Genes & Diseases Open Access Editors-in-Chief: Ailong Huang, Tong-Chuan He
Home Genes & Diseases All Issues Volume 12 Issue 2
Volume 12 Issue 2, March 2025
58 articles
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LETTERS
Letter | Open Access
Triplet therapy overcomes 3rd-EGFR TKI-resistant EGFR-L858R/T790M/C797S in trans and in cis/L718Q mutation
Published: 07 September 2024
2025, 12(2): 101408
Letter | Open Access
Unique presentation of a novel gain-of-function mutation in MTOR
Published: 02 September 2024
2025, 12(2): 101405
RAPID COMMUNICATIONS
Rapid Communication | Open Access
A novel metabolite-interacting protein (MIP)-based molecular subtyping construction and validation of IGFBP3 as a MIP-related oncogene in colorectal cancer
Published: 22 March 2024
2025, 12(2): 101272
Rapid Communication | Open Access
The important role and core marker gene of tumor-infiltrating plasma cells in the microenvironment of lung adenocarcinoma
Published: 22 March 2024
2025, 12(2): 101274
Rapid Communication | Open Access
Predicting anti-cancer drug sensitivity through WRE-XGBoost algorithm with weighted feature selection
Published: 22 March 2024
2025, 12(2): 101275
Rapid Communication | Open Access
Reduction of Atp5b protects mice from diet-induced obesity
Published: 22 March 2024
2025, 12(2): 101276
Rapid Communication | Open Access
Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma
Published: 26 March 2024
2025, 12(2): 101278
Rapid Communication | Open Access
Expanding the spectrum of novel candidate genes using trio exome sequencing and identification of monogenic cause in 27.5% of 320 families with steroid-resistant nephrotic syndrome
Published: 28 March 2024
2025, 12(2): 101280
Rapid Communication | Open Access
Actin polymerization regulates the osteogenesis of hASCs by influencing α-tubulin expression and Eg5 activity
Published: 26 July 2024
2025, 12(2): 101380
Rapid Communication | Open Access
NOP56 promotes hepatocellular carcinoma progression through 2′-O-methylation
Published: 08 August 2024
2025, 12(2): 101387
Rapid Communication | Open Access
TMEM132E ablation suppresses tumor progression and restores tamoxifen sensitivity by inducing ERα expression in triple-negative breast cancer
Published: 23 August 2024
2025, 12(2): 101396
Rapid Communication | Open Access
TULP4 degrades RYBP to enhance DNA damage repair and chemosensitivity of pancreatic ductal adenocarcinoma
Published: 05 April 2024
2025, 12(2): 101288
Rapid Communication | Open Access
Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor (csf1r)P853T/+ in CSF1R-microglial encephalopathy
Published: 05 April 2024
2025, 12(2): 101289
Rapid Communication | Open Access
Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma
Published: 08 April 2024
2025, 12(2): 101302
Rapid Communication | Open Access
De novo missense variants of UNC13A are implicated in epileptic encephalopathies and neurodevelopmental disorders
Published: 06 May 2024
2025, 12(2): 101315
Rapid Communication | Open Access
BBOX1, LACC1, MMP7 and SSTR1 as common predictors in obesity and non-alcoholic fatty liver disease
Published: 24 April 2024
2025, 12(2): 101310
Rapid Communication | Open Access
The AKT1-mTOR signaling cascade is crucial for SOX3 to promote hepatocarcinogenesis
Published: 07 May 2024
2025, 12(2): 101316
Rapid Communication | Open Access
PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma
Published: 07 May 2024
2025, 12(2): 101319
Rapid Communication | Open Access
Newly identified intronic and known pathogenic point mutations in SLC34A3/NPT2c cause hereditary hypophosphatemic rickets with hypercalciuria
Published: 07 May 2024
2025, 12(2): 101318
Rapid Communication | Open Access
SET-NUP214-induced hypermethylation landscape promotes abnormal overexpression of HOXC cluster genes in acute megakaryoblastic leukemia
Published: 07 May 2024
2025, 12(2): 101320
Rapid Communication | Open Access
Whole exome sequencing identifies KCNH7 variants associated with epilepsy in children
Published: 09 May 2024
2025, 12(2): 101322
Rapid Communication | Open Access
Concurrent PIK3CA and IDH1 variants in facial infiltrating lipomatosis with intracranial lesions
Published: 22 May 2024
2025, 12(2): 101324
Rapid Communication | Open Access
SIK2 promotes malignant features of human osteosarcoma via up-regulating MMP2 and β-catenin expression
Published: 26 June 2024
2025, 12(2): 101325
Rapid Communication | Open Access
Inhibition of ITGA2 suppresses cervical tumorigenesis and metastasis by targeting the AKT/mTOR signaling pathway
Published: 18 May 2024
2025, 12(2): 101328
Rapid Communication | Open Access
SNORD3B-2 promotes endometrial carcinoma progression by 2′-O-methylation modification of PLK1 and regulating RAB17 alternative splice
Published: 17 May 2024
2025, 12(2): 101329
Rapid Communication | Open Access
Investigation of the genome-wide signatures underlying the micropapillary carcinoma components in colorectal cancers
Published: 19 May 2024
2025, 12(2): 101331
Rapid Communication | Open Access
Identification of hypermethylated CpG sites mapped to LIFR as specific diagnostic biomarkers of colon cancer
Published: 19 May 2024
2025, 12(2): 101334
Rapid Communication | Open Access
Construction and validation of a novel SUMOylation-related lncRNAs signature for predicting the prognosis, tumor immune microenvironment, and therapeutic sensitivity of lung adenocarcinoma
