspired superlubricated electrospun nanofibrous membrane for preventing tissue adhesion. Nano Lett 20: 6420–6428 (2020)
[35]
Cheng L, Wang Y, Sun G, Wen S, Deng L, Zhang H, Cui W. Hydration-enhanced lubricating electrospun nanofibrous membranes prevent tissue adhesion. Research 2020: 4907185 (2020)
[36]
Yan Y, Neville A, Dowson D. Biotribocorrosion-an appraisal of the time interactions: I. The role of corrosion. J Phys D: Appl Phys 39: 3200–3205 (2006)
[37]
Yan Y, Neville A, Dowson D. Biotribocorrosion-an appraisal of the time interactions: II. Surface analysis. J Phys D: Appl Phys 39: 3206–3212 (2006)
[38]
Zhao W W, Wang H, Han Y, Wang H M, Sun Y L, Zhang H Y. Dopamine/phosphorylcholine copolymer as efficient joint lubricant and ROS scavenger for the treatment of osteoarthritis. ACS Appl Mater Interfaces 12: 51236–51248 (2020)
[39]
Zheng Y W, Yan Y F, Zhao W W, Wang H M, Sun Y L, Han J M, Zhang H Y. Self-assembled nanospheres with enhanced interfacial lubrication for the treatment of osteoarthritis. ACS Appl Mater Interfaces 14: 21773–21786 (2022)
[40]
Han Y, Zhao W W, Zheng Y W, Wang H M, Sun Y L, Zhang Y F, Luo J, Zhang H Y. Self-adhesive lubricated coating for enhanced bacterial resistance. Bioact Mater 6: 2535–2545 (2021)
[41]
Wang Y X, Sun Y L, Avestro A J, McGonigal P R, Zhang H Y. Supramolecular repair of hydration lubrication surfaces. Chem 8(2): 480–493 (2022)
[42]
Miao K, Wang J, Zhao Q, Wang K, Wen M, Zhang K. Water-based lubrication of niobium nitride. Friction 10: 842–853 (2022)
[43]
Zhang C, Chen J, Liu M, Liu Y, Liu Z, Chu H, Cheng Q, Wang J. Regulation mechanism of biomolecule interaction behaviors on the superlubricity of hydrophilic polymer coatings. Friction 10: 94–109 (2022)
[44]
Gao L, Zhao X, Ma S, Ma Z, Cai M, Liang Y-M, Zhou F. Constructing a biomimetic robust bi-layered hydrophilic lubrication coating on surface of silicone elastomer. Friction 10: 1046–1060 (2022)
[45]
Parada G, Yu Y, Riley W, Lojovich S, Tshikudi D, Ling Q, Zhang Y, Wang J, Ling L, Yang Y, Nadkarni S, Nabzdyk C, Zhao X. Ultrathin and robust hydrogel coatings on cardiovascular medical devices to mitigate thromboembolic and infectious complications. Adv Healthcare Mater 9: 2001116 (2020)
[46]
Cheng S, Liu X, Qian Y, Maitusong M, Yu K, Cao N, Fang J, Liu F, Chen J, Xu D, Zhu G, Ren T, Wang J A. Double-network hydrogel armored decellularized porcine pericardium as durable bioprosthetic heart valves. Adv Healthcare Mater 11: 2102059 (2022)
[47]
Park S K, Shin J H, Jung J H, Lee D Y, Choi D Y, Yoo S H. Polysaccharide-derivative coated intravascular catheters with superior multifunctional performance via simple and biocompatible method. Chem Eng J 433: 134565 (2022)
[48]
Zhang K, Yang J, Sun Y, Wang Y, Liang J, Luo J, Cui W, Deng L, Xu X, Wang B, Zhang H. Gelatin-based composite hydrogels with biomimetic lubrication and sustained drug release. Friction 10: 232–246 (2022)
[50]
Xu R, Cui X, Xin Q, Lu M, Li Z, Li J, Chen X. Zwitterionic PMCP-functionalized titanium surface resists protein adsorption, promotes cell adhesion, and enhances osteogenic activity. Colloids Surf B 206: 111928 (2021)
