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Nano Research 2022, 15(10): 9082-9091 https://doi.org/10.1007/s12274-022-4542-9
Research Article | Issue | Published: 29 June 2022

Versatile nanocomposite augments high-intensity focused ultrasound for high-efficacy sonodynamic therapy of glioma

Show Author's Information Yingyan Zheng1,2,§,  Dejun She1,2,§,  Huihui Huang5,§,  Lin Lin2,  Sunhui Chen3,  Yiping Lu2,  Li Liu4( ),  Zhiqing Pang3( ),  Bo Yin2( )
Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China
Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery Ministry of Education, Shanghai 201203, China
Department of Radiology, Shanghai Cancer Center, Fudan University, Shanghai 200032, China
Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350108, China

§ Yingyan Zheng, Dejun She, and Huihui Huang contributed equally to this work.

Keywords:
glioma, sonodynamic therapy, tumor microenvironment, high intensity focused ultrasound, responsive magnetic resonance imaging
Topics:
Theranostics
Cite this article:
Zheng Y, She D, Huang H, et al. Versatile nanocomposite augments high-intensity focused ultrasound for high-efficacy sonodynamic therapy of glioma. Nano Research, 2022, 15(10): 9082-9091. https://doi.org/10.1007/s12274-022-4542-9
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Abstract Full text Electronic supplementary material About this article

High-intensity focused ultrasound (HIFU), with inherent advantages of improved ultrasonic depth and low off-target damage, holds the promising capability for glioma treatment, but the relatively long therapeutic time and potential physical complications may hamper its clinical application. Herein, a bovine serum albumin (BSA)-based nanoplatform with in situ growth of MnO2 was synthesized, and Protoporphyrin IX (PpIX) was further anchored to obtain a versatile PpIX@MnO2@BSA nanoplatform (denoted as BMP). By employing HIFU as the exogenous irradiation source, a high-efficacy sonodynamic therapy (SDT) is developed, in which the excited BMP enables the production of tumoricidal reactive oxygen species (ROS). The inherent tumor microenvironment (TME)-responsive property of MnO2 endows BMP with specific T1-weighted magnetic resonance imaging (MRI) by releasing Mn2+, and the simultaneously generated O2 facilitates hypoxia alleviation as well as 1O2 generation. Compared with HIFU therapy alone, suppression of glioma growth and improved survival benefits are achieved through the designed TME-responsive nanocomposite under HIFU exposure. The high-efficacy SDT strategy combining BMP and HIFU demonstrated favorable TME-responsive T1-weighted MRI, hypoxic environment alleviation, and anti-tumor capability, providing a perspective paradigm for MRI-guided glioma treatment.


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Electronic supplementary material
About this article

Versatile nanocomposite augments high-intensity focused ultrasound for high-efficacy sonodynamic therapy of glioma

Show Author's information Yingyan Zheng1,2,§, Dejun She1,2,§, Huihui Huang5,§, Lin Lin2, Sunhui Chen3, Yiping Lu2, Li Liu4( ), Zhiqing Pang3( ), Bo Yin2( )
Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China
Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery Ministry of Education, Shanghai 201203, China
Department of Radiology, Shanghai Cancer Center, Fudan University, Shanghai 200032, China
Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350108, China

§ Yingyan Zheng, Dejun She, and Huihui Huang contributed equally to this work.

Abstract

High-intensity focused ultrasound (HIFU), with inherent advantages of improved ultrasonic depth and low off-target damage, holds the promising capability for glioma treatment, but the relatively long therapeutic time and potential physical complications may hamper its clinical application. Herein, a bovine serum albumin (BSA)-based nanoplatform with in situ growth of MnO2 was synthesized, and Protoporphyrin IX (PpIX) was further anchored to obtain a versatile PpIX@MnO2@BSA nanoplatform (denoted as BMP). By employing HIFU as the exogenous irradiation source, a high-efficacy sonodynamic therapy (SDT) is developed, in which the excited BMP enables the production of tumoricidal reactive oxygen species (ROS). The inherent tumor microenvironment (TME)-responsive property of MnO2 endows BMP with specific T1-weighted magnetic resonance imaging (MRI) by releasing Mn2+, and the simultaneously generated O2 facilitates hypoxia alleviation as well as 1O2 generation. Compared with HIFU therapy alone, suppression of glioma growth and improved survival benefits are achieved through the designed TME-responsive nanocomposite under HIFU exposure. The high-efficacy SDT strategy combining BMP and HIFU demonstrated favorable TME-responsive T1-weighted MRI, hypoxic environment alleviation, and anti-tumor capability, providing a perspective paradigm for MRI-guided glioma treatment.

Keywords: glioma, sonodynamic therapy, tumor microenvironment, high intensity focused ultrasound, responsive magnetic resonance imaging

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Publication history
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Acknowledgements

Publication history

Received: 12 February 2022
Revised: 15 May 2022
Accepted: 16 May 2022
Published: 29 June 2022
Issue date: October 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

The authors thank Dalong Ni, at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, for manuscript editing. We are also grateful to Minxia Wu, at Fujian Medical University, Fuzhou, China, for her assistance in nanoparticle characterization. This work was financially supported by the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01) and ZJ Lab, Shanghai Center for Brain-Inspired Technology, and the Youth Program of National Natural Science Foundation of China (No. 81901697).

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