Genes & Diseases Open Access Editors-in-Chief: Ailong Huang, Tong-Chuan He
Home Genes & Diseases All Issues Volume 11 Issue 1
Volume 11 Issue 1, January 2024
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PP. 1-508
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53 articles
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Editorials
Editorial | Open Access
Complete response of a locally advanced pulmonary hepatoid adenocarcinoma patient to perioperative XELOX-containing chemoimmunotherapy
Kaiyan Chen, Ying Yu, Zhiyu Huang, [...], Lei Gong, Yun Fan << Fewer
Published: 03 January 2023
2024, 11(1): 1-3
Editorial | Open Access
Deficiency of Trp53 and Rb1 in myeloid cell lineage spontaneously develops acute myeloid leukemia in a mouse model
Yang Li, Shu-ting Yang, Shuying Yang
Published: 30 December 2022
2024, 11(1): 4-6
Editorial | Open Access
A novel structural variant of RET causes familial Hirschsprung’s disease via nonsense-mediated mRNA decay
Qi Wang, Siyu Pu, Bo Xiang, Jing Chen
Published: 14 April 2023
2024, 11(1): 7-10
RAPID COMMUNICATIONS
Rapid Communication | Open Access
A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis
Xinghui Li, Haiping Wang, Yandi Wu, [...], Li Zou, Shijie Deng, Xinlu Fu, Tongsheng Huang, Conghui Shen, Teng Wu, Weibin Cai << Fewer
Published: 23 March 2023
2024, 11(1): 11-14
Rapid Communication | Open Access
Therapeutic genome editing of an aberrant splice site in β-thalassemia by CRISPR/Cas9 with multiple sgRNAs
Fei Yang, Shuqian Xu, Chao Huang, [...], Zhiqiang Shao, Yuefen Hu, Yang Yang, Yongrong Lai, Qing Ke, Dan Liang, Yuxuan Wu << Fewer
Published: 24 March 2023
2024, 11(1): 15-18
Rapid Communication | Open Access
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response
Zhenhai Li, Wenchao Xu, Feng Chen, [...], Jun Zhang, Wei-Guo Zhu << Fewer
Published: 31 December 2022
2024, 11(1): 19-22
Rapid Communication | Open Access
Development of novel 5-FU modified siRNA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake
Andrew Fesler, Ga-Ram Hwang, Jingfang Ju
Published: 29 December 2022
2024, 11(1): 23-25
Rapid Communication | Open Access
Distinct enhancer-promoter modes determine Sox2 regulation in mouse pluripotent cells
Lei Huang, Xiusheng Zhu, Qing Li, [...], Dashuai Kong, Qitong Huang, Jing Luo, Siyuan Kong, Yanling Peng, Yubo Zhang << Fewer
Published: 28 December 2022
2024, 11(1): 26-29
Rapid Communication | Open Access
Hypermethylation of the ALOX12 and CBS promoters in osteoporosis: Potential biomarkers for early diagnosis
Shang Guo, Yue Wu, Weekai Chia, [...], Peichun Hsu, Hongwei Wang, Yunliang Wang, Biao Zhong << Fewer
Published: 10 April 2023
2024, 11(1): 30-33
Rapid Communication | Open Access
Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates
Budhadev Baral, Dharmendra Kashyap, Nidhi Varshney, [...], Tarun Prakash Verma, Ajay Kumar Jain, Debi Chatterji, Vinod Kumar, Amit Mishra, Awanish Kumar, Hem Chandra Jha << Fewer
Published: 05 April 2023
2024, 11(1): 34-37
Rapid Communication | Open Access
Identification of gene classifier and modules associated with SARS-CoV-2 ARI in nasal swab
Pandikannan Krishnamoorthy, Athira S. Raj, Himanshu Kumar
Published: 05 April 2023
2024, 11(1): 38-41
Rapid Communication | Open Access
Integrated bulk and single-cell transcriptome data identify clinically relevant cell populations in clear cell renal cell carcinoma
Pingbao Zhang, Pu Zhang, Jun Gao, [...], Xiaosong Li, Chengcheng Wei, Weihui Liu, QingLiu He, Yuan Zhang << Fewer
Published: 07 April 2023
2024, 11(1): 42-45
Rapid Communication | Open Access
Transcriptomic analysis identifies the S100 calcium-binding protein β subunit (S100B) and intercellular adhesion molecule-1 (ICAM-1) as potential diagnostic biomarkers for acute cerebral infarction
Dan Cheng, Yushuo Wang, Jingna Li, [...], Yulan Yao, Simiao Zhang, Yunliang Wang << Fewer
