Genes & Diseases

ISSN 2352-4820 e-ISSN 2352-3042 CN 50-1221/R

Editors-in-Chief: Ailong Huang, Tong-Chuan He

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Volume 11

Issue 3, May 2024

66 articles

Contents(PDF)

Open Access

Publisher’s Note

Wendy Ye

https://doi.org/10.1016/S2352-3042(24)00023-0

Published: 27 February 2024

2024, 11 (3): 101226

Downloads: 9 | Views: 18 |

PDF (132 KB)

RESEARCH HIGHLIGHT

Open Access Editorial

The impact of broad glutamine metabolism inhibition on the tumor microenvironment

Tianhe Li, Yun-Ta Chuang, Tian-Li Wang

https://doi.org/10.1016/j.gendis.2023.05.003

Published: 20 June 2023

2024, 11 (3): 100984

Downloads: 2 | Views: 10 |

PDF (477.1 KB)

COMMENTARY

Open Access Discussion

Attempts to restore loss of function in damaged ACD cells open the way to non-mutational oncogenesis

Vladimir F. Niculescu

https://doi.org/10.1016/j.gendis.2023.101109

Published: 12 September 2023

2024, 11 (3): 101109

Downloads: 2 | Views: 9 |

PDF (216.1 KB)

LETTERS

Open Access Editorial

The germline genetics of mild-to-moderate penetrance: An intriguing role of PRAME in multiple carcinogenesis

Diaddin Hamdan, Van Tai Nguyen, Justine Paris, [...], Christophe Leboeuf, Morad El Bouchtaoui, Marc Espié, Anne Janin, Géraldine Falgarone, Mélanie Di Benedetto, Guilhem Bousquet << Fewer

https://doi.org/10.1016/j.gendis.2023.04.034

Published: 30 June 2023

2024, 11 (3): 101003

Downloads: 3 | Views: 34 |

PDF (1.1 MB)

Open Access Editorial

CD209 signaling pathway as a biomarker for cisplatin chemotherapy response in small cell lung cancer

Anqi Lin, Hong Yang, Jian Zhang, Peng Luo

https://doi.org/10.1016/j.gendis.2023.06.011

Published: 16 July 2023

2024, 11 (3): 101038

Downloads: 2 | Views: 16 |

PDF (1 MB)

Open Access Editorial

The prolactin receptor (PRLR) gene is linked to and associated with the comorbidity of depression and type 2 diabetes in Italian families

Mutaz Amin, Rongling Wu, Teodor T. Postolache, Claudia Gragnoli

https://doi.org/10.1016/j.gendis.2023.06.018

Published: 28 July 2023

2024, 11 (3): 101048

Downloads: 3 | Views: 10 |

PDF (373.6 KB)

RAPID COMMUNICATIONS

Open Access Rapid Communication

JW-1-283 inhibits melanoma tumor growth via stabilization of the p53 pathway

Yang Xie, Ruida Hou, Kelli L. Hartman, [...], Jianxiong Jiang, Zhongzhi Wu, Wei Li << Fewer

https://doi.org/10.1016/j.gendis.2023.06.009

Published: 17 July 2023

2024, 11 (3): 101036

Downloads: 2 | Views: 3 |

PDF (1.1 MB)

Open Access Rapid Communication

Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

Alberto Gómez-Carballa, María José Currás-Tuala, Sara Pischedda, [...], Miriam Cebey-López, José Gómez-Rial, Irene Rivero-Calle, Jacobo Pardo-Seco, Xabier Bello, Sandra Viz-Lasheras, Antonio Justicia-Grande, Julián Montoto-Louzao, Alba Camino-Mera, Isabel Ferreirós-Vidal, Máximo Fraga, José R. Antúnez, Rodolfo Gómez, Federico Martinón-Torres, Antonio Salas << Fewer

https://doi.org/10.1016/j.gendis.2023.05.001

Published: 19 June 2023

2024, 11 (3): 100981

Downloads: 2 | Views: 4 |

PDF (1.6 MB)

