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Open Access Review Article

NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation

Xiaoguang Liu, Yilei Zhang, Li Zhuang, [...], Kellen Olszewski, Boyi Gan << Fewer

https://doi.org/10.1016/j.gendis.2020.11.010

Published: 25 November 2020

2021, 8 (6): 731-745

Downloads: 5 | Views: 139 |

PDF (967.4 KB)

Open Access Review Article

The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases

Beijian Zhang, Hao Jiang, Zhen Dong, [...], Aijun Sun, Junbo Ge << Fewer

https://doi.org/10.1016/j.gendis.2020.07.011

Published: 31 July 2020

2021, 8 (6): 746-758

Downloads: 5 | Views: 138 |

PDF (1.3 MB)

Open Access Review Article

MicroRNA-9 as a paradoxical but critical regulator of cancer metastasis: Implications in personalized medicine

Yichen Liu, Qiong Zhao, Tao Xi, [...], Lufeng Zheng, Xiaoman Li << Fewer

https://doi.org/10.1016/j.gendis.2020.10.005

Published: 23 October 2020

2021, 8 (6): 759-768

Downloads: 1 | Views: 139 |

PDF (1.2 MB)

Open Access Review Article

Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology

Hui Nie, Zhujun Liao, Yutong Wang, [...], Jianhua Zhou, Xiaoyun He, Chunlin Ou << Fewer

https://doi.org/10.1016/j.gendis.2020.12.004

Published: 18 December 2020

2021, 8 (6): 769-780

Downloads: 1 | Views: 133 |

PDF (938 KB)

Open Access Review Article

The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer

Xingxing Huang, Ting Pan, Lili Yan, [...], Ting Jin, Ruonan Zhang, Bi Chen, Jiao Feng, Ting Duan, Yu Xiang, Mingming Zhang, Xiaying Chen, Zuyi Yang, Wenzheng Zhang, Xia Ding, Tian Xie, Xinbing Sui << Fewer

https://doi.org/10.1016/j.gendis.2020.10.002

Published: 13 October 2020

2021, 8 (6): 781-797

Downloads: 1 | Views: 133 |

PDF (1.7 MB)

Open Access Review Article

The multifaceted PDCD10/CCM3 gene

Mariaelena Valentino, Elisabetta Dejana, Matteo Malinverno

https://doi.org/10.1016/j.gendis.2020.12.008

Published: 30 December 2020

2021, 8 (6): 798-813

Downloads: 1 | Views: 139 |

PDF (2 MB)

Open Access Research Article

Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)

Xiaoxing Wu, Zhaoxia Li, Hongyu Zhang, [...], Fang He, Min Qiao, Huaxiu Luo, Jing Zhang, Meng Zhang, Yukun Mao, William Wagstaff, Yongtao Zhang, Changchun Niu, Xia Zhao, Hao Wang, Linjuan Huang, Deyao Shi, Qing Liu, Na Ni, Kai Fu, Rex C. Haydon, Russell R. Reid, Hue H. Luu, Tong-Chuan He, Ziwei Wang, Houjie Liang, Bing-Qiang Zhang, Ning Wang << Fewer

https://doi.org/10.1016/j.gendis.2021.01.004

Published: 28 January 2021

2021, 8 (6): 814-826

Downloads: 2 | Views: 149 |

PDF (4.1 MB)

Open Access Research Article

The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses

Yi Pan, Qingshang Li, Zhijun Cao, Shuliang Zhao

https://doi.org/10.1016/j.gendis.2020.08.010

Published: 01 September 2020

2021, 8 (6): 827-837

Downloads: 1 | Views: 139 |

PDF (2.3 MB)

Open Access Research Article

PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis

Chao Li, Shang-Ze Li, Xi-Cheng Huang, [...], Jie Chen, Wenbin Liu, Xiao-Dong Zhang, Xue-Min Song, Run-Lei Du << Fewer

https://doi.org/10.1016/j.gendis.2020.08.001

Published: 25 August 2020

2021, 8 (6): 838-848

Downloads: 2 | Views: 146 |

PDF (2.3 MB)

