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Nano Research 2017, 10(11): 3790-3810 https://doi.org/10.1007/s12274-017-1592-5
Research Article | Issue | Published: 08 June 2017

Generic synthesis and versatile applications of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures

Show Author's Information Guiju Tao1,2,  Zhengyuan Bai1,  Yu Chen3( ),  Heliang Yao4,  Meiying Wu3<,  Ping Huang3,  Luodan Yu3,  Jiamin Zhang5,  Chen Dai6,  Long Zhang1( )
Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai201800China
Sinopec Shanghai Research Institute of Petrochemical TechnologyShanghai201208China
State Key Laboratory of High Performance Ceramics and Superfine MicrostructureShanghai Institute of Ceramics, Chinese Academy of SciencesShanghai200050China
Analysis and Testing Center for Inorganic MaterialsShanghai Institute of Ceramics, Chinese Academy of SciencesShanghai200050China
Shanghai (Red Cross) Blood CenterShanghai Institute of Blood TransfusionShanghai200051China
Department of Ultrasoundthe East Hospital Affiliated to Tongji UniversityShanghai200120China

† Present address: Paui C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Keywords:
Janus, mesoporous organosilica, synthetic mechanism, drug carrier, blood compatibility
Cite this article:
Tao G, Bai Z, Chen Y, et al. Generic synthesis and versatile applications of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures. Nano Research, 2017, 10(11): 3790-3810. https://doi.org/10.1007/s12274-017-1592-5
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Abstract Full text Electronic supplementary material About this article

Precise control over the morphology, nanostructure, composition, and particle size of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles (MONs) still remains a major challenge, which severely restricts their broad applications. In this work, an efficient bridged organic group-determined growth strategy has been proposed for the facile synthesis of highly dispersed and uniform MONs with multifarious Janus morphologies, nanostructures, organic–inorganic hybrid compositions, and particle sizes, which can be easily controlled simply by varying the bridged organic groups and the concentration of bis-silylated organosilica precursors used in the synthesis. In addition, the formation mechanism of Janus MONs determined by the bridged organic group has been discussed. Based on the specific structures, compositions, and asymmetric morphologies, all the synthesized Janus MONs with hollow structures (JHMONs) demonstrate excellent performances in nanomedicine as desirable drug carriers with high drug-loading efficiencies/capacities, pH-responsive drug releasing, and enhanced therapeutic efficiencies, as attractive contrast-enhanced contrast agents for ultrasound imaging, and as excellent bilirubin adsorbents with noticeably high adsorption capacities and high blood compatibilities. The developed versatile synthetic strategy and the obtained JHMONs are extremely important in the development and applications of MONs, particularly in the areas of nanoscience and nanotechnology.


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Abstract
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Electronic supplementary material
About this article

Generic synthesis and versatile applications of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures

Show Author's information Guiju Tao1,2, Zhengyuan Bai1, Yu Chen3( ), Heliang Yao4, Meiying Wu3<, Ping Huang3, Luodan Yu3, Jiamin Zhang5, Chen Dai6, Long Zhang1( )
Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai201800China
Sinopec Shanghai Research Institute of Petrochemical TechnologyShanghai201208China
State Key Laboratory of High Performance Ceramics and Superfine MicrostructureShanghai Institute of Ceramics, Chinese Academy of SciencesShanghai200050China
Analysis and Testing Center for Inorganic MaterialsShanghai Institute of Ceramics, Chinese Academy of SciencesShanghai200050China
Shanghai (Red Cross) Blood CenterShanghai Institute of Blood TransfusionShanghai200051China
Department of Ultrasoundthe East Hospital Affiliated to Tongji UniversityShanghai200120China

† Present address: Paui C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Abstract

Precise control over the morphology, nanostructure, composition, and particle size of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles (MONs) still remains a major challenge, which severely restricts their broad applications. In this work, an efficient bridged organic group-determined growth strategy has been proposed for the facile synthesis of highly dispersed and uniform MONs with multifarious Janus morphologies, nanostructures, organic–inorganic hybrid compositions, and particle sizes, which can be easily controlled simply by varying the bridged organic groups and the concentration of bis-silylated organosilica precursors used in the synthesis. In addition, the formation mechanism of Janus MONs determined by the bridged organic group has been discussed. Based on the specific structures, compositions, and asymmetric morphologies, all the synthesized Janus MONs with hollow structures (JHMONs) demonstrate excellent performances in nanomedicine as desirable drug carriers with high drug-loading efficiencies/capacities, pH-responsive drug releasing, and enhanced therapeutic efficiencies, as attractive contrast-enhanced contrast agents for ultrasound imaging, and as excellent bilirubin adsorbents with noticeably high adsorption capacities and high blood compatibilities. The developed versatile synthetic strategy and the obtained JHMONs are extremely important in the development and applications of MONs, particularly in the areas of nanoscience and nanotechnology.

Keywords: Janus, mesoporous organosilica, synthetic mechanism, drug carrier, blood compatibility

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Publication history
Copyright
Acknowledgements

Publication history

Received: 10 January 2017
Revised: 12 March 2017
Accepted: 13 March 2017
Published: 08 June 2017
Issue date: November 2017

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2017

Acknowledgements

Acknowledgements

We greatly acknowledge financial support from the National Key Research and Development Program of China (No. 2016YFA0203700), Shanghai Natural Science Foundation (No. 16ZR1440300), the National Natural Science Foundation of China (Nos. 61275208, 51302293, and 51672303), Shanghai Rising-Star Program (No. 14QA1404100), Youth Innovation Promotion Association of the Chinese Academy of Sciences (No. 2013169) and Development Fund for Shanghai Talents (2015).

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