Open Access Rapid Communication

A simplified noncryogenic strategy to transport mesenchymal stem cells: Potential applications in cell therapy and regenerative medicine

Xiangyu Dong, Yannian Gou, Meichun Guo, [...], Jiamin Zhong, Aohua Li, Ailing Hao, Wei Zeng, Rex C. Haydon, Hue H. Luu, Russell R. Reid, Tongchuan He, Yan Xu, Jiaming Fan << Fewer

https://doi.org/10.1016/j.gendis.2023.07.002

Published: 24 August 2023

2024, 11 (3): 101073

Downloads: 2 | Views: 7 |

PDF (869.3 KB)

Open Access Rapid Communication

Juvenile cardiomyopathy with dystrophin deficiency

Yuhui Luo, Qinglan Shu, Yi Wang, [...], Min Gu, Hao Zhang, Siqi Hong, Rui Wang, Lixue Yin << Fewer

https://doi.org/10.1016/j.gendis.2023.04.019

Published: 19 June 2023

2024, 11 (3): 100980

Downloads: 2 | Views: 3 |

PDF (1.2 MB)

Open Access Rapid Communication

Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation: Evaluating susceptibility to the development of obesity and NAFLD

MJ Mahesh Kumar, Shailendra Arindkar, Masum Saini, Perumal Nagarajan

https://doi.org/10.1016/j.gendis.2023.04.020

Published: 21 June 2023

2024, 11 (3): 100982

Downloads: 2 | Views: 3 |

PDF (1.2 MB)

Open Access Rapid Communication

The characteristics of cerebrospinal fluid tumor microenvironment in a patient with leptomeningeal metastases from cancer of unknown primary

Haoyu Ruan, Zhe Wang, Xuemei Tang, [...], Qiong Zhan, Kun Chen, Lu Gao, Ming Guan << Fewer

https://doi.org/10.1016/j.gendis.2023.04.026

Published: 23 June 2023

2024, 11 (3): 100992

Downloads: 2 | Views: 3 |

PDF (1.1 MB)

Open Access Rapid Communication

Genetic and immunologic characteristics of colorectal cancer patients with KRAS mutations and predictive significance of tumor immune microenvironment in adjuvant chemotherapy

Zhengqi Wen, Wenliang Li, Chengmin Shi, [...], Junrui Ma, Sihui Zhao, Ruize Zhou, Xihong Liu, Rong Yang, Zhiping Zhang, Hushan Zhang, Bo Li << Fewer

https://doi.org/10.1016/j.gendis.2023.05.002

Published: 19 June 2023

2024, 11 (3): 100983

Downloads: 2 | Views: 3 |

PDF (547.4 KB)

Open Access Rapid Communication

Co-alteration of Myc and RTK-RAS pathways defines a liver-metastatic propensity and immune-cold subgroup of pancreatic adenocarcinoma

Yuyuan Zhang, Ziyang Zu, Hui Xu, [...], Siyuan Weng, Yuqing Ren, Quan Cheng, Peng Luo, Jian Zhang, Zaoqu Liu, Xinwei Han << Fewer

https://doi.org/10.1016/j.gendis.2023.05.006

Published: 29 June 2023

2024, 11 (3): 100993

Downloads: 2 | Views: 4 |

PDF (865.2 KB)

Open Access Rapid Communication

Gp130-dependent STAT3 activation in M–CSF–derived macrophages exaggerates tumor progression

Yuting Xu, Xiaoyu Xu, Qianyue Zhang, [...], Peizhe Lu, Chongjun Xiang, Lei Zhang, Chunhua Lin, Qiaoling Song << Fewer

https://doi.org/10.1016/j.gendis.2023.05.004

Published: 20 June 2023

2024, 11 (3): 100985

Downloads: 2 | Views: 3 |

PDF (1 MB)

Open Access Rapid Communication

RIOK1 synergizes with TRIP13 by regulating the E2F–Rb signaling pathway to promote the proliferation of esophageal cancer cells

