Genes & Diseases Open Access Editors-in-Chief: Ailong Huang, Tong-Chuan He
Home Genes & Diseases All Issues Volume 9 Issue 6
Volume 9 Issue 6, November 2022
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PP. 1389-1758
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35 articles
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RESEARCH HIGHLIGHTS
Research Highlight | Open Access
On demand CRISPR-mediated RNA N6-methyladenosine editing
Ying Xu, Fu-Sen Liang
Published: 03 June 2022
2022, 9(6): 1389-1390
Research Highlight | Open Access
Targeting p85β nuclear translocation for the tumors with PIK3CA helical domain mutations
Baoyu He, Yujun Hao
Published: 03 June 2022
2022, 9(6): 1391-1393
RAPID COMMUNICATIONS
Rapid Communication | Open Access
Highlighting novel genes associated with the classical Rett syndrome patient from India
Gomathi Mohan, Ranjan Jyoti Sarma, Mahalaxmi Iyer, [...], Nachimuthu Senthil Kumar, Balachandar Vellingiri << Fewer
Published: 06 January 2022
2022, 9(6): 1394-1396
Rapid Communication | Open Access
Sphingomyelin phosphodiesterase acid like 3B (SMPDL3b) regulates Perilipin5 (PLIN5) expression and mediates lipid droplet formation
Shamroop Kumar Mallela, Mengyuan Ge, Judith Molina, [...], Javier Varona Santos, Jin-Ju Kim, Alla Mitrofanova, Hassan Al-Ali, Brian Marples, Sandra Merscher, Alessia Fornoni << Fewer
Published: 03 February 2022
2022, 9(6): 1397-1400
Rapid Communication | Open Access
HBV sL13H mutation impairs its surface antigen expression and ability to induce autophagy
Jianbo Xia, Liang Cao, Zhenyu Zhao, [...], Yingying Deng, Mengji Lu, Chunchen Wu, Yong Lin << Fewer
Published: 02 March 2022
2022, 9(6): 1401-1404
Rapid Communication | Open Access
GSDMB N-terminal assembles in plasma membrane to execute pyroptotic cell death
Wenbin Gong, Peizhao Liu, Juanhan Liu, [...], Yangguang Li, Tao Zheng, Xiuwen Wu, Yun Zhao, Jianan Ren << Fewer
Published: 08 February 2022
2022, 9(6): 1405-1407
Rapid Communication | Open Access
Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers (TNBC)
Jiaxin Hong, Yao-An Shen, Chih-Yi Hsu, [...], Peng Huang, Alicja Tomaszewski, Edward Gabrielson, Ie-Ming Shih, Stephanie Gaillard, Tian-Li Wang << Fewer
Published: 21 March 2022
2022, 9(6): 1408-1411
Rapid Communication | Open Access
Haploinsufficiency of syncoilin leads to hypertrophic cardiomyopathy
Liang-Liang Fan, Zhuang-Zhuang Yuan, Zi-Jun Jiao, [...], Hui Zeng, Yi-Feng Yang, Zhi-Ping Tan << Fewer
Published: 23 March 2022
2022, 9(6): 1412-1414
Rapid Communication | Open Access
Targeting BMI1 mitigates chemoresistance in ovarian cancer
Anindya Dey, Shailendra Kumar Dhar Dwivedi, Lin Wang, [...], Md Nazir Hossen, Fiifi Neizer-Ashun, Magdalena Bieniasz, Priyabrata Mukherjee, John D. Baird, Marla Weetall, Resham Bhattacharya << Fewer
Published: 18 March 2022
2022, 9(6): 1415-1418
Rapid Communication | Open Access
SENP7 overexpression protects cancer cells from oxygen and glucose deprivation and associates with poor prognosis in colon cancer
Francisco Gallardo-Chamizo, Nieves Lara-Ureña, Juan F. Correa-Vázquez, [...], José C. Reyes, Benoit R. Gauthier, Mario García-Domínguez << Fewer
Published: 01 April 2022
2022, 9(6): 1419-1422
