Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R

Editors-in-Chief: Ailong Huang, Tong-Chuan He

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Volume 10

Issue 1, January 2023

pp.1-300 38 articles

RESEARCH HIGHLIGHTS

Open Access Research Highlight

Phase 'separating' 53BP1 from DSB repair

Youwei Zhang

https://doi.org/10.1016/j.gendis.2022.04.024

Published: 14 May 2022

2023, 10 (1): 1-3

Downloads: 4 | Views: 92 |

PDF (888.6 KB)

Open Access Research Highlight

Metagenomic markings of myeloid malignancies

An Dinh Duy Nguyen, Maryssa Shanteau-Jackson, Thomas LaFramboise

https://doi.org/10.1016/j.gendis.2022.06.004

Published: 02 July 2022

2023, 10 (1): 4-6

Downloads: 2 | Views: 129 |

PDF (593.8 KB)

Open Access Research Highlight

Does burning fat make tumor immune hot? Discovery of CD47 overexpression by radiation induced fatty acid oxidation

Nian Jiang, Bowen Xie, Ming Fan, Jian Jian Li

https://doi.org/10.1016/j.gendis.2022.07.019

Published: 13 August 2022

2023, 10 (1): 7-9

Downloads: 1 | Views: 146 |

PDF (561 KB)

RAPID COMMUNICATIONS

Open Access Rapid Communication

Nuclear lncRNA CERNA1 enhances the cisplatin-induced cell apoptosis and overcomes chemoresistance via epigenetic activation of BCL2L10 in ovarian cancer

Rui Xu, Hui Peng, Ning Yang, [...], Zhenping Liu, Wei Lu << Fewer

https://doi.org/10.1016/j.gendis.2021.12.018

Published: 11 February 2022

2023, 10 (1): 10-13

Downloads: 1 | Views: 134 |

PDF (893.2 KB)

Open Access Rapid Communication

PTGS2 identified as a biomarker of glucocorticoid-induced osteonecrosis of the femoral head and an enhancer of osteogenesis

Qingyu Zhang, Shun Lu, Dongsheng Zhou, [...], Jun Dong, Fanxiao Liu << Fewer

https://doi.org/10.1016/j.gendis.2022.01.005

Published: 16 March 2022

2023, 10 (1): 14-17

Downloads: 3 | Views: 224 |

PDF (1.3 MB)

Open Access Rapid Communication

Systematic comparison of experimental and human obstructive cholestasis reveals conservation of canonical pathway activation and biomarkers relevant for cholestatic liver disease

Eva Gijbels, Kevin De Muynck, Bart Vanderborght, [...], Tim Meese, Filip Van Nieuwerburgh, Aude Vanlander, Frederik Berrevoet, Bart Hendrikx, Anne Hoorens, Hans Van Vlierberghe, Mathieu Vinken, Lindsey Devisscher << Fewer

https://doi.org/10.1016/j.gendis.2022.02.003

Published: 14 March 2022

2023, 10 (1): 18-21

Downloads: 4 | Views: 139 |

PDF (668.5 KB)

Open Access Rapid Communication

Pivotal role of cytosolic phospholipase PLA2G4A in the pathogenesis of FLT3-ITD-mutated acute myeloid leukemia

Wen-Jing Lai, Fan Chen, Lingling Shu, [...], Xin-Ming Yang, Jimin Yuan, Jing-Bo Xu, Anskar Yu-Hung Leung, Bai-Liang He << Fewer

https://doi.org/10.1016/j.gendis.2022.02.002

Published: 12 March 2022

2023, 10 (1): 22-25

Downloads: 1 | Views: 133 |

PDF (1.1 MB)

Open Access Rapid Communication

Identification of hsa_circ_0092576 regulatory network in the pathogenesis of coronary heart disease

Abdullahi Dandare, Muhammad Rafiq, Afrose Liaquat, [...], Afraz Ahmad Raja, Muhammad Jawad Khan << Fewer

https://doi.org/10.1016/j.gendis.2021.12.027

Published: 01 March 2022

2023, 10 (1): 26-28

Downloads: 1 | Views: 123 |

PDF (480.9 KB)

Open Access Rapid Communication

Irisin regulates pancreatic lipases through PPARγ-PGCα-FNDC5 pathway

Horwitz Avital, Birk Ruth

https://doi.org/10.1016/j.gendis.2022.03.017

Published: 11 April 2022

2023, 10 (1): 29-32

Downloads: 1 | Views: 124 |

PDF (1,002 KB)

Open Access Rapid Communication

Lung adeno-squamous carcinoma modeling using oncogenic KRAS activation in human embryonic stem cell-derived alveolar organoids

