Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R

Editors-in-Chief: Ailong Huang, Tong-Chuan He

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Volume 11

Issue 2, March 2024

pp.509-1084 58 articles

RESEARCH HIGHLIGHT

Open Access Research Highlight

Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)

Ke Zhang, Elena Blokhina, Evgeny Krupitsky, [...], Marina Vetrova, Ti-Fei Yuan, Hua Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.04.003

Published: 24 May 2023

2024, 11 (2): 509-511

Downloads: 3 | Views: 85 |

PDF (368 KB)

RAPID COMMUNICATIONS

Open Access Rapid Communication

A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

June-Ha Shin, Hwa-Ryeon Kim, Jae-Seok Roe

https://doi.org/10.1016/j.gendis.2023.03.009

Published: 07 April 2023

2024, 11 (2): 512-515

Downloads: 2 | Views: 54 |

PDF (1.2 MB)

Open Access Rapid Communication

Genetic landscape and clinical significance of cuproptosis-related genes in liver hepatocellular carcinoma

Dingtao Hu, Yichuan Wang, Xu Shen, [...], Tiantian Mao, Xijun Liang, Tengjiao Wang, Weifeng Shen, Yugang Zhuang, Jin Ding << Fewer

https://doi.org/10.1016/j.gendis.2023.03.010

Published: 10 April 2023

2024, 11 (2): 516-519

Downloads: 3 | Views: 56 |

PDF (1.8 MB)

Open Access Rapid Communication

Identification of TP53 mutation-associated prognostic genes and investigation of the immune cell infiltration in patients with hepatocellular carcinoma

Qijun Yang, Lianke Gao, Yuhan Xu, [...], Gaoquan Cao, Yingcheng He, Wenyige Zhang, Xue Zhang, Chengfeng Wu, Kaili Liao, Xiaozhong Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.03.020

Published: 25 April 2023

2024, 11 (2): 520-523

Downloads: 2 | Views: 45 |

PDF (955.3 KB)

Open Access Rapid Communication

Lack of evidence for germline WWP1 pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTEN-hamartoma-tumor syndrome

Noemi Gonzalez-Abuin, Tirso Pons, Teresa Fuster, [...], Isabel Quintana, Mariona Terradas, Gemma Aiza, Joan Brunet, Gabriel Capellá, Heather Hampel, Laura Valle << Fewer

https://doi.org/10.1016/j.gendis.2023.03.011

Published: 07 April 2023

2024, 11 (2): 524-527

Downloads: 2 | Views: 56 |

PDF (229.6 KB)

Open Access Rapid Communication

Chemotherapy induces breast cancer stem cell enrichment through repression of glutathione S-transferase Mu

Jing He, Yiran Yu, Yilin He, [...], Jie He, Guangyu Ji, Haiquan Lu << Fewer

https://doi.org/10.1016/j.gendis.2023.04.005

Published: 09 May 2023

2024, 11 (2): 528-531

Downloads: 4 | Views: 96 |

PDF (1.5 MB)

Open Access Rapid Communication

Identification and global characterization of eccDNA reveals hallmarks in iron nanoparticles-treated breast cancer cells

Wenxiang Lu, Ying Wang, Tao Luo, [...], Fuyu Li, Yali Jiang, Jinke Wang, Weizhong Zhang, Yunfei Bai << Fewer

https://doi.org/10.1016/j.gendis.2023.04.002

Published: 08 May 2023

2024, 11 (2): 532-534

Downloads: 2 | Views: 78 |

PDF (843.1 KB)

Open Access Rapid Communication

Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells

Xi Kong, Peng Lu, Jinyue Zhang, [...], Zheng Bao, Chenghao Kuang, Bingqing Xie, Jianhua Peng, Ning Ma, Yong Jiang, Shigang Yin << Fewer

https://doi.org/10.1016/j.gendis.2023.04.001

Published: 08 May 2023

2024, 11 (2): 535-538

Downloads: 2 | Views: 82 |

PDF (858.2 KB)

Open Access Rapid Communication

High glucose promotes macrophage M1 polarization through miR-32/Mef2d/cAMP signaling pathway