Rapid Communication | Open Access
Ultra-conserved non-coding sequences within the FOXF1 enhancer are critical for human lung development
Przemyslaw Szafranski, Tadeusz Majewski, Esra Yıldız Bölükbaşı, [...], Tomasz Gambin, Justyna A. Karolak, Nahir Cortes-Santiago, Markus Bruckner, Gabriele Amann, Denisa Weis, Paweł Stankiewicz << Fewer
Published: 18 May 2022
2022, 9(6): 1423-1426
Rapid Communication | Open Access
Regulation of pancreatic cancer metastasis through the Gli2-YAP1 axis via regulation of anoikis
Beiqin Yu, Dongsheng Gu, Xiaoli Zhang, [...], Bingya Liu, Jingwu Xie << Fewer
Published: 24 May 2022
2022, 9(6): 1427-1430
REVIEW ARTICLES
Review Article | Open Access
tRNA-derived small RNAs: Mechanisms and potential roles in cancers
Yao Wang, Qiuyan Weng, Jiaxin Ge, [...], Xinjun Zhang, Junming Guo, Guoliang Ye << Fewer
Published: 10 January 2022
2022, 9(6): 1431-1442
Review Article | Open Access
Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine
Amoolya Kandettu, Divya Adiga, Vasudha Devi, [...], Padmanaban S. Suresh, Sanjiban Chakrabarty, Raghu Radhakrishnan, Shama Prasada Kabekkodu << Fewer
Published: 01 March 2022
2022, 9(6): 1443-1465
Review Article | Open Access
Super enhancers: Pathogenic roles and potential therapeutic targets for acute myeloid leukemia (AML)
Ziyang Cao, Yi Shu, Jinxia Wang, [...], Chunxia Wang, Tienan Feng, Li Yang, Jingbo Shao, Lin Zou << Fewer
Published: 23 March 2022
2022, 9(6): 1466-1477
Review Article | Open Access
Long noncoding RNA XIST: Mechanisms for X chromosome inactivation, roles in sex-biased diseases, and therapeutic opportunities
Jianjian Li, Zhe Ming, Liuyi Yang, [...], Tingxuan Wang, Gaowen Liu, Qing Ma << Fewer
Published: 29 April 2022
2022, 9(6): 1478-1492
Review Article | Open Access
Therapeutic potential for targeting Annexin A1 in fibrotic diseases
Zhibin Yan, Xurui Cheng, Tao Wang, [...], Xiangyu Hong, Gang Shao, Caiyun Fu << Fewer
Published: 18 June 2022
2022, 9(6): 1493-1505
Review Article | Open Access
ANO5-related muscle diseases: From clinics and genetics to pathology and research strategies
Jon Christiansen, Anne-Katrin Güttsches, Ulrike Schara-Schmidt, [...], Matthias Vorgerd, Christoph Heute, Corinna Preusse, Werner Stenzel, Andreas Roos << Fewer
Published: 14 February 2022
2022, 9(6): 1506-1520
Review Article | Open Access
Chaperone-assisted E3 ligase CHIP: A double agent in cancer
Sunny Kumar, Malini Basu, Mrinal K. Ghosh
Published: 01 September 2021
2022, 9(6): 1521-1555
Review Article | Open Access
LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases
Fangqi Xia, Yaqi Wang, Mengzhen Xue, [...], Leiqi Zhu, Dengke Jia, Yue Shi, Yan Gao, Luoying Li, Yuanyang Li, Silong Chen, Guangfu Xu, Ding Yuan, Chengfu Yuan << Fewer
Published: 16 August 2021
2022, 9(6): 1556-1565
Review Article | Open Access
The potential regulatory role of BMP9 in inflammatory responses
Tianzhu Song, Dingming Huang, Dongzhe Song
Published: 21 September 2021
2022, 9(6): 1566-1578
Open Access
Role of Receptor Interacting Protein (RIP) kinases in cancer
Kaylee Ermine, Jian Yu, Lin Zhang
Published: 18 November 2021
2022, 9(6): 1579-1593
Review Article | Open Access
Autophagy in pulmonary fibrosis: friend or foe?