[51]
Zhu Z, Gao Q, Long Z, Huo Q, Ge Y, Vianney N, Daliko N A, Meng Y, Qu J, Chen H, Wang B. Polydopamine/poly (sulfobetaine methacrylate) co-deposition coatings triggered by CuSO4/H2O2 on implants for improved surface hemocompatibility and antibacterial activity. Bioact Mater 6: 2546–2556 (2021)
[52]
Yao M, Sun H, Guo Z, Sun X, Yu Q, Wu X, Yu C, Zhang H, Yao F, Li J. A starch-based zwitterionic hydrogel coating for blood-contacting devices with durability and bio-functionality. Chem Eng J 421: 129702 (2021)
[53]
Yang L, Wu H, Liu Y, Xia Q, Yang Y, Chen N, Yang M, Luo R, Liu G, Wang Y. A robust mussel-inspired zwitterionic coating on biodegradable poly(L-lactide) stent with enhanced anticoagulant, anti-inflammatory, and anti-hyperplasia properties. Chem Eng J 427: 130910 (2022)
[54]
Han K, Park T Y, Yong K, Cha H J. Combinational biomimicking of lotus leaf, mussel, and sandcastle worm for robust superhydrophobic surfaces with biomedical multifunctionality: antithrombotic, antibiofouling, and tissue closure capabilities. ACS Appl Mater Interfaces 11: 9777–9785 (2019)
[55]
Zeng Q, Zheng C, Han K, Wu W, Qi H, Wang K, Sahu P, Dong R, Lu T. A biomimic superhydrophobic and anti-blood adhesion coating. Prog Org Coat 140: 105498 (2020)
[56]
Li M, Zheng C, Zhang S, Wu B, Ding K, Huang X, Lei Y, Wang Y. A hydrophobic antifouling surface coating on bioprosthetic heart valves for enhanced antithrombogenicity. J Biomed Mater Res Part B 110: 1082–1092 (2022)
[57]
Broos K, Feys H B, De Meyer S F, Vanhoorelbeke K, Deckmyn H. Platelets at work in primary hemostasis. Blood Rev 25: 155–167 (2011)
[58]
Griffin L, Douglass M, Goudie M, Hopkins S P, Schmiedt C, Handa H. Improved polymer hemocompatibility for blood-contacting applications via s-nitrosoglutathione impregnation. ACS Appl Mater Interfaces 14: 11116–11123 (2022)
[59]
Ganzarolli de Oliveira M. S-nitrosothiols as platforms for topical nitric oxide delivery. Basic Clin Pharmacol Toxicol 119: S49–S56 (2016)
[60]
Zhao Q, Fan Y, Zhang Y, Liu J, Li W, Weng Y. Copper-based SURMOFs for nitric oxide generation: hemocompatibility, vascular cell growth, and tissue response. ACS Appl Mater Interfaces 11: 7872–7883 (2019)
[61]
Jiang L, Yao H, Luo X, Zou D, Han C, Tang C, He Y, Yang P, Chen J, Zhao A, Huang N. Copper-mediated synergistic catalytic titanium dioxide nanofilm with nitric oxide generation and anti-protein fouling for enhanced hemocompatibility and inflammatory modulation. Appl Mater Today 20: 100663 (2020)
[62]
Yu H, Yu S, Qiu H, Gao P, Chen Y, Zhao X, Tu Q, Zhou M, Cai L, Huang N, Xiong K, Yang Z. Nitric oxide-generating compound and bio-clickable peptide mimic for synergistically tailoring surface anti-thrombogenic and anti-microbial dual-functions. Bioact Mater 6: 1618–1627 (2021)
[63]
Lyu N, Du Z, Qiu H, Gao P, Yao Q, Xiong K, Tu Q, Li X, Chen B, Wang M, Pan G, Huang N, Yang Z. Mimicking the nitric oxide-releasing and glycocalyx functions of endothelium on vascular stent surfaces. Adv Sci 7: 2002330 (2020)