Published: 28 May 2024
2025, 12(2): 101338
Rapid Communication | Open Access
A novel nested gene Aff3ir participates in vascular remodeling by enhancing endothelial cell differentiation in mice
Published: 27 May 2024
2025, 12(2): 101339
Rapid Communication | Open Access
Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy
Published: 29 May 2024
2025, 12(2): 101343
Rapid Communication | Open Access
Mutational single nucleotide polymorphism rs198389 and demethylation promoted natriuretic peptide B gene transcription in heart failure caused by dilated cardiomyopathy
Published: 31 May 2024
2025, 12(2): 101345
Rapid Communication | Open Access
Anoikis-related gene signature associates with the immune infiltration and predicts the prognosis of glioma patients
Published: 04 June 2024
2025, 12(2): 101346
Rapid Communication | Open Access
Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration
Published: 14 June 2024
2025, 12(2): 101349
Rapid Communication | Open Access
Gene expression analysis in subcutaneous adipose tissue reveals a predominant influence of lncRNAs during growth
Published: 14 June 2024
2025, 12(2): 101351
Rapid Communication | Open Access
Integrative analysis of the metabolomes and transcriptomes of Ebola virus-infected cells: Uncovering pathways related to hepatic apoptosis
Published: 16 July 2024
2025, 12(2): 101377
Rapid Communication | Open Access
Reactive oxygen species mediate ovarian cancer development, platinum resistance, and angiogenesis via CXCL8 and GSK-3β/p70S6K1 axis
Published: 17 July 2024
2025, 12(2): 101378
Rapid Communication | Open Access
ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR−/− hamsters
Published: 23 July 2024
2025, 12(2): 101379
Rapid Communication | Open Access
DARG: An integrated knowledge base for analyzing addictive drug-related genes
Published: 28 June 2024
2025, 12(2): 101369
REVIEW ARTICLES
Review Article | Open Access
Oncogenic activation of PIK3CA in cancers: Emerging targeted therapies in precision oncology
Published: 10 September 2024
2025, 12(2): 101430
Review Article | Open Access
Insights into targeting LKB1 in tumorigenesis
Published: 28 August 2024
2025, 12(2): 101402
Review Article | Open Access
GATA6 in pancreatic cancer initiation and progression
Published: 17 June 2024
2025, 12(2): 101353
Review Article | Open Access
Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs
Published: 09 March 2024
2025, 12(2): 101264
Review Article | Open Access
mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets
Published: 08 March 2024
2025, 12(2): 101260
Review Article | Open Access
Single nucleotide polymorphisms: Implications in the early diagnosis and targeted intervention of coronary microvascular dysfunction
Published: 28 February 2024
2025, 12(2): 101249
Review Article | Open Access
Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression
Published: 02 February 2024
2025, 12(2): 101240
Review Article | Open Access
To cleave or not and how? The DNA exonucleases and endonucleases in immunity
Published: 24 January 2024
2025, 12(2): 101219
Review Article | Open Access
FAM20C: A key protein kinase in multiple diseases
Published: 23 November 2023
2025, 12(2): 101179
Review Article | Open Access
Targeting the MYCN-MDM2 pathways for cancer therapy: Are they druggable?
Published: 27 October 2023
2025, 12(2): 101156
FULL LENGTH ARTICLES
Full Length Article | Open Access
Multi-time point transcriptomics and metabolomics reveal key transcription and metabolic features of hepatic ischemia-reperfusion injury in mice
Published: 17 November 2024
2025, 12(2): 101465
Full Length Article | Open Access
Ce6-GFFY is a novel photosensitizer for colorectal cancer therapy
Published: 28 October 2024
2025, 12(2): 101441
Full Length Article | Open Access
Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress
Published: 08 April 2024
2025, 12(2): 101292
Full Length Article | Open Access
The effect of long-term administration of green tea catechins on aging-related cardiac diastolic dysfunction and decline of troponin I
Published: 03 April 2024
2025, 12(2): 101284
Full Length Article | Open Access
Peritoneal adipose stem cell-derived extracellular vesicles mediate the regulation of ovarian cancer cell proliferation and migration through EGFR-NF-κB signaling
Published: 28 March 2024
2025, 12(2): 101283
Full Length Article | Open Access
TFE3-mediated neuroprotection: Clearance of aggregated α-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson’s disease
Published: 07 September 2024
2025, 12(2): 101429
Full Length Article | Open Access
Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis
Published: 02 February 2024
2025, 12(2): 101241
Full Length Article | Open Access
Fibrous scaffolds loaded with BMSC-derived apoptotic vesicles promote wound healing by inducing macrophage polarization
Published: 09 August 2024
2025, 12(2): 101388
Full Length Article | Open Access
Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation
Published: 15 September 2024
2025, 12(2): 101434
Full Length Article | Open Access
Melatonin ameliorates Slc26a2-associated chondrodysplasias by attenuating endoplasmic reticulum stress and apoptosis of chondrocytes
Published: 14 June 2024
2025, 12(2): 101350