AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Research Article
Article Link
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article

Systemic delivery of microRNA for treatment of brain ischemia

Chaoyong Liu1,2,3,§, Jing Wen7,§, Dai Li1,2,§, Hongzhao Qi6, Lina Nih4, Jialin Zhu1,2, Duo Xu4, Yu Ren8, Shanshan Zhang6, Donglin Han6, Huanhuan Jia8, Junhu Zhou1,2, Meng Qin3, Jialing Wu9, Xubo Yuan6, Ji Liu5( ), Jin Zhao6( ), Chunsheng Kang1,2 ( ), Yunfeng Lu4( )
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
Key Laboratory of Post-Trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Tianjin 300052, China
College of Life Science and Technology and Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
Department of Medicine, Tianjin Huanhu Hospital, Tianjin 300350, China
Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin 300350, China
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
Tianjin Research Center of Basic Medical Science, Tianjin Medical University, Tianjin 300070, China
Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China

§ Chaoyong Liu, Jing Wen, and Dai Li contributed equally to this work.

Show Author Information

Abstract

Brain ischemia is the second leading cause of death and the third leading cause of disability in the world. Systemic delivery of microRNA, a class of molecules that regulate the expression of cellular proteins associated with angiogenesis, cell growth, proliferation and differentiation, holds great promise for the treatment of brain ischemia. However, their therapeutic efficacy has been hampered by poor delivery efficiency of microRNA. We report herein a platform technology based on microRNA nanocapsules, which enables their effective delivery to the disease sites in the brain. Exemplified by microRNA-21, intravenous injection of the nanocapsules into a rat model of cerebral ischemia could effectively ameliorate the infarct volume, neurological deficit and histopathological severity.

Graphical Abstract

Keywords

polymer nanocapsulessmall RNA deliverymicroRNA-21brain ischemia

Electronic Supplementary Material

Download File(s)
12274_2021_3413_MOESM1_ESM.pdf (5.6 MB)

References

【1】
【1】
 
 
Crossref Google Scholar
Nano Research
Volume 14 Issue 9,
September 2021
Pages 3319-3328
DOI: 10.1007/s12274-021-3413-8

{{item.num}}

Comments on this article

Go to comment

< Back to all reports

Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

Review Comment

Cite this Report
Close
Close
Cite this article:
Liu C, Wen J, Li D, et al. Systemic delivery of microRNA for treatment of brain ischemia. Nano Research, 2021, 14(9): 3319-3328. https://doi.org/10.1007/s12274-021-3413-8
Topics:
Gene therapy
Part of a topical collection:
Seventh Nano Research Award

1679

Views

11

Crossref

11

Web of Science

11

Scopus

0

CSCD
Received: 14 November 2020
Revised: 10 February 2021
Accepted: 22 February 2021
Published: 26 April 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021