Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R

Editors-in-Chief: Ailong Huang, Tong-Chuan He

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Volume 9

Issue 2, March 2022

pp.285-575 25 articles

Contents(PDF)

RAPID COMMUNICATIONS

Open Access Rapid Communication

A complex signature network that controls the upregulation of PRMT5 in colorectal cancer

Han Wei, Antja-Voy Hartley, Aishat Motolani, [...], Guanglong Jiang, Ahmad Safa, Lakshmi Prabhu, Yunlong Liu, Tao Lu << Fewer

https://doi.org/10.1016/j.gendis.2021.11.001

Published: 26 November 2021

2022, 9 (2): 285-287

Downloads: 9 | Views: 199 |

PDF (739 KB)

Open Access Rapid Communication

A novel STK11 gene mutation (c.388dupG, p.Glu130Glyfs*33) in a Peutz-Jeghers family and evidence of higher gastric cancer susceptibility associated with alterations in STK11 region aa 107-170

Giovanna Forte, Filomena Cariola, Katia De Marco, [...], Andrea Manghisi, Filomena Anna Guglielmi, Raffaele Armentano, Giuseppe Lippolis, Pietro Giorgio, Cristiano Simone, Vittoria Disciglio << Fewer

https://doi.org/10.1016/j.gendis.2021.11.002

Published: 19 November 2021

2022, 9 (2): 288-291

Downloads: 4 | Views: 166 |

PDF (391.8 KB)

Open Access Rapid Communication

Two novel and one known pathogenic germline mutations in MMRs in Chinese families with Lynch syndrome

Juyi Li, Lin Zhu, Yuanyuan Li, [...], Hui Huang, Kaiyu Huang, Aiping Deng << Fewer

https://doi.org/10.1016/j.gendis.2021.10.006

Published: 16 November 2021

2022, 9 (2): 292-295

Downloads: 1 | Views: 172 |

PDF (1.6 MB)

REVIEW ARTICLES

Open Access Review Article

Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity

Liping Tan, Xuan Liu, Huan Dou, Yayi Hou

https://doi.org/10.1016/j.gendis.2020.10.006

Published: 27 October 2020

2022, 9 (2): 296-309

Downloads: 5 | Views: 358 |

PDF (901.5 KB)

Open Access Review Article

Tumor microenvironment pathways: Cross regulation in breast cancer metastasis

Rama Rao Malla, P. Kiran

https://doi.org/10.1016/j.gendis.2020.11.015

Published: 01 December 2020

2022, 9 (2): 310-324

Downloads: 4 | Views: 167 |

PDF (2.2 MB)

Open Access Review Article

Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential

Bei Wang, Wen Xu, Chengyu Hu, [...], Kai Liu, Jinlan Chen, Chong Guo, Chengfu Yuan << Fewer

https://doi.org/10.1016/j.gendis.2020.11.016

Published: 02 December 2020

2022, 9 (2): 325-333

Downloads: 5 | Views: 176 |

PDF (1,003.7 KB)

Open Access Review Article

Ferroptosis: An emerging therapeutic opportunity for cancer

Liyuan Wang, Xiaoguang Chen, Chunhong Yan

https://doi.org/10.1016/j.gendis.2020.09.005

Published: 29 September 2020

2022, 9 (2): 334-346

Downloads: 1 | Views: 173 |

PDF (1.3 MB)

Open Access Review Article

Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer

Feifei Pu, Fengxia Chen, Zhicai Zhang, [...], Deyao Shi, Binlong Zhong, Xiao Lv, Andrew Blake Tucker, Jiaming Fan, Alexander J. Li, Kevin Qin, Daniel Hu, Connie Chen, Hao Wang, Fang He, Na Ni, Linjuan Huang, Qing Liu, William Wagstaff, Hue H. Luu, Rex C. Haydon, Le Shen, Tong-Chuan He, Jianxiang Liu, Zengwu Shao << Fewer

https://doi.org/10.1016/j.gendis.2020.11.019

Published: 04 December 2020

2022, 9 (2): 347-357

Downloads: 2 | Views: 171 |

PDF (573.3 KB)

