Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R

Editors-in-Chief: Ailong Huang, Tong-Chuan He

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Volume 9

Issue 4, July 2022

pp.827-1151 28 articles

Contents(PDF)

COMMENTARY

Open Access Commentary

ISGylation orchestrates the degradation flux of cellular cargo toward lysosome

Min-Yi Huang, Jing Zhang, Lan Ouyang, Yang Wang

https://doi.org/10.1016/j.gendis.2021.09.003

Published: 02 October 2021

2022, 9 (4): 827-829

Downloads: 4 | Views: 150 |

PDF (602.1 KB)

RAPID COMMUNICATIONS

Open Access Rapid Communication

Dehydrozaluzanin C, a novel type of anti-bacterial agent which targets transporting proteins, Opp and OpuC

Xiangyang Qin, Jinmei Xu, Dandan Yin, [...], Fan Feng, Xianfei Zeng, Bing Niu, Xingbin Hu << Fewer

https://doi.org/10.1016/j.gendis.2021.11.009

Published: 09 December 2021

2022, 9 (4): 830-832

Downloads: 5 | Views: 177 |

PDF (746.3 KB)

Open Access Rapid Communication

Genome-wide DNA methylation profiling reveals candidate biomarkers and probable molecular mechanism of metabolic syndrome

Su-Jin Baek, Hyo-Jeong Ban, Sang-Min Park, [...], Soo Yeon Kim, Siwoo Lee, Hee-Jeong Jin << Fewer

https://doi.org/10.1016/j.gendis.2021.12.010

Published: 11 January 2022

2022, 9 (4): 833-836

Downloads: 1 | Views: 147 |

PDF (840.3 KB)

Open Access Rapid Communication

LncRNA MIR205HG expression predicts efficacy of neoadjuvant chemotherapy for patients with locally advanced breast cancer

Yaqian Xu, Chenwei Yuan, Jing Peng, [...], Liheng Zhou, Yanping Lin, Yaohui Wang, Jie Zhang, Jiayi Ma, Wenjin Yin, Jinsong Lu << Fewer

https://doi.org/10.1016/j.gendis.2021.10.001

Published: 01 November 2021

2022, 9 (4): 837-840

Downloads: 2 | Views: 133 |

PDF (378.3 KB)

Open Access Rapid Communication

Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing

Shang Jiunn Chuah, Chee Weng Yong, Kristeen Ye Wen Teo, [...], Jacob Ren Jie Chew, Yi Ann Cheow, Shipin Zhang, Raymond Chung Wen Wong, Asher Ah Tong Lim, Sai Kiang Lim, Wei Seong Toh << Fewer

https://doi.org/10.1016/j.gendis.2021.11.012

Published: 16 December 2021

2022, 9 (4): 841-844

Downloads: 2 | Views: 157 |

PDF (2.4 MB)

Open Access Rapid Communication

A novel microRNA miR-MTCO3P38 inhibits malignant progression via STAT3/PTTG1/MYC in hepatocellular carcinoma

Deliang Guo, Yang Gu, Dong Ma, [...], Pengpeng Liu, Baiyang Chen, Zhisu Liu, Ping Wu, Quanyan Liu << Fewer

https://doi.org/10.1016/j.gendis.2021.11.006

Published: 27 November 2021

2022, 9 (4): 845-848

Downloads: 5 | Views: 176 |

PDF (1.1 MB)

REVIEW ARTICLES

Open Access Review Article

MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers

Mehdi Sajjadi-Dokht, Talar Ahmad Merza Mohamad, Heshu Sulaiman Rahman, [...], Marwah Suliman Maashi, Svetlana Danshina, Navid Shomali, Saeed Solali, Faroogh Marofi, Elham Zeinalzadeh, Morteza Akbari, Ali Adili, Ramin Aslaminabad, Majid Farshdousti Hagh, Mostafa Jarahian << Fewer

https://doi.org/10.1016/j.gendis.2021.10.009

Published: 03 December 2021

2022, 9 (4): 849-867

Downloads: 8 | Views: 215 |

PDF (2.1 MB)

Open Access Review Article

Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer

Abhijit Das, Barshana Bhattacharya, Souvik Roy

https://doi.org/10.1016/j.gendis.2021.12.025

Published: 22 February 2022

2022, 9 (4): 868-888

Downloads: 2 | Views: 169 |

PDF (3.2 MB)

Open Access Review Article

miR-106b as an emerging therapeutic target in cancer

Surendra Kumar Sagar

https://doi.org/10.1016/j.gendis.2021.02.002

Published: 12 February 2021

2022, 9 (4): 889-899

Downloads: 3 | Views: 184 |

PDF (1.1 MB)

