Genes & Diseases Open Access Editors-in-Chief: Ailong Huang, Tong-Chuan He
Home Genes & Diseases All Issues Volume 11 Issue 5
Volume 11 Issue 5, September 2024
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RAPID COMMUNICATIONS
Rapid Communication | Open Access
Rare dentin defects: Understanding the pathophysiological mechanisms of COLXVA1 mutations
Isaac Maximiliano Bugueno, Tristan Rey, Alexandra Jimenez-Armijo, [...], Marzena Kawczynski, Naji Kharouf, Marie-Cécile Manière, Yann Herault, Agnès Bloch-Zupan, Virginie Haushalter-Laugel << Fewer
Published: 20 April 2024
2024, 11 (5): 101303
Rapid Communication | Open Access
Proteomic analysis of urinary exosomes reveals ferroptosis-associated proteins are involved in diabetic nephropathy
Kaida Mu, Yanping Yang, Xiaofei An, [...], Jie Zhu, Jing Zhang, Yanfei Jiang, Xiaorong Yang, Jinan Zhang << Fewer
Published: 02 November 2023
2024, 11 (5): 101138
Rapid Communication | Open Access
MACF1 deficiency suppresses tooth mineralization through IGF1 mediated crosstalk between odontoblasts and ameloblasts
Wuxia Qiu, Xiao Lin, Shaoqing Yang, [...], Zhihao Chen, Kewen Zhang, Chaofei Yang, Yu Li, Zhiping Miao, Xiaoni Deng, Xiaohong Duan, Airong Qian << Fewer
Published: 14 September 2023
2024, 11 (5): 101103
Rapid Communication | Open Access
Acyl-CoA thioesterase 7 is oncogenic in breast cancer by promoting oxidative phosphorylation via PGC1α
Xiangyu Sun, Qiang Zhang, Mozhi Wang, [...], Litong Yao, Xiang Li, Hongyi Cao, Yingying Xu << Fewer
Published: 20 October 2023
2024, 11 (5): 101149
Rapid Communication | Open Access
Clinical and genetic heterogeneity of adult polyglucosan body disease caused by GBE1 biallelic mutations in China
Yikun Chen, Yan Shi, Yuan Gao, [...], Yan Hu, Linying Zhou, Jingmei Hong, Shirui Gan, Xiang Lin, Wanjin Chen, Guorong Xu, Jin He << Fewer
Published: 16 October 2023
2024, 11 (5): 101140
Rapid Communication | Open Access
A novel copper metabolism-related signature model for predicting the prognosis, target drugs, and immunotherapy in stomach adenocarcinoma
Kai Zhuang, Siqi Tang, Haixin Feng, [...], Jinying Zhang, Ying Liu, Yong Liu, Yongjian Su, Jiaqi Yu, Zunnan Huang << Fewer
Published: 14 September 2023
2024, 11 (5): 101102
Rapid Communication | Open Access
SPNS1 ablation drives skeletal muscle atrophy by disrupting mitophagy, mitochondrial function, and apoptosis in mice
Xianzhong Zhang, Fengmin Zhang, Haofan Wu, [...], Zhen Yu, Chengle Zhuang << Fewer
Published: 07 September 2023
2024, 11 (5): 101083
Rapid Communication | Open Access
A new autophagy-related nomogram and mechanism in multiple myeloma
Hanying Huang, Yang Li, Ziang Zhu, [...], Yang Liu, Weida Wang, Shuzhao Chen, Xiaoping Wu, Yun Wang, Yanzhou Chen, Huanxin Lin, Yang Liang, Lingling Shu << Fewer
Published: 21 September 2023
2024, 11 (5): 101120
Rapid Communication | Open Access
Neurokinin-2 receptor antagonist SR48968 induced necroptosis of myeloid leukemia cells by calcium overload-driven reactive oxygen species accumulation
Zhibin Yan, Xiangyu Hong, Qihao Lin, [...], Leijie Wang, Gang Shao, Chentao Ge, Ruilong Xia, Caiyun Fu << Fewer
Published: 20 September 2023
2024, 11 (5): 101098
Rapid Communication | Open Access
MAL2 DNA methylation serves as a biomarker for the diagnosis and prognosis of glioma
Hao Luo, Xing Xiao, Weiliang Hou, [...], Jing Cai, Ming Chen, Qisheng Tang, Yusheng Tong, Zengxin Qi, Kaicheng Li, Liang Chen << Fewer