Cong Chen, Jingsong Cao, Yan Gao, [...], Xiaoping Xie, Zhibo Zhao, Qing Yuan, Yuqi He, Xuyu Zu, Jianghua Liu << Fewer

https://doi.org/10.1016/j.gendis.2023.03.029

Published: 03 May 2023

2024, 11 (2): 539-541

Downloads: 2 | Views: 74 |

PDF (739.9 KB)

Open Access Rapid Communication

The dysfunctional Wnt pathway down-regulates MLH1/SET expression and promotes microsatellite instability and immunotherapy response in colorectal cancer

Jiyan Wang, Tao He, Qingle Gao, [...], Hongkai Chang, Xintong Dai, Juze Yang, Shuangping Liu, Shuai Zhang, Changliang Shan, Chunze Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.03.026

Published: 28 April 2023

2024, 11 (2): 542-545

Downloads: 2 | Views: 70 |

PDF (938.4 KB)

Open Access Rapid Communication

Isolation and culture of human primary osteoblasts: Comparing the effects of differences in method details on osteoblast characteristics

Fei Chen, Yan Zhang, Pai Peng, [...], Xiao-Ting Huang, Zi-Han Qiu, Bao-Cheng Liu, Tie-Lin Yang, Bo Yang, Yan Guo << Fewer

https://doi.org/10.1016/j.gendis.2023.03.024

Published: 28 April 2023

2024, 11 (2): 546-549

Downloads: 2 | Views: 55 |

PDF (1.5 MB)

Open Access Rapid Communication

Bortezomib depended on PRDM1 and TP53 to exert therapeutic effect in activated B-cell-like diffuse large B-cell lymphoma

Jing Tang, Yue Li, Jiazhu Wu, [...], Haorui Shen, Hua Yin, Jinhua Liang, Li Wang, Jianyong Li, Yi Xia, Wei Xu << Fewer

https://doi.org/10.1016/j.gendis.2023.04.012

Published: 18 May 2023

2024, 11 (2): 550-553

Downloads: 3 | Views: 73 |

PDF (862.8 KB)

Open Access Rapid Communication

PLAU plays a functional role in driving lung squamous cell carcinoma metastasis

Pengbo Ning, Fuyu Du, Xiaocheng Gong, [...], Jingtong Yuan, Caixia Ding, Xilian Zhao, Wei Li << Fewer

https://doi.org/10.1016/j.gendis.2023.04.010

Published: 19 May 2023

2024, 11 (2): 554-557

Downloads: 4 | Views: 58 |

PDF (1,015.1 KB)

Open Access Rapid Communication

An analysis of the transcriptional landscape in hypoxia-treated primary nucleus pulposus cells

Zhicai Peng, Zhuo Wang, Shuaichi Guo, [...], Bing Tan, Ruichao Cao, Shengqiang Cheng, Jun Chen, Chunwang Xie, Dehong Mao, Zhenming Hu << Fewer

https://doi.org/10.1016/j.gendis.2023.04.009

Published: 18 May 2023

2024, 11 (2): 558-560

Downloads: 2 | Views: 61 |

PDF (971.7 KB)

Open Access Rapid Communication

Targeted NGS analysis reveals a complex genetic background of idiopathic erythrocytosis in a large Venetian family

Bertozzi Irene, Benetti Andrea, Regazzo Daniela, [...], Polese Francesca, Biagetti Giacomo, Ceolotto Giulio, Randi Maria Luigia << Fewer

https://doi.org/10.1016/j.gendis.2023.03.030

Published: 18 May 2023

2024, 11 (2): 561-563

Downloads: 2 | Views: 55 |

PDF (597.4 KB)

Open Access Rapid Communication

ZYX promotes invasion and metastasis of gastric cancer cells via WNK1/SNAI1axis

Yi Jiang, Dongfang Xiang, Xianmei Wen, [...], Mingmin He, Yan Qin, Xiaoxue Yao, Zexuan Yan, Xiuli Geng, Yong Ren, Xiongwei Cai, Youhong Cui, Yan Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.03.018

Published: 13 April 2023

2024, 11 (2): 564-567

Downloads: 2 | Views: 86 |

PDF (1.3 MB)