Chengyu Li, Deyuan Pan, Wan Lin, [...], Danxia Deng, Yingxin Zhou, Hui Zhao, Feng Pan, Liyan Xu, Enmin Li, Lin Long << Fewer

https://doi.org/10.1016/j.gendis.2023.04.024

Published: 24 June 2023

2024, 11 (3): 100990

Downloads: 2 | Views: 3 |

PDF (1,020.6 KB)

Open Access Rapid Communication

Differential expression profile of circular RNAs in mouse peritoneum with peritoneal fibrosis and the potential regulatory role of novel_circ_0007527

Yingfeng Shi, Yan Hu, Hui Chen, [...], Jinqing Li, Min Tao, Xun Zhou, Qin Zhong, Andong Qiu, Shougang Zhuang, Na Liu << Fewer

https://doi.org/10.1016/j.gendis.2023.04.025

Published: 23 June 2023

2024, 11 (3): 100991

Downloads: 2 | Views: 3 |

PDF (1 MB)

Open Access Rapid Communication

Genetic association analysis-based networks and classification of human UCP1 polymorphisms

Donghai Li

https://doi.org/10.1016/j.gendis.2023.04.028

Published: 24 June 2023

2024, 11 (3): 100995

Downloads: 2 | Views: 18 |

PDF (634 KB)

Open Access Rapid Communication

Two unrelated Alagille syndrome cases of South Indian origin: Showing multi-exonic deletion and a novel mutation in JAG1 gene

Aswathi N, Jincy M. Jose, Sreelata B. Nair, [...], Prabha S. N, Pappachan S << Fewer

https://doi.org/10.1016/j.gendis.2023.04.029

Published: 24 June 2023

2024, 11 (3): 100998

Downloads: 2 | Views: 3 |

PDF (766.3 KB)

Open Access Rapid Communication

Ribonucleotide reductase subunit M1 blocks glucose catabolism via phosphorylation of pyruvate kinase M2 in human esophageal squamous cell cancer

Jian Yang, Lingxiao Wang, Hui Sun, [...], Zhenxiang Zhao, Yanchuan Ma, Zhen Hu, Liqin Zhai, Yonggang Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.04.031

Published: 24 June 2023

2024, 11 (3): 101000

Downloads: 1 | Views: 3 |

PDF (792.9 KB)

Open Access Rapid Communication

Development and validation of an immunogenic cell death-related prognostic model, and landscape of the tumor immune microenvironment in glioblastoma

Sha Yang, Mei Deng, Yunbiao Xiong, [...], Bing Xiong, Junwu Fu, Jia Wang, Jiqin Zhang, Guoqiang Han, Jian Liu, Ying Tan << Fewer

https://doi.org/10.1016/j.gendis.2023.04.032

Published: 28 June 2023

2024, 11 (3): 101001

Downloads: 2 | Views: 3 |

PDF (383.3 KB)

Open Access Rapid Communication

Sirt5 desuccinylates Cdc42 to mediate osteoclastogenesis and bone remodeling in mice

Yuang Zhang, Jing Wang, Jing Luan, [...], Chuanju Liu, Yazhou Cui, Jinxiang Han << Fewer

https://doi.org/10.1016/j.gendis.2023.04.033

Published: 03 July 2023

2024, 11 (3): 101002

Downloads: 2 | Views: 3 |

PDF (945 KB)

Open Access Rapid Communication

Clinical management of a rare melanoma case arising from congenital melanocytic nevus

Ruixin Jiang, Yan Wang, Xuhui Ma, [...], Xinyang Xuanyuan, Yanjie Zhang, Bin Jiang, Weizhen Zhang, Hanlin Zeng << Fewer

https://doi.org/10.1016/j.gendis.2023.05.007

Published: 27 June 2023

2024, 11 (3): 101005

Downloads: 2 | Views: 8 |

PDF (1.5 MB)

Open Access Rapid Communication

Novel de novo TRPV4 mutation identified in a Chinese family with metatropic dysplasia inhibits chondrogenic differentiation

