Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R

Editors-in-Chief: Ailong Huang, Tong-Chuan He

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Volume 11

Issue 1, January 2024

pp.1-508 53 articles

Editorials

Open Access Editorial

Complete response of a locally advanced pulmonary hepatoid adenocarcinoma patient to perioperative XELOX-containing chemoimmunotherapy

Kaiyan Chen, Ying Yu, Zhiyu Huang, [...], Lei Gong, Yun Fan << Fewer

https://doi.org/10.1016/j.gendis.2022.12.006

Published: 03 January 2023

2024, 11 (1): 1-3

Downloads: 3 | Views: 52 |

PDF (643.5 KB)

Open Access Editorial

Deficiency of Trp53 and Rb1 in myeloid cell lineage spontaneously develops acute myeloid leukemia in a mouse model

Yang Li, Shu-ting Yang, Shuying Yang

https://doi.org/10.1016/j.gendis.2022.12.004

Published: 30 December 2022

2024, 11 (1): 4-6

Downloads: 5 | Views: 62 |

PDF (1.4 MB)

Open Access Editorial

A novel structural variant of RET causes familial Hirschsprung’s disease via nonsense-mediated mRNA decay

Qi Wang, Siyu Pu, Bo Xiang, Jing Chen

https://doi.org/10.1016/j.gendis.2023.03.008

Published: 14 April 2023

2024, 11 (1): 7-10

Downloads: 3 | Views: 75 |

PDF (944.2 KB)

RAPID COMMUNICATIONS

Open Access Rapid Communication

A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis

Xinghui Li, Haiping Wang, Yandi Wu, [...], Li Zou, Shijie Deng, Xinlu Fu, Tongsheng Huang, Conghui Shen, Teng Wu, Weibin Cai << Fewer

https://doi.org/10.1016/j.gendis.2023.01.011

Published: 23 March 2023

2024, 11 (1): 11-14

Downloads: 2 | Views: 51 |

PDF (1.3 MB)

Open Access Rapid Communication

Therapeutic genome editing of an aberrant splice site in β-thalassemia by CRISPR/Cas9 with multiple sgRNAs

Fei Yang, Shuqian Xu, Chao Huang, [...], Zhiqiang Shao, Yuefen Hu, Yang Yang, Yongrong Lai, Qing Ke, Dan Liang, Yuxuan Wu << Fewer

https://doi.org/10.1016/j.gendis.2023.01.010

Published: 24 March 2023

2024, 11 (1): 15-18

Downloads: 4 | Views: 56 |

PDF (959.1 KB)

Open Access Rapid Communication

BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response

Zhenhai Li, Wenchao Xu, Feng Chen, [...], Jun Zhang, Wei-Guo Zhu << Fewer

https://doi.org/10.1016/j.gendis.2022.12.001

Published: 31 December 2022

2024, 11 (1): 19-22

Downloads: 2 | Views: 54 |

PDF (884.9 KB)

Open Access Rapid Communication

Development of novel 5-FU modified siRNA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake

Andrew Fesler, Ga-Ram Hwang, Jingfang Ju

https://doi.org/10.1016/j.gendis.2022.11.020

Published: 29 December 2022

2024, 11 (1): 23-25

Downloads: 2 | Views: 84 |

PDF (600.3 KB)

Open Access Rapid Communication

Distinct enhancer-promoter modes determine Sox2 regulation in mouse pluripotent cells

Lei Huang, Xiusheng Zhu, Qing Li, [...], Dashuai Kong, Qitong Huang, Jing Luo, Siyuan Kong, Yanling Peng, Yubo Zhang << Fewer

https://doi.org/10.1016/j.gendis.2022.11.019

Published: 28 December 2022

2024, 11 (1): 26-29

Downloads: 2 | Views: 47 |

PDF (767.5 KB)

Open Access Rapid Communication

Hypermethylation of the ALOX12 and CBS promoters in osteoporosis: Potential biomarkers for early diagnosis

Shang Guo, Yue Wu, Weekai Chia, [...], Peichun Hsu, Hongwei Wang, Yunliang Wang, Biao Zhong << Fewer

https://doi.org/10.1016/j.gendis.2023.03.005

Published: 10 April 2023

2024, 11 (1): 30-33

Downloads: 4 | Views: 78 |

PDF (687.3 KB)

