Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R

Editors-in-Chief: Ailong Huang, Tong-Chuan He

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Volume 10

Issue 6, November 2023

pp.2195-2638 50 articles

RAPID COMMUNICATIONS

Open Access Rapid Communication

Targeting hypoxia-induced CBS expression inhibits breast cancer stem cells through the induction of ferroptosis

Guangyao Wei, Jia Liu, Jie Lan, [...], Guangyu Ji, Huize Xia, Zhiqun Zhao, Zhaoxue Yu, Rong Sun, Chuanzhao Zhang, Haiquan Lu << Fewer

https://doi.org/10.1016/j.gendis.2023.02.034

Published: 28 March 2023

2023, 10 (6): 2195-2198

Downloads: 5 | Views: 154 |

PDF (1 MB)

Open Access Rapid Communication

Myosin regulates intracellular force and guides collective cancer cell migration via the FAK-Rho/ROCK feedback loop

Xiang Qin, Yuchen He, Yixi Zhang, [...], Shun Li, Tingting Li, Fengming You, Yiyao Liu << Fewer

https://doi.org/10.1016/j.gendis.2023.02.037

Published: 29 March 2023

2023, 10 (6): 2199-2201

Downloads: 4 | Views: 127 |

PDF (1.6 MB)

Open Access Rapid Communication

HMGB3 is a potential diagnostic marker for early cervical lesion screening

Qianwen Cui, Jiarong Zhao, Qingmei Deng, [...], Yu Liu, Changfang Fu, Qiang Wu, Qiuyan Sun, Haiyan Weng, Haiming Dai, Wulin Yang << Fewer

https://doi.org/10.1016/j.gendis.2023.02.033

Published: 27 March 2023

2023, 10 (6): 2202-2205

Downloads: 2 | Views: 100 |

PDF (1.6 MB)

Open Access Rapid Communication

Gga3 gene-deleted C57BL/6J mice have elevated fasting blood glucose levels

Xiaohong Zhang, Song Yue, Dongjun Jiang, [...], Guoan Zhang, Jianli Liu, Xuezhi Li << Fewer

https://doi.org/10.1016/j.gendis.2023.02.031

Published: 27 March 2023

2023, 10 (6): 2206-2209

Downloads: 3 | Views: 118 |

PDF (891.1 KB)

Open Access Rapid Communication

Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells

Mathieu Adjemout, Bruno Pouvelle, Fatou Thiam, [...], Alassane Thiam, Magali Torres, Samia Nisar, Babacar Mbengue, Alioune Dieye, Pascal Rihet, Sandrine Marquet << Fewer

https://doi.org/10.1016/j.gendis.2023.02.029

Published: 27 March 2023

2023, 10 (6): 2210-2214

Downloads: 2 | Views: 139 |

PDF (963 KB)

Open Access Rapid Communication

Salvage treatment in IDH1 mutated acute lymphoblastic leukemia with venetoclax plus methotrexate and pegaspargase: A case report

Dan Li, Shuqi Zhao, Liping Mao, [...], Jie Jin, Jinghan Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.02.011

Published: 24 March 2023

2023, 10 (6): 2215-2217

Downloads: 1 | Views: 109 |

PDF (643.1 KB)

Open Access Rapid Communication

Interruption of bile acid enterohepatic circulation inhibits glycogen synthesis and promotes hepatocellular carcinoma progression

Jiyan Wang, Xintong Dai, Hongkai Chang, [...], Qingle Gao, Jianshuang Guo, Juze Yang, Shuai Zhang, Changliang Shan << Fewer

https://doi.org/10.1016/j.gendis.2023.02.026

Published: 27 March 2023

2023, 10 (6): 2218-2221

Downloads: 1 | Views: 119 |

PDF (1.4 MB)

Open Access Rapid Communication

Bilirubin inhibits lung carcinogenesis by up-regulating cystatin A expression in tumor-infiltrating macrophages