Ping Wei, Weizhe Shi, Tianying Nong, [...], Caixia Xian, Xia Li, Zhaohui Li, Xin Li, Jianping Wu, Liyuan Shang, Fulong Xu, Yibo Xu, Hongwen Xu, Mingwei Zhu << Fewer

https://doi.org/10.1016/j.gendis.2023.05.008

Published: 01 July 2023

2024, 11 (3): 101006

Downloads: 2 | Views: 3 |

PDF (1.1 MB)

Open Access Rapid Communication

A novel homozygous missense variant in ARSK causes MPS X, a new subtype of mucopolysaccharidosis

Miao Sun, Cornelia K. Kaminsky, Philip Deppe, [...], Mai-Britt Ilse, Frédéric M. Vaz, Barbara Plecko, Torben Lübke, Linda M. Randolph << Fewer

https://doi.org/10.1016/j.gendis.2023.06.003

Published: 10 July 2023

2024, 11 (3): 101025

Downloads: 2 | Views: 4 |

PDF (596.4 KB)

Open Access Rapid Communication

ADAM8 inactivation retards intervertebral disc degeneration in mice

Zuozhen Tian, Frances S. Shofer, Mingyue Fan, [...], Alec Z. Sandroni, Lutian Yao, Lin Han, Ling Qin, Motomi Enomoto-Iwamoto, Yejia Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.06.028

Published: 02 August 2023

2024, 11 (3): 101059

Downloads: 2 | Views: 3 |

PDF (1.5 MB)

Open Access Rapid Communication

CD9 role in proliferation, rejuvenation, and therapeutic applications

Sai Priyanka Kodam, Neda Baghban, Mujib Ullah

https://doi.org/10.1016/j.gendis.2023.05.009

Published: 30 June 2023

2024, 11 (3): 101008

Downloads: 2 | Views: 3 |

PDF (586 KB)

Open Access Rapid Communication

miR-378a-3p responds to physical activity by modulating insulin-mediated glucose uptake and tricarboxylic acid cycle in skeletal muscle

Zishuai Wang, Yilong Yao, Xinhua Hou, [...], Danyang Fan, Yanwen Liu, Adeyinka Abiola Adetula, Yalan Yang, Kui Li, Zhonglin Tang << Fewer

https://doi.org/10.1016/j.gendis.2023.06.021

Published: 28 July 2023

2024, 11 (3): 101052

Downloads: 2 | Views: 7 |

PDF (959.1 KB)

Open Access Rapid Communication

Curcumin modulates oxidative stress to inhibit pyroptosis and improve the inflammatory microenvironment to treat endometriosis

Jie Ding, Shanshan Mei, Kaili Wang, [...], Wen Cheng, Shuai Sun, Zhexin Ni, Xiaoqiu Wang, Chaoqin Yu << Fewer

https://doi.org/10.1016/j.gendis.2023.06.022

Published: 28 July 2023

2024, 11 (3): 101053

Downloads: 2 | Views: 3 |

PDF (1.2 MB)

Open Access Rapid Communication

Mutant rs189037 in ataxia-telangiectasia mutated gene had a negative association with metabolic syndrome but not cognitive decline in centenarians

Long Feng, Hongqi Huo, Qun Li, [...], Tao Yang, Yali Zhao, Pei Zhang, Ping Ping, Shihui Fu << Fewer

https://doi.org/10.1016/j.gendis.2023.06.023

Published: 02 August 2023

2024, 11 (3): 101054

Downloads: 2 | Views: 3 |

PDF (232.7 KB)

Open Access Rapid Communication

Ferroptosis mediators vary in metabolic syndrome, type-2 diabetes, and hypercholesterolemia: A meta-analysis report

Indra Kundu, Ashlesha Pande, Tannishtha Das, Susan Idicula-Thomas

https://doi.org/10.1016/j.gendis.2023.06.024

Published: 29 July 2023

2024, 11 (3): 101055

Downloads: 2 | Views: 5 |

PDF (868.8 KB)

Open Access Rapid Communication

The role of melatonin receptor 1B gene (MTNR1B) in the susceptibility to depression and type 2 diabetes comorbidity