Jianqi Feng, Lian Li, Zhihong Tan, [...], Shanshan Zhao, Xin Zhang, Jinhong Wang, Yaping Ye, Ying Lin, Zhili Rong << Fewer

https://doi.org/10.1016/j.gendis.2022.03.015

Published: 07 April 2022

2023, 10 (1): 33-36

Downloads: 1 | Views: 84 |

PDF (856.7 KB)

Open Access Rapid Communication

Simplifying genetic classifiers by six mutated genes in diffuse large B-cell lymphoma

Jinghan Wang, Fang Yu, Wenwen Wei, [...], Jiansong Huang, Yang Shao, Junrong Yan, Liping Mao, Wenjuan Yu, Wanzhuo Xie, Jie Jin << Fewer

https://doi.org/10.1016/j.gendis.2022.03.014

Published: 08 April 2022

2023, 10 (1): 37-40

Downloads: 1 | Views: 84 |

PDF (1.4 MB)

Open Access Rapid Communication

Prognostic value of the RNA editing enzyme: ADAR1, and its association with immune cells infiltration in pancreatic adenocarcinoma

Jialong Qi, You Zhou, Zhikai Zhu, [...], Chuanshan Xu, Wenjie Chen << Fewer

https://doi.org/10.1016/j.gendis.2022.03.011

Published: 21 April 2022

2023, 10 (1): 41-44

Downloads: 1 | Views: 131 |

PDF (1 MB)

Open Access Rapid Communication

Evidence that all Sorsby's fundus dystrophy mutations cause TIMP3 dimerization resulting in impaired inhibition of VEGFR2

Fatimah A. Alsaffar, Ahmed H. Mujamammi, Mohammed S.K. Aldughaim, [...], Martin J.H. Nicklin, Michael D. Barker << Fewer

https://doi.org/10.1016/j.gendis.2022.03.008

Published: 12 April 2022

2023, 10 (1): 45-47

Downloads: 1 | Views: 110 |

PDF (559.4 KB)

Open Access Rapid Communication

PD-L1 expression and smoke exposure as biomarkers for optimizing adjuvant therapy for patients with resected limited-stage small-cell lung carcinoma

Chengming Liu, Zhanyu Wang, Qingpeng Zeng, [...], Sufei Zheng, Xiaoli Feng, Qi Xue, Nan Sun, Jie He << Fewer

https://doi.org/10.1016/j.gendis.2022.02.017

Published: 31 March 2022

2023, 10 (1): 48-50

Downloads: 2 | Views: 123 |

PDF (712.7 KB)

Open Access Rapid Communication

Androgen receptor inhibits the hair follicle induction potential of dermal papilla cells by binding with Tcf4 at the A574 binding site

Nanlan Yu, Tianxing Hu, Haichao Yang, [...], Lian Zhang, Lin Zhu, Xiaofang Zhou, Fei Xiang, Xichuan Yang, Yuhong Li << Fewer

https://doi.org/10.1016/j.gendis.2022.04.015

Published: 07 May 2022

2023, 10 (1): 51-54

Downloads: 1 | Views: 117 |

PDF (1.1 MB)

Open Access Rapid Communication

Identification and validation of cardiac nonconserved human-specific enhancers

Yawen Zhang, Yiting Gui, Xudong Chen, [...], Feng Wang, Fang Wu, Youhua Wang, Xu Wang, Yonghao Gui, Qiang Li << Fewer

https://doi.org/10.1016/j.gendis.2022.03.005

Published: 30 March 2022

2023, 10 (1): 55-57

Downloads: 1 | Views: 117 |

PDF (694.9 KB)

Open Access Rapid Communication

KCNMA1 promotes obesity-related hypertension: Integrated analysis based on genome-wide association studies

Yingchao Zhou, Yuanyuan Zhao, Lingfeng Zha, [...], Mengchen Zhou, Mengru Wang, Xiang Cheng, Zhengrong Huang, Min Liu, Tie Ke, Xin Tu << Fewer

https://doi.org/10.1016/j.gendis.2022.04.025

Published: 19 May 2022

2023, 10 (1): 58-61

Downloads: 1 | Views: 90 |

PDF (1.2 MB)

Open Access Rapid Communication

Integration of ATAC-Seq and RNA-Seq identifies the key genes in myocardial ischemia

Jing Yuan, Jun-Meng Wang, Zhi-Wei Li, [...], Cheng-Shun Zhang, Bin Cheng, Su-Hao Yang, Ding-Jun Cai, Shu-Guang Yu << Fewer

https://doi.org/10.1016/j.gendis.2022.05.013

Published: 25 May 2022

2023, 10 (1): 62-64

Downloads: 4 | Views: 112 |

PDF (799.1 KB)