Published: 07 September 2023
2024, 11 (5): 101082
Rapid Communication | Open Access
Exome sequencing identifies a likely causative variant in 53% of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions
Konstantin Deutsch, Verena Klämbt, Thomas M. Kitzler, [...], Tilman Jobst-Schwan, Ronen Schneider, Florian Buerger, Steve Seltzsam, Sherif El Desoky, Jameela A. Kari, Farkhanda Hafeez, Maria Szczepańska, Loai A. Eid, Hazem S. Awad, Muna Al-Saffar, Neveen A. Soliman, Velibor Tasic, Camille Nicolas-Frank, Kirollos Yousef, Luca M. Schierbaum, Sophia Schneider, Abdul Halawi, Izzeldin Elmubarak, Katharina Lemberg, Shirlee Shril, Shrikant M. Mane, Nancy Rodig, Friedhelm Hildebrandt << Fewer
Published: 15 September 2023
2024, 11 (5): 101111
Rapid Communication | Open Access
USP45 acts as an oncogene to regulate the proliferation of esophageal cancer cells
Kai Li, Qian Wang, Hua Bian
Published: 30 September 2023
2024, 11 (5): 101135
Rapid Communication | Open Access
CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency
Yue Ding, Zheng Ye, Bo Ding, [...], Songwei Feng, Furong Du, Xuejiao Ma, Xiaoxuan Wang, Yang Shen << Fewer
Published: 19 December 2023
2024, 11 (5): 101200
Rapid Communication | Open Access
Genome-wide DNA methylome analysis reveals a critical role of methylation-dysregulated lncRNAs in autophagy regulation in glioblastoma
Hongying Zhao, Ying Liu, Meiting Fei, [...], Lin Bo, Lixia Wang, Yaopeng Shu, Peiqi Ben, Li Wang << Fewer
Published: 12 September 2023
2024, 11 (5): 101107
Rapid Communication | Open Access
Alterations in expression and localization of POMGNT1 in the APP/PS1 mouse model of Alzheimer's disease
Hanxiao Jiang, Yuxue Feng, Xia Hao, [...], Guiqiong He, Xiaofeng Li << Fewer
Published: 24 September 2023
2024, 11 (5): 101125
Rapid Communication | Open Access
Comprehensive identification and potential application of genetic alteration-driven enhancer RNAs for eRNA-targeted therapy in breast cancer
Hongying Zhao, Caiyu Zhang, Lin Bo, [...], Lixia Wang, Wangyang Liu, Yaopeng Shu, Kailai Liu, Ying Liu, Meiting Fei, Li Wang << Fewer
Published: 23 September 2023
2024, 11 (5): 101124
Rapid Communication | Open Access
Unique anti-angiogenic effects, pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis
Bo Liang, Rui Dong, Sze Wan Hung, [...], Yiran Li, Yuezhen Lin, Ling Wu, Tao Zhang, Gene Chi Wai Man, Hui Xu, Jacqueline Pui Wah Chung, Chi Chiu Wang << Fewer
Published: 11 November 2023
2024, 11 (5): 101166
Rapid Communication | Open Access
Prognosis prediction and immune microenvironment features of breast cancer indicated by a cuproptosis-associated long non-coding RNA signature
Siyi Liu, Juanchan Huang, Wei Zhao
Published: 22 September 2023
2024, 11 (5): 101110
Rapid Communication | Open Access
MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma
Haimin Song, Bowen Ni, Xuetao Peng, [...], Weijuan Xu, Shaochun Yang, Runwei Yang, Ziyu Wang, Kaishu Li, Rui Lin, Yunxiao Zhang, Jinglin Guo, Kezhi Wu, Guangwei Shi, Jichao Sun, Chunming He, Yawei Liu << Fewer
Published: 09 September 2023
2024, 11 (5): 101085
Rapid Communication | Open Access
Dominant negative effect as a novel mechanism of SPAST gene mutation in a large family with hereditary spastic paraplegia
Ke Deng, Haibo Ruan, Feifei Yu, [...], Zhenle Pei, Congjian Xu, Shuo Zhang << Fewer
Published: 27 October 2023
2024, 11 (5): 101152