Qingtian Huang, Na Zhang, Jiangtuan Wang, [...], Hua Xu, Leyi Yao, Qianqian Yang, Ding Yan, Xi Chen, Qian Xue, Min Xiao, Jiawen Wu, Xueheng Wu, Qin Liu, Daolin Tang, Xin Chen, Xiaofen Li, Jinbao Liu << Fewer

https://doi.org/10.1016/j.gendis.2023.02.024

Published: 27 March 2023

2023, 10 (6): 2222-2225

Downloads: 1 | Views: 174 |

PDF (1.2 MB)

Open Access Rapid Communication

Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma

Meng Sha, Chuan Shen, Seogsong Jeong, [...], Ning Xu, Chen Chen, Hua-lian Hang, Ying Tong, Jie Cao << Fewer

https://doi.org/10.1016/j.gendis.2023.02.023

Published: 28 March 2023

2023, 10 (6): 2226-2228

Downloads: 2 | Views: 112 |

PDF (929.9 KB)

Open Access Rapid Communication

Exploring the anti-cancer effects of Panax notoginseng through network pharmacology and molecular modeling

Erin M. Thorpe, Michael Kalafatis, Yan Xu

https://doi.org/10.1016/j.gendis.2023.02.022

Published: 27 March 2023

2023, 10 (6): 2229-2232

Downloads: 2 | Views: 95 |

PDF (1.4 MB)

Open Access Rapid Communication

Circulating fibroblasts present neutrophil-like features in severe COVID-19 cases revealed by single-cell landscape analyses

Xiangjun Liu, Jingang Gui, Xiaolin Wang

https://doi.org/10.1016/j.gendis.2023.02.032

Published: 27 March 2023

2023, 10 (6): 2233-2236

Downloads: 2 | Views: 123 |

PDF (1.4 MB)

Open Access Rapid Communication

Nucleolin promotes tumor growth in colorectal cancer by enhancing hnRNPA1-mediated PKM2 alternative splicing

Xue Wang, Han Cheng, Die Hu, [...], Ying Chen, Waseem Hassan, Jing Zhao, Jiuming Li, Zhaohui Huang << Fewer

https://doi.org/10.1016/j.gendis.2023.02.020

Published: 27 March 2023

2023, 10 (6): 2237-2240

Downloads: 2 | Views: 130 |

PDF (1.3 MB)

Open Access Rapid Communication

A novel acquired EGFR-SEPT14 fusion confers differential drug resistance to EGFR inhibitors in lung adenocarcinoma

Weidong Wang, Wang Lv, Hui Wang, [...], Yang Xu, Junrong Yan, Han-Ming Shen, Liqun Shan, Jian Hu << Fewer

https://doi.org/10.1016/j.gendis.2023.02.019

Published: 24 April 2023

2023, 10 (6): 2241-2244

Downloads: 1 | Views: 110 |

PDF (983.7 KB)

Open Access Rapid Communication

Characterization of somatic mutations of colorectal tumor in a patient with concurrent APC and MLH1 germline mutations

Yunsheng Cheng, Yanyan Xu, Xiaopeng Zhang, [...], Jian Qi, Jialiang Wang, Yanzhe Liu, Kun Wan, YanWei Liu, Liang Yu, Hongzhi Wang, Jinfu Nie, Bo Hong, Yong Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.02.017

Published: 27 March 2023

2023, 10 (6): 2245-2247

Downloads: 3 | Views: 131 |

PDF (745.9 KB)

Open Access Rapid Communication

Targeted down-regulation of Hipp1 ameliorates tau-induced deficits in Drosophila melanogaster

Sung Yeon Park, Jieun Seo, Seulbee Lee, [...], Joohyung Kim, Sang Jeong Kim, Seungbok Lee, Yang-Sook Chun << Fewer

https://doi.org/10.1016/j.gendis.2023.02.009

Published: 24 March 2023

2023, 10 (6): 2248-2251

Downloads: 2 | Views: 138 |

PDF (997.8 KB)

