Copper catalysis plays a crucial role in organic synthesis providing a wide spectrum of important transformations over decades. Success in homogeneous copper catalysis has often relied on the appropriate modulation of coordinating ligands, whereas the development of the corresponding heterogeneous variant has relatively gained less attentions. In this review, we aim to deliver a comprehensive summary of a number of seminal heterogenized Cu-catalyzed homogenous catalysis reported over the last decade. The scope of this review is classified by the type of transformations in which the catalyst’s preparation and activity including the relationship between structure and activity are underscored. In this way, this review highlights the potential and synthetic perspectives of heterogeneous copper catalysis in both academic and industry.