This work was supported by the National Key R&D Program of China (Nos. 2020YFA0712102, 2018YFA0902600, 2021YFF0701800, 2020YFA0211100), the National Natural Science Foundation of China (Nos. 52222214, 22020102003, 22125701, 21907088, 51922077, 51872205), the Youth Innovation Promotion Association of CAS (No. 2020228), Natural Science Foundation of Jilin Province (No. 20210101366JC), the Foundation of National Facility for Translational Medicine (Shanghai) (No. TMSK-2020-012). All animal experiments were conducted in compliance with the Animal Management Rules of the Ministry of Health of the People’s Republic of China and with the approval of the Institutional Animal Care and Use Committee of the Animal Experiment Center of Peking University (No. LA2019313).