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Nano Research 2023, 16(4): 5247-5255 https://doi.org/10.1007/s12274-022-5153-1
Research Article | Issue | Published: 05 December 2022

Enhancing bioactivity and stability of polymer-based material-tissue interface through coupling multiscale interfacial interactions with atomic-thin TiO2 nanosheets

Show Author's Information Rongchen Xu1,2,§,  Xiaodan Mu1,§,  Zunhan Hu3,§,  Chongzhi Jia1,  Zhenyu Yang4,  Zhongliang Yang1,  Yiping Fan1,  Xiaoyu Wang1,5,  Yuefeng Wu6,  Xiaotong Lu6,  Jihua Chen4( ),  Guolei Xiang6( ),  Hongbo Li1( )
Department of Stomatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
Department of Stomatology, The Third Medical Center, Chinese PLA General Hospital, Beijing 100039, China
Department of Stomatology, Kunming Medical University, Kunming 650500, China
National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China
Department of Stomatology, The Strategic Support Force Medical Center, Beijing 100101, China
State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China

§ Rongchen Xu, Xiaodan Mu, and Zunhan Hu contributed equally to this work.

Keywords:
biomaterial, TiO2 nanosheets, material–tissue interface, pulpo-dentinal complex, resin composite
Topics:
Nano biology
Cite this article:
Xu R, Mu X, Hu Z, et al. Enhancing bioactivity and stability of polymer-based material-tissue interface through coupling multiscale interfacial interactions with atomic-thin TiO2 nanosheets. Nano Research, 2023, 16(4): 5247-5255. https://doi.org/10.1007/s12274-022-5153-1
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Abstract Full text Electronic supplementary material About this article

Stable and bioactive material–tissue interface (MTF) basically determines the clinical applications of biomaterials in wound healing, sustained drug release, and tissue engineering. Although many inorganic nanomaterials have been widely explored to enhance the stability and bioactivity of polymer-based biomaterials, most are still restricted by their stability and biocompatibility. Here we demonstrate the enhanced bioactivity and stability of polymer-matrix bio-composite through coupling multiscale material–tissue interfacial interactions with atomically thin TiO2 nanosheets. Resin modified with TiO2 nanosheets displays improved mechanical properties, hydrophilicity, and stability. Also, we confirm that this resin can effectively stimulate the adhesion, proliferation, and differentiation into osteogenic and odontogenic lineages of human dental pulp stem cells using in vitro cell–resin interface model. TiO2 nanosheets can also enhance the interaction between demineralized dentinal collagen and resin. Our results suggest an approach to effectively up-regulate the stability and bioactivity of MTFs by designing biocompatible materials at the sub-nanoscale.


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About this article

Enhancing bioactivity and stability of polymer-based material-tissue interface through coupling multiscale interfacial interactions with atomic-thin TiO2 nanosheets

Show Author's information Rongchen Xu1,2,§, Xiaodan Mu1,§, Zunhan Hu3,§, Chongzhi Jia1, Zhenyu Yang4, Zhongliang Yang1, Yiping Fan1, Xiaoyu Wang1,5, Yuefeng Wu6, Xiaotong Lu6, Jihua Chen4( ), Guolei Xiang6( ), Hongbo Li1( )
Department of Stomatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
Department of Stomatology, The Third Medical Center, Chinese PLA General Hospital, Beijing 100039, China
Department of Stomatology, Kunming Medical University, Kunming 650500, China
National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China
Department of Stomatology, The Strategic Support Force Medical Center, Beijing 100101, China
State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China

§ Rongchen Xu, Xiaodan Mu, and Zunhan Hu contributed equally to this work.

Abstract

Stable and bioactive material–tissue interface (MTF) basically determines the clinical applications of biomaterials in wound healing, sustained drug release, and tissue engineering. Although many inorganic nanomaterials have been widely explored to enhance the stability and bioactivity of polymer-based biomaterials, most are still restricted by their stability and biocompatibility. Here we demonstrate the enhanced bioactivity and stability of polymer-matrix bio-composite through coupling multiscale material–tissue interfacial interactions with atomically thin TiO2 nanosheets. Resin modified with TiO2 nanosheets displays improved mechanical properties, hydrophilicity, and stability. Also, we confirm that this resin can effectively stimulate the adhesion, proliferation, and differentiation into osteogenic and odontogenic lineages of human dental pulp stem cells using in vitro cell–resin interface model. TiO2 nanosheets can also enhance the interaction between demineralized dentinal collagen and resin. Our results suggest an approach to effectively up-regulate the stability and bioactivity of MTFs by designing biocompatible materials at the sub-nanoscale.

Keywords: biomaterial, TiO2 nanosheets, material–tissue interface, pulpo-dentinal complex, resin composite

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Publication history
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Acknowledgements

Publication history

Received: 09 August 2022
Revised: 30 September 2022
Accepted: 03 October 2022
Published: 05 December 2022
Issue date: April 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 82001110, 82071154, 21801012, 81720108011, 81470773, and 81571013).

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