Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R

Editors-in-Chief: Ailong Huang, Tong-Chuan He

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Volume 10

Issue 5, September 2023

pp.1727-2193 51 articles

Contents(PDF)

RAPID COMMUNICATIONS

Open Access Rapid Communication

NRF2 participates in the suppressive tumor immune microenvironment of KRAS/KEAP1 co-mutant non-small cell lung cancer by inhibiting the STING pathway

Sun Xiaodan, Zhao Peiyan, Li Hui, [...], Liu Yan, Cheng Ying << Fewer

https://doi.org/10.1016/j.gendis.2022.10.009

Published: 25 October 2022

2023, 10 (5): 1727-1730

Downloads: 2 | Views: 113 |

PDF (1.1 MB)

Open Access Rapid Communication

ARIG inhibition improves the prognosis of liver cancer through autophagy regulation and tumor immunity enhancement

Jiaqi Chen, Xiaoting Zhang, Weijian Hu, [...], Yang Bai, Yi Zhou << Fewer

https://doi.org/10.1016/j.gendis.2022.10.007

Published: 18 October 2022

2023, 10 (5): 1731-1734

Downloads: 3 | Views: 85 |

PDF (1,010.7 KB)

Open Access Rapid Communication

Development of an orally bioavailable selective inhibitor of the menin-MLL

Hai-Jing Zhong, Wanhe Wang, Wei Zhou, [...], Jia-Xin Liang, Yung-Chi Cheng, Dik-Lung Ma, Chung-Hang Leung << Fewer

https://doi.org/10.1016/j.gendis.2022.10.005

Published: 18 October 2022

2023, 10 (5): 1735-1738

Downloads: 2 | Views: 135 |

PDF (657.8 KB)

Open Access Rapid Communication

ZRANB1 is an NBS1 deubiquitinase and a potential target to overcome radioresistance and PARP inhibitor resistance in triple-negative breast cancer

Ying Mei, Qinglei Hang, Hongqi Teng, [...], Fan Yao, Mei-Kuang Chen, Mien-Chie Hung, Yutong Sun, Li Ma << Fewer

https://doi.org/10.1016/j.gendis.2022.09.013

Published: 15 October 2022

2023, 10 (5): 1739-1742

Downloads: 3 | Views: 116 |

PDF (851.6 KB)

Open Access Rapid Communication

Cysteine mutations impair the structural stability of phosphomannomutase 2 (PMM2) in glycosylation-associated metabolic disorders

Yunfan Pan, Li Lin, Fan Yu, [...], Jingmiao Sun, Guannan Bai, Xinyu He, Jianhua Mao, Lidan Hu << Fewer

https://doi.org/10.1016/j.gendis.2022.10.002

Published: 12 October 2022

2023, 10 (5): 1743-1746

Downloads: 2 | Views: 108 |

PDF (1.1 MB)

Open Access Rapid Communication

SIRT6 promotes autophagy through direct interaction with ULK1 and competitive binding to PUMA

Zhongguang Wu, Lanhui Hong, Guang Luo, [...], Siyao Lu, Yanqiu Li, Jiangang Wang, Yingjie Zhang, Lingling Zhang << Fewer

https://doi.org/10.1016/j.gendis.2022.09.012

Published: 13 October 2022

2023, 10 (5): 1747-1750

Downloads: 1 | Views: 93 |

PDF (1.3 MB)

Open Access Rapid Communication

m⁶A levels and expression of its modification genes show significant differences in breast cancer molecular subtypes

Tamara Kleinbielen, Felix Olasagasti, Elena Beristain, [...], Amparo Viguri-Díaz, Isabel Guerra-Merino, Africa García-Orad, Marian M. de Pancorbo << Fewer

https://doi.org/10.1016/j.gendis.2022.11.015

Published: 24 December 2022

2023, 10 (5): 1751-1754

Downloads: 2 | Views: 88 |

PDF (903.7 KB)

