Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R
Editors-in-Chief: Ailong Huang, Tong-Chuan He
Open Access
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Volume 10
Issue 3, May 2023
pp.639-1129 58 articles
RAPID COMMUNICATIONS
Open Access Rapid Communication
Activation of Wnt/β-catenin signaling in abdominal aortic aneurysm: A potential therapeutic opportunity?
https://doi.org/10.1016/j.gendis.2022.05.017
Published: 03 June 2022
2023, 10 (3): 639-642
Downloads: 1 | Views: 106 | PDF (1 MB)
Open Access Rapid Communication
C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice
https://doi.org/10.1016/j.gendis.2022.05.035
Published: 17 June 2022
2023, 10 (3): 643-646
Downloads: 1 | Views: 98 | PDF (1.4 MB)
Open Access Rapid Communication
GeDiPNet: Online resource of curated gene-disease associations for polypharmacological targets discovery
https://doi.org/10.1016/j.gendis.2022.05.034
Published: 13 June 2022
2023, 10 (3): 647-649
Downloads: 3 | Views: 98 | PDF (697.9 KB)
Open Access Rapid Communication
Decreased expression of m6A demethylase ALKBH5 in decidua contributes to preeclampsia via m6A-CORIN-HuR pathway
https://doi.org/10.1016/j.gendis.2022.05.032
Published: 10 June 2022
2023, 10 (3): 650-653
Downloads: 1 | Views: 88 | PDF (757.6 KB)
Open Access Rapid Communication
A SLC31A1-MEK-DNMT1-miR-124 feedback loop contributes to pancreatic cancer progression
https://doi.org/10.1016/j.gendis.2022.05.033
Published: 11 June 2022
2023, 10 (3): 654-656
Downloads: 1 | Views: 68 | PDF (1.2 MB)
Open Access Rapid Communication
Genomic analysis of schistosomiasis-associated colorectal cancer reveals a unique mutational landscape and therapeutic implications
https://doi.org/10.1016/j.gendis.2022.05.026
Published: 07 June 2022
2023, 10 (3): 657-659
Downloads: 1 | Views: 88 | PDF (946.5 KB)
Open Access Rapid Communication
Variations in EXD3 caused congenital cataracts in three Chinese families
https://doi.org/10.1016/j.gendis.2022.05.025
Published: 08 June 2022
2023, 10 (3): 660-663
Downloads: 2 | Views: 91 | PDF (658.2 KB)
Open Access Rapid Communication
Two human monoclonal SARS-CoV-2 antibodies that maintain neutralizing potency against the SARS-CoV-2 Omicron BA.1 and BA.2 variants
https://doi.org/10.1016/j.gendis.2022.05.027
Published: 07 June 2022
2023, 10 (3): 664-667
Downloads: 1 | Views: 96 | PDF (858.5 KB)
Open Access Rapid Communication
3′-UTR of the SARS-CoV-2 genome as a possible source of piRNAs
https://doi.org/10.1016/j.gendis.2022.05.028
Published: 08 June 2022
2023, 10 (3): 668-670
Downloads: 3 | Views: 86 | PDF (686.7 KB)
Open Access Rapid Communication
Haploinsufficiency of KCNAB3 causes sudden cardiac death through delayed inactivation of Kv1.5 channel upon depolarization and induced myocardial apoptosis
https://doi.org/10.1016/j.gendis.2022.05.023
Published: 04 June 2022
2023, 10 (3): 671-674
Downloads: 1 | Views: 77 | PDF (909.1 KB)
Open Access Rapid Communication
miR-126-5p affects the chemosensitivity of colorectal cancer cells by regulating SPRED1, ERK1/2 pathway and apoptosis
https://doi.org/10.1016/j.gendis.2022.05.024
Published: 04 June 2022
2023, 10 (3): 675-678
Downloads: 1 | Views: 81 | PDF (1,007.1 KB)
Open Access Rapid Communication
Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRγ signaling
https://doi.org/10.1016/j.gendis.2022.06.003
Published: 01 July 2022
2023, 10 (3): 679-682
Downloads: 2 | Views: 148 | PDF (774.4 KB)
Open Access Rapid Communication
Circulating miR-548c-3p possesses good diagnostic potential for metabolic syndrome
https://doi.org/10.1016/j.gendis.2022.06.008
Published: 14 July 2022
2023, 10 (3): 683-686
Downloads: 1 | Views: 99 | PDF (633.9 KB)
Open Access Rapid Communication
A controlled random gene perturbation method identifies ARPC1B gene as a key regulator of cancer metastasis
https://doi.org/10.1016/j.gendis.2022.06.006
Published: 07 July 2022