[64]
Rezaie A R, Giri H. Anticoagulant and signaling functions of antithrombin. J Thromb Haemostasis 18: 3142–3153 (2020)
[65]
Qiu M, Huang S, Luo C, Wu Z, Liang B, Huang H, Ci Z, Zhang D, Han L, Lin J. Pharmacological and clinical application of heparin progress: An essential drug for modern medicine. Biomed Pharmacother 139: 111561 (2021)
[66]
Yu C, Yang H, Wang L, Thomson J A, Turng L-S, Guan G. Surface modification of polytetrafluoroethylene (PTFE) with a heparin-immobilized extracellular matrix (ECM) coating for small-diameter vascular grafts applications. Mater Sci Eng C 128: 112301 (2021)
[67]
Johnbosco C, Zschoche S, Nitschke M, Hahn D, Werner C, Maitz M F. Bioresponsive starPEG-heparin hydrogel coatings on vascular stents for enhanced hemocompatibility. Mater Sci Eng C 128: 112268 (2021)
[68]
Qiu H, Qi P, Liu J, Yang Y, Tan X, Xiao Y, Maitz M F, Huang N, Yang Z. Biomimetic engineering endothelium-like coating on cardiovascular stent through heparin and nitric oxide-generating compound synergistic modification strategy. Biomaterials 207: 10–22 (2019)
[69]
Du H, Li C, Luan Y, Liu Q, Yang W, Yu Q, Li D, Brash J L, Chen H. An antithrombotic hydrogel with thrombin-responsive fibrinolytic activity: breaking down the clot as it forms. Mater Horiz 3: 556–562 (2016)
[70]
Li C, Du H, Yang A, Jiang S, Li Z, Li D, Brash J L, Chen H. Thrombosis-responsive thrombolytic coating based on thrombin-degradable tissue plasminogen activator (t-PA) nanocapsules. Adv Funct Mater 27: 1703934 (2017)
[71]
Cihova M, Müller E, Chandorkar Y, Thorwarth K, Fortunato G, Maniura-Weber K, Löffler J F, Rottmar M. Palladium-based metallic glass with high thrombogenic resistance for blood-contacting medical devices. Adv Funct Mater 32: 2108256 (2022)
[72]
Wang Y, Wu H, Zhou Z, Maitz Manfred F, Liu K, Zhang B, Yang L, Luo R, Wang Y. A thrombin-triggered self-regulating anticoagulant strategy combined with anti-inflammatory capacity for blood-contacting implants. Sci Adv 8: eabm3378 (2022)
[73]
Sun Q, Si J, Zhao L, Wei T, Wang T, Li F, Li Y, Shafiq M, Wang L, Liu R, Zhi D, Wang K. Direct thrombin inhibitor-bivalirudin improved the hemocompatibility of electrospun polycaprolactone vascular grafts. Composites Part B 234: 109702 (2022)
[74]
Zhao J, Bai L, Muhammad K, Ren X-k, Guo J, Xia S, Zhang W, Feng Y. Construction of hemocompatible and histocompatible surface by grafting antithrombotic peptide ACH11 and hydrophilic PEG. ACS Biomater Sci Eng 5: 2846–2857 (2019)
[75]
Memic A, Colombani T, Eggermont L J, Rezaeeyazdi M, Steingold J, Rogers Z J, Navare K J, Mohammed H S, Bencherif S A. Latest advances in cryogel technology for biomedical applications. Adv Ther 2: 1800114 (2019)
[76]
Xie X, Li D, Chen Y, Shen Y, Yu F, Wang W, Yuan Z, Morsi Y, Wu J, Mo X. Conjugate electrospun 3D gelatin nanofiber sponge for rapid hemostasis. Adv Healthcare Mater 10: 2100918 (2021)
[77]
Cui Y, Huang Z, Lei L, Li Q, Jiang J, Zeng Q, Tang A, Yang H, Zhang Y. Robust hemostatic bandages based on nanoclay electrospun membranes. Nat Commun 12: 5922 (2021)