Open Access Rapid Communication

The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations

Congling Qiu, Joyce Tsz Wai Chan, David Wei Zhang, [...], Io Nam Wong, Yaling Zeng, Betty Yuen Kwan Law, Simon Wing Fai Mok, Ivo Ricardo De Seabra Rodrigues Dias, Wenfeng Liu, Liang Liu, Vincent Kam Wai Wong << Fewer

https://doi.org/10.1016/j.gendis.2023.02.007

Published: 24 March 2023

2023, 10 (6): 2252-2255

Downloads: 7 | Views: 160 |

PDF (1.2 MB)

Open Access Rapid Communication

OStme: Online consensus survival analysis web server for tumor microenvironment components of pan-cancers

Longxiang Xie, Qiang Wang, Xiaoyu Ma, [...], Guo Zhao, Zhongyi Yan, Huimin Li, Wan Zhu, Zhanjie Zuo, Xiangqian Guo << Fewer

https://doi.org/10.1016/j.gendis.2023.02.043

Published: 03 April 2023

2023, 10 (6): 2256-2259

Downloads: 1 | Views: 103 |

PDF (931.4 KB)

Open Access Rapid Communication

Development of a dual targeting scaffold of SET7/MLL inhibitor for castration-resistant prostate cancer treatment

Guodong Li, Qi Huang, Vincent Kam Wai Wong, [...], Wanhe Wang, Chung-Hang Leung << Fewer

https://doi.org/10.1016/j.gendis.2023.01.034

Published: 24 March 2023

2023, 10 (6): 2260-2262

Downloads: 1 | Views: 119 |

PDF (600.2 KB)

Open Access Rapid Communication

A novel variant of GALC in a familial case of Krabbe disease: Insights from structural bioinformatics and molecular dynamics simulation

Ikram Ullah, Muhammad Waqas, Muhammad Ilyas, [...], Sobia Ahsan Halim, Akmal Ahmad, Natalia Dominik, Wahid Ullah, Muhammad Abbas, Muhammad Aamir, SYNaPS Study Group, Queen Square Genomics, Henry Houlden, Stephanie Efthymiou, Ajmal Khan, Ahmed Al-Harrasi << Fewer

https://doi.org/10.1016/j.gendis.2023.01.018

Published: 23 April 2023

2023, 10 (6): 2263-2266

Downloads: 3 | Views: 120 |

PDF (1.8 MB)

Open Access Rapid Communication

Skp2 is a novel regulator of LSD1 expression and function in gastric cancer

Moges Dessale Asmamaw, Li-Rong Zhang, Hong-Min Liu, [...], Xiao-Jing Shi, Ying Liu << Fewer

https://doi.org/10.1016/j.gendis.2023.01.015

Published: 23 March 2023

2023, 10 (6): 2267-2269

Downloads: 4 | Views: 123 |

PDF (572.6 KB)

Open Access Rapid Communication

Unsupervised machine learning-based clustering identifies unique molecular signatures of colorectal cancer with distinct clinical outcomes

Manish Pratap Singh, Sandhya Rai, Sarvesh K. Gupta, [...], Nand K. Singh, Sameer Srivastava << Fewer

https://doi.org/10.1016/j.gendis.2023.01.023

Published: 24 March 2023

2023, 10 (6): 2270-2273

Downloads: 1 | Views: 127 |

PDF (964.6 KB)

Open Access Rapid Communication

Immunogenomic classification of lung squamous cell carcinoma characterizes tumor immune microenvironment and predicts cancer therapy

Denggang Fu, Biyu Zhang, Yinghua Zhang, [...], Jueping Feng, Hua Jiang << Fewer

https://doi.org/10.1016/j.gendis.2023.01.022

Published: 28 March 2023

2023, 10 (6): 2274-2277

Downloads: 2 | Views: 129 |

PDF (916.6 KB)

Open Access Rapid Communication

m⁶A regulator-mediated methylation modification patterns and tumor immune microenvironment characterization in endometrial cancer

Kexin Li, Shanrong Shu, Jiahua Zou, [...], Manmei Li, Zhong Liu << Fewer

https://doi.org/10.1016/j.gendis.2023.01.021

Published: 24 March 2023

2023, 10 (6): 2278-2281

Downloads: 1 | Views: 156 |

PDF (948.5 KB)