Open Access Rapid Communication

Clinical utilization of olaparib, a PARP inhibitor, in BRCA1-mutant metastatic acral melanoma

Ruixin Jiang, Xianbin Liang, Ye Tao, [...], Ronghui Xia, Ming Lei, Bin Jiang, Robert L. Judson-Torres, Yanjie Zhang, Weizhen Zhang, Hanlin Zeng << Fewer

https://doi.org/10.1016/j.gendis.2022.11.014

Published: 24 December 2022

2023, 10 (5): 1755-1758

Downloads: 1 | Views: 84 |

PDF (1.2 MB)

Open Access Rapid Communication

Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation pathways

Colemonts-Vroninks Haaike, Norman P. Brendan, Van Laere Sven, [...], Davison S. Andrew, Marcélis Lionel, Casimir Georges, Goyens Philippe, Claes Paul, De Bundel Dimitri, Martens Geert, Ranganath Lakshminarayan Rao, Vanhaecke Tamara, Gallagher James A, De Kock Joery << Fewer

https://doi.org/10.1016/j.gendis.2022.11.013

Published: 26 December 2022

2023, 10 (5): 1759-1762

Downloads: 1 | Views: 72 |

PDF (399.9 KB)

Open Access Rapid Communication

A lncRNA MEG3 variant enhances telomerase activity by increasing DNA damage repair ability in human liver cancer stem cells

Yanan Lu, Shujie Li, Shuting Song, [...], Liyan Wang, Yingjie Chen, Xiaoxue Jiang, Sijie Xie, Rushi Qin, Dongdong Lu << Fewer

https://doi.org/10.1016/j.gendis.2022.11.012

Published: 24 December 2022

2023, 10 (5): 1763-1766

Downloads: 3 | Views: 87 |

PDF (597 KB)

Open Access Rapid Communication

Potential glioblastoma biomarkers identified by mass spectroscopy and iTRAQ labeling

Ruili Feng, Mingyu Chen, Guanghong Luo, [...], Yanlu Chen, Jiao Wang, Jian Xu, Ming Xu, Ping Zhong, Tieqiao Wen << Fewer

https://doi.org/10.1016/j.gendis.2022.11.010

Published: 23 December 2022

2023, 10 (5): 1767-1770

Downloads: 1 | Views: 92 |

PDF (1.1 MB)

Open Access Rapid Communication

Identification of methylated differentially expressed hub genes in systemic lupus erythematosus patients by WGCNA-based epigenome-wide and transcriptome-wide analysis

Qiao Zhou, Li Long, Xixi Chen, [...], Xiaobo Huang, Shaoping Deng, Yi Wang << Fewer

https://doi.org/10.1016/j.gendis.2022.11.008

Published: 21 December 2022

2023, 10 (5): 1771-1774

Downloads: 1 | Views: 103 |

PDF (1.5 MB)

Open Access Rapid Communication

MZF1 (Myeloid Zinc Finger 1) activates transcriptional activity of p53 and suppresses breast cancer cell proliferation via acetyltransferase PCAF (P300/CBP associated factor)

Bowen Li, Shujing Li, Xiaoxia Shi, [...], Yini Zhang, Zhiqiang Xin, Yuxi Yang, Binggong Zhao, Ping Ren, Huijian Wu << Fewer

https://doi.org/10.1016/j.gendis.2022.11.005

Published: 14 December 2022

2023, 10 (5): 1775-1778

Downloads: 3 | Views: 118 |

PDF (920.2 KB)

Open Access Rapid Communication

Inhibition of lysine-specific demethylase 1 (LSD1) prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma

Pengxing He, Linna Du, Pan Hao, [...], Han Yang, Yufei Ren, Huiqin Kang, Yanli Ding, Wen Zhao, Yichao Xu, Hongmin Liu << Fewer

https://doi.org/10.1016/j.gendis.2022.11.002

Published: 05 December 2022

2023, 10 (5): 1779-1782

Downloads: 2 | Views: 91 |

PDF (1.1 MB)