[78]
He H, Zhou W, Gao J, Wang F, Wang S, Fang Y, Gao Y, Chen W, Zhang W, Weng Y, Wang Z, Liu H. Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity. Nat Commun 13: 552 (2022)
[79]
Zhu T, Wu J, Zhao N, Cai C, Qian Z, Si F, Luo H, Guo J, Lai X, Shao L, Xu J. Superhydrophobic/Superhydrophilic janus fabrics reducing blood loss. Adv Healthcare Mater 7: 1701086 (2018)
[80]
Wei X, Ding S, Liu S, Yang K, Cai J, Li F, Wang C, Lin S, Tian F. Polysaccharides-modified chitosan as improved and rapid hemostasis foam sponges. Carbohydr Polym 264: 118028 (2021)
[81]
Song X, Zhao Y, Liu Y, Zhang W, Yuan X, Xu L, Zhang J. Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges. Carbohydr Polym 273: 118615 (2021)
[82]
He Y, Wang J, Si Y, Wang X, Deng H, Sheng Z, Li Y, Liu J, Zhao J. A novel gene recombinant collagen hemostatic sponge with excellent biocompatibility and hemostatic effect. Int J Biol Macromol 178: 296–305 (2021)
[83]
Goncharuk O, Korotych O, Samchenko Y, Kernosenko L, Kravchenko A, Shtanova L, Tsуmbalуuk O, Poltoratska T, Pasmurtseva N, Mamyshev I, Pakhlov E, Siryk O. Hemostatic dressings based on poly(vinyl formal) sponges. Mater Sci Eng C 129: 112363 (2021)
[84]
Wei W, Liu J, Peng Z, Liang M, Wang Y, Wang X. Gellable silk fibroin-polyethylene sponge for hemostasis. Artif Cells Nanomed Biotechnol 48: 28–36 (2020)
[85]
Yuan H, Chen L, Hong F F. A biodegradable antibacterial nanocomposite based on oxidized bacterial nanocellulose for rapid hemostasis and wound healing. ACS Appl Mater Interfaces 12: 3382–3392 (2020)
[86]
Liang Y, Li M, Huang Y, Guo B. An integrated strategy for rapid hemostasis during tumor resection and prevention of postoperative tumor recurrence of hepatocellular carcinoma by antibacterial shape memory cryogel. Small 17: 2101356 (2021)
[87]
Zhao Y-F, Zhao J-Y, Hu W-Z, Ma K, Chao Y, Sun P-J, Fu X-B, Zhang H. Synthetic poly(vinyl alcohol)–chitosan as a new type of highly efficient hemostatic sponge with blood-triggered swelling and high biocompatibility. J Mater Chem B 7: 1855–1866 (2019)
[88]
Zhang Z, Kuang G, Zong S, Liu S, Xiao H, Chen X, Zhou D, Huang Y. Sandwich-like fibers/sponge composite combining chemotherapy and hemostasis for efficient postoperative prevention of tumor recurrence and metastasis. Adv Mater 30: 1803217 (2018)
[89]
Du X, Wu L, Yan H, Jiang Z, Li S, Li W, Bai Y, Wang H, Cheng Z, Kong D, Wang L, Zhu M. Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing. Nat Commun 12: 4733 (2021)
[90]
Zheng C, Bai Q, Wu W, Han K, Zeng Q, Dong K, Zhang Y, Lu T. Study on hemostatic effect and mechanism of starch-based nano-microporous particles. Int J Biol Macromol 179: 507–518 (2021)
[91]
Zhang X, Jiang L, Li X, Zheng L, Dang R, Liu X, Wang X, Chen L, Zhang Y S, Zhang J, Yang D. A bioinspired hemostatic powder derived from the skin secretion of andrias davidianus for rapid hemostasis and intraoral wound healing. Small 18: 2101699 (2022)
[92]
Liu J-Y, Hu Y, Li L, Wang C, Wang J, Li Y, Chen D, Ding X, Shen C, Xu F-J. Biomass-derived multilayer-structured microparticles for accelerated hemostasis and bone repair. Adv Sci 7: 2002243 (2020)