Open Access Rapid Communication

Interaction of piRNA-like sequences from the 3′-UTR of SARS-CoV-2 with mRNA regions

Laura Pérez-Campos Mayoral, María Teresa Hernández-Huerta, Carlos Romero Díaz, [...], Carlos Alberto Matias-Cervantes, Eduardo Pérez-Campos Mayoral, Margarito Martínez Cruz, Juan de Dios Ruiz-Rosado, Edgar Gustavo Ramos Martínez, Marco Antonio Sánchez Medina, Eduardo Pérez-Campos << Fewer

https://doi.org/10.1016/j.gendis.2023.01.012

Published: 22 March 2023

2023, 10 (6): 2282-2284

Downloads: 1 | Views: 111 |

PDF (854.1 KB)

REVIEW ARTICLES

Open Access Review Article

Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury

Yu Yang, Xianhe Lin

https://doi.org/10.1016/j.gendis.2022.02.012

Published: 29 March 2022

2023, 10 (6): 2285-2295

Downloads: 3 | Views: 107 |

PDF (955.5 KB)

Open Access Review Article

Critical involvement of circular RNAs in virus-associated cancers

Arghavan Zebardast, Tayebeh Latifi, Moein shirzad, [...], Golnaz Goodarzi, Saeed Ebrahimi Fana, Sadra Samavarchi Tehrani, Yousef Yahyapour << Fewer

https://doi.org/10.1016/j.gendis.2022.04.009

Published: 07 May 2022

2023, 10 (6): 2296-2305

Downloads: 2 | Views: 148 |

PDF (693.4 KB)

Open Access Review Article

BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations

Tao Ma, Yan Chen, Zhi-Gang Yi, [...], Yan-Hong Li, Jun Bai, Li-Juan Li, Lian-Sheng Zhang << Fewer

https://doi.org/10.1016/j.gendis.2022.03.004

Published: 28 March 2022

2023, 10 (6): 2306-2319

Downloads: 1 | Views: 120 |

PDF (1.1 MB)

Open Access Review Article

The crucial roles of m⁶A RNA modifications in cutaneous cancers: Implications in pathogenesis, metastasis, drug resistance, and targeted therapies

Cong Huang, Kaoyuan Zhang, Yang Guo, [...], Changbing Shen, Xiaoming Liu, Haiyan Huang, Xia Dou, Bo Yu << Fewer

https://doi.org/10.1016/j.gendis.2022.03.006

Published: 01 April 2022

2023, 10 (6): 2320-2330

Downloads: 2 | Views: 113 |

PDF (1.1 MB)

Open Access Review Article

De novo nucleotide biosynthetic pathway and cancer

Jie Chen, Siqi Yang, Yingge Li, [...], Xu Ziwen, Pingfeng Zhang, Qibin Song, Yi Yao, Huadong Pei << Fewer

https://doi.org/10.1016/j.gendis.2022.04.018

Published: 16 May 2022

2023, 10 (6): 2331-2338

Downloads: 1 | Views: 121 |

PDF (922.8 KB)

Open Access Review Article

The implication of pyroptosis in cancer immunology: Current advances and prospects

Wei Liu, Jinwu Peng, Muzhang Xiao, [...], Yuan Cai, Bi Peng, Wenqin Zhang, Jianbo Li, Fanhua Kang, Qianhui Hong, Qiuju Liang, Yuanliang Yan, Zhijie Xu << Fewer

https://doi.org/10.1016/j.gendis.2022.04.019

Published: 12 May 2022

2023, 10 (6): 2339-2350

Downloads: 1 | Views: 121 |

PDF (1.4 MB)

Open Access Review Article

Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases

Chaoqun Huang, Wei Chen, Xinxia Wang

https://doi.org/10.1016/j.gendis.2022.04.014

Published: 06 May 2022

2023, 10 (6): 2351-2365

Downloads: 2 | Views: 102 |

PDF (1.4 MB)

Open Access Review Article

A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)