Open Access Rapid Communication

Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

Budhadev Baral, Dharmendra Kashyap, Nidhi Varshney, [...], Tarun Prakash Verma, Ajay Kumar Jain, Debi Chatterji, Vinod Kumar, Amit Mishra, Awanish Kumar, Hem Chandra Jha << Fewer

https://doi.org/10.1016/j.gendis.2023.03.003

Published: 05 April 2023

2024, 11 (1): 34-37

Downloads: 2 | Views: 54 |

PDF (1.2 MB)

Open Access Rapid Communication

Identification of gene classifier and modules associated with SARS-CoV-2 ARI in nasal swab

Pandikannan Krishnamoorthy, Athira S. Raj, Himanshu Kumar

https://doi.org/10.1016/j.gendis.2023.03.004

Published: 05 April 2023

2024, 11 (1): 38-41

Downloads: 2 | Views: 60 |

PDF (1.2 MB)

Open Access Rapid Communication

Integrated bulk and single-cell transcriptome data identify clinically relevant cell populations in clear cell renal cell carcinoma

Pingbao Zhang, Pu Zhang, Jun Gao, [...], Xiaosong Li, Chengcheng Wei, Weihui Liu, QingLiu He, Yuan Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.03.007

Published: 07 April 2023

2024, 11 (1): 42-45

Downloads: 2 | Views: 73 |

PDF (1 MB)

Open Access Rapid Communication

Transcriptomic analysis identifies the S100 calcium-binding protein β subunit (S100B) and intercellular adhesion molecule-1 (ICAM-1) as potential diagnostic biomarkers for acute cerebral infarction

Dan Cheng, Yushuo Wang, Jingna Li, [...], Yulan Yao, Simiao Zhang, Yunliang Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.03.006

Published: 07 April 2023

2024, 11 (1): 46-48

Downloads: 2 | Views: 47 |

PDF (427.8 KB)

Open Access Rapid Communication

Single-cell RNA sequencing reveals abnormal transcriptome signature of erythroid progenitors in pure red cell aplasia

Yumei Liu, Haiyue Niu, Jie Ren, [...], Zhiqin Wang, Li Yan, Limin Xing, Zonghong Shao, Rong Fu, Zhigang Cai, Huaquan Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.03.002

Published: 05 April 2023

2024, 11 (1): 49-52

Downloads: 2 | Views: 50 |

PDF (1.1 MB)

Open Access Rapid Communication

Distinct clinical profiles and mutation landscapes of gliomas originating from the neocortex, mesocortex, and cerebellum

Ye Cheng, Lei Zhang, Xiaolong Wu, [...], Hiroaki Wakimoto, Haoming Geng, Yukui Wei, Geng Xu, Xinru Xiao, Jie Bai, Yaming Wang, Zeliang Hu, Leiming Wang, Qingtang Lin << Fewer

https://doi.org/10.1016/j.gendis.2023.02.044

Published: 05 April 2023

2024, 11 (1): 53-56

Downloads: 2 | Views: 80 |

PDF (1.1 MB)

Open Access Rapid Communication

Hepatocyte-specific deletion of Mettl3 promotes hepatocellular carcinoma in mice

Chunhong Liu, Xinzhi Li, Zhicheng Yao, [...], Xueying Li, Zheng Chen << Fewer

https://doi.org/10.1016/j.gendis.2023.02.048

Published: 05 April 2023

2024, 11 (1): 57-59

Downloads: 3 | Views: 60 |

PDF (1 MB)

Open Access Rapid Communication

C19MC miRNA-520G induces SP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma

Goodwin G. Jinesh, Marian T. Smallin, Nino Mtchedlidze, [...], Isha Godwin, Marco Napoli, Nicole Hackel, Manali S. Phadke, Avani A. Deshpande, Xiaobo Li, John H. Lockhart, Jaden R. Baldwin, Suehelay Acevedo-Acevedo, Yifeng Gao, Michelle A. Reiser, Keiran S.M. Smalley, Elsa R. Flores, Andrew S. Brohl << Fewer

https://doi.org/10.1016/j.gendis.2023.02.047

Published: 05 April 2023

2024, 11 (1): 60-63

Downloads: 2 | Views: 32 |

PDF (1.5 MB)