Open Access Review Article

The paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine

Duguang Li, Xiaoxiao Fan, Yirun Li, [...], Jing Yang, Hui Lin << Fewer

https://doi.org/10.1016/j.gendis.2020.11.014

Published: 01 December 2020

2022, 9 (2): 358-369

Downloads: 1 | Views: 182 |

PDF (1 MB)

Open Access Review Article

Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants

Haiming Wang, Zifan Liu, Junjie Shao, [...], Min Jiang, Xuechun Lu, Lejian Lin, Lin Wang, Qiang Xu, Haomin Zhang, Xin Li, Jingjing Zhou, Yundai Chen, Ran Zhang << Fewer

https://doi.org/10.1016/j.gendis.2020.11.003

Published: 10 November 2020

2022, 9 (2): 370-380

Downloads: 8 | Views: 202 |

PDF (1.1 MB)

Open Access Review Article

Histidine-rich glycoprotein (HRGP): Pleiotropic and paradoxical effects on macrophage, tumor microenvironment, angiogenesis, and other physiological and pathological processes

Yixiao Pan, Lu Deng, Hai Wang, [...], Kang He, Qiang Xia << Fewer

https://doi.org/10.1016/j.gendis.2020.07.015

Published: 08 August 2020

2022, 9 (2): 381-392

Downloads: 4 | Views: 161 |

PDF (1.2 MB)

FULL LENGTH ARTICLES

Open Access Full Length Article

Development of a tRNA-derived small RNA diagnostic and prognostic signature in liver cancer

Yi Zuo, Shaoqiu Chen, Lingling Yan, [...], Ling Hu, Scott Bowler, Emory Zitello, Gang Huang, Youping Deng << Fewer

https://doi.org/10.1016/j.gendis.2021.01.006

Published: 28 January 2021

2022, 9 (2): 393-400

Downloads: 3 | Views: 197 |

PDF (1.9 MB)

Open Access Full Length Article

Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia

Min Wu, Maolin Liao, Rongfeng Huang, [...], Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xiao << Fewer

https://doi.org/10.1016/j.gendis.2020.05.005

Published: 21 May 2020

2022, 9 (2): 401-414

Downloads: 2 | Views: 156 |

PDF (4.1 MB)

Open Access Full Length Article

The combination of novel immune checkpoints HHLA2 and ICOSLG: A new system to predict survival and immune features in esophageal squamous cell carcinoma

Chaoqi Zhang, Feng Wang, Nan Sun, [...], Zhen Zhang, Guochao Zhang, Zhihui Zhang, Yuejun Luo, Yun Che, Hong Cheng, Jiagen Li, Jie He << Fewer

https://doi.org/10.1016/j.gendis.2020.08.003

Published: 21 August 2020

2022, 9 (2): 415-428

Downloads: 2 | Views: 167 |

PDF (3.9 MB)

Open Access Full Length Article

Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration

Min Xu, Yu-Meng Wang, Wan-Qing Li, [...], Cheng-Long Huang, Jun Li, Wen-Hua Xie, Hong-Xiang Zeng, Lin-Fen Tao, Xi Li << Fewer

https://doi.org/10.1016/j.gendis.2020.08.009

Published: 31 August 2020

2022, 9 (2): 429-442

Downloads: 6 | Views: 176 |

PDF (3.3 MB)

Open Access Full Length Article

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

Xiujin Shen, Chunhua Weng, Yucheng Wang, [...], Cuili Wang, Shi Feng, Xiayu Li, Heng Li, Hong Jiang, Haibing Wang, Jianghua Chen << Fewer

https://doi.org/10.1016/j.gendis.2020.07.005

Published: 17 July 2020

2022, 9 (2): 443-455

Downloads: 1 | Views: 170 |

PDF (4.9 MB)

Open Access Full Length Article

Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p

Yun Bai, Xiaoshan Gong, Rui Dong, [...], Zhen Cao, Ce Dou, Chuan Liu, Jianmei Li, Fei Kang, Jingjin Dai, Chunrong Zhao, Zhansong Tian, Jiulin Tan, Qijie Dai, Shiwu Dong << Fewer

https://doi.org/10.1016/j.gendis.2020.07.013

Published: 10 August 2020

2022, 9 (2): 456-465

Downloads: 1 | Views: 164 |

PDF (2.5 MB)