2023, 10 (3): 687-689
Downloads: 2 | Views: 117 | PDF (687.7 KB)
Open Access Rapid Communication
A novel ABHD5 mutation in two Chanarin Dorfman siblings with severe and heterogeneous clinical phenotype
https://doi.org/10.1016/j.gendis.2022.08.005
Published: 30 August 2022
2023, 10 (3): 690-693
Downloads: 1 | Views: 122 | PDF (873.2 KB)
Open Access Rapid Communication
Liver HMGCS2 is critical in the maintenance of liver lipid homeostasis during fasting
https://doi.org/10.1016/j.gendis.2022.08.004
Published: 24 August 2022
2023, 10 (3): 694-697
Downloads: 1 | Views: 113 | PDF (1.1 MB)
Open Access Rapid Communication
A revision of the InfiniumPurify R package for genome-wide correction of tumor purity in Infinium DNA methylation array data
https://doi.org/10.1016/j.gendis.2022.08.003
Published: 22 August 2022
2023, 10 (3): 698-700
Downloads: 1 | Views: 107 | PDF (351.4 KB)
Open Access Rapid Communication
A patient with glycogen storage disease type IA combined with hepatic adenoma: A case report
https://doi.org/10.1016/j.gendis.2022.08.002
Published: 22 August 2022
2023, 10 (3): 701-704
Downloads: 2 | Views: 103 | PDF (1.4 MB)
Open Access Rapid Communication
Development of a high-fidelity Cas9-dependent adenine base editor (ABE) system for genome editing with high-fidelity Cas9 variants
https://doi.org/10.1016/j.gendis.2022.07.022
Published: 20 August 2022
2023, 10 (3): 705-707
Downloads: 2 | Views: 89 | PDF (592.7 KB)
Open Access Rapid Communication
Investigation of prodromal features in metabolic syndrome based on transcriptome analysis
https://doi.org/10.1016/j.gendis.2022.07.021
Published: 19 August 2022
2023, 10 (3): 708-711
Downloads: 1 | Views: 63 | PDF (964.4 KB)
Open Access Rapid Communication
LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin
https://doi.org/10.1016/j.gendis.2022.12.022
Published: 26 March 2023
2023, 10 (3): 712-715
Downloads: 1 | Views: 112 | PDF (798.7 KB)
Open Access Rapid Communication
An interleukin 10 Receptor alpha (IL-10RA) variant with a compound heterozygote mutation shows normal IL-10 signaling activity
https://doi.org/10.1016/j.gendis.2022.09.007
Published: 28 September 2022
2023, 10 (3): 716-718
Downloads: 1 | Views: 108 | PDF (731.3 KB)
Open Access Rapid Communication
FXR suppresses colorectal cancer by inhibiting the Wnt/β-catenin pathway via activation of TLE3
https://doi.org/10.1016/j.gendis.2022.09.006
Published: 04 October 2022
2023, 10 (3): 719-722
Downloads: 1 | Views: 107 | PDF (1.3 MB)
Open Access Rapid Communication
NSP16 promotes the expression of TMPRSS2 to enhance SARS-CoV-2 cell entry
https://doi.org/10.1016/j.gendis.2022.09.005
Published: 23 September 2022
2023, 10 (3): 723-726
Downloads: 2 | Views: 117 | PDF (1,018.9 KB)
Open Access Rapid Communication
Comparison analysis of multiple-omics data between female germline stem cells and spermatogonial stem cells
https://doi.org/10.1016/j.gendis.2022.09.003
Published: 20 September 2022
2023, 10 (3): 727-730
Downloads: 1 | Views: 86 | PDF (1 MB)
Open Access Rapid Communication
Myelin protein zero (P0)- and Wnt1-Cre marked muscle resident neural crest-derived mesenchymal progenitor cells give rise to heterotopic ossification in mouse models
https://doi.org/10.1016/j.gendis.2022.09.002
Published: 19 September 2022
2023, 10 (3): 731-734
Downloads: 3 | Views: 104 | PDF (1.6 MB)
Open Access Rapid Communication
The LIFR-targeting small molecules EC330/EC359 are potent ferroptosis inducers
https://doi.org/10.1016/j.gendis.2022.10.016
Published: 14 November 2022
2023, 10 (3): 735-738
Downloads: 6 | Views: 185 | PDF (1.1 MB)
Open Access Rapid Communication
Altered expression of m1A regulatory genes is associated with oncogenic pathways, overall survival, and infiltration of immune cells in diverse human cancers
https://doi.org/10.1016/j.gendis.2022.11.001
Published: 15 November 2022
2023, 10 (3): 739-742
Downloads: 2 | Views: 99 | PDF (1.5 MB)