Yan Lv, Xiao Ma, Yuxin Ma, [...], Yuxin Du, Jifeng Feng << Fewer

https://doi.org/10.1016/j.gendis.2022.05.020

Published: 04 June 2022

2023, 10 (6): 2366-2382

Downloads: 3 | Views: 153 |

PDF (1.1 MB)

Open Access Review Article

Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development

Zhongrui Ma, Xinxing Lyu, Ning Qin, [...], Haoyu Liu, Mengrui Zhang, Yongchao Lai, Bo Dong, Peiyuan Lu << Fewer

https://doi.org/10.1016/j.gendis.2022.05.021

Published: 03 June 2022

2023, 10 (6): 2383-2392

Downloads: 3 | Views: 121 |

PDF (1.3 MB)

Open Access Review Article

Clinical relevance of circulating non-coding RNAs in metabolic diseases: Emphasis on obesity, diabetes, cardiovascular diseases and metabolic syndrome

Abdullahi Dandare, Muhammad Jawad Khan, Aisha Naeem, Afrose Liaquat

https://doi.org/10.1016/j.gendis.2022.05.022

Published: 03 June 2022

2023, 10 (6): 2393-2413

Downloads: 1 | Views: 121 |

PDF (2 MB)

Open Access Review Article

Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment

Qianqian Zhou, Yanhua Chen, Ruolei Wang, [...], Fengjing Jia, Feng He, Fuwen Yuan << Fewer

https://doi.org/10.1016/j.gendis.2022.11.016

Published: 27 December 2022

2023, 10 (6): 2414-2424

Downloads: 2 | Views: 120 |

PDF (2 MB)

Open Access Review Article

The organization and function of the Golgi apparatus in dendrite development and neurological disorders

Meilan Chen, Lu Xu, Yi Wu, [...], Peter Soba, Chun Hu << Fewer

https://doi.org/10.1016/j.gendis.2022.11.009

Published: 20 December 2022

2023, 10 (6): 2425-2442

Downloads: 2 | Views: 151 |

PDF (1.5 MB)

Open Access Review Article

Epigenetic regulation of mesenchymal stem cell aging through histone modifications

Yanping Sun, Haoyu Zhang, Tao Qiu, [...], Li Liao, Xiaoxia Su << Fewer

https://doi.org/10.1016/j.gendis.2022.10.030

Published: 05 December 2022

2023, 10 (6): 2443-2456

Downloads: 1 | Views: 127 |

PDF (1 MB)

Open Access Review Article

New insights into the suppression of inflammation and lipid accumulation by JAZF1

Wujun Chen, Yingjie Zhong, Yang Yuan, [...], Meng Zhu, Wenchao Hu, Ning Liu, Dongming Xing << Fewer

https://doi.org/10.1016/j.gendis.2022.10.029

Published: 02 December 2022

2023, 10 (6): 2457-2469

Downloads: 2 | Views: 144 |

PDF (1.5 MB)

Open Access Review Article

Lysine succinylation, the metabolic bridge between cancer and immunity

Rui Shen, Hongyun Ruan, Shuye Lin, [...], Bin Liu, Hang Song, Lu Li, Teng Ma << Fewer

https://doi.org/10.1016/j.gendis.2022.10.028

Published: 01 December 2022

2023, 10 (6): 2470-2478

Downloads: 1 | Views: 117 |

PDF (1,011.7 KB)

Open Access Review Article

Functions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases

Qianqian Xue, Yanyan Yang, Hong Li, [...], Xiaoxin Li, Lu Zou, Tianxiang Li, Huibo Ma, Hongzhao Qi, Jianxun Wang, Tao Yu << Fewer

https://doi.org/10.1016/j.gendis.2022.10.025

Published: 29 November 2022

2023, 10 (6): 2479-2490

Downloads: 3 | Views: 132 |

PDF (1.1 MB)

Open Access Review Article

Long noncoding RNA study: Genome-wide approaches

Shuang Tao, Yarui Hou, Liting Diao, [...], Yanxia Hu, Wanyi Xu, Shujuan Xie, Zhendong Xiao << Fewer

https://doi.org/10.1016/j.gendis.2022.10.024

Published: 29 November 2022

2023, 10 (6): 2491-2510

Downloads: 1 | Views: 127 |

PDF (1.8 MB)

