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Friction 2023, 11(7): 1194-1211 https://doi.org/10.1007/s40544-022-0648-z
Research Article | Open Access | Issue | Published: 17 October 2022

Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release

Show Author's Information Xiaowei MAO1,2,†,  Kexin CHEN3,†,  Yanlong ZHAO2,  Chunrong Xiong1,  Jing LUO4,  Yuguang WANG5( ),  Bo WANG6( ),  Hongyu ZHANG2( )
School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China
State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
Peking University School of Nursing & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100191, China
Beijing Research Institute of Automation for Machinery Industry Co., Ltd., Beijing 100120, China
Center of Digital Dentistry, Peking University School and Hospital of Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing 100081, China
College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China

† Xiaowei MAO and Kexin CHEN contributed equally to this work.

Keywords:
surface functionalization, hydration lubrication, osteoarthritis, mesoporous silica nanoparticles, phosphorylcholine coating
Cite this article:
MAO X, CHEN K, ZHAO Y, et al. Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release. Friction, 2023, 11(7): 1194-1211. https://doi.org/10.1007/s40544-022-0648-z
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Abstract Full text About this article

Osteoarthritis is associated with the significantly increased friction of the joint, which results in progressive and irreversible damage to the articular cartilage. A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage osteoarthritis. In the present study, bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages, a biomimetic self-adhesive dopamine methacrylamide–poly(2-methacryloyloxyethyl phosphorylcholine) (DMA–MPC) copolymer was designed and synthesized via free radical polymerization. The copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles (bMSNs) by the dip-coating method to prepare the dual-functional nanoparticles (bMSNs@DMA–MPC), which were evaluated using a series of surface characterizations including the transmission electron microscope (TEM), Fourier transform infrared (FTIR) spectrum, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), etc. The tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug, i.e., diclofenac sodium (DS). In addition, the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 d. Furthermore, the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β (IL-1β) and interleukin-6 (IL-6). In summary, the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.


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About this article

Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release

Show Author's information Xiaowei MAO1,2,†, Kexin CHEN3,†, Yanlong ZHAO2, Chunrong Xiong1, Jing LUO4, Yuguang WANG5( ), Bo WANG6( ), Hongyu ZHANG2( )
School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China
State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
Peking University School of Nursing & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100191, China
Beijing Research Institute of Automation for Machinery Industry Co., Ltd., Beijing 100120, China
Center of Digital Dentistry, Peking University School and Hospital of Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing 100081, China
College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China

† Xiaowei MAO and Kexin CHEN contributed equally to this work.

Abstract

Osteoarthritis is associated with the significantly increased friction of the joint, which results in progressive and irreversible damage to the articular cartilage. A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage osteoarthritis. In the present study, bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages, a biomimetic self-adhesive dopamine methacrylamide–poly(2-methacryloyloxyethyl phosphorylcholine) (DMA–MPC) copolymer was designed and synthesized via free radical polymerization. The copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles (bMSNs) by the dip-coating method to prepare the dual-functional nanoparticles (bMSNs@DMA–MPC), which were evaluated using a series of surface characterizations including the transmission electron microscope (TEM), Fourier transform infrared (FTIR) spectrum, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), etc. The tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug, i.e., diclofenac sodium (DS). In addition, the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 d. Furthermore, the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β (IL-1β) and interleukin-6 (IL-6). In summary, the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.

Keywords: surface functionalization, hydration lubrication, osteoarthritis, mesoporous silica nanoparticles, phosphorylcholine coating

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Publication history
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Publication history

Received: 12 February 2022
Revised: 02 April 2022
Accepted: 08 May 2022
Published: 17 October 2022
Issue date: July 2023

Copyright

© The author(s) 2022.

Acknowledgements

This study was financially supported by the National Natural Science Foundation of China (52022043 and 21868011), Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program (20191080593), Precision Medicine Foundation, Tsinghua University, China (10001020107), the National Key R&D Program of China (2017YFC1103800), and Research Fund of State Key Laboratory of Tribology, Tsinghua University, China (SKLT2022C18).

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