Special Issue Editors

Leading Editors：

• Chuanfeng Tang, Associate Professor, State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China. Email: tangchuanfeng@njucm.edu.cn.
• Jianmei Li, Professor, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China. Email: lijianmei@njnu.edu.cn.

Co-editors：

• Yemin Wang, Assistant Professor, Department of Pathology and Laboratory Medicine, University of British Columbia; Senior Research Scientist, Ovarian Cancer Research Centre, Vancouver Coastal Health Research Institute, 2660 Oak Street, Vancouver BC, V6H3Z6, Canada. Email: wang@ubc.ca
• Shengjie Li, Associate Professor, Jiangsu Provincial Key Laboratory of Resource Utilization of Food and Medicine Substances, Nanjing Xiaozhuang University, Nanjing 211171, China. Email: lishengjie@njxzc.edu.cn.
• Shaoxing Guan, Associate Professor, Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou City, Guangzhou, P. R. China. Email: guanshx6@mail.sysu.edu.cn
• Dehui Qian, Institute of Cardiovascular Diseases of PLA, Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China. Email: doctorqiandehui@163.com
• Jian Lu, Associate Professor, Department of Physiology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Email: lujian1993@njucm.edu.cn
• Xiaoli Wang, Lecturer, School of Basic Medicine, Nanjing Medical University, Nanjing 2111666, China. Email: xiaoli@njmu.edu.cn

 Description

In the contemporary milieu, conventional "medicinal supplements" are increasingly perceived as an unhealthy approach. Instead, the embrace of "food & medicine homologous substances" by the masses is gaining traction.

A growing body of evidence underscores the crucial role of specific nutrients and compounds derived from food & medicine homologous sources in maintaining the health and optimal functionality of the nervous system. These homologous substances, rich in vitamins, minerals, antioxidants, and dietary fiber, are widely recognized for their potential to preserve the integrity of the blood-brain barrier, mitigate neuroinflammation, and promote hippocampal neurogenesis, thereby contributing to overall brain health.

This Research Topic aims to investigate the potential health benefits of food & medicine homologous substances in the management of neurological disorders, including headache, depression, Alzheimer's disease, and Parkinson's disease, with a particular focus on their effects on disease-associated neuroinflammation, blood-brain barrier disruption, impaired neurogenesis, and cognitive deficits such as memory impairment. This special issue endeavors to elucidate the underlying mechanisms by advocating for the balanced intake of food & medicine homologous substances to reduce the risk of neurological disorders and enhance neurological well-being.

Articles on themes of interest include but are not limited to:

1. Clinical evaluation of the effects of food & medicine homologous substances on brain health
2. Artificial intelligence-based mining of active ingredients from food & medicine homologous substances and mechanistic insights into their brain health-promoting effects
3. Functions and mechanisms of bioactive molecules derived from food & medicine homologous substances—including polysaccharides, polyphenols, flavonoids, and dietary fiber—in modulating multi-target pathways to maintain brain health
4. The role of oxidative stress in neurological disorders and the protective effects of antioxidants from food & medicine homologous substances
5. Protective mechanisms of food & medicine homologous substances and their bioactive compounds against neuroinflammation, blood-brain barrier disruption, and impaired neurogenesis
6. Application of fermentation technologies to enhance the content and bioavailability of active ingredients from food & medicine homologous substances
7. Regulatory effects of food & medicine homologous substances, or their fermented postbiotics and metabolites, on brain health via the gut–brain axis, liver–brain axis, and related pathways

Keywords: Food & medicine homology resources; active ingredients; brain health; fermentation; artificial intelligence

Instructions for submission:

The Editorial Manager System is ready for article submission towards the Virtual special issue: SI: Brain Health Strategies Based on Food & Medicine Homology Resources: From Bioactive Components to Neuroprotective Mechanisms

The submission website for this journal is located at: https://mc03.manuscriptcentral.com/fmhr

To ensure that all manuscripts are correctly identified for inclusion into the special issue, it is important that authors select – Brain-HSB

when they reach the “Article Type” step in the submission process.

Benefits of publishing with Food & Medicine Homology Resources

• Open access (unlimited and free access for readers, and high visibility on SciOpen). https://www.sciopen.com/journal/3136-103X
• Free of any charge.
• Precise push, good reference effect.

December 30,Submission Deadline:  2026

Publication Data: May 2027