Open Access Review Article

Long noncoding RNAs (lncRNAs) in human lymphomas

Ali Gholami, Khosro Farhadi, Fatemeh Sayyadipour, [...], Masoud Soleimani, Fakhredin Saba << Fewer

https://doi.org/10.1016/j.gendis.2021.02.001

Published: 12 February 2021

2022, 9 (4): 900-914

Downloads: 4 | Views: 182 |

PDF (1.9 MB)

Open Access Review Article

Calcineurin in development and disease

Lei Chen, Min Song, Chunyan Yao

https://doi.org/10.1016/j.gendis.2021.03.002

Published: 15 March 2021

2022, 9 (4): 915-927

Downloads: 3 | Views: 202 |

PDF (1.2 MB)

Open Access Review Article

Mutational landscape of gastric adenocarcinoma in Latin America: A genetic approach for precision medicine

Dennis Cerrato-Izaguirre, Yolanda I. Chirino, Claudia M. García-Cuellar, [...], Miguel Santibáñez-Andrade, Diddier Prada, Angélica Hernández-Guerrero, Octavio Alonso Larraga, Javier Camacho, Yesennia Sánchez-Pérez << Fewer

https://doi.org/10.1016/j.gendis.2021.04.002

Published: 24 April 2021

2022, 9 (4): 928-940

Downloads: 2 | Views: 183 |

PDF (1.5 MB)

Open Access Review Article

The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases

Luigi Cristiano

https://doi.org/10.1016/j.gendis.2021.03.009

Published: 16 April 2021

2022, 9 (4): 941-958

Downloads: 2 | Views: 165 |

PDF (1.7 MB)

Open Access Review Article

The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential

Xiaokai Zhang, Yang Zhang, Aijun Sun, Junbo Ge

https://doi.org/10.1016/j.gendis.2021.04.001

Published: 24 April 2021

2022, 9 (4): 959-972

Downloads: 10 | Views: 279 |

PDF (1 MB)

Open Access Review Article

Targeting LIF/LIFR signaling in cancer

Suryavathi Viswanadhapalli, Kalarickal V. Dileep, Kam Y.J. Zhang, [...], Hareesh B. Nair, Ratna K. Vadlamudi << Fewer

https://doi.org/10.1016/j.gendis.2021.04.003

Published: 29 April 2021

2022, 9 (4): 973-980

Downloads: 3 | Views: 202 |

PDF (1.6 MB)

Open Access Review Article

Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy

Meilin Chen, Yijun Liu, Yuqin Yang, [...], Yanbing Qiu, Zhicheng Wang, Xiaoxu Li, Wenling Zhang << Fewer

https://doi.org/10.1016/j.gendis.2021.04.008

Published: 03 June 2021

2022, 9 (4): 981-999

Downloads: 1 | Views: 273 |

PDF (1.4 MB)

Open Access Review Article

Twists and turns of the genetic story of mevalonate kinase-associated diseases: A review

Isabelle Touitou

https://doi.org/10.1016/j.gendis.2021.05.002

Published: 09 June 2021

2022, 9 (4): 1000-1007

Downloads: 6 | Views: 184 |

PDF (1.1 MB)

FULL LENGTH ARTICLES

Open Access Full Length Article

Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering

Murat Taner Vurat, Şükran Şeker, Özge Lalegül-Ülker, [...], Mahmut Parmaksiz, Ayşe Eser Elçin, Yaşar Murat Elçin << Fewer

https://doi.org/10.1016/j.gendis.2020.11.011

Published: 28 November 2020

2022, 9 (4): 1008-1023

Downloads: 3 | Views: 140 |

PDF (3.8 MB)

Open Access Full Length Article

Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin

Chunyun Pu, Shaorong Tian, Sanxiu He, [...], Weihong Chen, Yuanyuan He, Hongyan Ren, Jing Zhu, Jun Tang, Xiaolan Huang, Ying Xiang, Yixiao Fu, Tingxiu Xiang << Fewer

https://doi.org/10.1016/j.gendis.2020.11.013

Published: 02 December 2020

2022, 9 (4): 1024-1037

Downloads: 6 | Views: 171 |

PDF (5 MB)

Open Access Full Length Article

MiR-743a-5p regulates differentiation of myoblast by targeting Mob1b in skeletal muscle development and regeneration

YongSheng Zhang, YiLong Yao, ZiShuai Wang, [...], Dan Lu, YuanYuan Zhang, Adeyinka Abiola Adetula, SiYuan Liu, Min Zhu, YaLan Yang, XinHao Fan, MuYa Chen, YiJie Tang, Yun Chen, YuWen Liu, GuoQiang Yi, ZhongLin Tang << Fewer

https://doi.org/10.1016/j.gendis.2020.11.018

Published: 03 December 2020

2022, 9 (4): 1038-1048

Downloads: 2 | Views: 174 |

PDF (3.6 MB)

