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Nano Research 2020, 13(7): 1810-1824 https://doi.org/10.1007/s12274-020-2664-5
Review Article | Issue | Published: 06 March 2020

Progress in transdermal drug delivery systems for cancer therapy

Show Author's Information Tianyue Jiang1,  Guo Xu1,  Guojun Chen2,3,  Yu Zheng1,  Bingfang He1( ),  Zhen Gu2,3( )
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
Jonsson Comprehensive Cancer Center and California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
Keywords:
immunotherapy, drug delivery, cancer therapy, combination therapy, chemotherapy, transdermal delivery
Topics:
Chemotherapy DiseasesDrug deliveryDrug productsGene therapy OncologyTargeted drug delivery
Cite this article:
Jiang T, Xu G, Chen G, et al. Progress in transdermal drug delivery systems for cancer therapy. Nano Research, 2020, 13(7): 1810-1824. https://doi.org/10.1007/s12274-020-2664-5
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Abstract Full text About this article

Transdermal drug delivery is an appealing option except for oral and hypodermic administration. With the advancement of skin penetration strategies, various anticancer therapeutics ranging from lipophilic small-molecule drugs to hydrophilic biomacromolecules, can be administered transdermally, offering an optional regimen to treat skin cancers. In addition, the activation of the skin immune systems can also assist the treatment of distal sites. Current approaches on enhancing the transdermal delivery efficacy of anticancer drugs are summarized in this review. We also survey recent advances in micro- and nanotechnology-based transdermal formulations for cancer treatment, such as chemotherapy, gene therapy, immunotherapy, phototherapy and combination therapy. New penetration enhancers, materials, formulations and their hypothesized mechanisms for transdermal delivery are highlighted. Advantages and limitations regarding the state-of-the-art transdermal delivery technologies, as well as future perspective are also discussed.


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About this article

Progress in transdermal drug delivery systems for cancer therapy

Show Author's information Tianyue Jiang1, Guo Xu1, Guojun Chen2,3, Yu Zheng1, Bingfang He1( ), Zhen Gu2,3( )
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
Jonsson Comprehensive Cancer Center and California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA

Abstract

Transdermal drug delivery is an appealing option except for oral and hypodermic administration. With the advancement of skin penetration strategies, various anticancer therapeutics ranging from lipophilic small-molecule drugs to hydrophilic biomacromolecules, can be administered transdermally, offering an optional regimen to treat skin cancers. In addition, the activation of the skin immune systems can also assist the treatment of distal sites. Current approaches on enhancing the transdermal delivery efficacy of anticancer drugs are summarized in this review. We also survey recent advances in micro- and nanotechnology-based transdermal formulations for cancer treatment, such as chemotherapy, gene therapy, immunotherapy, phototherapy and combination therapy. New penetration enhancers, materials, formulations and their hypothesized mechanisms for transdermal delivery are highlighted. Advantages and limitations regarding the state-of-the-art transdermal delivery technologies, as well as future perspective are also discussed.

Keywords: immunotherapy, drug delivery, cancer therapy, combination therapy, chemotherapy, transdermal delivery

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Publication history
Copyright
Acknowledgements

Publication history

Received: 13 December 2019
Revised: 16 January 2020
Accepted: 16 January 2020
Published: 06 March 2020
Issue date: July 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

This work was supported by the Natural Science Foundation of Jiangsu Province of China for Excellent Young Scholars (No. BK20190084), the Young Elite Scientists Sponsorship Program by CAST and National Students’ platform for Innovation and Entrepreneurship Training Program (No. 201910291094Z) to T. Y. J. and the UCLA start-up package to Z. G.

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