Rapid Communication | Open Access
Comprehensive analysis of mitochondrial dynamic-related genes on their functions and prognostic values for glioblastoma multiforme
Zhu Xie, Wei Hua, Hongyan Wang
Published: 09 September 2023
2024, 11 (5): 101084
Rapid Communication | Open Access
Integrative analysis of tumor stemness and immune microenvironment deciphers novel molecular subtypes in hepatocellular carcinoma
Zhiyi Wang, Shuang Chen, Dongxiao Li, [...], Hui Xu, Siyuan Weng, Yuyuan Zhang, Yuqing Ren, Chunguang Guo, Xiuling Li, Zaoqu Liu, Xinwei Han << Fewer
Published: 07 September 2023
2024, 11 (5): 101077
Rapid Communication | Open Access
EZH2 is a prognostic factor associated with tumor stemness and immune infiltration in skull base chordoma
Qian Liu, Mingxuan Li, Yujia Xiong, [...], Yutao Shen, Tianshun Ma, Tianhao Zhang, Xiaohong R. Yang, Yazhuo Zhang, Jiwei Bai << Fewer
Published: 11 October 2023
2024, 11 (5): 101133
Rapid Communication | Open Access
Efficacy of rapid antigen self-testing for SARS-CoV-2 screening: Real-world evidence from a prospective cohort study
Yaoyue Hu, Bin Peng, Jie Fan, [...], Zhu Yang, Jianjiang Xue, Quanxin Long, Jie Xia, Yuan Hu, Xuefei Cai, Li Zhou, Ailong Huang << Fewer
Published: 28 October 2023
2024, 11 (5): 101151
Rapid Communication | Open Access
Promising prognostic value of ATP binding cassette transporters and their correlation with tumor-infiltrating immune cells in lung adenocarcinoma
Linzi Wei, Qian Yu, Xueying Yang
Published: 14 September 2023
2024, 11 (5): 101099
Rapid Communication | Open Access
Tumor immunological phenotype-derived gene classification predicts prognosis, treatment response, and drug candidates in ovarian cancer
Chengbin Guo, Yuqin Tang, Zhihai Liu, [...], Chuanliang Chen, Xun Hu, Yongqiang Zhang << Fewer
Published: 21 November 2023
2024, 11 (5): 101173
Rapid Communication | Open Access
Traction force with extracellular matrix mediated by cytoskeleton influences metastasis through SLC8A1 induced Wnt-β-catenin pathway in endometrial cancer
Xingchen Li, Xin Xu, Jianliu Wang
Published: 26 September 2023
2024, 11 (5): 101128
Rapid Communication | Open Access
Depletion of anti-CD47mAb in plasma by genetically modified cells for pre-transfusion testing
Fei Wang, Wenting Wang, Xiaoshuang Wu, [...], Zhixin Liu, Yafen Wang, Rong Zhang, Shunli Gu, Qunxing An, Yaozhen Chen, Xingbin Hu << Fewer
Published: 13 September 2023
2024, 11 (5): 101104
Rapid Communication | Open Access
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia
Liang Zhou, Youyou Li, Jiaren Li, [...], Hanyu Yao, Jin Huang, Cheng Li, Long Wang << Fewer
Published: 28 November 2023
2024, 11 (5): 101184
Rapid Communication | Open Access
Serum metabolic profiling implicates mTOR activation and insulin resistance in the development of pulmonary hypertension in a rat model of pressure overload-induced heart failure
Qi Zhou, Chao Tang, Xinke Xu, [...], Junhao Hu, Shengsen Yao, Bo Dong, Xiaojing Wu << Fewer
Published: 14 September 2023
2024, 11 (5): 101097
Rapid Communication | Open Access
Helicobacter pylori mediated niche environment aberrations promote the progression of gastric cancer
Teng Yan, Hang Sun, Yuhui Liao, Jiajian Zhou
Published: 06 January 2024
2024, 11 (5): 101207
Rapid Communication | Open Access
MMP-9 deficiency accelerates the progress of periodontitis