[93]
Cheng H, Shi W, Feng L, Bao J, Chen Q, Zhao W, Zhao C. Facile and green approach towards biomass-derived hydrogel powders with hierarchical micro-nanostructures for ultrafast hemostasis. J Mater Chem B 9: 6678–6690 (2021)
[94]
Li J, Gao L, Xu R, Ma S, Ma Z, Liu Y, Wu Y, Feng L, Cai M, Zhou F. Fibers reinforced composite hydrogels with improved lubrication and load-bearing capacity. Friction 10: 54–67 (2022)
[95]
Maleki A, He J, Bochani S, Nosrati V, Shahbazi M-A, Guo B. Multifunctional photoactive hydrogels for wound healing acceleration. ACS Nano 15: 18895–18930 (2021)
[96]
Satyanarayana N, Sinha S K, Shen L. Effect of molecular structure on friction and wear of polymer thin films deposited on Si surface. Tribol Lett 28: 71–80 (2007)
[97]
Myshkin N K, Kovalev A. Polymer mechanics and tribology. Ind Lubr Tribol 70: 764–772 (2018)
[98]
Myshkin, N., Kovalev, A. Adhesion and surface forces in polymer tribology—A review. Friction 6: 143–155 (2018)
[99]
Pourshahrestani S, Zeimaran E, Kadri N A, Mutlu N, Boccaccini A R. Polymeric hydrogel systems as emerging biomaterial platforms to enable hemostasis and wound healing. Adv Healthcare Mater 9: 2000905 (2020)
[100]
Xia L, Wang S, Jiang Z, Chi J, Yu S, Li H, Zhang Y, Li L, Zhou C, Liu W, Han B. Hemostatic performance of chitosan-based hydrogel and its study on biodistribution and biodegradability in rats. Carbohydr Polym 264: 117965 (2021)
[101]
Cao J, Xiao L, Shi X. Injectable drug-loaded polysaccharide hybrid hydrogels for hemostasis. RSC Adv 9: 36858–36866 (2019)
[102]
Chen Z, Wu H, Wang H, Zaldivar-Silva D, Agüero L, Liu Y, Zhang Z, Yin Y, Qiu B, Zhao J, Lu X, Wang S. An injectable anti-microbial and adhesive hydrogel for the effective noncompressible visceral hemostasis and wound repair. Mater Sci Eng C 129: 112422 (2021)
[103]
Li Z, Zhao Y, Ouyang X, Yang Y, Chen Y, Luo Q, Zhang Y, Zhu D, Yu X, Li L. Biomimetic hybrid hydrogel for hemostasis, adhesion prevention and promoting regeneration after partial liver resection. Bioact Mater 11: 41–51 (2022)
[104]
Hong Y, Zhou F, Hua Y, Zhang X, Ni C, Pan D, Zhang Y, Jiang D, Yang L, Lin Q, Zou Y, Yu D, Arnot D E, Zou X, Zhu L, Zhang S, Ouyang H. A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds. Nat Commun 10: 2060 (2019)
[105]
Han K, Bai Q, Wu W, Sun N, Cui N, Lu T. Gelatin-based adhesive hydrogel with self-healing, hemostasis, and electrical conductivity. Int J Biol Macromol 183: 2142–2151 (2021)
[106]
Lu S, Zhang X, Tang Z, Xiao H, Zhang M, Liu K, Chen L, Huang L, Ni Y, Wu H. Mussel-inspired blue-light-activated cellulose-based adhesive hydrogel with fast gelation, rapid haemostasis and antibacterial property for wound healing. Chem Eng J 417: 129329 (2021)
[107]
Li W, Liu H, Mi Y, Zhang M, Shi J, Zhao M, Ramos M A, Hu T S, Li J, Xu M, Xu Q. Robust and conductive hydrogel based on mussel adhesive chemistry for remote monitoring of body signals. Friction 10: 80–93 (2022)
[108]