Open Access Rapid Communication

Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways

Ying Li, Lingli Ding, Yage Zhang, [...], Bingyu Zhou, Gene Chi Wai Man, Min Wang, Jinglan Li, Yamei Liu, Weiping Lin, Haibin Wang, Sien Lin, Liangliang Xu << Fewer

https://doi.org/10.1016/j.gendis.2023.02.041

Published: 04 April 2023

2024, 11 (1): 64-66

Downloads: 2 | Views: 68 |

PDF (1 MB)

Open Access Rapid Communication

Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

Souvik Kar, Andrea Perrelli, Kiran Kumar Bali, [...], Raffaella Mastrocola, Arpita Kar, Bushra Khan, Luis Gand, Arnab Nayak, Christian Hartmann, Wolfram S. Kunz, Amir Samii, Helmut Bertalanffy, Saverio Francesco Retta << Fewer

https://doi.org/10.1016/j.gendis.2023.02.045

Published: 03 April 2023

2024, 11 (1): 67-71

Downloads: 2 | Views: 100 |

PDF (903.5 KB)

Open Access Rapid Communication

A BBS4 mutation causes autosomal dominant polycystic liver disease

Yalu Cui, Wenping Xu, Jinpei Liu, [...], Shuqing Liu, Wei Huang, Yihai Shi, Xin Zhang, Cuihua Lu, Weifen Xie << Fewer

https://doi.org/10.1016/j.gendis.2023.02.042

Published: 05 April 2023

2024, 11 (1): 72-75

Downloads: 2 | Views: 54 |

PDF (1,015.5 KB)

Open Access Rapid Communication

Clinical and genomic analysis of baseline and acquired MET fusions with an intact kinase domain in lung cancer patients

Bo Jin, Yutong Ma, Qian Wu, [...], Qiuxiang Ou, Yang Shao, Shun Xu << Fewer

https://doi.org/10.1016/j.gendis.2023.02.046

Published: 05 April 2023

2024, 11 (1): 76-79

Downloads: 2 | Views: 56 |

PDF (1.1 MB)

Open Access Rapid Communication

The single-cell landscape reveals unique tumor subsets and microenvironments associated with poor clinical outcomes in primary testicular diffuse large B-cell lymphoma

Zhouliang Bian, Benhong Gu, Guohai Shi, [...], Jiahui Guo, Dong Li, Hanlin Zeng, Bin Jiang, Daliu Min, Hengchuan Su, Yanjie Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.02.036

Published: 19 April 2023

2024, 11 (1): 80-83

Downloads: 2 | Views: 212 |

PDF (1.4 MB)

Open Access Rapid Communication

A novel mutation of glycogen synthase kinase-3β leads to a reduced level of GSK3β protein in a patient with dilated cardiomyopathy

Ke Gong, Zhiping Tan, Haidan Liu, [...], Xiaobo Liao, Xinmin Zhou, Bangliang Yin, Shi Zeng, Yao Yao, Yifeng Yang, Li Xie << Fewer

https://doi.org/10.1016/j.gendis.2023.02.040

Published: 01 April 2023

2024, 11 (1): 84-86

Downloads: 2 | Views: 80 |

PDF (1.1 MB)

Open Access Rapid Communication

RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations

Hongxia Zhang, Yueya Zhong, Yuanming He, [...], Yujia Xu, Ying Ren, Haixia Zhuang, Tong Sun, Zhigang Zhu, Xinliang Mao << Fewer

https://doi.org/10.1016/j.gendis.2023.04.004

Published: 10 May 2023

2024, 11 (1): 87-90

Downloads: 2 | Views: 50 |

PDF (1.2 MB)

Open Access Rapid Communication

DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis

Qiuxia Cui, Jian Sun, Jingping Yuan, [...], Juanjuan Li, Chuanyu Yang, Guangshi Du, Chengang Zhou, Pu Qiu, Jidong Gao, Yuanqi Zhang, Dewei Jiang, Ceshi Chen << Fewer

https://doi.org/10.1016/j.gendis.2023.03.028

Published: 02 May 2023

2024, 11 (1): 91-94

Downloads: 2 | Views: 53 |

PDF (1.2 MB)

