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Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals (NCs) to function as the fluorescent probes for early tumor diagnosis. However, the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications. To conquer this challenge, we herein introduce a nature inspired "stress-response" method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h. We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability, biocompatibility, and low cytotoxicity. Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis, and can highly anticipate the further in vivo biomedical applications that light up live cells.

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Publication history
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Acknowledgements

Publication history

Received: 28 October 2019
Revised: 01 February 2020
Accepted: 04 February 2020
Published: 16 March 2020
Issue date: March 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

The author thank Professor Peng Wang for experimental assistance in STEM-HAADF measurements. This work was supported primarily by the National Key Research and Development Program of China (No. 2018YFE0208500), the Major Research Plan of the National Natural Science Foundation of China (No. 91963206), the National Natural Science Foundation of China (Nos. U1508202 and 51627810), the Natural Science Foundation of Jiangsu Province (No. SBK2018022120), the open fund of Wuhan National Laboratory for Optoelectronics (No. 2018WNLOKF020), the open fund of Jiangsu Key Laboratory of Electrochemical Energy Storage Technologies (No. EEST2018-1), and the civil aerospace technology preliminary research project of the State Administration of Science, Technology and Industry for National Defense.

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