Mutaz Amin, Benjamin Rafla, Rongling Wu, [...], Teodor T. Postolache, Claudia Gragnoli << Fewer

https://doi.org/10.1016/j.gendis.2023.06.036

Published: 04 August 2023

2024, 11 (3): 101067

Downloads: 2 | Views: 29 |

PDF (368.5 KB)

Open Access Rapid Communication

Characterization of the molecular dysfunctions occurring in Aicardi-Goutières syndrome patients with mutations in ADAR1

Sofian Al Wardat, Loredana Frassinelli, Elisa Orecchini, [...], Federica Rey, Silvia Anna Ciafrè, Silvia Galardi, Jessica Garau, Stella Gagliardi, Simona Orcesi, Davide Tonduti, Stephana Carelli, Cristina Cereda, Ernesto Picardi, Alessandro Michienzi << Fewer

https://doi.org/10.1016/j.gendis.2023.05.020

Published: 13 July 2023

2024, 11 (3): 101028

Downloads: 2 | Views: 3 |

PDF (631.3 KB)

Open Access Rapid Communication

Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway

Hui Wang, Zhonghao Li, Qisheng Wang, [...], Weixin Lin, Ziting Zhou, Xinru Mu, Yongwei Jiang, Shengfeng Lu, Shaodong Chen, Zhigang Lu << Fewer

https://doi.org/10.1016/j.gendis.2023.05.026

Published: 28 July 2023

2024, 11 (3): 101049

Downloads: 2 | Views: 3 |

PDF (1.5 MB)

Open Access Rapid Communication

MPDZ variants associated with epilepsies and/or febrile seizures and the individualized genotype-phenotype correlation

Junxia Luo, Yun Li, Yong Lv, [...], Xin Li, Bing Qin, Chuanfang Cheng, Xiaorong Liu, Weiping Liao, Jie Wang, Zaifen Gao << Fewer

https://doi.org/10.1016/j.gendis.2023.06.006

Published: 13 July 2023

2024, 11 (3): 101032

Downloads: 2 | Views: 3 |

PDF (1.2 MB)

Open Access Rapid Communication

Potential risk genes for primary Sjögren's syndrome from a meta-analysis by linear regression and random forest classification

Tomás Cerdó, Teresa Torres Moral

https://doi.org/10.1016/j.gendis.2023.05.015

Published: 04 July 2023

2024, 11 (3): 101016

Downloads: 2 | Views: 20 |

PDF (1.1 MB)

Open Access Rapid Communication

CHD4-induced up-regulation of ERα activity contributes to breast cancer progression

Aman Sattout, Xiaomin Yu, Zhuo Sun, [...], Yanan Li, Yulin Li, Shujing Li, Wei Huo, Huijian Wu << Fewer

https://doi.org/10.1016/j.gendis.2023.101108

Published: 15 September 2023

2024, 11 (3): 101108

Downloads: 2 | Views: 6 |

PDF (528.3 KB)

Open Access Rapid Communication

Mechanical sensor PDLIM5 promotes the osteogenesis of human adipose-derived stem cells through microfilament alterations

Yuchao Yang, Shutong Wu, Rongmei Qu, [...], Congrong Wang, Jinyang Wang, Asmat Ullah Khan, You Pan, Wenqing Liu, Jinhui Zhu, Muhammad Akram Khan, Chujiang Xu, Jingxing Dai, Jun Ouyang << Fewer

https://doi.org/10.1016/j.gendis.2023.06.001

Published: 11 July 2023

2024, 11 (3): 101023

Downloads: 2 | Views: 5 |

PDF (878.5 KB)

Open Access Rapid Communication

Network analyses: Inhibition of androgen receptor signaling reduces inflammation in the lung through AR-MAF-IL6 signaling axes

Albert R. Wang, Andrew M. Baschnagel, Zijian Ni, [...], Sean R. Brennan, Hypatia K. Newton, Darya Buehler, Christina Kendziorski, Randall J. Kimple, Gopal Iyer << Fewer

https://doi.org/10.1016/j.gendis.2023.07.001

Published: 18 August 2023

2024, 11 (3): 101072

Downloads: 2 | Views: 6 |

PDF (1.4 MB)