Open Access Rapid Communication

Predictive value of T cell receptor repertoire profiling for immunosuppressive therapy in severe aplastic anemia

Cunte Chen, Yuling Zhang, Dongpei Lu, [...], Zelong Zhang, Jun Yang, Xiaowei Chen, Ming Zhou, Wenjian Mo, Caixia Wang, Qinghua Cai, Yumiao Li, Ruiqing Zhou, Shilin Xu, Wei Zhou, Tingfen Deng, Shiyi Pan, Yanli Xu, Shunqing Wang, Yuping Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.03.027

Published: 29 April 2023

2024, 11 (1): 95-98

Downloads: 2 | Views: 53 |

PDF (721 KB)

Open Access Rapid Communication

DNA methylation of SMPD3-based diagnostic biomarkers of NASH and mild fibrosis

Na Wu, Mofan Feng, Siran Yue, [...], Xinyu Shi, Nan Tang, Yalan Xiong, Jianying Wang, Lei Zhang, Hualing Song, Yi Shi, Guang He, Guang Ji, Baocheng Liu << Fewer

https://doi.org/10.1016/j.gendis.2023.03.023

Published: 26 April 2023

2024, 11 (1): 99-102

Downloads: 2 | Views: 48 |

PDF (1.5 MB)

REVIEW ARTICLES

Open Access Review Article

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

Kevin Qin, Michael Yu, Jiaming Fan, [...], Hongwei Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Connie Chen, Yonghui Wang, Annie Wang, Zander Schwartz, Jeffrey Hong, Lily Song, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin H. Ho, Jason Strelzow, Russell R. Reid, Tong-Chuan He, Lewis L. Shi << Fewer

https://doi.org/10.1016/j.gendis.2023.01.030

Published: 24 March 2023

2024, 11 (1): 103-134

Downloads: 6 | Views: 116 |

PDF (2.8 MB)

Open Access Review Article

Effects of microenvironment and biological behavior on the paracrine function of stem cells

Zhixin Xue, Yunjun Liao, Ye Li

https://doi.org/10.1016/j.gendis.2023.03.013

Published: 11 April 2023

2024, 11 (1): 135-147

Downloads: 3 | Views: 77 |

PDF (426.6 KB)

Open Access Review Article

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

Divya Ajmeera, Rajanna Ajumeera

https://doi.org/10.1016/j.gendis.2022.12.013

Published: 20 January 2023

2024, 11 (1): 148-175

Downloads: 2 | Views: 87 |

PDF (3.6 MB)

Open Access Review Article

Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression

Zhuang Chen, Qiming Wang, Jinbo Liu, [...], Wenkang Wang, Weitang Yuan, Yang Liu, Zhenqiang Sun, Chengzeng Wang << Fewer

https://doi.org/10.1016/j.gendis.2022.12.011

Published: 19 January 2023

2024, 11 (1): 176-188

Downloads: 3 | Views: 268 |

PDF (2.1 MB)

Open Access Review Article

Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

Ebrahim H. Maleki, Ahmad Reza Bahrami, Maryam M. Matin

https://doi.org/10.1016/j.gendis.2022.11.025

Published: 14 January 2023

2024, 11 (1): 189-204

Downloads: 2 | Views: 53 |

PDF (1.7 MB)

Open Access Review Article

Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy

Pengcheng Zhao, Longyan Xie, Lei Yu, Ping Wang

https://doi.org/10.1016/j.gendis.2022.12.008

Published: 11 January 2023

2024, 11 (1): 205-217

Downloads: 2 | Views: 93 |

PDF (1.4 MB)

Open Access Review Article

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

Zanwen Zuo, Zerong Zhou, Yuzhou Chang, [...], Yan Liu, Yuping Shen, Qizhang Li, Lei Zhang << Fewer

https://doi.org/10.1016/j.gendis.2022.11.022

Published: 28 December 2022

2024, 11 (1): 218-233

Downloads: 5 | Views: 102 |

PDF (2.3 MB)

Open Access Review Article

HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies

Yan Zhao, Cheng Xing, Yating Deng, [...], Can Ye, Hongling Peng << Fewer

https://doi.org/10.1016/j.gendis.2023.02.039

Published: 30 March 2023

2024, 11 (1): 234-251

Downloads: 2 | Views: 66 |

PDF (2.2 MB)