Chun-Yan Wan, Yixin Yin, Xiaoyan Li, [...], Meng Meng Liu, Graham Goldman, Li-An Wu, Feng Wang, Dao-Shu Luo, Zhuo Chen, Wen-An Xu, Stephen Chen, Mary MacDougall, Merry L. Lindsey, Zhi Chen, Shuo Chen << Fewer
Published: 28 January 2024
2024, 11 (5): 101231
Rapid Communication | Open Access
CD147 facilitates cisplatin resistance in ovarian cancer through FOXM1 degradation inhibition
Miao Wang, Lin Chen, Yu Wang, [...], Tian Fan, Chunyu Zhu, Zhixian Li, Lei Mou, Hong Yang, Airong Qian, Yu Li << Fewer
Published: 24 March 2024
2024, 11 (5): 101277
REVIEW ARTICLES
Review Article | Open Access
The regulatory role of m6A modification in the maintenance and differentiation of embryonic stem cells
Jin Zhang, Lingling Tong, Yuchen Liu, [...], Xiang Li, Jiayi Wang, Ruoxin Lin, Ziyu Zhou, Yunbing Chen, Yanxi Chen, Yirong Liu, Di Chen << Fewer
Published: 19 December 2023
2024, 11 (5): 101199
Review Article | Open Access
Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Xudong Li, Wei Li, Yanli Zhang, [...], Linping Xu, Yongping Song << Fewer
Published: 26 October 2023
2024, 11 (5): 101150
Review Article | Open Access
Recent advancement of sonogenetics: A promising noninvasive cellular manipulation by ultrasound
Jin Tang, Mingxuan Feng, Dong Wang, [...], Liang Zhang, Ke Yang << Fewer
Published: 15 September 2023
2024, 11 (5): 101112
Review Article | Open Access
LncRNAs are involved in regulating ageing and age-related disease through the adenosine monophosphate-activated protein kinase signalling pathway
Jiamei Li, Feng Xiao, Siqi Wang, [...], Xiaolan Fan, Zhi He, Taiming Yan, Jia Zhang, Mingyao Yang, Deying Yang << Fewer
Published: 18 July 2023
2024, 11 (5): 101042
Review Article | Open Access
Mechanism and application of feedback loops formed by mechanotransduction and histone modifications
Han Sun, Yafang Gao, Xinyu Ma, [...], Yizhou Deng, Lintao Bi, Lisha Li << Fewer
Published: 02 August 2023
2024, 11 (5): 101061
Review Article | Open Access
Protein lysine crotonylation in cellular processions and disease associations
Hongling Zhao, Yang Han, Pingkun Zhou, [...], Hua Guan, Shanshan Gao << Fewer
Published: 02 August 2023
2024, 11 (5): 101060
Review Article | Open Access
The landscape of epigenetic regulation and therapeutic application of N6-methyladenosine modifications in non-coding RNAs
Gui-e Xu, Xuan Zhao, Guoping Li, [...], Priyanka Gokulnath, Lijun Wang, Junjie Xiao << Fewer
Published: 18 July 2023
2024, 11 (5): 101045
Review Article | Open Access
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development
Qing Ma, Guang Chen, Ying Li, [...], Zhenming Guo, Xue Zhang << Fewer
Published: 16 July 2023
2024, 11 (5): 101021
Review Article | Open Access
M6A modification in cardiovascular disease: With a focus on programmed cell death
Wen Li, Yao Liu, Ruiyan Xu, [...], Yuan Zong, Lu He, Jun Hu, Guohua Li << Fewer
Published: 14 July 2023
2024, 11 (5): 101039
Review Article | Open Access
Homeostatic regulation of NAD(H) and NADP(H) in cells
Luojun Chen, Xiaoke Xing, Pingfeng Zhang, [...], Lulu Chen, Huadong Pei << Fewer
Published: 17 October 2023
2024, 11 (5): 101146
Review Article | Open Access
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression
Dong Wang, Yan Zhang, Qingbo Li, [...], Yu Li, Wen Li, Ao Zhang, Jingxuan Xu, Jingyan Meng, Lin Tang, Shuhua Lyu << Fewer
Published: 06 July 2023
2024, 11 (5): 101020
Review Article | Open Access
Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies
