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Nano Research 2022, 15(9): 8636-8647 https://doi.org/10.1007/s12274-022-4455-7
Research Article | Issue | Published: 14 June 2022

One-step nanoarchitectonics of a multiple functional hydrogel based on cellulose nanocrystals for effective tumor therapy

Show Author's Information Tianxing Chen1,2,§,  Tengteng Yao2,3,§,  Hui Pan1,  Hui Peng4,  Andrew K. Whittaker4,  Yao Li1,  Shenmin Zhu1( ),  Zhaoyang Wang2( )
State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Department of Ophthalmology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200092, China
Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
Australian Institute for Bioengineering and Nanotechnology and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, Brisbane, QLD 4072, Australia

§ Tianxing Chen and Tengteng Yao contributed equally to this work.

Keywords:
carbon dots, magnetic nanoparticles, tumor therapy, cellulose nanocrystals, injectable hydrogel
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Chen T, Yao T, Pan H, et al. One-step nanoarchitectonics of a multiple functional hydrogel based on cellulose nanocrystals for effective tumor therapy. Nano Research, 2022, 15(9): 8636-8647. https://doi.org/10.1007/s12274-022-4455-7
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Abstract Full text Electronic supplementary material About this article

Hypoxia is a huge barrier for the development of photodynamic therapy (PDT). Chemodynamic therapy (CDT) could provide a possible solution to this dilemma. In this work, a controlled Schiff-base reaction was conducted between amido groups on the surface of carbon dots (CDs) and aldehyde groups on aldehyde-modified cellulose nanocrystals (mCNCs) as well as aldehyde-mCNCs decorated with Fe3O4 nanoparticles. In this process, the mCNCs not only prevent the agglomeration of Fe3O4 but also form hydrogels with CDs. The CDs act as both photothermal agent and photosensitizer. The hypoxia could be effectively relieved through the Fenton reaction due to the addition of Fe3O4, and the ·OH produced in the reaction further induces CDT and enhances tumor therapy efficiency. The therapy performance was further verified through in vitro cell experiments and in vivo animal experiments. This convenient method provides inspirations for the design and preparation of advanced biomaterials with multiple functions for cancer therapy.


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Abstract
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Electronic supplementary material
About this article

One-step nanoarchitectonics of a multiple functional hydrogel based on cellulose nanocrystals for effective tumor therapy

Show Author's information Tianxing Chen1,2,§, Tengteng Yao2,3,§, Hui Pan1, Hui Peng4, Andrew K. Whittaker4, Yao Li1, Shenmin Zhu1( ), Zhaoyang Wang2( )
State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Department of Ophthalmology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200092, China
Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
Australian Institute for Bioengineering and Nanotechnology and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, Brisbane, QLD 4072, Australia

§ Tianxing Chen and Tengteng Yao contributed equally to this work.

Abstract

Hypoxia is a huge barrier for the development of photodynamic therapy (PDT). Chemodynamic therapy (CDT) could provide a possible solution to this dilemma. In this work, a controlled Schiff-base reaction was conducted between amido groups on the surface of carbon dots (CDs) and aldehyde groups on aldehyde-modified cellulose nanocrystals (mCNCs) as well as aldehyde-mCNCs decorated with Fe3O4 nanoparticles. In this process, the mCNCs not only prevent the agglomeration of Fe3O4 but also form hydrogels with CDs. The CDs act as both photothermal agent and photosensitizer. The hypoxia could be effectively relieved through the Fenton reaction due to the addition of Fe3O4, and the ·OH produced in the reaction further induces CDT and enhances tumor therapy efficiency. The therapy performance was further verified through in vitro cell experiments and in vivo animal experiments. This convenient method provides inspirations for the design and preparation of advanced biomaterials with multiple functions for cancer therapy.

Keywords: carbon dots, magnetic nanoparticles, tumor therapy, cellulose nanocrystals, injectable hydrogel

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Publication history
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Acknowledgements

Publication history

Received: 10 March 2022
Revised: 16 April 2022
Accepted: 20 April 2022
Published: 14 June 2022
Issue date: September 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by Ministry of Education Joint Foundation (No. 6141A02022264), the National Natural Science Foundation of China (Nos. 51672173, U1733130, and 81770934), Shanghai Science and Technology Committee (Nos. 21ZR1435700, 18520744700, and 18JC1410500), Translational Medicine National Key Science and Technology Infrastructure (Shanghai) Open Project (No. TMSK2020128), Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (No. 20181810), Clinical research MDT project of the Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine (No. 201905). We also thank Shanghai Synchrotron Radiation Facility (SSRF). The Australian National Fabrication Facility, Queensland Node, is also acknowledged for access to some items of equipment.

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