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Research Article

Multiscale structural design of MnO2@GO superoxide dismutase nanozyme for protection against antioxidant damage

Yue Yu1, Yinuo Zhang1, Yu Wang2, Wenxing Chen3, Zhanjun Guo1( ), Ningning Song1( ), Minmin Liang1 ( )
Experimental Center of Advanced Materials, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China
Shanghai Synchrotron Radiation Facilities, Shanghai Institute of Applied Physics, Chinese Academy of Science, Shanghai 201204, China
Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China
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Graphical Abstract

Inspired by the structure of natural Mn-superoxide dismutase (Mn-SOD), the MnO2@GO-SOD nanozyme was constructed with graphene oxide (GO) sheets as frameworks, and δ-MnO2 nanoflakes as the active sites. The as-synthesized nanozyme exhibited layered structures with honeycomb-like morphology, which largely promoted the SOD-like activity and provided the nanozyme catalytic specificity.

Abstract

Rational design of metallic active sites and its microenvironment is critical for constructing superoxide dismutase (SOD) nanozymes. Here, we reported a novel SOD nanozyme design, with employing graphene oxide (GO) as the framework, and δ-MnO2 as the active sites, to mimic the natural Mn-SOD. This MnO2@GO nanozyme exhibited multiscale laminated structures with honeycomb-like morphology, providing highly specific surface area for ·O2− adsorption and confined spaces for subsequent catalytic reactions. Thus, the nanozyme achieved superlative SOD-like catalytic performance with inhibition rate of 95.5%, which is 222.6% and 1605.4% amplification over GO and MnO2 nanoparticles, respectively. Additionally, such unique hierarchical structural design endows MnO2@GO with catalytic specificity, which was not present in the individual component (GO or MnO2). This multiscale structural design provides new strategies for developing highly active and specific SOD nanozymes.

Keywords

MnO2@graphene oxide (MnO2@GO) nanozymesuperoxide dismutase (SOD)-like activityactivityspecificityantioxidation

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Nano Research
Volume 16 Issue 8,
August 2023
Pages 10763-10769
DOI: 10.1007/s12274-023-5760-5
Cite this article:
Yu Y, Zhang Y, Wang Y, et al. Multiscale structural design of MnO2@GO superoxide dismutase nanozyme for protection against antioxidant damage. Nano Research, 2023, 16(8): 10763-10769. https://doi.org/10.1007/s12274-023-5760-5
Topics:
Nanocatalysts

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Received: 10 March 2023
Revised: 11 April 2023
Accepted: 19 April 2023
Published: 25 May 2023
© Tsinghua University Press 2023
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