Juan Y, Vittorio S, Aldrik H V, Martien A C S, Marleen K. Reaction pathways in catechol/primary amine mixtures: a window on crosslinking chemistry. PLoS ONE 11: e0166490 (2016)
[109]
Qiao Z, Lv X, He S, Bai S, Liu X, Hou L, He J, Tong D, Ruan R, Zhang J, Ding J, Yang H. A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings. Bioact Mater 6: 2829–2840 (2021)
[110]
Pan G, Li F, He S, Li W, Wu Q, He J, Ruan R, Xiao Z, Zhang J, Yang H. Mussel- and barnacle cement proteins-inspired dual-bionic bioadhesive with repeatable wet-tissue adhesion, multimodal self-healing, and antibacterial capability for nonpressing hemostasis and promoted wound healing. Adv Funct Mater 32: 2200908 (2022)
[111]
Bu Y, Zhang L, Sun G, Sun F, Liu J, Yang F, Tang P, Wu D. Tetra-PEG based hydrogel sealants for in vivo visceral hemostasis. Adv Mater 31: 1901580 (2019)
[112]
Zhang K, Chen X, Xue Y, Lin J, Liang X, Zhang J, Zhang J, Chen G, Cai C, Liu J. Tough hydrogel bioadhesives for sutureless wound sealing, hemostasis and biointerfaces. Adv Funct Mater 32: 2111465 (2022)
[113]
Yuk H, Varela C E, Nabzdyk C S, Mao X, Padera R F, Roche E T, Zhao X. Dry double-sided tape for adhesion of wet tissues and devices. Nature 575: 169–174 (2019)
[114]
He J, Zhang Z, Yang Y, Ren F, Li J, Zhu S, Ma F, Wu R, Lv Y, He G, Guo B, Chu D. Injectable self-healing adhesive pH-responsive hydrogels accelerate gastric hemostasis and wound healing. Nano-Micro Lett 13: 80 (2021)
[115]
Rahman M M, Garcia N, Loh Y S, Marks D C, Banakh I, Jagadeesan P, Cameron N R, Yung-Chih C, Costa M, Peter K, Cleland H, Akbarzadeh S. A platelet-derived hydrogel improves neovascularisation in full thickness wounds. Acta Biomater 136: 199–209 (2021)
[116]
Lee J H, Jung H, Song J, Choi E S, You G, Mok H. Activated platelet-derived vesicles for efficient hemostatic activity. Macromol Biosci 20: 1900338 (2020)
[117]
Mendes B B, Gómez-Florit M, Araújo A C, Prada J, Babo P S, Domingues R M A, Reis R L, Gomes M E. Intrinsically bioactive cryogels based on platelet lysate nanocomposites for hemostasis applications. Biomacromolecules 21: 3678–3692 (2020)
[118]
Wang H, Zhu Y, Zhang L, Liu H, Liu C, Zhang B, Song Y, Hu Y, Pang Z. Nanoplateletsomes for rapid hemostasis performance. Chin Chem Lett 33(6): 2937–2941 (2022)
[119]
Li Q, Hu E, Yu K, Xie R, Lu F, Lu B, Bao R, Zhao T, Dai F, Lan G. Self-propelling janus particles for hemostasis in perforating and irregular wounds with massive hemorrhage. Adv Funct Mater 30: 2004153 (2020)
[120]
Shi Y, Ding X, Cao Y, Zhou H, Yu W, Liu M, Yin J, Liu H, Wang J, Huang C, Gong C, Wei H, Zhao G. Preparation and application of quick hemostatic gauze based on biomimetic mineralized thrombin. Biomater Sci 9: 6098–6107 (2021)
[121]
Leng F, Lei S, Luo B, Lv S, Huang L, Jiang X. Size-tunable and biodegradable thrombin-functionalized carboxymethyl chitin microspheres for endovascular embolization. Carbohydr Polym 286: 119274 (2022)
[122]
Lu B, Hu E, Xie R, Yu K, Lu F, Bao R, Wang C, Lan G, Dai F. Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes. Bioact Mater 16: 372–387 (2022)