Published: 07 April 2023
2024, 11(1): 46-48
Rapid Communication | Open Access
Single-cell RNA sequencing reveals abnormal transcriptome signature of erythroid progenitors in pure red cell aplasia
Yumei Liu, Haiyue Niu, Jie Ren, [...], Zhiqin Wang, Li Yan, Limin Xing, Zonghong Shao, Rong Fu, Zhigang Cai, Huaquan Wang << Fewer
Published: 05 April 2023
2024, 11(1): 49-52
Rapid Communication | Open Access
Distinct clinical profiles and mutation landscapes of gliomas originating from the neocortex, mesocortex, and cerebellum
Ye Cheng, Lei Zhang, Xiaolong Wu, [...], Hiroaki Wakimoto, Haoming Geng, Yukui Wei, Geng Xu, Xinru Xiao, Jie Bai, Yaming Wang, Zeliang Hu, Leiming Wang, Qingtang Lin << Fewer
Published: 05 April 2023
2024, 11(1): 53-56
Rapid Communication | Open Access
Hepatocyte-specific deletion of Mettl3 promotes hepatocellular carcinoma in mice
Chunhong Liu, Xinzhi Li, Zhicheng Yao, [...], Xueying Li, Zheng Chen << Fewer
Published: 05 April 2023
2024, 11(1): 57-59
Rapid Communication | Open Access
C19MC miRNA-520G induces SP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma
Goodwin G. Jinesh, Marian T. Smallin, Nino Mtchedlidze, [...], Isha Godwin, Marco Napoli, Nicole Hackel, Manali S. Phadke, Avani A. Deshpande, Xiaobo Li, John H. Lockhart, Jaden R. Baldwin, Suehelay Acevedo-Acevedo, Yifeng Gao, Michelle A. Reiser, Keiran S.M. Smalley, Elsa R. Flores, Andrew S. Brohl << Fewer
Published: 05 April 2023
2024, 11(1): 60-63
Rapid Communication | Open Access
Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways
Ying Li, Lingli Ding, Yage Zhang, [...], Bingyu Zhou, Gene Chi Wai Man, Min Wang, Jinglan Li, Yamei Liu, Weiping Lin, Haibin Wang, Sien Lin, Liangliang Xu << Fewer
Published: 04 April 2023
2024, 11(1): 64-66
Rapid Communication | Open Access
Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease
Souvik Kar, Andrea Perrelli, Kiran Kumar Bali, [...], Raffaella Mastrocola, Arpita Kar, Bushra Khan, Luis Gand, Arnab Nayak, Christian Hartmann, Wolfram S. Kunz, Amir Samii, Helmut Bertalanffy, Saverio Francesco Retta << Fewer
Published: 03 April 2023
2024, 11(1): 67-71
Rapid Communication | Open Access
A BBS4 mutation causes autosomal dominant polycystic liver disease
Yalu Cui, Wenping Xu, Jinpei Liu, [...], Shuqing Liu, Wei Huang, Yihai Shi, Xin Zhang, Cuihua Lu, Weifen Xie << Fewer
Published: 05 April 2023
2024, 11(1): 72-75
Rapid Communication | Open Access
Clinical and genomic analysis of baseline and acquired MET fusions with an intact kinase domain in lung cancer patients
Bo Jin, Yutong Ma, Qian Wu, [...], Qiuxiang Ou, Yang Shao, Shun Xu << Fewer
Published: 05 April 2023
2024, 11(1): 76-79
Rapid Communication | Open Access
The single-cell landscape reveals unique tumor subsets and microenvironments associated with poor clinical outcomes in primary testicular diffuse large B-cell lymphoma
Zhouliang Bian, Benhong Gu, Guohai Shi, [...], Jiahui Guo, Dong Li, Hanlin Zeng, Bin Jiang, Daliu Min, Hengchuan Su, Yanjie Zhang << Fewer
Published: 19 April 2023
2024, 11(1): 80-83
Rapid Communication | Open Access
A novel mutation of glycogen synthase kinase-3β leads to a reduced level of GSK3β protein in a patient with dilated cardiomyopathy
Ke Gong, Zhiping Tan, Haidan Liu, [...], Xiaobo Liao, Xinmin Zhou, Bangliang Yin, Shi Zeng, Yao Yao, Yifeng Yang, Li Xie << Fewer
Published: 01 April 2023
2024, 11(1): 84-86
Rapid Communication | Open Access
RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations
Hongxia Zhang, Yueya Zhong, Yuanming He, [...], Yujia Xu, Ying Ren, Haixia Zhuang, Tong Sun, Zhigang Zhu, Xinliang Mao << Fewer
Published: 10 May 2023
2024, 11(1): 87-90
Rapid Communication | Open Access
DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis
Qiuxia Cui, Jian Sun, Jingping Yuan, [...], Juanjuan Li, Chuanyu Yang, Guangshi Du, Chengang Zhou, Pu Qiu, Jidong Gao, Yuanqi Zhang, Dewei Jiang, Ceshi Chen << Fewer