Open Access Full Length Article

Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways

Chunmei Yang, Lulu Zhang, Huakun Huang, [...], Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yanran Huang, Xiaoji Luo, Jinyong Luo << Fewer

https://doi.org/10.1016/j.gendis.2020.07.014

Published: 08 August 2020

2022, 9 (2): 466-478

Downloads: 4 | Views: 165 |

PDF (4.8 MB)

Open Access Full Length Article

Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease

Lulin Huang, Li Fang, Qian Liu, [...], Abolfazl Doostparast Torshizi, Kai Wang << Fewer

https://doi.org/10.1016/j.gendis.2021.05.004

Published: 09 June 2021

2022, 9 (2): 479-493

Downloads: 2 | Views: 269 |

PDF (6.8 MB)

Open Access Full Length Article

Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway

Ruigong Zhu, Xian Ji, Xuan Wu, [...], Jiajing Chen, Xuesong Li, Hong Jiang, Haiping Fu, Hui Wang, Zhe Lin, Xin Tang, Shixiu Sun, Qingguo Li, Bingjian Wang, Hongshan Chen << Fewer

https://doi.org/10.1016/j.gendis.2020.08.005

Published: 21 August 2020

2022, 9 (2): 494-509

Downloads: 2 | Views: 222 |

PDF (4.3 MB)

Open Access Full Length Article

Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways

Hao Yuan, Xuelian Wu, Xiaomin Wang, Chengfu Yuan

https://doi.org/10.1016/j.gendis.2020.06.001

Published: 21 June 2020

2022, 9 (2): 510-521

Downloads: 3 | Views: 231 |

PDF (4 MB)

Open Access Full Length Article

Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies

Shenglong Li, Wang Wang, Tingting Li, [...], Xiaojian Han, Chao Hu, Yingming Wang, Meiying Shen, Li Du, Yaru Nai, Jianwei Wang, Aishun Jin << Fewer

https://doi.org/10.1016/j.gendis.2020.12.007

Published: 23 December 2020

2022, 9 (2): 522-530

Downloads: 2 | Views: 183 |

PDF (1.8 MB)

Open Access Full Length Article

Hypercalciuria switches Ca²⁺ signaling in proximal tubular cells, induces oxidative damage to promote calcium nephrolithiasis

Samuel Shin, Cliff-Lawrence Ibeh, Eugenia Awuah Boadi, [...], Bok-Eum Choi, Sanjit K. Roy, Bidhan C. Bandyopadhyay << Fewer

https://doi.org/10.1016/j.gendis.2021.04.006

Published: 15 May 2021

2022, 9 (2): 531-548

Downloads: 3 | Views: 192 |

PDF (4.2 MB)

Open Access Full Length Article

Beclin-1/LC3-Ⅱ dependent macroautophagy was uninfluenced in ischemia-challenged vascular endothelial cells

Yaping Ma, Chaofan Li, Yan He, [...], Tiwei Fu, Li Song, Qingsong Ye, Fugui Zhang << Fewer

https://doi.org/10.1016/j.gendis.2021.02.010

Published: 01 March 2021

2022, 9 (2): 549-561

Downloads: 4 | Views: 178 |

PDF (3.1 MB)

Open Access Full Length Article

Protein phosphatase 6 (Pp6) is crucial for regulatory T cell function and stability in autoimmunity

Wei Cai, Junxun Zhang, Hong Zhou, [...], Xiangxiao Li, Fangzhou Lou, Yang Sun, Zhenyao Xu, Jing Bai, Qianqian Yin, Zhikai Wang, Libo Sun, Xiaojie Cai, Sibei Tang, Yue Wu, Li Fan, Hong Wang, Honglin Wang, Qun Li << Fewer

https://doi.org/10.1016/j.gendis.2021.07.005

Published: 17 August 2021

2022, 9 (2): 562-575

Downloads: 2 | Views: 163 |

PDF (3.1 MB)