Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R

Editors-in-Chief: Ailong Huang, Tong-Chuan He

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Volume 9

Issue 6, November 2022

pp.1389-1758 35 articles

Contents(PDF)

RESEARCH HIGHLIGHTS

Open Access Research Highlight

On demand CRISPR-mediated RNA N6-methyladenosine editing

Ying Xu, Fu-Sen Liang

https://doi.org/10.1016/j.gendis.2022.05.019

Published: 03 June 2022

2022, 9 (6): 1389-1390

Downloads: 7 | Views: 207 |

PDF (316.2 KB)

Open Access Research Highlight

Targeting p85β nuclear translocation for the tumors with PIK3CA helical domain mutations

Baoyu He, Yujun Hao

https://doi.org/10.1016/j.gendis.2022.05.018

Published: 03 June 2022

2022, 9 (6): 1391-1393

Downloads: 4 | Views: 180 |

PDF (669.7 KB)

RAPID COMMUNICATIONS

Open Access Rapid Communication

Highlighting novel genes associated with the classical Rett syndrome patient from India

Gomathi Mohan, Ranjan Jyoti Sarma, Mahalaxmi Iyer, [...], Nachimuthu Senthil Kumar, Balachandar Vellingiri << Fewer

https://doi.org/10.1016/j.gendis.2021.12.002

Published: 06 January 2022

2022, 9 (6): 1394-1396

Downloads: 9 | Views: 213 |

PDF (451.4 KB)

Open Access Rapid Communication

Sphingomyelin phosphodiesterase acid like 3B (SMPDL3b) regulates Perilipin5 (PLIN5) expression and mediates lipid droplet formation

Shamroop Kumar Mallela, Mengyuan Ge, Judith Molina, [...], Javier Varona Santos, Jin-Ju Kim, Alla Mitrofanova, Hassan Al-Ali, Brian Marples, Sandra Merscher, Alessia Fornoni << Fewer

https://doi.org/10.1016/j.gendis.2021.12.014

Published: 03 February 2022

2022, 9 (6): 1397-1400

Downloads: 51 | Views: 183 |

PDF (476.9 KB)

Open Access Rapid Communication

HBV sL13H mutation impairs its surface antigen expression and ability to induce autophagy

Jianbo Xia, Liang Cao, Zhenyu Zhao, [...], Yingying Deng, Mengji Lu, Chunchen Wu, Yong Lin << Fewer

https://doi.org/10.1016/j.gendis.2022.01.004

Published: 02 March 2022

2022, 9 (6): 1401-1404

Downloads: 2 | Views: 201 |

PDF (671.1 KB)

Open Access Rapid Communication

GSDMB N-terminal assembles in plasma membrane to execute pyroptotic cell death

Wenbin Gong, Peizhao Liu, Juanhan Liu, [...], Yangguang Li, Tao Zheng, Xiuwen Wu, Yun Zhao, Jianan Ren << Fewer

https://doi.org/10.1016/j.gendis.2021.12.022

Published: 08 February 2022

2022, 9 (6): 1405-1407

Downloads: 3 | Views: 169 |

PDF (565.3 KB)

Open Access Rapid Communication

Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers (TNBC)

Jiaxin Hong, Yao-An Shen, Chih-Yi Hsu, [...], Peng Huang, Alicja Tomaszewski, Edward Gabrielson, Ie-Ming Shih, Stephanie Gaillard, Tian-Li Wang << Fewer

https://doi.org/10.1016/j.gendis.2022.02.009

Published: 21 March 2022

2022, 9 (6): 1408-1411

Downloads: 2 | Views: 189 |

PDF (954 KB)

Open Access Rapid Communication

Haploinsufficiency of syncoilin leads to hypertrophic cardiomyopathy

Liang-Liang Fan, Zhuang-Zhuang Yuan, Zi-Jun Jiao, [...], Hui Zeng, Yi-Feng Yang, Zhi-Ping Tan << Fewer

https://doi.org/10.1016/j.gendis.2022.02.011

Published: 23 March 2022

2022, 9 (6): 1412-1414

Downloads: 1 | Views: 176 |

PDF (1.1 MB)