Charlotte Hill, Yihua Wang
Published: 23 October 2021
2022, 9(6): 1594-1607
Review Article | Open Access
Melanoma: Molecular genetics, metastasis, targeted therapies, immunotherapies, and therapeutic resistance
William Wagstaff, Rimel N. Mwamba, Karina Grullon, [...], Mikhayla Armstrong, Piao Zhao, Bryce Hendren-Santiago, Kevin H. Qin, Alexander J. Li, Daniel A. Hu, Andrew Youssef, Russell R. Reid, Hue H. Luu, Le Shen, Tong-Chuan He, Rex C. Haydon << Fewer
Published: 27 April 2022
2022, 9(6): 1608-1623
FULL LENGTH ARTICLES
Full Length Article | Open Access
Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma
Qingqing Liu, Zhenni Wang, Yan Jiang, [...], Fengling Shao, Yue Ma, Mingzhao Zhu, Qing Luo, Yang Bi, Lijian Cao, Liang Peng, Jianwu Zhou, Zhenzhen Zhao, Xiaobin Deng, Tong-Chuan He, Shan Wang << Fewer
Published: 04 February 2022
2022, 9(6): 1624-1638
Full Length Article | Open Access
Genetic profiles of familial late-onset Alzheimer's disease in China: The Shanghai FLOAD study
Xin-Yi Xie, Qian-Hua Zhao, Qiang Huang, [...], Eric Dammer, Sheng-di Chen, Ru-Jing Ren, Gang Wang << Fewer
Published: 01 June 2021
2022, 9(6): 1639-1649
Full Length Article | Open Access
PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling
Sicheng Chen, Mengjun Bie, Xiaowen Wang, [...], Mengtian Fan, Bin Chen, Qiong Shi, Yingjiu Jiang << Fewer
Published: 01 July 2021
2022, 9(6): 1650-1661
Full Length Article | Open Access
Whole-exome sequencing of a multicenter cohort identifies genetic changes associated with clinical phenotypes in pediatric nephrotic syndrome
Jia Jiao, Li Wang, Fenfen Ni, [...], Mo Wang, Shipin Feng, Xiaojie Gao, Han Chan, Xueying Yang, Hao Lee, Huan Chi, Xuelan Chen, Daoqi Wu, Gaofu Zhang, Baohui Yang, Anshuo Wang, Qin Yang, Junli Wan, Sijie Yu, Xiaoqin Li, Mei Wang, Xiaofeng Chen, Xianying Mai, Xiongzhong Ruan, Haiping Yang, Qiu Li << Fewer
Published: 05 May 2022
2022, 9(6): 1662-1673
Full Length Article | Open Access
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells
Shasha Cheng, Guan-Jun Yang, Wanhe Wang, [...], Dik-Lung Ma, Chung-Hang Leung << Fewer
Published: 10 July 2021
2022, 9(6): 1674-1688
Full Length Article | Open Access
Intranuclear cardiac troponin I plays a functional role in regulating Atp2a2 expression in cardiomyocytes
Qian Lu, Bo Pan, Haobo Bai, [...], Weian Zhao, Lingjuan Liu, Gu Li, Ruimin Liu, Tiewei Lv, Xupei Huang, Xi Li, Jie Tian << Fewer
Published: 15 May 2021
2022, 9(6): 1689-1700
Full Length Article | Open Access
G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction
Tianhan Li, Juhui Qiu, Tingting Jia, [...], Yinming Liang, Kun Zhang, Wenhua Yan, Zhengjun Hou, Shiwei Yang, Lushan Liu, Wenhao Xiong, Yaokai Chen, Guixue Wang << Fewer
Published: 19 November 2021
2022, 9(6): 1701-1715
Full Length Article | Open Access
Tetratricopeptide repeat domain 36 deficiency mitigates renal tubular injury by inhibiting TGF-β1-induced epithelial–mesenchymal transition in a mouse model of chronic kidney disease
Xin Yan, Rui Peng, Yilu Ni, [...], Lei Chen, Qingling He, Qianyin Li, Qin Zhou << Fewer
Published: 14 May 2021
2022, 9(6): 1716-1726
Full Length Article | Open Access
Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma
Nattawan Suwannakul, Napat Armartmuntree, Raynoo Thanan, [...], Kaoru Midorikawa, Tetsuo Kon, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murata << Fewer
Published: 02 October 2021
2022, 9(6): 1727-1741
Full Length Article | Open Access
All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis
Yanting Sun, Yun He, Jishuang Tong, [...], Daijiang Liu, Haodong Zhang, Tongchuan He, Yang Bi << Fewer
Published: 05 May 2022
2022, 9(6): 1742-1756
CORRIGENDUM
Open Access
Corrigendum to “Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through Angiopoietin-like protein 4” [Genes & Diseases 9(2022) 443–455]
Xiujin Shen, Chunhua Weng, Yucheng Wang, [...], Cuili Wang, Shi Feng, Xiayu Li, Heng Li, Hong Jiang, Haibing Wang, Jianghua Chen << Fewer
Published: 21 March 2022
2022, 9(6): 1757-1758