Open Access Rapid Communication

Overactivation of histone deacetylases and EZH2 in Wilms tumorigenesis

Chao-Hui Chen, Nguyen Yen Nhi Ngo, Alun Wang, [...], Samir El-Dahr, Hongbing Liu << Fewer

https://doi.org/10.1016/j.gendis.2022.10.026

Published: 28 November 2022

2023, 10 (5): 1783-1786

Downloads: 4 | Views: 116 |

PDF (1 MB)

Open Access Rapid Communication

Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells

Yuanfa Yao, Hanbing Li, Xinyi Wang, [...], Yuanhai Sun, Xuqin Zhao, Weiwei Zha, Jiaqiang Zhou, Derek Toomre, Junfen Fu, Yingke Xu << Fewer

https://doi.org/10.1016/j.gendis.2023.01.007

Published: 03 February 2023

2023, 10 (5): 1787-1790

Downloads: 3 | Views: 125 |

PDF (857.1 KB)

Open Access Rapid Communication

Transient HSP90 inhibition enhances the sensitivity of mantle cell lymphoma to poly (ADP-ribose) polymerase (PARP) inhibitors

Chaowen Shi, Dewan Ren, Yufeng Gao, [...], YaMei Dang, Zhigang Tu, Hanqing Liu << Fewer

https://doi.org/10.1016/j.gendis.2023.01.006

Published: 21 April 2023

2023, 10 (5): 1791-1794

Downloads: 1 | Views: 103 |

PDF (1 MB)

Open Access Rapid Communication

Role of lncRNA MALAT1 in UVA-induced corneal endothelial senescence

Yujie Qiao, Bin Zhang, Yani Wang, [...], Tian Sang, Shengqian Dou, Chunxiao Dong, Qun Wang, Qingjun Zhou << Fewer

https://doi.org/10.1016/j.gendis.2023.01.004

Published: 21 April 2023

2023, 10 (5): 1795-1798

Downloads: 3 | Views: 117 |

PDF (1.2 MB)

Open Access Rapid Communication

Exosomal lncRNA LINC01268 promotes pancreatic cancer progression via the miR-217-KIF2A-PI3K/AKT axis

Shanshan Liu, Yang Di, Qiuyue Li, [...], Litian Chen, Yan Ma, Xiaomeng He, Christopher Corpe, Xiaoyan Zhang, Jianqing Xu, Jin Wang << Fewer

https://doi.org/10.1016/j.gendis.2022.12.018

Published: 18 April 2023

2023, 10 (5): 1799-1801

Downloads: 2 | Views: 114 |

PDF (624.9 KB)

Open Access Rapid Communication

Single-cell analyses identify anaphase-promoting complex subunit 11 as a switch controlling neuronal differentiation of glioblastoma cells

Runwei Yang, Ziyu Wang, Songtao Qi, [...], Bowen Ni, Jinglin Guo, Kaishu Li, Haimin Song, Sidi Xie, Yunxiao Zhang, Xirang Wang, Chunmao He, Guanglong Huang, Yawei Liu << Fewer

https://doi.org/10.1016/j.gendis.2022.12.017

Published: 03 February 2023

2023, 10 (5): 1802-1805

Downloads: 2 | Views: 91 |

PDF (1,019.4 KB)

Open Access Rapid Communication

Construction of a novel predictive model with seven metabolism-related genes for hepatocellular carcinoma by machine learning

Lisha Mou, Lin Liu, Yumiao Qiu, [...], Yingying Liang, Zuhui Pu << Fewer

https://doi.org/10.1016/j.gendis.2022.12.014

Published: 23 January 2023

2023, 10 (5): 1806-1808

Downloads: 1 | Views: 116 |

PDF (681.3 KB)

Open Access Rapid Communication

Targeting DNA-PKcs promotes anti-tumoral immunity via triggering cytosolic DNA sensing and inducing an inflamed tumor immuno-microenvironment in metastatic triple-negative breast cancer