Open Access Rapid Communication
Novel mutations in RSPH4A and TTN genes lead to primary ciliary dyskinesia-hereditary myopathy with early respiratory failure overlap syndrome
https://doi.org/10.1016/j.gendis.2022.10.013
Published: 29 October 2022
2023, 10 (3): 743-745
Downloads: 1 | Views: 114 | PDF (690.9 KB)
Open Access Rapid Communication
Exploration of the common gene and potential molecular mechanisms between Herpes simplex virus 1 infection and Alzheimer’s disease
https://doi.org/10.1016/j.gendis.2022.10.012
Published: 09 November 2022
2023, 10 (3): 746-749
Downloads: 4 | Views: 105 | PDF (709.7 KB)
Open Access Full Length Article
Downregulated nuclear lncRNA NRON inhibits SHP2/Wnt/β-catenin signaling and cardiomyocyte differentiation during the development of Tetralogy of Fallot
https://doi.org/10.1016/j.gendis.2022.10.010
Published: 23 October 2022
2023, 10 (3): 750-752
Downloads: 17 | Views: 134 | PDF (618.3 KB)
Open Access Rapid Communication
Wnt genes in colonic polyposis predisposition
https://doi.org/10.1016/j.gendis.2022.12.002
Published: 29 December 2022
2023, 10 (3): 753-757
Downloads: 1 | Views: 119 | PDF (241.6 KB)
REVIEW ARTICLES
Open Access Review Article
New insights into the roles for DYRK family in mammalian development and congenital diseases
https://doi.org/10.1016/j.gendis.2021.12.004
Published: 06 January 2022
2023, 10 (3): 758-770
Downloads: 1 | Views: 103 | PDF (1.5 MB)
Open Access Review Article
Mechanistic insight into lysyl oxidase in vascular remodeling and angiogenesis
https://doi.org/10.1016/j.gendis.2022.05.011
Published: 26 May 2022
2023, 10 (3): 771-785
Downloads: 1 | Views: 158 | PDF (2.1 MB)
Open Access Review Article
Parkinson’s disease: From genetics to molecular dysfunction and targeted therapeutic approaches
https://doi.org/10.1016/j.gendis.2021.12.015
Published: 05 February 2022
2023, 10 (3): 786-798
Downloads: 2 | Views: 113 | PDF (1.5 MB)
Open Access Review Article
New insight of obesity-associated NAFLD: Dysregulated “crosstalk” between multi-organ and the liver?
https://doi.org/10.1016/j.gendis.2021.12.013
Published: 28 January 2022
2023, 10 (3): 799-812
Downloads: 1 | Views: 168 | PDF (1.3 MB)
Open Access Review Article
The emerging role of Arid5a in cancer: A new target for tumors
https://doi.org/10.1016/j.gendis.2021.12.012
Published: 25 January 2022
2023, 10 (3): 813-824
Downloads: 2 | Views: 131 | PDF (1.6 MB)
Open Access Review Article
Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
https://doi.org/10.1016/j.gendis.2021.12.011
Published: 02 February 2022
2023, 10 (3): 825-847
Downloads: 3 | Views: 128 | PDF (1.9 MB)
Open Access Review Article
Emerging role of ubiquitination/deubiquitination modification of PD-1/PD-L1 in cancer immunotherapy
https://doi.org/10.1016/j.gendis.2022.01.002
Published: 18 February 2022
2023, 10 (3): 848-863
Downloads: 4 | Views: 148 | PDF (1.4 MB)
Open Access Review Article
Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system
https://doi.org/10.1016/j.gendis.2021.12.024
Published: 12 February 2022
2023, 10 (3): 864-876
Downloads: 2 | Views: 109 | PDF (1.5 MB)
Open Access Review Article
Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes
https://doi.org/10.1016/j.gendis.2021.12.023
Published: 17 February 2022
2023, 10 (3): 877-890
Downloads: 8 | Views: 188 | PDF (1.3 MB)
Open Access Review Article
Targeting SAMHD1: To overcome multiple anti-cancer drugs resistance in hematological malignancies
https://doi.org/10.1016/j.gendis.2022.06.001
Published: 26 June 2022
2023, 10 (3): 891-900
Downloads: 1 | Views: 113 | PDF (1.5 MB)
Open Access Review Article
Regulation mechanism and pathogenic role of lncRNA plasmacytoma variant translocation 1 (PVT1) in human diseases
https://doi.org/10.1016/j.gendis.2022.05.037
Published: 29 June 2022
2023, 10 (3): 901-914
Downloads: 2 | Views: 137 | PDF (1.8 MB)
Open Access Review Article
Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes
https://doi.org/10.1016/j.gendis.2022.06.005
Published: 04 July 2022
2023, 10 (3): 915-930
Downloads: 3 | Views: 121 | PDF (3.5 MB)
Open Access Review Article
Endometrial stem/progenitor cells: Properties, origins, and functions
https://doi.org/10.1016/j.gendis.2022.08.009
Published: 31 August 2022
2023, 10 (3): 931-947
Downloads: 1 | Views: 127 | PDF (1.4 MB)
Open Access Review Article
Molecular and cellular pathophysiology of circulating cardiomyocyte-specific cell free DNA (cfDNA): Biomarkers of heart failure and potential therapeutic targets
https://doi.org/10.1016/j.gendis.2022.08.008
Published: 31 August 2022
2023, 10 (3): 948-959
Downloads: 2 | Views: 222 | PDF (2.2 MB)
Open Access Review Article
Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics
https://doi.org/10.1016/j.gendis.2022.07.023
Published: 23 August 2022
2023, 10 (3): 960-989
Downloads: 3 | Views: 131 | PDF (3.3 MB)
Open Access Review Article
Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies
https://doi.org/10.1016/j.gendis.2022.07.009
Published: 06 August 2022
2023, 10 (3): 990-1004
Downloads: 1 | Views: 147 | PDF (2.4 MB)
Open Access Review Article
Circulating and non-circulating proteins and nucleic acids as biomarkers and therapeutic molecules in ovarian cancer
https://doi.org/10.1016/j.gendis.2022.07.004
Published: 05 August 2022
2023, 10 (3): 1005-1018
Downloads: 2 | Views: 112 | PDF (1.2 MB)
FULL LENGTH ARTICLES
Open Access Full Length Article
Durability of Hepatitis B surface antigen seroclearance in patients experienced nucleoside analogs or interferon monotherapy: A real-world data from Electronic Health Record
https://doi.org/10.1016/j.gendis.2022.03.003
Published: 26 March 2022
2023, 10 (3): 1019-1028
Downloads: 1 | Views: 152 | PDF (1.3 MB)
Open Access Full Length Article
Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis
https://doi.org/10.1016/j.gendis.2022.08.012
Published: 05 September 2022
2023, 10 (3): 1029-1039
Downloads: 2 | Views: 141 | PDF (3.5 MB)
Open Access Full Length Article
LncRNA H19 mediates BMP9-induced angiogenesis in mesenchymal stem cells by promoting the p53-Notch1 angiogenic signaling axis
https://doi.org/10.1016/j.gendis.2022.04.013
Published: 10 May 2022
2023, 10 (3): 1040-1054
Downloads: 2 | Views: 168 | PDF (5.3 MB)
Open Access Full Length Article
Mitochondria-derived small RNAs as diagnostic biomarkers in lung cancer patients through a novel ratio-based expression analysis methodology
https://doi.org/10.1016/j.gendis.2022.07.013
Published: 07 August 2022
2023, 10 (3): 1055-1061
Downloads: 1 | Views: 152 | PDF (1.6 MB)
Open Access Full Length Article
Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice
https://doi.org/10.1016/j.gendis.2022.05.003
Published: 19 May 2022
2023, 10 (3): 1062-1074
Downloads: 2 | Views: 133 | PDF (3.1 MB)
Open Access Full Length Article
A novel aptamer-based small RNA delivery platform and its application to cancer therapy
https://doi.org/10.1016/j.gendis.2022.05.004
Published: 20 May 2022
2023, 10 (3): 1075-1089
Downloads: 1 | Views: 104 | PDF (3.5 MB)
Open Access Full Length Article
Clinical heterogeneity of NLRP12-associated autoinflammatory diseases
https://doi.org/10.1016/j.gendis.2022.05.012
Published: 27 May 2022
2023, 10 (3): 1090-1100
Downloads: 5 | Views: 103 | PDF (2.1 MB)
Open Access Full Length Article
Prolonged control of insulin-dependent diabetes via intramuscular expression of plasmid-encoded single-strand insulin analogue
https://doi.org/10.1016/j.gendis.2022.05.009
Published: 24 May 2022
2023, 10 (3): 1101-1113
Downloads: 3 | Views: 148 | PDF (3 MB)
Open Access Full Length Article
The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype
https://doi.org/10.1016/j.gendis.2022.09.010
Published: 05 October 2022
2023, 10 (3): 1114-1129
Downloads: 1 | Views: 155 | PDF (6.2 MB)