Genes & Diseases Open Access Editors-in-Chief: Ailong Huang, Tong-Chuan He
Home Genes & Diseases All Issues Volume 10 Issue 1
Volume 10 Issue 1, January 2023
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PP. 1-300
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38 articles
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RESEARCH HIGHLIGHTS
Research Highlight | Open Access
Phase 'separating' 53BP1 from DSB repair
Youwei Zhang
Published: 14 May 2022
2023, 10(1): 1-3
Research Highlight | Open Access
Metagenomic markings of myeloid malignancies
An Dinh Duy Nguyen, Maryssa Shanteau-Jackson, Thomas LaFramboise
Published: 02 July 2022
2023, 10(1): 4-6
Research Highlight | Open Access
Does burning fat make tumor immune hot? Discovery of CD47 overexpression by radiation induced fatty acid oxidation
Nian Jiang, Bowen Xie, Ming Fan, Jian Jian Li
Published: 13 August 2022
2023, 10(1): 7-9
RAPID COMMUNICATIONS
Rapid Communication | Open Access
Nuclear lncRNA CERNA1 enhances the cisplatin-induced cell apoptosis and overcomes chemoresistance via epigenetic activation of BCL2L10 in ovarian cancer
Rui Xu, Hui Peng, Ning Yang, [...], Zhenping Liu, Wei Lu << Fewer
Published: 11 February 2022
2023, 10(1): 10-13
Rapid Communication | Open Access
PTGS2 identified as a biomarker of glucocorticoid-induced osteonecrosis of the femoral head and an enhancer of osteogenesis
Qingyu Zhang, Shun Lu, Dongsheng Zhou, [...], Jun Dong, Fanxiao Liu << Fewer
Published: 16 March 2022
2023, 10(1): 14-17
Rapid Communication | Open Access
Systematic comparison of experimental and human obstructive cholestasis reveals conservation of canonical pathway activation and biomarkers relevant for cholestatic liver disease
Eva Gijbels, Kevin De Muynck, Bart Vanderborght, [...], Tim Meese, Filip Van Nieuwerburgh, Aude Vanlander, Frederik Berrevoet, Bart Hendrikx, Anne Hoorens, Hans Van Vlierberghe, Mathieu Vinken, Lindsey Devisscher << Fewer
Published: 14 March 2022
2023, 10(1): 18-21
Rapid Communication | Open Access
Pivotal role of cytosolic phospholipase PLA2G4A in the pathogenesis of FLT3-ITD-mutated acute myeloid leukemia
Wen-Jing Lai, Fan Chen, Lingling Shu, [...], Xin-Ming Yang, Jimin Yuan, Jing-Bo Xu, Anskar Yu-Hung Leung, Bai-Liang He << Fewer
Published: 12 March 2022
2023, 10(1): 22-25
Rapid Communication | Open Access
Identification of hsa_circ_0092576 regulatory network in the pathogenesis of coronary heart disease
Abdullahi Dandare, Muhammad Rafiq, Afrose Liaquat, [...], Afraz Ahmad Raja, Muhammad Jawad Khan << Fewer
Published: 01 March 2022
2023, 10(1): 26-28
Rapid Communication | Open Access
Irisin regulates pancreatic lipases through PPARγ-PGCα-FNDC5 pathway
Horwitz Avital, Birk Ruth
Published: 11 April 2022
2023, 10(1): 29-32
Rapid Communication | Open Access
Lung adeno-squamous carcinoma modeling using oncogenic KRAS activation in human embryonic stem cell-derived alveolar organoids
Jianqi Feng, Lian Li, Zhihong Tan, [...], Shanshan Zhao, Xin Zhang, Jinhong Wang, Yaping Ye, Ying Lin, Zhili Rong << Fewer
Published: 07 April 2022
2023, 10(1): 33-36
Rapid Communication | Open Access
Simplifying genetic classifiers by six mutated genes in diffuse large B-cell lymphoma
Jinghan Wang, Fang Yu, Wenwen Wei, [...], Jiansong Huang, Yang Shao, Junrong Yan, Liping Mao, Wenjuan Yu, Wanzhuo Xie, Jie Jin << Fewer
Published: 08 April 2022
2023, 10(1): 37-40
Rapid Communication | Open Access
Prognostic value of the RNA editing enzyme: ADAR1, and its association with immune cells infiltration in pancreatic adenocarcinoma