Open Access Rapid Communication

Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression

Hongjia Zhang, Xueqian Sun, Zhanming Li, [...], Tingting Liu, Fang Zhang, Xinyu Meng, Kaimi Li, Jianhua Xu, Wei He, Bo Jing, Tong Wang, Na Ni, Beibei Sun, Feng Yao, Yadi Wu, Qi Wang, Jing Du, Eugene Y. Chin, Binhua P. Zhou, Ping Jiang, Lishun Wang, Jiong Deng << Fewer

https://doi.org/10.1016/j.gendis.2023.04.030

Published: 24 June 2023

2024, 11 (3): 100999

Downloads: 2 | Views: 3 |

PDF (1.1 MB)

Open Access Rapid Communication

Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

Chen Tan, Lingwa Wang, Yifan Yang, [...], Shizhi He, George G. Chen, Jason YK. Chan, Michael CF. Tong, C.A. van Hasselt, Wenbin Xu, Ling Feng, Ru Wang, Jugao Fang << Fewer

https://doi.org/10.1016/j.gendis.2023.05.018

Published: 16 July 2023

2024, 11 (3): 101022

Downloads: 2 | Views: 3 |

PDF (1 MB)

Open Access Rapid Communication

Increased N6-methyladenosine is related to the promotion of the methyltransferase METTL14 in ovarian aging

Chunfeng Qian, Zhenxing Liu, Yonghong Qian, [...], Jie Ding, Rulei Chen, Han Su, Minghong Shen, Hong Li, Boxian Huang << Fewer

https://doi.org/10.1016/j.gendis.2023.06.019

Published: 24 July 2023

2024, 11 (3): 101050

Downloads: 2 | Views: 3 |

PDF (1.2 MB)

REVIEW ARTICLES

Open Access Review Article

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

Michael Yu, Kevin Qin, Jiaming Fan, [...], Guozhi Zhao, Piao Zhao, Wei Zeng, Connie Chen, Annie Wang, Yonghui Wang, Jiamin Zhong, Yi Zhu, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin Ho, Michael J. Lee, Jason Strelzow, Russell R. Reid, Tong-Chuan He << Fewer

https://doi.org/10.1016/j.gendis.2023.04.042

Published: 22 July 2023

2024, 11 (3): 101026

Downloads: 2 | Views: 21 |

PDF (2.9 MB)

Open Access Review Article

Pretreating and normalizing metabolomics data for statistical analysis

Jun Sun, Yinglin Xia

https://doi.org/10.1016/j.gendis.2023.04.018

Published: 07 July 2023

2024, 11 (3): 100979

Downloads: 2 | Views: 23 |

PDF (1 MB)

Open Access Review Article

Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis

Shuyu Li, Zichen Xu, Yi Wang, [...], Lizhao Chen, Xiangxiu Wang, Yanghao Zhou, Daoxi Lei, Guangchao Zang, Guixue Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.06.016

Published: 17 July 2023

2024, 11 (3): 101046

Downloads: 2 | Views: 11 |

PDF (1.9 MB)

Open Access Review Article

Microbiome and intestinal pathophysiology in post-acute sequelae of COVID-19

Jilei Zhang, Yongguo Zhang, Yinglin Xia, Jun Sun

https://doi.org/10.1016/j.gendis.2023.03.034

Published: 19 June 2023

2024, 11 (3): 100978

Downloads: 4 | Views: 30 |

PDF (1.4 MB)

Open Access Review Article

Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies

Salma Nassor Juma, Junguang Liao, Yuping Huang, [...], Rexhina Vlashi, Qingwan Wang, Bocong Wu, Dan Wang, Mengrui Wu, Guiqian Chen << Fewer

https://doi.org/10.1016/j.gendis.2023.04.021

Published: 19 June 2023

2024, 11 (3): 100986

Downloads: 3 | Views: 16 |

PDF (2.4 MB)