Published: 02 May 2023
2024, 11(1): 91-94
Rapid Communication | Open Access
Predictive value of T cell receptor repertoire profiling for immunosuppressive therapy in severe aplastic anemia
Cunte Chen, Yuling Zhang, Dongpei Lu, [...], Zelong Zhang, Jun Yang, Xiaowei Chen, Ming Zhou, Wenjian Mo, Caixia Wang, Qinghua Cai, Yumiao Li, Ruiqing Zhou, Shilin Xu, Wei Zhou, Tingfen Deng, Shiyi Pan, Yanli Xu, Shunqing Wang, Yuping Zhang << Fewer
Published: 29 April 2023
2024, 11(1): 95-98
Rapid Communication | Open Access
DNA methylation of SMPD3-based diagnostic biomarkers of NASH and mild fibrosis
Na Wu, Mofan Feng, Siran Yue, [...], Xinyu Shi, Nan Tang, Yalan Xiong, Jianying Wang, Lei Zhang, Hualing Song, Yi Shi, Guang He, Guang Ji, Baocheng Liu << Fewer
Published: 26 April 2023
2024, 11(1): 99-102
REVIEW ARTICLES
Review Article | Open Access
Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk
Kevin Qin, Michael Yu, Jiaming Fan, [...], Hongwei Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Connie Chen, Yonghui Wang, Annie Wang, Zander Schwartz, Jeffrey Hong, Lily Song, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin H. Ho, Jason Strelzow, Russell R. Reid, Tong-Chuan He, Lewis L. Shi << Fewer
Published: 24 March 2023
2024, 11(1): 103-134
Review Article | Open Access
Effects of microenvironment and biological behavior on the paracrine function of stem cells
Zhixin Xue, Yunjun Liao, Ye Li
Published: 11 April 2023
2024, 11(1): 135-147
Review Article | Open Access
Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance
Divya Ajmeera, Rajanna Ajumeera
Published: 20 January 2023
2024, 11(1): 148-175
Review Article | Open Access
Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression
Zhuang Chen, Qiming Wang, Jinbo Liu, [...], Wenkang Wang, Weitang Yuan, Yang Liu, Zhenqiang Sun, Chengzeng Wang << Fewer
Published: 19 January 2023
2024, 11(1): 176-188
Review Article | Open Access
Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance
Ebrahim H. Maleki, Ahmad Reza Bahrami, Maryam M. Matin
Published: 14 January 2023
2024, 11(1): 189-204
Review Article | Open Access
Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy
Pengcheng Zhao, Longyan Xie, Lei Yu, Ping Wang
Published: 11 January 2023
2024, 11(1): 205-217
Review Article | Open Access
Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
Zanwen Zuo, Zerong Zhou, Yuzhou Chang, [...], Yan Liu, Yuping Shen, Qizhang Li, Lei Zhang << Fewer
Published: 28 December 2022
2024, 11(1): 218-233
Review Article | Open Access
HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies
Yan Zhao, Cheng Xing, Yating Deng, [...], Can Ye, Hongling Peng << Fewer
Published: 30 March 2023
2024, 11(1): 234-251
Review Article | Open Access
The role of m6A RNA methylation in autoimmune diseases: Novel therapeutic opportunities
Yunan Shan, Wei Chen, Yanbin Li
Published: 24 March 2023
2024, 11(1): 252-267
Review Article | Open Access
Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine
Mohadeseh Khoshandam, Hossein Soltaninejad, Marziyeh Mousazadeh, [...], Amir Ali Hamidieh, Saman Hosseinkhani << Fewer
Published: 25 March 2023
2024, 11(1): 268-282
Review Article | Open Access
Recombinant adeno-associated virus 8 vector in gene therapy: Opportunities and challenges
Liyuan Zhao, Zixuan Yang, Minhui Zheng, [...], Lei Shi, Mengyun Gu, Gang Liu, Feng Miao, Yan Chang, Fanghua Huang, Naping Tang << Fewer
Published: 24 March 2023
2024, 11(1): 283-293
Review Article | Open Access
Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases
Qi Li, Anran Huo, Mengqi Li, [...], Jiali Wang, Qiao Yin, Lumiao Chen, Xin Chu, Yuan Qin, Yuwan Qi, Yang Li, Hengxiang Cui, Qifei Cong << Fewer
Published: 27 March 2023
2024, 11(1): 294-305
Review Article | Open Access
Mechanism of PARP inhibitor resistance and potential overcoming strategies