Open Access Review Article

The role of m⁶A RNA methylation in autoimmune diseases: Novel therapeutic opportunities

Yunan Shan, Wei Chen, Yanbin Li

https://doi.org/10.1016/j.gendis.2023.02.013

Published: 24 March 2023

2024, 11 (1): 252-267

Downloads: 4 | Views: 82 |

PDF (1.8 MB)

Open Access Review Article

Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

Mohadeseh Khoshandam, Hossein Soltaninejad, Marziyeh Mousazadeh, [...], Amir Ali Hamidieh, Saman Hosseinkhani << Fewer

https://doi.org/10.1016/j.gendis.2023.02.027

Published: 25 March 2023

2024, 11 (1): 268-282

Downloads: 2 | Views: 83 |

PDF (863.3 KB)

Open Access Review Article

Recombinant adeno-associated virus 8 vector in gene therapy: Opportunities and challenges

Liyuan Zhao, Zixuan Yang, Minhui Zheng, [...], Lei Shi, Mengyun Gu, Gang Liu, Feng Miao, Yan Chang, Fanghua Huang, Naping Tang << Fewer

https://doi.org/10.1016/j.gendis.2023.02.010

Published: 24 March 2023

2024, 11 (1): 283-293

Downloads: 2 | Views: 82 |

PDF (1.2 MB)

Open Access Review Article

Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases

Qi Li, Anran Huo, Mengqi Li, [...], Jiali Wang, Qiao Yin, Lumiao Chen, Xin Chu, Yuan Qin, Yuwan Qi, Yang Li, Hengxiang Cui, Qifei Cong << Fewer

https://doi.org/10.1016/j.gendis.2023.02.016

Published: 27 March 2023

2024, 11 (1): 294-305

Downloads: 2 | Views: 69 |

PDF (1.5 MB)

Open Access Review Article

Mechanism of PARP inhibitor resistance and potential overcoming strategies

Xiaoyu Fu, Ping Li, Qi Zhou, [...], Ruyuan He, Guannan Wang, Shiya Zhu, Amir Bagheri, Gary Kupfer, Huadong Pei, Juanjuan Li << Fewer

https://doi.org/10.1016/j.gendis.2023.02.014

Published: 24 March 2023

2024, 11 (1): 306-320

Downloads: 4 | Views: 72 |

PDF (1.5 MB)

Open Access Review Article

The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

Md Rakibul Alam, Md Mizanur Rahman, Zhiguo Li

https://doi.org/10.1016/j.gendis.2023.01.026

Published: 24 March 2023

2024, 11 (1): 321-334

Downloads: 2 | Views: 86 |

PDF (1.2 MB)

Open Access Review Article

The essential roles of m⁶A modification in osteogenesis and common bone diseases

Yuxi Gu, Yidan Song, Yihua Pan, Jun Liu

https://doi.org/10.1016/j.gendis.2023.01.032

Published: 28 March 2023

2024, 11 (1): 335-345

Downloads: 2 | Views: 80 |

PDF (1.2 MB)

Open Access Review Article

Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease

Huanyu Luo, Anahid Ahmadi Birjandi, Feilong Ren, [...], Tianmeng Sun, Paul T. Sharpe, Hongchen Sun, Zhengwen An << Fewer

https://doi.org/10.1016/j.gendis.2023.03.015

Published: 12 April 2023

2024, 11 (1): 346-357

Downloads: 2 | Views: 112 |

PDF (1.2 MB)

Open Access Review Article

Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis

Xinrui Dong, Ye Li, Xiaonan Sheng, [...], Weihang Zhou, Aijun Sun, Huijuan Dai << Fewer

https://doi.org/10.1016/j.gendis.2023.03.019

Published: 25 April 2023

2024, 11 (1): 358-366

Downloads: 2 | Views: 113 |

PDF (1.3 MB)

Open Access Review Article

Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword

Yunchao Zhang, Jiayu Tang, Cheng Wang, [...], Qinxiu Zhang, Anqi Zeng, Linjiang Song << Fewer

https://doi.org/10.1016/j.gendis.2023.04.015

Published: 16 June 2023

2024, 11 (1): 367-381

Downloads: 2 | Views: 68 |

PDF (2 MB)

