Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy

Li WAN; Yi WANG; Xiaolong TAN; Yulong SUN; Jing LUO; Hongyu ZHANG

doi:10.1007/s40544-020-0391-2

Friction 2022, 10(1): 68-79 https://doi.org/10.1007/s40544-020-0391-2

Research Article |

Open Access | Issue | Published: 22 May 2020

Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy

Show Author's Information Hide Author's Information Li WAN^{¹^,²^,^†}, Yi WANG^{¹^,^†}, Xiaolong TAN^¹, Yulong SUN^¹, Jing LUO^³, Hongyu ZHANG^¹(

)

1State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China

2College of Mining, Guizhou University, Guiyang 550025, China

3Beijing Research Institute of Automation for Machinery Industry Co., Ltd., Beijing 100120, China

† These authors contributed equally to this work.

Keywords:

lubrication, drug delivery, osteoarthritis, biodegradable, mesoporous silica nanoparticles

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WAN L, WANG Y, TAN X, et al. Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy. Friction, 2022, 10(1): 68-79. https://doi.org/10.1007/s40544-020-0391-2

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Abstract

Osteoarthritis is characterized by lubrication failure of the articular cartilage and severe inflammation of the joint capsule. Lubricating mesoporous silica nanoparticles (MSNs) have been developed for the treatment of osteoarthritis based on enhanced lubrication and local drug delivery. However, MSNs are difficult to degrade in vivo in a short time, resulting in potential toxic effect due to bioaccumulation. In this study, biodegradable MSNs (bMSNs) were prepared through an oil-water biphase stratification method, and modified with poly(2-methacryloyloxyethyl phosphocholine) (PMPC) to synthesize lubricating drug-loaded nanoparticles (bMSNs-NH₂@PMPC) by photopolymerization. The in vitro degradation test demonstrated that the bMSNs and bMSNs-NH₂@PMPC almost degraded within 7 days. The tribiological test showed that the lubrication property of the bMSNs-NH₂@PMPC was greatly improved, with a reduction of 50% in the friction coefficient (COF) compared with the bMSNs. It was attributed to hydration lubrication mechanism by which a tenacious hydration layer is formed surrounding the zwitterionic headgroups (N⁺(CH₃)₃ and PO₄^- ) in PMPC polyelectrolyte polymer. Additionally, the bMSNs-NH₂@PMPC maintained excellent lubrication property under degradation and achieved sustained drug release behavior compared with the bMSNs. In summary, the biodegradable bMSNs-NH₂@PMPC developed in this study with the properties of enhanced lubrication and drug delivery may be a promising approach for osteoarthritis therapy.

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Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy

Show Author's information Hide Author's Information Li WAN^{¹^,²^,^†}, Yi WANG^{¹^,^†}, Xiaolong TAN^¹, Yulong SUN^¹, Jing LUO^³, Hongyu ZHANG^¹(

)

1State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China

2College of Mining, Guizhou University, Guiyang 550025, China

3Beijing Research Institute of Automation for Machinery Industry Co., Ltd., Beijing 100120, China

† These authors contributed equally to this work.

Abstract

Keywords: lubrication, drug delivery, osteoarthritis, biodegradable, mesoporous silica nanoparticles

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Acknowledgements

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Publication history

Received: 22 January 2020

Revised: 12 March 2020

Accepted: 27 March 2020

Published: 22 May 2020

Issue date: January 2022

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Acknowledgements

This study was ﬁnancially supported by National Natural Science Foundation of China (51675296), Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program (20191080593), Tsinghua University Initiative Scientific Research Program (20197050026), Foshan-Tsinghua Innovation Special Fund (FTISF), Research Fund of State Key Laboratory of Tribology, Tsinghua University, China (SKLT2020C11), and Ng Teng Fong Charitable Foundation (202-276-132-13).

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