Xiaoyu Fu, Ping Li, Qi Zhou, [...], Ruyuan He, Guannan Wang, Shiya Zhu, Amir Bagheri, Gary Kupfer, Huadong Pei, Juanjuan Li << Fewer
Published: 24 March 2023
2024, 11(1): 306-320
Review Article | Open Access
The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy
Md Rakibul Alam, Md Mizanur Rahman, Zhiguo Li
Published: 24 March 2023
2024, 11(1): 321-334
Review Article | Open Access
The essential roles of m6A modification in osteogenesis and common bone diseases
Yuxi Gu, Yidan Song, Yihua Pan, Jun Liu
Published: 28 March 2023
2024, 11(1): 335-345
Review Article | Open Access
Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease
Huanyu Luo, Anahid Ahmadi Birjandi, Feilong Ren, [...], Tianmeng Sun, Paul T. Sharpe, Hongchen Sun, Zhengwen An << Fewer
Published: 12 April 2023
2024, 11(1): 346-357
Review Article | Open Access
Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis
Xinrui Dong, Ye Li, Xiaonan Sheng, [...], Weihang Zhou, Aijun Sun, Huijuan Dai << Fewer
Published: 25 April 2023
2024, 11(1): 358-366
Review Article | Open Access
Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword
Yunchao Zhang, Jiayu Tang, Cheng Wang, [...], Qinxiu Zhang, Anqi Zeng, Linjiang Song << Fewer
Published: 16 June 2023
2024, 11(1): 367-381
FULL LENGTH ARTICLES
Full Length Article | Open Access
RNA m6A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression
Zheng Zhang, Keren Zhou, Li Han, [...], Andrew Small, Jianhuang Xue, Huilin Huang, Hengyou Weng, Rui Su, Brandon Tan, Chao Shen, Wei Li, Zhicong Zhao, Ying Qing, Xi Qin, Kitty Wang, Keith Leung, Mark Boldin, Chun-Wei Chen, David Ann, Zhijian Qian, Xiaolan Deng, Jianjun Chen, Zhenhua Chen << Fewer
Published: 28 March 2023
2024, 11(1): 382-396
Full Length Article | Open Access
Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin
Zhe Chen, Qian Guo, Shichen Huang, [...], Lei Li, Feng Wu, Zhilong Liu, Zhigang Li, Tao Chen, Guanbin Song, Shuangnian Xu, Jieping Chen, Yu Hou << Fewer
Published: 25 January 2023
2024, 11(1): 397-412
Full Length Article | Open Access
Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia
Dongsheng Zhang, Wenjuan Tang, Haitao Niu, [...], William Tse, Hai-Bin Ruan, Helmut Dolznig, Thomas Knösel, Friedrich Karl-Heinz, Madeleine Themanns, Jiang Wang, Mingquan Song, Lee Denson, Lukas Kenner, Richard Moriggl, Yi Zheng, Xiaonan Han << Fewer
Published: 02 January 2023
2024, 11(1): 413-429
Full Length Article | Open Access
Zinc finger protein 831 promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the STAT3/Bcl2 signaling pathway
Jun Fan, Zhe Zhang, Hongqiang Chen, [...], Dongjiao Chen, Wenbo Yuan, Jingzhi Li, Yong Zeng, Shimeng Zhou, Shu Zhang, Gang Zhang, Jiashen Xiong, Lu Zhou, Jing Xu, Wenbin Liu, Yan Xu << Fewer
Published: 29 December 2022
2024, 11(1): 430-448
Full Length Article | Open Access
CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury
Yixin Ma, Lili Huang, Zheng Zhang, [...], Pengfei Yang, Qingsong Chen, Xujia Zeng, Fangyan Tan, Chunxia Wang, Xiongzhong Ruan, Xiaohui Liao << Fewer
Published: 03 January 2023
2024, 11(1): 449-463
Full Length Article | Open Access
IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization
Mengtian Fan, Nana Geng, Xingyue Li, [...], Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo << Fewer
Published: 29 December 2022
2024, 11(1): 464-478
Full Length Article | Open Access
A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis
Yanran Bi, Ruiling Zheng, Jiahao Hu, [...], Ruiqing Shi, Junfeng Shi, Yutao Wang, Peng Wang, Wenyi Jiang, Gyudong Kim, Zhiguo Liu, Xiaokun Li, Li Lin << Fewer
Published: 03 April 2023
2024, 11(1): 479-494
Full Length Article | Open Access
IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53
Baoyu He, Jing Liang, Qianqian Qin, [...], Yuqin Zhang, Shuo Shi, Jinghe Cao, Zhixin Zhang, Qingli Bie, Rou Zhao, Li Wei, Baogui Zhang, Bin Zhang << Fewer
Published: 23 April 2023
2024, 11(1): 495-508