Open Access Rapid Communication

Pan-cancer immunogenic death analysis identifies key roles of CXCR3 and CCL18 in hepatocellular carcinoma

Jia Guo, Xin Sun, Guowei Pan, [...], Ce Li, Xin He, Xiaofang Che, Zan Teng, Xiujuan Qu, Yunpeng Liu, Bowen Yang << Fewer

https://doi.org/10.1016/j.gendis.2023.04.007

Published: 10 May 2023

2024, 11 (2): 568-570

Downloads: 2 | Views: 64 |

PDF (1 MB)

Open Access Rapid Communication

Integrated analysis of single-cell and bulk RNA sequencing data reveals immune-related lncRNA-mRNA prognostic signature in triple-negative breast cancer

Hongying Zhao, Lei Yu, Lixia Wang, [...], Xiangzhe Yin, Kailai Liu, Wangyang Liu, Shihua Lin, Li Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.04.006

Published: 10 May 2023

2024, 11 (2): 571-574

Downloads: 2 | Views: 100 |

PDF (1.2 MB)

Open Access Rapid Communication

Neutrophil extracellular traps induced by interleukin 8 via CXCR1/2 promote the progression of gastric carcinoma through transcription factor IIB-related factor 1 and cyclin

Qianling Wang, Yiyin Zhang, Wenxi Ding, [...], Cheng Feng, Yuyan Wang, Xiaoli Wei, Ziting Qu, Hui Wang, Xiaoying Liu, Hua Wang, Kangsheng Gu << Fewer

https://doi.org/10.1016/j.gendis.2023.03.025

Published: 26 April 2023

2024, 11 (2): 575-578

Downloads: 2 | Views: 74 |

PDF (1.2 MB)

Open Access Rapid Communication

METTL1 promotes colorectal cancer cell proliferation by attenuating CHEK2-induced G1/S phase arrest

Houxiang Jiang, Ying Liu, Huibin Song, [...], Jinquan Xia, Ying Tian, Luolin Wang, Mingwei Li, Zhenyu Xu, Zhenglei Xu, Chang Zou << Fewer

https://doi.org/10.1016/j.gendis.2023.04.011

Published: 18 May 2023

2024, 11 (2): 579-581

Downloads: 2 | Views: 91 |

PDF (720.7 KB)

Open Access Rapid Communication

Nicotine up-regulates SLC7A5 expression depending on TRIM29 in non-small cell lung cancer

Dahua Liu, Haolin Ren, Guimin Wen, Pu Xia

https://doi.org/10.1016/j.gendis.2023.04.016

Published: 16 June 2023

2024, 11 (2): 582-584

Downloads: 2 | Views: 79 |

PDF (624.8 KB)

Open Access Rapid Communication

Non-invasive prenatal testing can detect silent cancers in expecting mothers

Alessandro Ottaiano, Monica Ianniello, Nadia Petrillo, [...], Mariachiara Santorsola, Luigia De Falco, Salvatore Giovanni Castaldi, Maria Antonietta Castaldi, Valentina Giudice, Carmine Selleri, Giovanni Savarese << Fewer

https://doi.org/10.1016/j.gendis.2023.04.008

Published: 18 May 2023

2024, 11 (2): 585-588

Downloads: 2 | Views: 93 |

PDF (222.2 KB)

Open Access Rapid Communication

Targeted nanopore sequencing for the identification of novel PRMT1 circRNAs unveils a diverse transcriptional profile of this gene in breast cancer cells

Maria Papatsirou, Andreas Scorilas, Diamantis C. Sideris, Christos K. Kontos

https://doi.org/10.1016/j.gendis.2023.04.013

Published: 18 May 2023

2024, 11 (2): 589-592

Downloads: 2 | Views: 52 |

PDF (1.4 MB)

Open Access Rapid Communication

Gene expression profiles contribute to robustly predicting prognosis in hepatocellular carcinoma

Long Liu, Yuhui Wang, Yuyuan Zhang, [...], Siyuan Weng, Hui Xu, Zaoqu Liu, Xinwei Han << Fewer

https://doi.org/10.1016/j.gendis.2023.01.025

Published: 24 March 2023

2024, 11 (2): 593-596

Downloads: 2 | Views: 92 |

PDF (1.7 MB)