Chao Ma, Yuanhua Qin, Ying Wang, [...], Chuanliang Zhu, Xingjie Gao, Pingping Zhang, Yupeng Gu, Shuailong Zhang, Jintao Lin, Jiahui Wang, Weifeng Mao << Fewer

https://doi.org/10.1016/j.gendis.2023.01.001

Published: 04 February 2023

2023, 10 (5): 1809-1811

Downloads: 2 | Views: 100 |

PDF (907.8 KB)

Open Access Rapid Communication

Profiling the m⁶A-regulated RNA expression patterns and alternative splicing features in esophageal carcinoma

Lingsuo Kong, Fei Gao, Fangfang Zhao, [...], Ran Xia, Cifeng Cai, Weixin Wang, Dabing Huang, Zhenyu Li, Qiyi Yi, Chunbao Zang, Youguang Pu << Fewer

https://doi.org/10.1016/j.gendis.2022.12.009

Published: 13 January 2023

2023, 10 (5): 1812-1815

Downloads: 1 | Views: 114 |

PDF (888.1 KB)

Open Access Rapid Communication

Biallelic mutations in UGDH cause congenital microcephaly

Li Shu, Guangyao Xie, Daoqi Mei, [...], Rui Xu, Shixian Liu, Bo Xiao, Xing Li, Yuanyuan Xie, Xiao Mao, Hua Wang << Fewer

https://doi.org/10.1016/j.gendis.2022.12.007

Published: 11 January 2023

2023, 10 (5): 1816-1819

Downloads: 3 | Views: 128 |

PDF (774.8 KB)

REVIEW ARTICLES

Open Access Review Article

KRAB-ZFPs and cancer stem cells identity

Anna Olechnowicz, Urszula Oleksiewicz, Marta Machnik

https://doi.org/10.1016/j.gendis.2022.03.013

Published: 09 April 2022

2023, 10 (5): 1820-1832

Downloads: 2 | Views: 119 |

PDF (1 MB)

Open Access Review Article

The functional role of Higd1a in mitochondrial homeostasis and in multiple disease processes

Jie-Ying Zhu, Min Chen, Wang-Jing Mu, [...], Hong-Yang Luo, Liang Guo << Fewer

https://doi.org/10.1016/j.gendis.2022.03.018

Published: 22 April 2022

2023, 10 (5): 1833-1845

Downloads: 1 | Views: 141 |

PDF (1.8 MB)

Open Access Review Article

Hereditary severe insulin resistance syndrome: Pathogenesis, pathophysiology, and clinical management

Junaid Iqbal, Hong-Li Jiang, Hui-Xuan Wu, [...], Long Li, Ying-Hui Zhou, Nan Hu, Fen Xiao, Ting Wang, Shi-Na Xu, Hou-De Zhou << Fewer

https://doi.org/10.1016/j.gendis.2022.03.016

Published: 11 April 2022

2023, 10 (5): 1846-1856

Downloads: 4 | Views: 124 |

PDF (713.4 KB)

Open Access Review Article

Application and progress of the detection technologies in hepatocellular carcinoma

Qi Yan, Yuan-song Sun, Ran An, [...], Fang Liu, Qi Fang, Zhen Wang, Tao Xu, Lijian Chen, Jian Du << Fewer

https://doi.org/10.1016/j.gendis.2022.04.003

Published: 22 April 2022

2023, 10 (5): 1857-1869

Downloads: 2 | Views: 140 |

PDF (1.2 MB)

Open Access Review Article

Hydrogen sulfide-induced post-translational modification as a potential drug target

Hao-Jie Chen, Lei Qian, Ke Li, [...], Yang-Zhe Qin, Jing-Jing Zhou, Xin-Ying Ji, Dong-Dong Wu << Fewer

https://doi.org/10.1016/j.gendis.2022.03.022

Published: 20 April 2022

2023, 10 (5): 1870-1882

Downloads: 2 | Views: 129 |

PDF (2.3 MB)