[123]
Mendes L G, Ferreira F V, Sielski M S, Livi S, Rocco S A, Sforça M L, Burga-Sánchez J, Vicente C P, Mei L H I. Electrospun nanofibrous architectures of thrombin-loaded poly (ethylene oxide) for faster in vivo wound clotting. ACS Appl Bio Mater 4: 5240–5250 (2021)
[124]
Chen J, Qiu L, Li Q, Ai J, Liu H, Chen Q. Rapid hemostasis accompanied by antibacterial action of calcium crosslinking tannic acid-coated mesoporous silica/silver Janus nanoparticles. Mater Sci Eng C 123: 111958 (2021)
[125]
Liang Y, Xu C, Li G, Liu T, Liang J F, Wang X. Graphene-kaolin composite sponge for rapid and riskless hemostasis. Colloids Surf B Biointerfaces 169: 168–175 (2018)
[126]
Wang C, Zhou H, Niu H, Ma X, Yuan Y, Hong H, Liu C. Tannic acid-loaded mesoporous silica for rapid hemostasis and antibacterial activity. Biomater Sci 6: 3318–3331 (2018)
[127]
Wang C, Niu H, Ma X, Hong H, Yuan Y, Liu C. Bioinspired, injectable, quaternized hydroxyethyl cellulose composite hydrogel coordinated by mesocellular silica foam for rapid, noncompressible hemostasis and wound healing. ACS Appl Mater Interfaces 11: 34595–34608 (2019)
[128]
Fan X, Wang S, Fang Y, Li P, Zhou W, Wang Z, Chen M, Liu H. Tough polyacrylamide-tannic acid-kaolin adhesive hydrogels for quick hemostatic application. Mater Sci Eng C 109: 110649 (2020)
[129]
Wang Y, Kim K, Lee M S, Lee H. Hemostatic ability of chitosan-phosphate inspired by coagulation mechanisms of platelet polyphosphates. Macromol Biosci 18: 1700378 (2018)
[130]
Cao C, Yang N, Zhao Y, Yang D, Hu Y, Yang D, Song X, Wang W, Dong X. Biodegradable hydrogel with thermo-response and hemostatic effect for photothermal enhanced anti-infective therapy. Nano Today 39: 101165 (2021)
[131]
Dai M, Li M, Gong J, Meng L, Zhang B, Zhang Y, Yin Y, Wang J. Silk fibroin/gelatin/calcium alginate composite materials: Preparation, pore characteristics, comprehensive hemostasis in vitro. Mater Des 216: 110577 (2022)
[132]
Sundaram M N, Mony U, Varma P K, Rangasamy J. Vasoconstrictor and coagulation activator entrapped chitosan based composite hydrogel for rapid bleeding control. Carbohydr Polym 258: 117634 (2021)
[133]
Mahmoodzadeh A, Moghaddas J, Jarolmasjed S, Ebrahimi Kalan A, Edalati M, Salehi R. Biodegradable cellulose-based superabsorbent as potent hemostatic agent. Chem Eng J 418: 129252 (2021)
[134]
Park J-Y, Kyung K-H, Tsukada K, Kim S-H, Shiratori S. Biodegradable polycaprolactone nanofibers with β-chitosan and calcium carbonate produce a hemostatic effect. Polymer 123: 194–202 (2017)
[135]
Yu L, Shang X, Chen H, Xiao L, Zhu Y, Fan J. A tightly-bonded and flexible mesoporous zeolite-cotton hybrid hemostat. Nat Commun 10: 1932 (2019)
[136]
Ponsen A-C, Proust R, Soave S, Mercier-Nomé F, Garcin I, Combettes L, Lataillade J-J, Uzan G. A new hemostatic agent composed of Zn2+-enriched Ca2+ alginate activates vascular endothelial cells in vitro and promotes tissue repair in vivo. Bioact Mater 18: 368–382 (2022)
[137]
Ahmed N S, Lopes-Pires M, Pugh N. Zinc: An endogenous and exogenous regulator of platelet function during hemostasis and thrombosis. Platelets 32: 880–887 (2021)