REVIEW ARTICLES

Open Access Review Article

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

Yu Zhang, Xinliang Gu, Yang Li, [...], Yuejiao Huang, Shaoqing Ju << Fewer

https://doi.org/10.1016/j.gendis.2023.02.053

Published: 13 April 2023

2024, 11 (2): 597-613

Downloads: 2 | Views: 64 |

PDF (2.1 MB)

Open Access Review Article

Cancer organoids: A platform in basic and translational research

Xin Ma, Qin Wang, Guozheng Li, [...], Hui Li, Shouping Xu, Da Pang << Fewer

https://doi.org/10.1016/j.gendis.2023.02.052

Published: 12 April 2023

2024, 11 (2): 614-632

Downloads: 2 | Views: 86 |

PDF (1.5 MB)

Open Access Review Article

Single-cell RNA sequencing in juvenile idiopathic arthritis

Xiwen Luo, Xuemei Tang

https://doi.org/10.1016/j.gendis.2023.04.014

Published: 24 May 2023

2024, 11 (2): 633-644

Downloads: 2 | Views: 123 |

PDF (1.2 MB)

Open Access Review Article

The emerging roles of lysine-specific demethylase 4A in cancer: Implications in tumorigenesis and therapeutic opportunities

Guanjun Yang, Changyun Li, Fan Tao, [...], Yanjun Liu, Minghui Zhu, Yu Du, Chenjie Fei, Qiusheng She, Jiong Chen << Fewer

https://doi.org/10.1016/j.gendis.2022.12.020

Published: 23 March 2023

2024, 11 (2): 645-663

Downloads: 2 | Views: 92 |

PDF (2.9 MB)

Open Access Review Article

The generation and use of animal models of osteosarcoma in cancer research

Feifei Pu, Haoyu Guo, Deyao Shi, [...], Fengxia Chen, Yizhong Peng, Xin Huang, Jianxiang Liu, Zhicai Zhang, Zengwu Shao << Fewer

https://doi.org/10.1016/j.gendis.2022.12.021

Published: 24 March 2023

2024, 11 (2): 664-674

Downloads: 2 | Views: 67 |

PDF (1.2 MB)

Open Access Review Article

CRISPR/Cas9 system and its applications in nervous system diseases

Haibin Jiang, Mengyan Tang, Zidi Xu, [...], Yanan Wang, Mopu Li, Shuyin Zheng, Jianghu Zhu, Zhenlang Lin, Min Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.03.017

Published: 13 April 2023

2024, 11 (2): 675-686

Downloads: 2 | Views: 91 |

PDF (759.6 KB)

Open Access Review Article

The journey towards physiology and pathology: Tracing the path of neuregulin 4

Min Chen, Jieying Zhu, Hongyang Luo, [...], Wangjing Mu, Liang Guo << Fewer

https://doi.org/10.1016/j.gendis.2023.03.021

Published: 25 April 2023

2024, 11 (2): 687-700

Downloads: 2 | Views: 57 |

PDF (1.9 MB)

Open Access Review Article

The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities

Minjie Wu, Heng Dong, Chao Xu, [...], Mengqing Sun, Haojin Gao, Fangtian Bu, Jianxiang Chen << Fewer

https://doi.org/10.1016/j.gendis.2023.03.012

Published: 11 April 2023

2024, 11 (2): 701-710

Downloads: 2 | Views: 97 |

PDF (1.7 MB)

Open Access Review Article

Decoding m⁶A mRNA methylation by reader proteins in liver diseases

Lijiao Sun, Xin Chen, Sai Zhu, [...], Jianan Wang, Shaoxi Diao, Jinyu Liu, Jinjin Xu, Xiaofeng Li, Yingyin Sun, Cheng Huang, Xiaoming Meng, Xiongwen Lv, Jun Li << Fewer

https://doi.org/10.1016/j.gendis.2023.02.054

Published: 13 April 2023

2024, 11 (2): 711-726

Downloads: 2 | Views: 92 |

PDF (2.1 MB)