Open Access Review Article

Synthetic lethal approaches to target cancers with loss of PTEN function

Ayse Ertay, Rob M. Ewing, Yihua Wang

https://doi.org/10.1016/j.gendis.2022.12.015

Published: 01 February 2023

2023, 10 (6): 2511-2527

Downloads: 6 | Views: 157 |

PDF (2.2 MB)

Open Access Review Article

Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair

Haochen Wang, Hui Yu, Tianyu Huang, [...], Bin Wang, Lin Xiang << Fewer

https://doi.org/10.1016/j.gendis.2022.12.012

Published: 16 January 2023

2023, 10 (6): 2528-2539

Downloads: 4 | Views: 179 |

PDF (1 MB)

FULL LENGTH ARTICLES

Open Access Full Length Article

Dynamic human retinal pigment epithelium (RPE) and choroid architecture based on single-cell transcriptomic landscape analysis

Lulin Huang, Lin Ye, Runze Li, [...], Shanshan Zhang, Chao Qu, Shujin Li, Jie Li, Mu Yang, Biao Wu, Ran Chen, Guo Huang, Bo Gong, Zheng Li, Hongjie Yang, Man Yu, Yi Shi, Changguan Wang, Wei Chen, Zhenglin Yang << Fewer

https://doi.org/10.1016/j.gendis.2022.11.007

Published: 15 December 2022

2023, 10 (6): 2540-2556

Downloads: 2 | Views: 115 |

PDF (8.3 MB)

Open Access Full Length Article

DNA damage-mediated cellular senescence promotes hand-foot syndrome that can be relieved by thymidine prodrug

Bingxue Yang, Xinran Xie, Zhaoyu Wu, [...], Dazhao Lv, Jiajun Hu, Yuyun Chen, Jiaxing Li, Shuyue Luo, Jiacheng Li, Jie Luo, Shiyi Zhang << Fewer

https://doi.org/10.1016/j.gendis.2022.10.004

Published: 18 October 2022

2023, 10 (6): 2557-2571

Downloads: 3 | Views: 170 |

PDF (4.8 MB)

Open Access Full Length Article

Defective EMC1 drives abnormal retinal angiogenesis via Wnt/β-catenin signaling and may be associated with the pathogenesis of familial exudative vitreoretinopathy

Shujin Li, Mu Yang, Rulian Zhao, [...], Li Peng, Wenjing Liu, Xiaoyan Jiang, Yunqi He, Erkuan Dai, Lin Zhang, Yeming Yang, Yi Shi, Peiquan Zhao, Zhenglin Yang, Xianjun Zhu << Fewer

https://doi.org/10.1016/j.gendis.2022.10.003

Published: 11 October 2022

2023, 10 (6): 2572-2585

Downloads: 3 | Views: 144 |

PDF (5.4 MB)

Open Access Full Length Article

A novel in vitro prognostic model of bladder cancer based on urine-derived living tumor cells

Jiaqi Wang, Jiying Zhu, Junchi Hu, [...], Ziruoyu Wang, Xiaobo Wang, Jianbo Pan, Yiwei Chu, Zengxia Li, Wei Jiang, Chunmin Liang, Jun Hou, Jianming Guo, Yongjun Dang, Shuai Jiang << Fewer

https://doi.org/10.1016/j.gendis.2022.10.022

Published: 26 November 2022

2023, 10 (6): 2586-2596

Downloads: 3 | Views: 110 |

PDF (2.6 MB)

Open Access Full Length Article

Uncovering the prominent role of satellite cells in paravertebral muscle development and aging by single-nucleus RNA sequencing

Xin Qiu, Hao-Yu Wang, Zhen-Yu Yang, [...], Li-Ming Sun, Shu-Nan Liu, Chui-Qin Fan, Feng Zhu << Fewer

https://doi.org/10.1016/j.gendis.2023.01.005

Published: 03 February 2023

2023, 10 (6): 2597-2613

Downloads: 4 | Views: 160 |