Open Access Rapid Communication

Targeting BMI1 mitigates chemoresistance in ovarian cancer

Anindya Dey, Shailendra Kumar Dhar Dwivedi, Lin Wang, [...], Md Nazir Hossen, Fiifi Neizer-Ashun, Magdalena Bieniasz, Priyabrata Mukherjee, John D. Baird, Marla Weetall, Resham Bhattacharya << Fewer

https://doi.org/10.1016/j.gendis.2022.02.006

Published: 18 March 2022

2022, 9 (6): 1415-1418

Downloads: 4 | Views: 170 |

PDF (1.2 MB)

Open Access Rapid Communication

SENP7 overexpression protects cancer cells from oxygen and glucose deprivation and associates with poor prognosis in colon cancer

Francisco Gallardo-Chamizo, Nieves Lara-Ureña, Juan F. Correa-Vázquez, [...], José C. Reyes, Benoit R. Gauthier, Mario García-Domínguez << Fewer

https://doi.org/10.1016/j.gendis.2022.02.019

Published: 01 April 2022

2022, 9 (6): 1419-1422

Downloads: 4 | Views: 133 |

PDF (927.4 KB)

Open Access Rapid Communication

Ultra-conserved non-coding sequences within the FOXF1 enhancer are critical for human lung development

Przemyslaw Szafranski, Tadeusz Majewski, Esra Yıldız Bölükbaşı, [...], Tomasz Gambin, Justyna A. Karolak, Nahir Cortes-Santiago, Markus Bruckner, Gabriele Amann, Denisa Weis, Paweł Stankiewicz << Fewer

https://doi.org/10.1016/j.gendis.2022.05.002

Published: 18 May 2022

2022, 9 (6): 1423-1426

Downloads: 4 | Views: 153 |

PDF (1.7 MB)

Open Access Rapid Communication

Regulation of pancreatic cancer metastasis through the Gli2-YAP1 axis via regulation of anoikis

Beiqin Yu, Dongsheng Gu, Xiaoli Zhang, [...], Bingya Liu, Jingwu Xie << Fewer

https://doi.org/10.1016/j.gendis.2022.05.010

Published: 24 May 2022

2022, 9 (6): 1427-1430

Downloads: 3 | Views: 166 |

PDF (638.7 KB)

REVIEW ARTICLES

Open Access Review Article

tRNA-derived small RNAs: Mechanisms and potential roles in cancers

Yao Wang, Qiuyan Weng, Jiaxin Ge, [...], Xinjun Zhang, Junming Guo, Guoliang Ye << Fewer

https://doi.org/10.1016/j.gendis.2021.12.009

Published: 10 January 2022

2022, 9 (6): 1431-1442

Downloads: 4 | Views: 212 |

PDF (1.6 MB)

Open Access Review Article

Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

Amoolya Kandettu, Divya Adiga, Vasudha Devi, [...], Padmanaban S. Suresh, Sanjiban Chakrabarty, Raghu Radhakrishnan, Shama Prasada Kabekkodu << Fewer

https://doi.org/10.1016/j.gendis.2021.12.026

Published: 01 March 2022

2022, 9 (6): 1443-1465

Downloads: 3 | Views: 202 |

PDF (2.1 MB)

Open Access Review Article

Super enhancers: Pathogenic roles and potential therapeutic targets for acute myeloid leukemia (AML)

Ziyang Cao, Yi Shu, Jinxia Wang, [...], Chunxia Wang, Tienan Feng, Li Yang, Jingbo Shao, Lin Zou << Fewer

https://doi.org/10.1016/j.gendis.2022.01.006

Published: 23 March 2022

2022, 9 (6): 1466-1477

Downloads: 2 | Views: 196 |

PDF (1.3 MB)

Open Access Review Article

Long noncoding RNA XIST: Mechanisms for X chromosome inactivation, roles in sex-biased diseases, and therapeutic opportunities

Jianjian Li, Zhe Ming, Liuyi Yang, [...], Tingxuan Wang, Gaowen Liu, Qing Ma << Fewer

https://doi.org/10.1016/j.gendis.2022.04.007

Published: 29 April 2022

2022, 9 (6): 1478-1492

Downloads: 2 | Views: 178 |

PDF (1.5 MB)

Open Access Review Article

Therapeutic potential for targeting Annexin A1 in fibrotic diseases

Zhibin Yan, Xurui Cheng, Tao Wang, [...], Xiangyu Hong, Gang Shao, Caiyun Fu << Fewer

https://doi.org/10.1016/j.gendis.2022.05.038

Published: 18 June 2022

2022, 9 (6): 1493-1505

Downloads: 2 | Views: 196 |

PDF (4 MB)