Open Access Review Article

WNT/β-catenin signaling in hepatocellular carcinoma: The aberrant activation, pathogenic roles, and therapeutic opportunities

Anna Gajos-Michniewicz, Malgorzata Czyz

https://doi.org/10.1016/j.gendis.2023.02.050

Published: 08 April 2023

2024, 11 (2): 727-746

Downloads: 2 | Views: 79 |

PDF (3 MB)

Open Access Review Article

Cardiac regeneration: Pre-existing cardiomyocyte as the hub of novel signaling pathway

Tao Wang, Xinzhe Chen, Kai Wang, [...], Jie Ju, Xue Yu, Wanpeng Yu, Cuiyun Liu, Yin Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.01.031

Published: 24 March 2023

2024, 11 (2): 747-759

Downloads: 2 | Views: 71 |

PDF (1.7 MB)

Open Access Review Article

Hippo-YAP/TAZ signaling in breast cancer: Reciprocal regulation of microRNAs and implications in precision medicine

Farzad Sadri, Seyede fatemeh Hosseini, Zohreh Rezaei, Mohammad Fereidouni

https://doi.org/10.1016/j.gendis.2023.01.017

Published: 23 March 2023

2024, 11 (2): 760-771

Downloads: 2 | Views: 93 |

PDF (2.1 MB)

Open Access Review Article

Vault RNAs (vtRNAs): Rediscovered non-coding RNAs with diverse physiological and pathological activities

Mahsa Aghajani Mir

https://doi.org/10.1016/j.gendis.2023.01.014

Published: 23 March 2023

2024, 11 (2): 772-787

Downloads: 2 | Views: 78 |

PDF (1.5 MB)

Open Access Review Article

RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunities

Ankit Srivastava, Deeksha Rikhari, Sameer Srivastava

https://doi.org/10.1016/j.gendis.2023.01.013

Published: 19 April 2023

2024, 11 (2): 788-806

Downloads: 4 | Views: 74 |

PDF (1.4 MB)

Open Access Review Article

Immune checkpoint inhibitors break whose heart? Perspectives from cardio-immuno-oncology

Yingying He, Hui Yu, Shuang Dai, [...], Miao He, Ling Ma, Zihan Xu, Feng Luo, Li Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.01.024

Published: 24 March 2023

2024, 11 (2): 807-818

Downloads: 2 | Views: 84 |

PDF (1.7 MB)

Open Access Review Article

Fantastic voyage: The journey of NLRP3 inflammasome activation

Xiangyong Que, Sihao Zheng, Qibin Song, [...], Huadong Pei, Pingfeng Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.01.009

Published: 23 March 2023

2024, 11 (2): 819-829

Downloads: 2 | Views: 100 |

PDF (1.2 MB)

Open Access Review Article

Signaling pathways governing the behaviors of leukemia stem cells

Shirin Azizidoost, Ava Nasrolahi, Mohadeseh Sheykhi-Sabzehpoush, [...], Amir Anbiyaiee, Seyed Esmaeil Khoshnam, Maryam Farzaneh, Shahab Uddin << Fewer

https://doi.org/10.1016/j.gendis.2023.01.008

Published: 23 March 2023

2024, 11 (2): 830-846

Downloads: 2 | Views: 96 |

PDF (1.3 MB)

Open Access Review Article

DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects

Xinhui Wang, Yaqi Dong, Hong Zhang, [...], Yinghui Zhao, Tianshu Miao, Ghazal Mohseni, Lutao Du, Chuanxin Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.02.038

Published: 30 March 2023

2024, 11 (2): 847-860

Downloads: 2 | Views: 96 |

PDF (1.9 MB)

Open Access Review Article

Oncogenic MORC2 in cancer development and beyond

Shan Zhang, Ayao Guo, Huan Wang, [...], Jia Liu, Chenshuang Dong, Junyi Ren, Guiling Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.05.010

Published: 03 July 2023

2024, 11 (2): 861-873

Downloads: 2 | Views: 67 |

PDF (2.3 MB)

Open Access Review Article

Crosstalk between glioblastoma and tumor microenvironment drives proneural-mesenchymal transition through ligand-receptor interactions