Open Access Research Article

Suppression of a core metabolic enzyme dihydrolipoamide dehydrogenase (dld) protects against amyloid beta toxicity in C. elegans model of Alzheimer's disease

Waqar Ahmad, Paul R. Ebert

https://doi.org/10.1016/j.gendis.2020.08.004

Published: 20 August 2020

2021, 8 (6): 849-866

Downloads: 1 | Views: 134 |

PDF (3.3 MB)

Open Access Research Article

Sulfuretin exerts diversified functions in the processing of amyloid precursor protein

Jian Chen, Biao Luo, Bi-Rou Zhong, [...], Kun-Yi Li, Qi-Xin Wen, Li Song, Xiao-Jiao Xiang, Gui-Feng Zhou, Li-Tian Hu, Xiao-Juan Deng, Yuan-Lin Ma, Guo-Jun Chen << Fewer

https://doi.org/10.1016/j.gendis.2020.11.008

Published: 21 November 2020

2021, 8 (6): 867-881

Downloads: 2 | Views: 107 |

PDF (2.4 MB)

Open Access Research Article

CMTM3 suppresses bone formation and osteogenic differentiation of mesenchymal stem cells through inhibiting Erk1/2 and RUNX2 pathways

Dongwei Fan, Daoyang Fan, Wanqiong Yuan

https://doi.org/10.1016/j.gendis.2020.12.003

Published: 17 December 2020

2021, 8 (6): 882-890

Downloads: 2 | Views: 117 |

PDF (2 MB)

Open Access Research Article

PGC-1α promotes mitochondrial respiration and biogenesis during the differentiation of hiPSCs into cardiomyocytes

Qin Zhou, Hao Xu, Liang Yan, [...], Liang Ye, Xinyuan Zhang, Bin Tan, Qin Yi, Jie Tian, Jing Zhu << Fewer

https://doi.org/10.1016/j.gendis.2020.12.006

Published: 23 December 2020

2021, 8 (6): 891-906

Downloads: 1 | Views: 97 |

PDF (3.4 MB)

Open Access Research Article

Phenotypic characterization of patients with activated PI3Kδ syndrome 1 presenting with features of systemic lupus erythematosus

Yanping Wang, Qiuyun Yang, Xuemei Chen, [...], Wenjing Tang, Lina Zhou, Zhi Chen, Yunfei An, Zhiyong Zhang, Xuemei Tang, Xiaodong Zhao << Fewer

https://doi.org/10.1016/j.gendis.2020.04.012

Published: 30 April 2020

2021, 8 (6): 907-917

Downloads: 1 | Views: 113 |

PDF (1.9 MB)

Open Access Research Article

Argonaute (AGO) proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells (MSCs)

Yukun Mao, Na Ni, Linjuan Huang, [...], Jiaming Fan, Hao Wang, Fang He, Qing Liu, Deyao Shi, Kai Fu, Mikhail Pakvasa, William Wagstaff, Andrew Blake Tucker, Connie Chen, Russell R. Reid, Rex C. Haydon, Sherwin H. Ho, Michael J. Lee, Tong-Chuan He, Jian Yang, Le Shen, Lin Cai, Hue H. Luu << Fewer

https://doi.org/10.1016/j.gendis.2021.04.004

Published: 13 May 2021

2021, 8 (6): 918-930

Downloads: 2 | Views: 156 |

PDF (4.9 MB)

Open Access Research Article

The combination of methylenehydrofolate reductase C677T polymorphism screening and gastrointestinal tumor markers detection may be an early screening method for gastrointestinal cancer related to helicobacter pylori infection

Xiaoxing Wu, Bin Peng, Kun Qian, [...], Wei Zhang, Jiang Min, Mingjun Zhang, Fanling Zeng, Ziwei Wang << Fewer

https://doi.org/10.1016/j.gendis.2021.02.011

Published: 02 March 2021

2021, 8 (6): 931-938

Downloads: 2 | Views: 122 |