Open Access Rapid Communication

SEMA4D acts as a novel oligogenic pathogenic gene of idiopathic hypogonadotropic hypogonadism through the PlexinB1/MET/RND1/RHOA/RAF1/MAPK signaling axis

Daoqi Wang, Yonghua Niu, Jiahong Tan, [...], Jiaxin Wang, Le Ling, Yinwei Chen, Jianan Gong, Hao Xu, Qing Ling, Jianhe Liu, Jihong Liu << Fewer

https://doi.org/10.1016/j.gendis.2022.05.030

Published: 11 June 2022

2023, 10 (1): 65-68

Downloads: 1 | Views: 117 |

PDF (1.1 MB)

Open Access Rapid Communication

Inhibition of ALDH2 by disulfiram leads to synthetic lethality via ROS strikes twice in ARID1A-deficient cholangiocarcinoma

Tingming Liang, Lin Jia, Rui Duan, [...], Lulu Shen, Dekang Ren, Yujie Ren, Yuyang Dou, Li Guo << Fewer

https://doi.org/10.1016/j.gendis.2022.02.005

Published: 16 March 2022

2023, 10 (1): 69-71

Downloads: 1 | Views: 78 |

PDF (1 MB)

Open Access Rapid Communication

Identification of Epsin1 as a regulator for hepatic lipid and glucose metabolism

Xiaohua Huang, Long Jin, Zhengfeng Fang, [...], Lianqiang Che, Yan Lin, Shengyu Xu, Yong Zhuo, Mingzhou Li, De Wu, Bin Feng << Fewer

https://doi.org/10.1016/j.gendis.2022.05.016

Published: 28 May 2022

2023, 10 (1): 72-75

Downloads: 1 | Views: 113 |

PDF (1.3 MB)

REVIEW ARTICLES

Open Access Review Article

Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials

Yanlin Song, Zhenfei Bi, Yu Liu, [...], Furong Qin, Yuquan Wei, Xiawei Wei << Fewer

https://doi.org/10.1016/j.gendis.2022.05.006

Published: 20 May 2022

2023, 10 (1): 76-88

Downloads: 3 | Views: 97 |

PDF (806.3 KB)

Open Access Review Article

The IL13α 2R paves the way for anti-glioma nanotherapy

Ilya V. Ulasov, Anton Borovjagin, Anastasia Laevskaya, [...], Margarita Kamynina, Peter Timashev, Laura Cerchia, Elena A. Rozhkova << Fewer

https://doi.org/10.1016/j.gendis.2021.08.006

Published: 15 September 2021

2023, 10 (1): 89-100

Downloads: 1 | Views: 150 |

PDF (1.3 MB)

Open Access Review Article

PCK1 dysregulation in cancer: Metabolic reprogramming, oncogenic activation, and therapeutic opportunities

Jin Xiang, Kai Wang, Ni Tang

https://doi.org/10.1016/j.gendis.2022.02.010

Published: 22 March 2022

2023, 10 (1): 101-112

Downloads: 1 | Views: 137 |

PDF (1.9 MB)

Open Access Review Article

Pathogenic roles of long noncoding RNAs in melanoma: Implications in diagnosis and therapies

Yuai Xiao, Yu Xia, Yuchong Wang, Chunyu Xue

https://doi.org/10.1016/j.gendis.2021.08.007

Published: 17 September 2021

2023, 10 (1): 113-125

Downloads: 3 | Views: 103 |

PDF (1.5 MB)

Open Access Review Article

N6-methyladenosine (m6A) modification of ribosomal RNAs (rRNAs): Critical roles in mRNA translation and diseases

Kexin Lei, Shuibin Lin, Quan Yuan

https://doi.org/10.1016/j.gendis.2021.10.005

Published: 19 November 2021

2023, 10 (1): 126-134

Downloads: 2 | Views: 138 |

PDF (934.5 KB)

Open Access Review Article

Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response

Yuanliang Yan, Jinwu Peng, Qiuju Liang, [...], Xinxin Ren, Yuan Cai, Bi Peng, Xi Chen, Xiang Wang, Qiaoli Yi, Zhijie Xu << Fewer

https://doi.org/10.1016/j.gendis.2021.10.004

Published: 10 November 2021

2023, 10 (1): 135-150

Downloads: 3 | Views: 98 |

PDF (1.5 MB)