Open Access Review Article

Nicotinamide N-methyltransferase and liver diseases

Guangyu Liang, Ying Li, Yan Lin, [...], Xiao Yang, Jiankun Yang, Shaobo Hu, Anding Liu << Fewer

https://doi.org/10.1016/j.gendis.2022.03.019

Published: 20 April 2022

2023, 10 (5): 1883-1893

Downloads: 1 | Views: 109 |

PDF (649.9 KB)

Open Access Review Article

The biogenesis and secretion of exosomes and multivesicular bodies (MVBs): Intercellular shuttles and implications in human diseases

Minxue Xu, Jie Ji, Dandan Jin, [...], Yue Wu, Tong Wu, Renjie Lin, Shengze Zhu, Feng Jiang, Yifei Ji, Baijun Bao, Mei Li, Weisong Xu, Mingbing Xiao << Fewer

https://doi.org/10.1016/j.gendis.2022.03.021

Published: 22 April 2022

2023, 10 (5): 1894-1907

Downloads: 3 | Views: 139 |

PDF (2 MB)

Open Access Review Article

Structure, function, and pathology of Neurexin-3

Rui Zhang, HanXiao Jiang, YuanJie Liu, GuiQiong He

https://doi.org/10.1016/j.gendis.2022.04.008

Published: 30 April 2022

2023, 10 (5): 1908-1919

Downloads: 1 | Views: 183 |

PDF (2.1 MB)

Open Access Review Article

Emerging roles of circular RNAs in stem cells

Mengru Wang, Juan Wu, Pan Wu, Yuhong Li

https://doi.org/10.1016/j.gendis.2022.05.015

Published: 31 May 2022

2023, 10 (5): 1920-1936

Downloads: 1 | Views: 102 |

PDF (1.5 MB)

Open Access Review Article

Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy?

Longfei Deng, Ping Liang, Hongjuan Cui

https://doi.org/10.1016/j.gendis.2022.03.007

Published: 02 April 2022

2023, 10 (5): 1937-1955

Downloads: 3 | Views: 133 |

PDF (1.6 MB)

Open Access Review Article

The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation

Junyang Huang, Kun Zhang, Ruolin Du, [...], Wanling Liu, Haijun Zhang, Tian Tian, Yazhou Wang, Guixue Wang, Tieying Yin << Fewer

https://doi.org/10.1016/j.gendis.2022.08.015

Published: 05 September 2022

2023, 10 (5): 1956-1968

Downloads: 5 | Views: 134 |

PDF (1.4 MB)

Open Access Review Article

Multilevel regulation of N⁶-methyladenosine RNA modifications: Implications in tumorigenesis and therapeutic opportunities

Lili Feng, Rongrong Du, Baitong Chang, [...], Min Li, Jie Tian, Shengjun Wang << Fewer

https://doi.org/10.1016/j.gendis.2022.08.018

Published: 07 September 2022

2023, 10 (5): 1969-1981

Downloads: 1 | Views: 136 |

PDF (1.4 MB)

Open Access Review Article

TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities

Yunfei Huo, Ke Cao, Buxin Kou, [...], Mengyin Chai, Shuangshuang Dou, Dexi Chen, Ying Shi, Xiaoni Liu << Fewer

https://doi.org/10.1016/j.gendis.2022.08.014

Published: 05 September 2022

2023, 10 (5): 1982-1993

Downloads: 2 | Views: 110 |

PDF (2.3 MB)

Open Access Review Article

Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases

Hongliang Liu, Wenjing Hao, Jiao Yang, [...], Yuliang Zhang, Xinfang Wang, Chunming Zhang << Fewer

https://doi.org/10.1016/j.gendis.2022.10.015

Published: 29 October 2022

2023, 10 (5): 1994-2012

Downloads: 2 | Views: 122 |

PDF (2.5 MB)