Yancheng Lai, Xiaole Lu, Yankai Liao, [...], Pei Ouyang, Hai Wang, Xian Zhang, Guanglong Huang, Songtao Qi, Yaomin Li << Fewer

https://doi.org/10.1016/j.gendis.2023.05.025

Published: 19 July 2023

2024, 11 (2): 874-889

Downloads: 2 | Views: 73 |

PDF (1.5 MB)

Open Access Review Article

IGF2BPs as novel m⁶A readers: Diverse roles in regulating cancer cell biological functions, hypoxia adaptation, metabolism, and immunosuppressive tumor microenvironment

Meiqi Duan, Haiyang Liu, Shasha Xu, [...], Zhi Yang, Fusheng Zhang, Guang Wang, Yutian Wang, Shan Zhao, Xiaofeng Jiang << Fewer

https://doi.org/10.1016/j.gendis.2023.06.017

Published: 20 July 2023

2024, 11 (2): 890-920

Downloads: 2 | Views: 101 |

PDF (2.4 MB)

FULL LENGTH ARTICLES

Open Access Full Length Article

Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

Hui-Qing Zhang, Fanyang Kong, Xiangyu Kong, [...], Tingting Jiang, Muyuan Ma, Shaojiang Zheng, Junli Guo, Keping Xie << Fewer

https://doi.org/10.1016/j.gendis.2023.01.019

Published: 31 March 2023

2024, 11 (2): 921-934

Downloads: 2 | Views: 73 |

PDF (3.7 MB)

Open Access Full Length Article

X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity

Yifan Hong, Xiazhu Zhou, Qi Li, [...], Jing Chen, Yuexin Wei, Chunlan Long, Lianju Shen, Xiangqin Zheng, Dinggang Li, Xia Wang, Chenjun Yu, Shengde Wu, Guanghui Wei << Fewer

https://doi.org/10.1016/j.gendis.2023.02.030

Published: 27 March 2023

2024, 11 (2): 935-951

Downloads: 2 | Views: 71 |

PDF (4.8 MB)

Open Access Full Length Article

Cellular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression

Zhenhao Zhang, Doudou Jing, Baijun Xuan, [...], Zhicai Zhang, Wei Wu, Zengwu Shao << Fewer

https://doi.org/10.1016/j.gendis.2023.02.028

Published: 27 March 2023

2024, 11 (2): 952-963

Downloads: 3 | Views: 73 |

PDF (4.8 MB)

Open Access Full Length Article

Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling

Chengzhi Wu, Hengyu Liu, Dongmei Zhong, [...], Xiaoming Yang, Zhiheng Liao, Yuyu Chen, Shun Zhang, Deying Su, Baolin Zhang, Chuan Li, Liru Tian, Caixia Xu, Peiqiang Su << Fewer

https://doi.org/10.1016/j.gendis.2023.02.012

Published: 24 March 2023

2024, 11 (2): 964-977

Downloads: 2 | Views: 90 |

PDF (6.2 MB)

Open Access Full Length Article

SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer

Ming-Yan Shi, Yarong Wang, Ying Shi, [...], Ruofei Tian, Xiaohong Chen, Hai Zhang, Ke Wang, Zhinan Chen, Ruo Chen << Fewer

https://doi.org/10.1016/j.gendis.2023.02.015

Published: 24 March 2023

2024, 11 (2): 978-992

Downloads: 2 | Views: 112 |

PDF (4.9 MB)

Open Access Full Length Article

The m⁶A regulator KIAA1429 stabilizes RAB27B mRNA and promotes the progression of chronic myeloid leukemia and resistance to targeted therapy

Fangyi Yao, Fangmin Zhong, Junyao Jiang, [...], Ying Cheng, Shuai Xu, Jing Liu, Jin Lin, Jing Zhang, Shuqi Li, Meiyong Li, Yanmei Xu, Bo Huang, Xiaozhong Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.03.016

Published: 12 April 2023

2024, 11 (2): 993-1008

Downloads: 2 | Views: 89 |

PDF (5.3 MB)