Open Access Review Article

Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies

Xinghan Liu, Lijie Yin, Sunan Shen, Yayi Hou

https://doi.org/10.1016/j.gendis.2021.09.006

Published: 18 October 2021

2023, 10 (1): 151-164

Downloads: 1 | Views: 165 |

PDF (958 KB)

Open Access Review Article

mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases

Siyao Guo, Shuibin Lin

https://doi.org/10.1016/j.gendis.2021.09.005

Published: 18 October 2021

2023, 10 (1): 165-174

Downloads: 1 | Views: 142 |

PDF (1.3 MB)

Open Access Review Article

Adipose-derived stem cells and obesity: The spear and shield relationship

Hong Yang, Chaowei Li, Yizhou Li, [...], Ruiqing Tai, Chao Sun << Fewer

https://doi.org/10.1016/j.gendis.2021.09.004

Published: 02 October 2021

2023, 10 (1): 175-186

Downloads: 2 | Views: 164 |

PDF (2.1 MB)

Open Access Review Article

SPINOPHILIN: A multiplayer tumor suppressor

Eva M. Verdugo-Sivianes, Amancio Carnero

https://doi.org/10.1016/j.gendis.2021.12.021

Published: 03 February 2022

2023, 10 (1): 187-198

Downloads: 1 | Views: 139 |

PDF (1.2 MB)

Open Access Review Article

Drugging IGF-1R in cancer: New insights and emerging opportunities

Panpan Wang, Victor CY. Mak, Lydia WT. Cheung

https://doi.org/10.1016/j.gendis.2022.03.002

Published: 23 March 2022

2023, 10 (1): 199-211

Downloads: 1 | Views: 166 |

PDF (1.3 MB)

FULL LENGTH ARTICLES

Open Access Full Length Article

Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma

Xiaofeng Zuo, Peixin Meng, Yuxin Bao, [...], Chuntao Tao, Yitao Wang, Xianjun Liu, Youquan Bu, Jiang Zhu << Fewer

https://doi.org/10.1016/j.gendis.2021.05.003

Published: 14 June 2021

2023, 10 (1): 212-227

Downloads: 6 | Views: 166 |

PDF (5.9 MB)

Open Access Full Length Article

Etiological roles of core promoter variation in triple-negative breast cancer

Teng Huang, Jiaheng Li, San Ming Wang

https://doi.org/10.1016/j.gendis.2022.01.003

Published: 24 February 2022

2023, 10 (1): 228-238

Downloads: 1 | Views: 165 |

PDF (1.4 MB)

Open Access Full Length Article

Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe^−/− mice

Kun Zhang, Xian Qin, Juhui Qiu, [...], Tong Sun, Kai Qu, Ahmad Ud Din, Wenhua Yan, Tianhan Li, Yidan Chen, Wei Gu, Xiancai Rao, Guixue Wang << Fewer

https://doi.org/10.1016/j.gendis.2021.09.007

Published: 16 October 2021

2023, 10 (1): 239-253

Downloads: 1 | Views: 141 |

PDF (4.6 MB)

Open Access Full Length Article

LOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma

Xiang Chen, Margaret Clement, M. John Hicks, [...], Poonam Sarkar, M. Waleed Gaber, Tsz-Kwong Man << Fewer

https://doi.org/10.1016/j.gendis.2021.12.016

Published: 29 January 2022

2023, 10 (1): 254-266

Downloads: 5 | Views: 175 |

PDF (3.5 MB)

Open Access Full Length Article

Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue

Lakshmi Prabhu, Matthew Martin, Lan Chen, [...], Özlem Demir, Jiamin Jin, Xiumei Huang, Aishat Motolani, Mengyao Sun, Guanglong Jiang, Harikrishna Nakshatri, Melissa L. Fishel, Steven Sun, Ahmad Safa, Rommie E. Amaro, Mark R. Kelley, Yunlong Liu, Zhong-Yin Zhang, Tao Lu << Fewer

https://doi.org/10.1016/j.gendis.2022.04.001

Published: 13 April 2022

2023, 10 (1): 267-283

Downloads: 2 | Views: 112 |

PDF (3.5 MB)

Open Access Full Length Article

Liquiritigenin promotes osteogenic differentiation and prevents bone loss via inducing auto-lysosomal degradation and inhibiting apoptosis

Yu Qiu, Yueyang Zhao, Zhimin Long, [...], Aijia Song, Peng Huang, Kejian Wang, Ling Xu, David Paul Molloy, Guiqiong He << Fewer

https://doi.org/10.1016/j.gendis.2021.06.008

Published: 13 July 2021

2023, 10 (1): 284-300

Downloads: 2 | Views: 143 |

PDF (7.8 MB)