Drug delivery plays a significant role in achieving spatiotemporal transportation of therapeutics for precise and efficient clinical disease treatment, sometimes even equally important with carried drugs. On the path of pursuing highly promising therapeutics, nanotechnology embraces a bright future by enabling drugs with controllable physical properties, release behavior, biocompatibility or other chemical/biological features, which are usually essential for precision therapeutics. In view of this, this collection includes the latest nanoscience and nanotechnology-related research, reviews, or opinions devoted to intelligent drug delivery.