Open Access Full Length Article

Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder

Gaojia Zhang, Ling Li, Yan Kong, [...], Dandan Xu, Yu Bao, Zhiting Zhang, Zhixiang Liao, Jiao Jiao, Dandan Fan, Xiaojing Long, Ji Dai, Chunming Xie, Zhiqiang Meng, Zhijun Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.02.049

Published: 10 April 2023

2024, 11 (2): 1009-1021

Downloads: 2 | Views: 74 |

PDF (1.7 MB)

Open Access Full Length Article

E674Q (Shanghai APP mutant), a novel amyloid precursor protein mutation, in familial late-onset Alzheimer’s disease

Yongfang Zhang, Xinyi Xie, Boyu Chen, [...], Lina Pan, Jianping Li, Wanbing Wang, Jintao Wang, Ran Tang, Qiang Huang, Xiaofen Chen, Rujing Ren, Zhentao Zhang, Wei Fu, Gang Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.02.051

Published: 10 April 2023

2024, 11 (2): 1022-1034

Downloads: 2 | Views: 81 |

PDF (3.1 MB)

Open Access Full Length Article

The endoplasmic reticulum membrane protein complex subunit Emc6 is essential for rhodopsin localization and photoreceptor cell survival

Kuanxiang Sun, Lu Liu, Xiaoyan Jiang, [...], Heting Wang, Lin Wang, Yeming Yang, Wenjing Liu, Lin Zhang, Xiaohui Zhao, Xianjun Zhu << Fewer

https://doi.org/10.1016/j.gendis.2023.03.033

Published: 23 May 2023

2024, 11 (2): 1035-1049

Downloads: 3 | Views: 77 |

PDF (6.3 MB)

Open Access Full Length Article

Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways

Xiaoxuan Wang, Lijuan Luo, Jingtao Xu, [...], Qiuping Lu, Haichao Xia, Yanran Huang, Lulu Zhang, Liping Xie, Habu Jiwa, Shiqiong Liang, Xiaoji Luo, Jinyong Luo << Fewer

https://doi.org/10.1016/j.gendis.2023.03.031

Published: 18 May 2023

2024, 11 (2): 1050-1065

Downloads: 2 | Views: 77 |

PDF (7.9 MB)

Open Access Full Length Article

Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

Junyan Yan, Lu Xiao, Di Feng, [...], Baolin Chen, Ting Yang, Bei Tong, Ruifang Luo, Yuting Wang, Jie Chen << Fewer

https://doi.org/10.1016/j.gendis.2023.03.032

Published: 24 May 2023

2024, 11 (2): 1066-1081

Downloads: 2 | Views: 75 |

PDF (3.5 MB)

Corrigenda

Open Access Corrigendum

Corrigendum to ‘A novel STK11 gene mutation (c.388dupG, p.Glu130Glyfs*33) in a Peutz-Jeghers family and evidence of higher gastric cancer susceptibility associated with alterations in STK11 region aa 107–170’ [Gene Dis (9) (2022) 288–291]

Giovanna Forte, Filomena Cariola, Katia De Marco, [...], Andrea Manghisi, Filomena Anna Guglielmi, Raffaele Armentano, Giuseppe Lippolis, Pietro Giorgio, Cristiano Simone, Vittoria Disciglio << Fewer

https://doi.org/10.1016/j.gendis.2023.08.001

Published: 02 August 2023

2024, 11 (2): 1082-1083

Downloads: 3 | Views: 74 |

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Open Access Corrigendum

Corrigendum to ‘Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes’ [Gene Dis (10) (2023), 1187–1189]

Giovanna Forte, Filomena Cariola, Antonia Lucia Buonadonna, [...], Anna Filomena Guglielmi, Andrea Manghisi, Katia De Marco, Valentina Grossi, Candida Fasano, Martina Lepore Signorile, Paola Sanese, Rosanna Bagnulo, Nicoletta Resta, Vittoria Disciglio, Cristiano Simone << Fewer

https://doi.org/10.1016/j.gendis.2023.08.002

Published: 02 August 2023

2024, 11 (2): 1084

Downloads: 1 | Views: 109 |

PDF (193.6 KB)