[138]
Xu Y, Fang Y, Ou Y, Yan L, Chen Q, Sun C, Chen J, Liu H. Zinc metal–organic Framework@Chitin composite sponge for rapid hemostasis and antibacterial infection. ACS Sustainable Chem Eng 8: 18915–18925 (2020)
[139]
Wang Y, Ying M, Zhang M, Ren X, Kim I S. Development of antibacterial and hemostatic PCL/Zein/ZnO-quaternary ammonium salts NPs composite mats as wound dressings. Macromol Mater Eng 306: 2100587 (2021)
[140]
Lan G, Li Q, Lu F, Yu K, Lu B, Bao R, Dai F. Improvement of platelet aggregation and rapid induction of hemostasis in chitosan dressing using silver nanoparticles. Cellulose 27: 385–400 (2020)
[141]
Zhu Y, Liu H, Qin S, yang C, Lv Q, Wang Z, Wang L. Antibacterial sericin cryogels promote hemostasis by facilitating the activation of coagulation pathway and platelets. Adv Healthcare Mater 11: 2102717 (2022)
[142]
Liu J, Zhou X, Zhang Y, Wang A, Zhu W, Xu M, Zhuang S. Rapid hemostasis and high bioactivity cerium-containing mesoporous bioglass for hemostatic materials. J Biomed Mater Res B 110: 1255–1264 (2022)
[143]
Liu J, Zhou X, Zhang Y, Zhu W, Wang A, Xu M, Zhuang S. Rapid hemostasis and excellent antibacterial cerium-containing mesoporous bioactive glass/chitosan composite sponge for hemostatic material. Mater Today Chem 23: 100735 (2022)
[144]
Wang Z, Paul S, Stein L H, Salemi A, Mitra S. Recent developments in blood-compatible superhydrophobic surfaces. Polymers 14: 1075 (2022)
[145]
Xia X, Xu X, Wang B, Zhou D, Zhang W, Xie X, Lai H, Xue J, Rai A, Li Z, Peng X, Zhao P, Bian L, Chiu P W-Y. Adhesive hemostatic hydrogel with ultrafast gelation arrests acute upper gastrointestinal hemorrhage in pigs. Adv Funct Mater 32: 2109332 (2022)
[146]
Han T Y, Zhang S W, Zhang C H. Unlocking the secrets behind liquid superlubricity: A state-of-the-art review on phenomena and mechanisms. Friction 10(8): 1137–1165 (2022)
[147]
Liu W R, Simič R, Liu Y H, Spencer N D. Effect of contact geometry on the friction of acrylamide hydrogels with different surface structures. Friction 10(3): 360–373 (2022)
[148]
Zhou J, Wu Y, Zhang X, Lai J, Li Y, Xing J, Teng L, Chen J. Enzyme catalyzed hydrogel as versatile bioadhesive for tissue wound hemostasis, bonding, and continuous repair. Biomacromolecules 22: 1346–1356 (2021)
Publication history
Copyright
Acknowledgements
Rights and permissions
Publication history
Received: 24 April 2022
Revised: 23 June 2022
Accepted: 16 October 2022
Published:
11 February 2023
Issue date: August 2023
Copyright
© The author(s) 2022.
Acknowledgements
This study was financially supported by National Natural Science Foundation of China (52022043), Precision Medicine Foundation, Tsinghua University, China (10001020120), Capital’s Funds for Health Improvement and Research (2020-2Z-40810), Natural Science Foundation of Hebei Province (H2021201005), and Research Project of State Key Laboratory of Mechanical System and Vibration (MSV202209).
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
FEEDBACK 
TOP