Open Access Review Article

ANO5-related muscle diseases: From clinics and genetics to pathology and research strategies

Jon Christiansen, Anne-Katrin Güttsches, Ulrike Schara-Schmidt, [...], Matthias Vorgerd, Christoph Heute, Corinna Preusse, Werner Stenzel, Andreas Roos << Fewer

https://doi.org/10.1016/j.gendis.2022.01.001

Published: 14 February 2022

2022, 9 (6): 1506-1520

Downloads: 7 | Views: 198 |

PDF (1.3 MB)

Open Access Review Article

Chaperone-assisted E3 ligase CHIP: A double agent in cancer

Sunny Kumar, Malini Basu, Mrinal K. Ghosh

https://doi.org/10.1016/j.gendis.2021.08.003

Published: 01 September 2021

2022, 9 (6): 1521-1555

Downloads: 2 | Views: 183 |

PDF (3 MB)

Open Access Review Article

LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases

Fangqi Xia, Yaqi Wang, Mengzhen Xue, [...], Leiqi Zhu, Dengke Jia, Yue Shi, Yan Gao, Luoying Li, Yuanyang Li, Silong Chen, Guangfu Xu, Ding Yuan, Chengfu Yuan << Fewer

https://doi.org/10.1016/j.gendis.2021.07.003

Published: 16 August 2021

2022, 9 (6): 1556-1565

Downloads: 2 | Views: 227 |

PDF (739.1 KB)

Open Access Review Article

The potential regulatory role of BMP9 in inflammatory responses

Tianzhu Song, Dingming Huang, Dongzhe Song

https://doi.org/10.1016/j.gendis.2021.08.010

Published: 21 September 2021

2022, 9 (6): 1566-1578

Downloads: 2 | Views: 168 |

PDF (1.1 MB)

Open Access

Role of Receptor Interacting Protein (RIP) kinases in cancer

Kaylee Ermine, Jian Yu, Lin Zhang

https://doi.org/10.1016/j.gendis.2021.10.007

Published: 18 November 2021

2022, 9 (6): 1579-1593

Downloads: 2 | Views: 190 |

PDF (1.5 MB)

Open Access Review Article

Autophagy in pulmonary fibrosis: friend or foe?

Charlotte Hill, Yihua Wang

https://doi.org/10.1016/j.gendis.2021.09.008

Published: 23 October 2021

2022, 9 (6): 1594-1607

Downloads: 1 | Views: 199 |

PDF (718.4 KB)

Open Access Review Article

Melanoma: Molecular genetics, metastasis, targeted therapies, immunotherapies, and therapeutic resistance

William Wagstaff, Rimel N. Mwamba, Karina Grullon, [...], Mikhayla Armstrong, Piao Zhao, Bryce Hendren-Santiago, Kevin H. Qin, Alexander J. Li, Daniel A. Hu, Andrew Youssef, Russell R. Reid, Hue H. Luu, Le Shen, Tong-Chuan He, Rex C. Haydon << Fewer

https://doi.org/10.1016/j.gendis.2022.04.004

Published: 27 April 2022

2022, 9 (6): 1608-1623

Downloads: 3 | Views: 284 |

PDF (3.2 MB)

FULL LENGTH ARTICLES

Open Access Full Length Article

Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma

Qingqing Liu, Zhenni Wang, Yan Jiang, [...], Fengling Shao, Yue Ma, Mingzhao Zhu, Qing Luo, Yang Bi, Lijian Cao, Liang Peng, Jianwu Zhou, Zhenzhen Zhao, Xiaobin Deng, Tong-Chuan He, Shan Wang << Fewer

https://doi.org/10.1016/j.gendis.2021.12.020

Published: 04 February 2022

2022, 9 (6): 1624-1638

Downloads: 5 | Views: 211 |

PDF (5.2 MB)

Open Access Full Length Article

Genetic profiles of familial late-onset Alzheimer's disease in China: The Shanghai FLOAD study

Xin-Yi Xie, Qian-Hua Zhao, Qiang Huang, [...], Eric Dammer, Sheng-di Chen, Ru-Jing Ren, Gang Wang << Fewer

https://doi.org/10.1016/j.gendis.2021.05.001

Published: 01 June 2021

2022, 9 (6): 1639-1649

Downloads: 5 | Views: 196 |

PDF (1.6 MB)

