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Nano Research 2023, 16(5): 7312-7322 https://doi.org/10.1007/s12274-023-5392-9
Research Article | Issue | Published: 10 February 2023

Metalloprotein-inspired supramolecular photodynamic nanodrugs by multicomponent coordination for deep penetration and enhanced biofilm eradication

Show Author's Information Zhuo-Ran Yang1,§,  Jingyi Xiong1,§,  Sirui Wei2,  Kehan Du1,  Huimin Qin1,  Teng Ma1,  Niannian Lv1,  Xinyu Yu2,  Hao Jiang1( ),  Jintao Zhu1( )
Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

§ Zhuo-Ran Yang and Jingyi Xiong contributed equally to this work.

Keywords:
photodynamic therapy, supramolecular assembly, coordination, deep penetration, biofilm eradication
Topics:
Nano biology
Cite this article:
Yang Z-R, Xiong J, Wei S, et al. Metalloprotein-inspired supramolecular photodynamic nanodrugs by multicomponent coordination for deep penetration and enhanced biofilm eradication. Nano Research, 2023, 16(5): 7312-7322. https://doi.org/10.1007/s12274-023-5392-9
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Abstract Full text Electronic supplementary material About this article

Bacterial infections exacerbate the formation of bacterial biofilms, leading to resistance to traditional drugs, persistent infection, and even threatening patient’s life. Efficient antimicrobial materials against drug-resistant bacterial biofilms are highly desired. In this study, a photodynamic nanodrug with bacterial targeting was constructed by cooperative coordination of zinc ion with an antimicrobial peptide with hydrophobic tripeptides on the side chains and the photosensitizer chlorin e6. The supramolecular nanodrug with a uniform spherical structure possessed high photosensitizer loading capacity and enhanced photodynamic efficacy, which could deep penetrate and eradicate methicillin-resistant Staphylococcus aureus (MRSA) biofilms upon 655 nm laser irradiation. Furthermore, in vivo experiments verified the efficient elimination of MRSA biofilms on implanted catheters. This study provides a novel strategy to fabricate metalloprotein-inspired supramolecular photodynamic nanodrugs against drug-resistant bacterial biofilms-associated infections in vivo.


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Abstract
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Electronic supplementary material
About this article

Metalloprotein-inspired supramolecular photodynamic nanodrugs by multicomponent coordination for deep penetration and enhanced biofilm eradication

Show Author's information Zhuo-Ran Yang1,§, Jingyi Xiong1,§, Sirui Wei2, Kehan Du1, Huimin Qin1, Teng Ma1, Niannian Lv1, Xinyu Yu2, Hao Jiang1( ), Jintao Zhu1( )
Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

§ Zhuo-Ran Yang and Jingyi Xiong contributed equally to this work.

Abstract

Bacterial infections exacerbate the formation of bacterial biofilms, leading to resistance to traditional drugs, persistent infection, and even threatening patient’s life. Efficient antimicrobial materials against drug-resistant bacterial biofilms are highly desired. In this study, a photodynamic nanodrug with bacterial targeting was constructed by cooperative coordination of zinc ion with an antimicrobial peptide with hydrophobic tripeptides on the side chains and the photosensitizer chlorin e6. The supramolecular nanodrug with a uniform spherical structure possessed high photosensitizer loading capacity and enhanced photodynamic efficacy, which could deep penetrate and eradicate methicillin-resistant Staphylococcus aureus (MRSA) biofilms upon 655 nm laser irradiation. Furthermore, in vivo experiments verified the efficient elimination of MRSA biofilms on implanted catheters. This study provides a novel strategy to fabricate metalloprotein-inspired supramolecular photodynamic nanodrugs against drug-resistant bacterial biofilms-associated infections in vivo.

Keywords: photodynamic therapy, supramolecular assembly, coordination, deep penetration, biofilm eradication

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Publication history
Copyright
Acknowledgements

Publication history

Received: 02 September 2022
Revised: 06 December 2022
Accepted: 08 December 2022
Published: 10 February 2023
Issue date: May 2023

Copyright

© Tsinghua University Press 2023

Acknowledgements

Acknowledgements

The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (No. 52173124) and the Fundamental Research Funds for the Central Universities (No. 2172019kfyXJJS070). The authors are grateful to HUST Analytical and Testing Center for their supports on its facilities.

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