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Nano Research 2019, 12(3): 637-642 https://doi.org/10.1007/s12274-019-2271-5
Research Article | Issue | Published: 28 December 2018

Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function

Show Author's Information Dawei Jiang1,2,§,  Hyung-Jun Im1,3,§,  Madeline E. Boleyn1,4,§,  Christopher G. England1,  Dalong Ni1,  Lei Kang1,5,  Jonathan W. Engle1,  Peng Huang2( ),  Xiaoli Lan6( ),  Weibo Cai1( )
Departments of Radiology and Medical Physics,University of Wisconsin-Madison,Madison, Wisconsin,53705,USA;
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging,Carson International Cancer Center, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University,Shenzhen,518060,China;
Graduate School of Convergence Science and Technology,Seoul National University,Seoul,08826,Republic of Korea;
Departments of Mathematics, and Biology,University of Wisconsin-Madison,Wisconsin,53705,USA;
Department of Nuclear Medicine,Peking University First Hospital,Beijing,100034,China;
Department of Nuclear Medicine,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Key Laboratory of Molecular Imaging, No. 1277 Jiefang Ave,Wuhan,430022,China;

§Dawei Jiang, Hyung-Jun Im, and Madeline E. Boleyn contributed equally to this work.

Keywords:
DNA nanotechnology, positron emission tomography (PET) imaging, DNA tetrahedron nanoparticle, renal clearance, kidney dysfunction
Topics:
DNA MammalsMedical applicationsNanoparticlesPositrons
Cite this article:
Jiang D, Im H-J, Boleyn ME, et al. Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function. Nano Research, 2019, 12(3): 637-642. https://doi.org/10.1007/s12274-019-2271-5
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Abstract Full text Electronic supplementary material About this article

DNA tetrahedron nanostructure (DTN) is one of the simplest DNA nanostructures and has been successfully applied for biosensing, imaging, and treatment of cancer. To facilitate its biomedical applications and potential clinical translation, fundamental understanding of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearance of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide insight for future optimization of DNA nanostructures for biomedical applications.


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Electronic supplementary material
About this article

Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function

Show Author's information Dawei Jiang1,2,§, Hyung-Jun Im1,3,§, Madeline E. Boleyn1,4,§, Christopher G. England1, Dalong Ni1, Lei Kang1,5, Jonathan W. Engle1, Peng Huang2( ), Xiaoli Lan6( ), Weibo Cai1( )
Departments of Radiology and Medical Physics,University of Wisconsin-Madison,Madison, Wisconsin,53705,USA;
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging,Carson International Cancer Center, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University,Shenzhen,518060,China;
Graduate School of Convergence Science and Technology,Seoul National University,Seoul,08826,Republic of Korea;
Departments of Mathematics, and Biology,University of Wisconsin-Madison,Wisconsin,53705,USA;
Department of Nuclear Medicine,Peking University First Hospital,Beijing,100034,China;
Department of Nuclear Medicine,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Key Laboratory of Molecular Imaging, No. 1277 Jiefang Ave,Wuhan,430022,China;

§Dawei Jiang, Hyung-Jun Im, and Madeline E. Boleyn contributed equally to this work.

Abstract

DNA tetrahedron nanostructure (DTN) is one of the simplest DNA nanostructures and has been successfully applied for biosensing, imaging, and treatment of cancer. To facilitate its biomedical applications and potential clinical translation, fundamental understanding of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearance of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide insight for future optimization of DNA nanostructures for biomedical applications.

Keywords: DNA nanotechnology, positron emission tomography (PET) imaging, DNA tetrahedron nanoparticle, renal clearance, kidney dysfunction

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Publication history
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Acknowledgements

Publication history

Received: 08 October 2018
Revised: 04 December 2018
Accepted: 15 December 2018
Published: 28 December 2018
Issue date: March 2019

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Acknowledgements

Acknowledgements

This work was supported by the University of Wisconsin-Madison, the National Institutes of Health (NIBIB/NCI P30CA014520, T32CA009206), the American Cancer Society (125246-RSG-13-099-01-CCE), the National Natural Science Foundation of China (Nos. 51573096, 51703132, 31771036, and 81630049) and the Basic Research Program of Shenzhen (Nos. JCYJ20170412111100742 and JCYJ20160422091238319), the Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project (No. 2018B030308003), and Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China (No. 161032).

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