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Research Article | Open Access

Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy

Li WAN1,2,†, Yi WANG1,†, Xiaolong TAN1, Yulong SUN1, Jing LUO3, Hongyu ZHANG1( )
State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
College of Mining, Guizhou University, Guiyang 550025, China
Beijing Research Institute of Automation for Machinery Industry Co., Ltd., Beijing 100120, China

† These authors contributed equally to this work.

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Abstract

Osteoarthritis is characterized by lubrication failure of the articular cartilage and severe inflammation of the joint capsule. Lubricating mesoporous silica nanoparticles (MSNs) have been developed for the treatment of osteoarthritis based on enhanced lubrication and local drug delivery. However, MSNs are difficult to degrade in vivo in a short time, resulting in potential toxic effect due to bioaccumulation. In this study, biodegradable MSNs (bMSNs) were prepared through an oil-water biphase stratification method, and modified with poly(2-methacryloyloxyethyl phosphocholine) (PMPC) to synthesize lubricating drug-loaded nanoparticles (bMSNs-NH2@PMPC) by photopolymerization. The in vitro degradation test demonstrated that the bMSNs and bMSNs-NH2@PMPC almost degraded within 7 days. The tribiological test showed that the lubrication property of the bMSNs-NH2@PMPC was greatly improved, with a reduction of 50% in the friction coefficient (COF) compared with the bMSNs. It was attributed to hydration lubrication mechanism by which a tenacious hydration layer is formed surrounding the zwitterionic headgroups (N+(CH3)3 and PO4- ) in PMPC polyelectrolyte polymer. Additionally, the bMSNs-NH2@PMPC maintained excellent lubrication property under degradation and achieved sustained drug release behavior compared with the bMSNs. In summary, the biodegradable bMSNs-NH2@PMPC developed in this study with the properties of enhanced lubrication and drug delivery may be a promising approach for osteoarthritis therapy.

Keywords

biodegradablemesoporous silica nanoparticleslubricationdrug deliveryosteoarthritis

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Friction
Volume 10 Issue 1,
January 2022
Pages 68-79
DOI: 10.1007/s40544-020-0391-2
Cite this article:
WAN L, WANG Y, TAN X, et al. Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy. Friction, 2022, 10(1): 68-79. https://doi.org/10.1007/s40544-020-0391-2

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Received: 22 January 2020
Revised: 12 March 2020
Accepted: 27 March 2020
Published: 22 May 2020
© The author(s) 2020

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