Jialong Qi, You Zhou, Zhikai Zhu, [...], Chuanshan Xu, Wenjie Chen << Fewer
Published: 21 April 2022
2023, 10(1): 41-44
Rapid Communication | Open Access
Evidence that all Sorsby's fundus dystrophy mutations cause TIMP3 dimerization resulting in impaired inhibition of VEGFR2
Fatimah A. Alsaffar, Ahmed H. Mujamammi, Mohammed S.K. Aldughaim, [...], Martin J.H. Nicklin, Michael D. Barker << Fewer
Published: 12 April 2022
2023, 10(1): 45-47
Rapid Communication | Open Access
PD-L1 expression and smoke exposure as biomarkers for optimizing adjuvant therapy for patients with resected limited-stage small-cell lung carcinoma
Chengming Liu, Zhanyu Wang, Qingpeng Zeng, [...], Sufei Zheng, Xiaoli Feng, Qi Xue, Nan Sun, Jie He << Fewer
Published: 31 March 2022
2023, 10(1): 48-50
Rapid Communication | Open Access
Androgen receptor inhibits the hair follicle induction potential of dermal papilla cells by binding with Tcf4 at the A574 binding site
Nanlan Yu, Tianxing Hu, Haichao Yang, [...], Lian Zhang, Lin Zhu, Xiaofang Zhou, Fei Xiang, Xichuan Yang, Yuhong Li << Fewer
Published: 07 May 2022
2023, 10(1): 51-54
Rapid Communication | Open Access
Identification and validation of cardiac nonconserved human-specific enhancers
Yawen Zhang, Yiting Gui, Xudong Chen, [...], Feng Wang, Fang Wu, Youhua Wang, Xu Wang, Yonghao Gui, Qiang Li << Fewer
Published: 30 March 2022
2023, 10(1): 55-57
Rapid Communication | Open Access
KCNMA1 promotes obesity-related hypertension: Integrated analysis based on genome-wide association studies
Yingchao Zhou, Yuanyuan Zhao, Lingfeng Zha, [...], Mengchen Zhou, Mengru Wang, Xiang Cheng, Zhengrong Huang, Min Liu, Tie Ke, Xin Tu << Fewer
Published: 19 May 2022
2023, 10(1): 58-61
Rapid Communication | Open Access
Integration of ATAC-Seq and RNA-Seq identifies the key genes in myocardial ischemia
Jing Yuan, Jun-Meng Wang, Zhi-Wei Li, [...], Cheng-Shun Zhang, Bin Cheng, Su-Hao Yang, Ding-Jun Cai, Shu-Guang Yu << Fewer
Published: 25 May 2022
2023, 10(1): 62-64
Rapid Communication | Open Access
SEMA4D acts as a novel oligogenic pathogenic gene of idiopathic hypogonadotropic hypogonadism through the PlexinB1/MET/RND1/RHOA/RAF1/MAPK signaling axis
Daoqi Wang, Yonghua Niu, Jiahong Tan, [...], Jiaxin Wang, Le Ling, Yinwei Chen, Jianan Gong, Hao Xu, Qing Ling, Jianhe Liu, Jihong Liu << Fewer
Published: 11 June 2022
2023, 10(1): 65-68
Rapid Communication | Open Access
Inhibition of ALDH2 by disulfiram leads to synthetic lethality via ROS strikes twice in ARID1A-deficient cholangiocarcinoma
Tingming Liang, Lin Jia, Rui Duan, [...], Lulu Shen, Dekang Ren, Yujie Ren, Yuyang Dou, Li Guo << Fewer
Published: 16 March 2022
2023, 10(1): 69-71
Rapid Communication | Open Access
Identification of Epsin1 as a regulator for hepatic lipid and glucose metabolism
Xiaohua Huang, Long Jin, Zhengfeng Fang, [...], Lianqiang Che, Yan Lin, Shengyu Xu, Yong Zhuo, Mingzhou Li, De Wu, Bin Feng << Fewer
Published: 28 May 2022
2023, 10(1): 72-75
REVIEW ARTICLES
Review Article | Open Access
Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials
Yanlin Song, Zhenfei Bi, Yu Liu, [...], Furong Qin, Yuquan Wei, Xiawei Wei << Fewer
Published: 20 May 2022
2023, 10(1): 76-88
Review Article | Open Access
The IL13α 2R paves the way for anti-glioma nanotherapy
Ilya V. Ulasov, Anton Borovjagin, Anastasia Laevskaya, [...], Margarita Kamynina, Peter Timashev, Laura Cerchia, Elena A. Rozhkova << Fewer
Published: 15 September 2021
2023, 10(1): 89-100
Review Article | Open Access