Jiankun Fan, Zhigang Li, Li Pei, Yu Hou
Published: 28 February 2024
2024, 11 (5): 101252
Review Article | Open Access
Vitamin D binding protein in psychiatric and neurological disorders: Implications for diagnosis and treatment
Ling Li, Bing Han, Yan Kong, [...], Gaojia Zhang, Zhijun Zhang << Fewer
Published: 15 April 2024
2024, 11 (5): 101309
FULL LENGTH ARTICLES
Full Length Article | Open Access
Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium
Jinxuan Zheng, Rongcheng Yu, Yiqi Tang, [...], Sihui Su, Sainan Wang, Chenxi Liao, Xuecong Li, Jiabin Liao, Dongsheng Yu, Tingting Ai, Wei Zhao, Vicky Yau, Chufeng Liu, Liping Wu, Yang Cao << Fewer
Published: 12 December 2023
2024, 11 (5): 101194
Full Length Article | Open Access
XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation
Yun Zhang, Susan Lin, Jing Yao, [...], Wantong Cai, Huaqiu Chen, Ailikemu Aierken, Zhe Wang, Weihong Song << Fewer
Published: 19 October 2023
2024, 11 (5): 101148
Full Length Article | Open Access
Profibrotic role of the SOX9–MMP10–ECM biosynthesis axis in the tracheal fibrosis after injury and repair
Lei Gu, Anmao Li, Chunyan He, [...], Rui Xiao, Jiaxin Liao, Li Xu, Junhao Mu, Xiaohui Wang, Mingjin Yang, Jinyue Jiang, Yang Bai, Xingxing Jin, Meiling Xiao, Xia Zhang, Tairong Tan, Yang Xiao, Jing Lin, Yishi Li, Shuliang Guo << Fewer
Published: 15 July 2023
2024, 11 (5): 101040
Full Length Article | Open Access
Multi-omics integration reveals potential stage-specific druggable targets in T-cell acute lymphoblastic leukemia
Zijun Yan, Jie Xia, Ziyang Cao, [...], Hongyang Zhang, Jinxia Wang, Tienan Feng, Yi Shu, Lin Zou << Fewer
Published: 26 April 2023
2024, 11 (5): 100949
Full Length Article | Open Access
PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype
Fengsheng Dai, Yixiao Yuan, Jiaqi Hao, [...], Xing Cheng, Xiangyi Zhou, Li Zhou, Rui Tian, Yi Zhao, Tingxiu Xiang << Fewer
Published: 21 September 2023
2024, 11 (5): 101106
Full Length Article | Open Access
Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging
Wenchao Wang, Junjie Qian, Mingge Shang, [...], Yiting Qiao, Jiacheng Huang, Xinxin Gao, Zhou Ye, Xinyu Tong, Kangdi Xu, Xiang Li, Zhengtao Liu, Lin Zhou, Shusen Zheng << Fewer
Published: 07 November 2023
2024, 11 (5): 101161
Full Length Article | Open Access
Narciclasine induces colon carcinoma cell apoptosis by inhibiting the IL-17A/Act1/TRAF6/NF-κB signaling pathway
Huiming Deng, Qiang Liu, Siman Yu, [...], Lifan Zhong, Lianfang Gan, Huiquan Gu, Qianru Wang, Ruxin Cheng, Yong Liu, Li Liu, Ling Huang, Ronghua Xu << Fewer
Published: 13 April 2023
2024, 11 (5): 100938
Full Length Article | Open Access
Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis
Jianxiong Xu, Jinxuan Wang, Hongping Zhang, [...], Yidan Chen, Xiaojuan Zhang, Ying Zhang, Ming Xie, Jun Xiao, Juhui Qiu, Guixue Wang << Fewer
Published: 02 March 2024
2024, 11 (5): 101250
Full Length Article | Open Access
Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression
Lixin Liang, Tian Cai, Xiaojia Li, [...], Jianhong An, Sen Yu, Yang Zhang, Fengjie Guo, Fang Wei, Jie He, Keping Xie, Tingting Jiang << Fewer
Published: 22 December 2023
2024, 11 (5): 101203
Full Length Article | Open Access
Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signaling
Zhirong Zhang, Jiayao Yang, Rui Liu, [...], Jing Ma, Kai Wang, Xiaojun Wang, Ni Tang << Fewer
Published: 03 April 2024
2024, 11 (5): 101285