FULL LENGTH ARTICLES

Open Access Full Length Article

RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

Zheng Zhang, Keren Zhou, Li Han, [...], Andrew Small, Jianhuang Xue, Huilin Huang, Hengyou Weng, Rui Su, Brandon Tan, Chao Shen, Wei Li, Zhicong Zhao, Ying Qing, Xi Qin, Kitty Wang, Keith Leung, Mark Boldin, Chun-Wei Chen, David Ann, Zhijian Qian, Xiaolan Deng, Jianjun Chen, Zhenhua Chen << Fewer

https://doi.org/10.1016/j.gendis.2023.01.016

Published: 28 March 2023

2024, 11 (1): 382-396

Downloads: 3 | Views: 77 |

PDF (3.4 MB)

Open Access Full Length Article

Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

Zhe Chen, Qian Guo, Shichen Huang, [...], Lei Li, Feng Wu, Zhilong Liu, Zhigang Li, Tao Chen, Guanbin Song, Shuangnian Xu, Jieping Chen, Yu Hou << Fewer

https://doi.org/10.1016/j.gendis.2023.01.002

Published: 25 January 2023

2024, 11 (1): 397-412

Downloads: 3 | Views: 123 |

PDF (5.3 MB)

Open Access Full Length Article

Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

Dongsheng Zhang, Wenjuan Tang, Haitao Niu, [...], William Tse, Hai-Bin Ruan, Helmut Dolznig, Thomas Knösel, Friedrich Karl-Heinz, Madeleine Themanns, Jiang Wang, Mingquan Song, Lee Denson, Lukas Kenner, Richard Moriggl, Yi Zheng, Xiaonan Han << Fewer

https://doi.org/10.1016/j.gendis.2022.11.024

Published: 02 January 2023

2024, 11 (1): 413-429

Downloads: 2 | Views: 66 |

PDF (7.1 MB)

Open Access Full Length Article

Zinc finger protein 831 promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the STAT3/Bcl2 signaling pathway

Jun Fan, Zhe Zhang, Hongqiang Chen, [...], Dongjiao Chen, Wenbo Yuan, Jingzhi Li, Yong Zeng, Shimeng Zhou, Shu Zhang, Gang Zhang, Jiashen Xiong, Lu Zhou, Jing Xu, Wenbin Liu, Yan Xu << Fewer

https://doi.org/10.1016/j.gendis.2022.11.023

Published: 29 December 2022

2024, 11 (1): 430-448

Downloads: 2 | Views: 64 |

PDF (6.3 MB)

Open Access Full Length Article

CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury

Yixin Ma, Lili Huang, Zheng Zhang, [...], Pengfei Yang, Qingsong Chen, Xujia Zeng, Fangyan Tan, Chunxia Wang, Xiongzhong Ruan, Xiaohui Liao << Fewer

https://doi.org/10.1016/j.gendis.2022.12.003

Published: 03 January 2023

2024, 11 (1): 449-463

Downloads: 2 | Views: 64 |

PDF (5.2 MB)

Open Access Full Length Article

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

Mengtian Fan, Nana Geng, Xingyue Li, [...], Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo << Fewer

https://doi.org/10.1016/j.gendis.2022.11.021

Published: 29 December 2022

2024, 11 (1): 464-478

Downloads: 3 | Views: 70 |

PDF (5.9 MB)

Open Access Full Length Article

A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis

Yanran Bi, Ruiling Zheng, Jiahao Hu, [...], Ruiqing Shi, Junfeng Shi, Yutao Wang, Peng Wang, Wenyi Jiang, Gyudong Kim, Zhiguo Liu, Xiaokun Li, Li Lin << Fewer

https://doi.org/10.1016/j.gendis.2023.02.035

Published: 03 April 2023

2024, 11 (1): 479-494

Downloads: 2 | Views: 67 |

PDF (6.7 MB)

Open Access Full Length Article

IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53

Baoyu He, Jing Liang, Qianqian Qin, [...], Yuqin Zhang, Shuo Shi, Jinghe Cao, Zhixin Zhang, Qingli Bie, Rou Zhao, Li Wei, Baogui Zhang, Bin Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.01.027

Published: 23 April 2023

2024, 11 (1): 495-508

Downloads: 2 | Views: 101 |

PDF (4.2 MB)