PCK1 dysregulation in cancer: Metabolic reprogramming, oncogenic activation, and therapeutic opportunities
Jin Xiang, Kai Wang, Ni Tang
Published: 22 March 2022
2023, 10(1): 101-112
Review Article | Open Access
Pathogenic roles of long noncoding RNAs in melanoma: Implications in diagnosis and therapies
Yuai Xiao, Yu Xia, Yuchong Wang, Chunyu Xue
Published: 17 September 2021
2023, 10(1): 113-125
Review Article | Open Access
N6-methyladenosine (m6A) modification of ribosomal RNAs (rRNAs): Critical roles in mRNA translation and diseases
Kexin Lei, Shuibin Lin, Quan Yuan
Published: 19 November 2021
2023, 10(1): 126-134
Review Article | Open Access
Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response
Yuanliang Yan, Jinwu Peng, Qiuju Liang, [...], Xinxin Ren, Yuan Cai, Bi Peng, Xi Chen, Xiang Wang, Qiaoli Yi, Zhijie Xu << Fewer
Published: 10 November 2021
2023, 10(1): 135-150
Review Article | Open Access
Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies
Xinghan Liu, Lijie Yin, Sunan Shen, Yayi Hou
Published: 18 October 2021
2023, 10(1): 151-164
Review Article | Open Access
mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases
Siyao Guo, Shuibin Lin
Published: 18 October 2021
2023, 10(1): 165-174
Review Article | Open Access
Adipose-derived stem cells and obesity: The spear and shield relationship
Hong Yang, Chaowei Li, Yizhou Li, [...], Ruiqing Tai, Chao Sun << Fewer
Published: 02 October 2021
2023, 10(1): 175-186
Review Article | Open Access
SPINOPHILIN: A multiplayer tumor suppressor
Eva M. Verdugo-Sivianes, Amancio Carnero
Published: 03 February 2022
2023, 10(1): 187-198
Review Article | Open Access
Drugging IGF-1R in cancer: New insights and emerging opportunities
Panpan Wang, Victor CY. Mak, Lydia WT. Cheung
Published: 23 March 2022
2023, 10(1): 199-211
FULL LENGTH ARTICLES
Full Length Article | Open Access
Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma
Xiaofeng Zuo, Peixin Meng, Yuxin Bao, [...], Chuntao Tao, Yitao Wang, Xianjun Liu, Youquan Bu, Jiang Zhu << Fewer
Published: 14 June 2021
2023, 10(1): 212-227
Full Length Article | Open Access
Etiological roles of core promoter variation in triple-negative breast cancer
Teng Huang, Jiaheng Li, San Ming Wang
Published: 24 February 2022
2023, 10(1): 228-238
Full Length Article | Open Access
Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe−/− mice
Kun Zhang, Xian Qin, Juhui Qiu, [...], Tong Sun, Kai Qu, Ahmad Ud Din, Wenhua Yan, Tianhan Li, Yidan Chen, Wei Gu, Xiancai Rao, Guixue Wang << Fewer
Published: 16 October 2021
2023, 10(1): 239-253
Full Length Article | Open Access
LOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma
Xiang Chen, Margaret Clement, M. John Hicks, [...], Poonam Sarkar, M. Waleed Gaber, Tsz-Kwong Man << Fewer
Published: 29 January 2022
2023, 10(1): 254-266
Full Length Article | Open Access
Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue
Lakshmi Prabhu, Matthew Martin, Lan Chen, [...], Özlem Demir, Jiamin Jin, Xiumei Huang, Aishat Motolani, Mengyao Sun, Guanglong Jiang, Harikrishna Nakshatri, Melissa L. Fishel, Steven Sun, Ahmad Safa, Rommie E. Amaro, Mark R. Kelley, Yunlong Liu, Zhong-Yin Zhang, Tao Lu << Fewer
Published: 13 April 2022
2023, 10(1): 267-283
Full Length Article | Open Access
Liquiritigenin promotes osteogenic differentiation and prevents bone loss via inducing auto-lysosomal degradation and inhibiting apoptosis
Yu Qiu, Yueyang Zhao, Zhimin Long, [...], Aijia Song, Peng Huang, Kejian Wang, Ling Xu, David Paul Molloy, Guiqiong He << Fewer
Published: 13 July 2021
2023, 10(1): 284-300