Open Access Full Length Article

PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling

Sicheng Chen, Mengjun Bie, Xiaowen Wang, [...], Mengtian Fan, Bin Chen, Qiong Shi, Yingjiu Jiang << Fewer

https://doi.org/10.1016/j.gendis.2021.05.005

Published: 01 July 2021

2022, 9 (6): 1650-1661

Downloads: 4 | Views: 191 |

PDF (3 MB)

Open Access Full Length Article

Whole-exome sequencing of a multicenter cohort identifies genetic changes associated with clinical phenotypes in pediatric nephrotic syndrome

Jia Jiao, Li Wang, Fenfen Ni, [...], Mo Wang, Shipin Feng, Xiaojie Gao, Han Chan, Xueying Yang, Hao Lee, Huan Chi, Xuelan Chen, Daoqi Wu, Gaofu Zhang, Baohui Yang, Anshuo Wang, Qin Yang, Junli Wan, Sijie Yu, Xiaoqin Li, Mei Wang, Xiaofeng Chen, Xianying Mai, Xiongzhong Ruan, Haiping Yang, Qiu Li << Fewer

https://doi.org/10.1016/j.gendis.2022.03.023

Published: 05 May 2022

2022, 9 (6): 1662-1673

Downloads: 1 | Views: 195 |

PDF (2 MB)

Open Access Full Length Article

Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells

Shasha Cheng, Guan-Jun Yang, Wanhe Wang, [...], Dik-Lung Ma, Chung-Hang Leung << Fewer

https://doi.org/10.1016/j.gendis.2021.06.005

Published: 10 July 2021

2022, 9 (6): 1674-1688

Downloads: 2 | Views: 190 |

PDF (3.3 MB)

Open Access Full Length Article

Intranuclear cardiac troponin I plays a functional role in regulating Atp2a2 expression in cardiomyocytes

Qian Lu, Bo Pan, Haobo Bai, [...], Weian Zhao, Lingjuan Liu, Gu Li, Ruimin Liu, Tiewei Lv, Xupei Huang, Xi Li, Jie Tian << Fewer

https://doi.org/10.1016/j.gendis.2021.04.007

Published: 15 May 2021

2022, 9 (6): 1689-1700

Downloads: 3 | Views: 227 |

PDF (2.6 MB)

Open Access Full Length Article

G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction

Tianhan Li, Juhui Qiu, Tingting Jia, [...], Yinming Liang, Kun Zhang, Wenhua Yan, Zhengjun Hou, Shiwei Yang, Lushan Liu, Wenhao Xiong, Yaokai Chen, Guixue Wang << Fewer

https://doi.org/10.1016/j.gendis.2021.11.003

Published: 19 November 2021

2022, 9 (6): 1701-1715

Downloads: 2 | Views: 199 |

PDF (4.7 MB)

Open Access Full Length Article

Tetratricopeptide repeat domain 36 deficiency mitigates renal tubular injury by inhibiting TGF-β1-induced epithelial–mesenchymal transition in a mouse model of chronic kidney disease

Xin Yan, Rui Peng, Yilu Ni, [...], Lei Chen, Qingling He, Qianyin Li, Qin Zhou << Fewer

https://doi.org/10.1016/j.gendis.2021.04.005

Published: 14 May 2021

2022, 9 (6): 1716-1726

Downloads: 3 | Views: 191 |

PDF (3.4 MB)

Open Access Full Length Article

Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma

Nattawan Suwannakul, Napat Armartmuntree, Raynoo Thanan, [...], Kaoru Midorikawa, Tetsuo Kon, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murata << Fewer

https://doi.org/10.1016/j.gendis.2021.09.002

Published: 02 October 2021

2022, 9 (6): 1727-1741

Downloads: 5 | Views: 227 |

PDF (4.2 MB)

Open Access Full Length Article

All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis

Yanting Sun, Yun He, Jishuang Tong, [...], Daijiang Liu, Haodong Zhang, Tongchuan He, Yang Bi << Fewer

https://doi.org/10.1016/j.gendis.2022.04.011

Published: 05 May 2022

2022, 9 (6): 1742-1756

Downloads: 6 | Views: 189 |