Open Access Review Article

Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma

Meiyu Qu, Qiangqiang He, Jiahao Luo, [...], Tingyu Shen, Ruibo Gao, Yana Xu, Chengyun Xu, Muhammad Qasim Barkat, Ling-Hui Zeng, Ximei Wu << Fewer

https://doi.org/10.1016/j.gendis.2022.10.014

Published: 09 November 2022

2023, 10 (5): 2013-2028

Downloads: 1 | Views: 115 |

PDF (3.6 MB)

Open Access Review Article

The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment

Yan Zhang, Qiu Peng, Jinhua Zheng, [...], Yuzhong Yang, Xuemei Zhang, Aiyu Ma, Yuxia Qin, Zailong Qin, Xiang Zheng << Fewer

https://doi.org/10.1016/j.gendis.2022.10.006

Published: 19 October 2022

2023, 10 (5): 2029-2037

Downloads: 1 | Views: 119 |

PDF (1.3 MB)

Open Access Review Article

NK2 homeobox gene cluster: Functions and roles in human diseases

Catia Mio, Federica Baldan, Giuseppe Damante

https://doi.org/10.1016/j.gendis.2022.10.001

Published: 11 October 2022

2023, 10 (5): 2038-2048

Downloads: 1 | Views: 133 |

PDF (1.1 MB)

Open Access Review Article

The transcriptional regulators of virulence for Pseudomonas aeruginosa: Therapeutic opportunity and preventive potential of its clinical infections

Xiaolong Shao, Chunyan Yao, Yiqing Ding, [...], Haiyan Hu, Guoliang Qian, Mingliang He, Xin Deng << Fewer

https://doi.org/10.1016/j.gendis.2022.09.009

Published: 01 October 2022

2023, 10 (5): 2049-2063

Downloads: 2 | Views: 172 |

PDF (4.5 MB)

Open Access Review Article

The emerging role of snoRNAs in human disease

Xinhai Zhang, Chenglong Wang, Shujun Xia, [...], Fei Xiao, Jianping Peng, Yuxuan Gao, Fengbin Yu, Chuandong Wang, Xiaodong Chen << Fewer

https://doi.org/10.1016/j.gendis.2022.11.018

Published: 26 December 2022

2023, 10 (5): 2064-2081

Downloads: 1 | Views: 106 |

PDF (948.7 KB)

FULL LENGTH ARTICLES

Open Access Full Length Article

LRP1B suppresses HCC progression through the NCSTN/PI3K/AKT signaling axis and affects doxorubicin resistance

Xiangyu Zhai, Zhijia Xia, Gang Du, [...], Xinlu Zhang, Tong Xia, Delin Ma, Xiaosong Li, Bin Jin, Hao Zhang << Fewer

https://doi.org/10.1016/j.gendis.2022.10.021

Published: 23 November 2022

2023, 10 (5): 2082-2096

Downloads: 1 | Views: 131 |

PDF (6.5 MB)

Open Access Full Length Article

DLX5 promotes Col10a1 expression and chondrocyte hypertrophy and is involved in osteoarthritis progression

Jinnan Chen, Fangzhou Chen, Xuan Wu, [...], Huiqin Bian, Chen Chen, Xiaojing Zhang, Ruoxuan Hei, Xiaotong Yang, Haochun Yuan, Qian Wang, Yaojuan Lu, Longwei Qiao, Qiping Zheng << Fewer

https://doi.org/10.1016/j.gendis.2022.12.016

Published: 01 February 2023

2023, 10 (5): 2097-2108

Downloads: 3 | Views: 167 |

PDF (2.4 MB)

Open Access Full Length Article

Identification of inflammatory factor-related genes associated with the prognosis and immune cell infiltration in colorectal cancer patients

Jialing Hu, Yingcheng He, Kaili Liao, [...], Qijun Yang, Yuhan Xu, Gaoquan Cao, Xiaozhong Wang << Fewer

https://doi.org/10.1016/j.gendis.2022.07.015

Published: 07 August 2022

2023, 10 (5): 2109-2124

Downloads: 5 | Views: 163 |