Open Access Full Length Article

Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity

Yi-Lin Chiu, Yi-Ying Wu, Robert B. Barndt, [...], Yu-Wen Lin, Hou-Ping Sytwo, Amy Cheng, Kacy Yang, Khee-Siang Chan, Jehng-Kang Wang, Michael D. Johnson, Chen-Yong Lin << Fewer

https://doi.org/10.1016/j.gendis.2020.12.001

Published: 09 December 2020

2022, 9 (4): 1049-1061

Downloads: 4 | Views: 233 |

PDF (1.5 MB)

Open Access Full Length Article

BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis

Xiaorong Wang, Mengmeng Sang, Shengnan Gong, [...], Zhichuan Chen, Xi Zhao, Guishuan Wang, Zhiran Li, Yingying Huang, Shitao Chen, Gangcai Xie, Enkui Duan, Fei Sun << Fewer

https://doi.org/10.1016/j.gendis.2020.12.012

Published: 09 January 2021

2022, 9 (4): 1062-1073

Downloads: 3 | Views: 177 |

PDF (2.9 MB)

Open Access Full Length Article

AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo

Chi Heon Kim, Colleen Oliver, Hamid Dar, [...], Hicham Drissi, Steven M. Presciutti << Fewer

https://doi.org/10.1016/j.gendis.2020.12.009

Published: 30 December 2020

2022, 9 (4): 1074-1085

Downloads: 5 | Views: 188 |

PDF (1.9 MB)

Open Access Full Length Article

Downregulation of nc886 contributes to prostate cancer cell invasion and TGFβ1-induced EMT

Ronghui Yang, Lingkun Zuo, Hui Ma, [...], Ying Zhou, Ping Zhou, Liyong Wang, Miao Wang, Mahrukh Latif, Lu Kong << Fewer

https://doi.org/10.1016/j.gendis.2020.12.010

Published: 09 February 2021

2022, 9 (4): 1086-1098

Downloads: 1 | Views: 183 |

PDF (3.6 MB)

Open Access Full Length Article

Circulating exosome-like vesicles of humans with nondiabetic obesity impaired islet β-cell proliferation, which was associated with decreased Omentin-1 protein cargo

Qian Ge, Xinxin Xie, Xiangjun Chen, [...], Rongfeng Huang, Cheng-Xue Rui, Qianna Zhen, Renzhi Hu, Min Wu, Xiaoqiu Xiao, Xi Li << Fewer

https://doi.org/10.1016/j.gendis.2020.12.011

Published: 02 January 2021

2022, 9 (4): 1099-1113

Downloads: 4 | Views: 208 |

PDF (2.3 MB)

Open Access Full Length Article

Targeting m6A modification inhibits herpes virus 1 infection

Zhuoying Feng, Fanghang Zhou, Miaomiao Tan, [...], Tingting Wang, Ying Chen, Wenwen Xu, Bin Li, Xin Wang, Xin Deng, Ming-Liang He << Fewer

https://doi.org/10.1016/j.gendis.2021.02.004

Published: 22 February 2021

2022, 9 (4): 1114-1128

Downloads: 8 | Views: 186 |

PDF (3.3 MB)

Open Access Full Length Article

Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism

Brendan P. Norman, Andrew S. Davison, Juliette H. Hughes, [...], Hazel Sutherland, Peter JM. Wilson, Neil G. Berry, Andrew T. Hughes, Anna M. Milan, Jonathan C. Jarvis, Norman B. Roberts, Lakshminarayan R. Ranganath, George Bou-Gharios, James A. Gallagher << Fewer

https://doi.org/10.1016/j.gendis.2021.02.007

Published: 22 February 2021

2022, 9 (4): 1129-1142

Downloads: 6 | Views: 173 |

PDF (2.7 MB)

Open Access Full Length Article

Salivary microbiota may predict the presence of esophageal squamous cell carcinoma

Junmin Wei, Ruifeng Li, Yanxian Lu, [...], Fan Meng, Bohong Xian, Xiaorong Lai, Xiayi Lin, Yu Deng, Dongyang Yang, Huabin Zhang, Liangfang Li, Xiaosong Ben, Guibin Qiao, Wanwei Liu, Zijun Li << Fewer

https://doi.org/10.1016/j.gendis.2021.02.006

Published: 24 February 2021

2022, 9 (4): 1143-1151

Downloads: 2 | Views: 150 |

PDF (1.3 MB)