Open Access Review Article

Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network

Shuo Li, Tiande Zou, Jun Chen, [...], Jiaming Li, Jinming You << Fewer

https://doi.org/10.1016/j.gendis.2023.06.033

Published: 02 August 2023

2024, 11 (3): 101064

Downloads: 2 | Views: 16 |

PDF (1.2 MB)

Open Access Review Article

FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases

Wei Shen, Modan Yang, Hao Chen, [...], Chiyu He, Huigang Li, Xinyu Yang, Jianyong Zhuo, Zuyuan Lin, Zhihang Hu, Di Lu, Xiao Xu << Fewer

https://doi.org/10.1016/j.gendis.2023.05.019

Published: 13 July 2023

2024, 11 (3): 101027

Downloads: 2 | Views: 22 |

PDF (1.2 MB)

Open Access Review Article

Tumor microenvironment of cancer stem cells: Perspectives on cancer stem cell targeting

Qianqian Guo, Yi Zhou, Tianyuan Xie, [...], Yin Yuan, Huilong Li, Wanjin Shi, Lufeng Zheng, Xiaoman Li, Wenzhou Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.05.024

Published: 19 July 2023

2024, 11 (3): 101043

Downloads: 2 | Views: 12 |

PDF (2.2 MB)

Open Access Review Article

Mitochondrial diseases and mtDNA editing

Min Song, Lingqun Ye, Yongjin Yan, [...], Xuechun Li, Xinglong Han, Shijun Hu, Miao Yu << Fewer

https://doi.org/10.1016/j.gendis.2023.06.026

Published: 09 August 2023

2024, 11 (3): 101057

Downloads: 2 | Views: 14 |

PDF (812.5 KB)

Open Access Review Article

Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

David Sánchez-Marín, Macrina Beatriz Silva-Cázares, Fany Iris Porras-Reyes, [...], Rebeca García-Román, Alma D. Campos-Parra << Fewer

https://doi.org/10.1016/j.gendis.2023.101136

Published: 11 October 2023

2024, 11 (3): 101136

Downloads: 2 | Views: 15 |

PDF (773.3 KB)

Open Access Review Article

Mitochondrial dysfunction: A promising therapeutic target for liver diseases

Ping Chen, Lichao Yao, Mengqin Yuan, [...], Zheng Wang, Qiuling Zhang, Yingan Jiang, Lanjuan Li << Fewer

https://doi.org/10.1016/j.gendis.2023.101115

Published: 17 September 2023

2024, 11 (3): 101115

Downloads: 2 | Views: 13 |

PDF (1.4 MB)

FULL LENGTH ARTICLES

Open Access Full Length Article

Regulation of AMPK activation by extracellular matrix stiffness in pancreatic cancer

Xin Xu, Yuan Fang, Somaira Nowsheen, [...], Ye-Xiong Li, Zhenkun Lou, Min Deng << Fewer

https://doi.org/10.1016/j.gendis.2023.05.022

Published: 14 July 2023

2024, 11 (3): 101035

Downloads: 2 | Views: 9 |

PDF (2.5 MB)

Open Access Full Length Article

Integrative transcriptome analysis identifies MYBL2 as a poor prognosis marker for osteosarcoma and a pan-cancer marker of immune infiltration

Xinzhu Qiu, Hongbo He, Hao Zeng, [...], Xiaopeng Tong, Can Zhang, Yupeng Liu, Zhan Liao, Qing Liu << Fewer

https://doi.org/10.1016/j.gendis.2023.04.035

Published: 11 July 2023

2024, 11 (3): 101004

Downloads: 2 | Views: 10 |

PDF (7.4 MB)

Open Access Full Length Article

Aberrant LETM1 elevation dysregulates mitochondrial functions and energy metabolism and promotes lung metastasis in osteosarcoma

Yulu Shi, Quan Kang, Hong Zhou, [...], Xiaohan Yue, Yang Bi, Qing Luo << Fewer

https://doi.org/10.1016/j.gendis.2023.05.005

Published: 23 June 2023

2024, 11 (3): 100988

Downloads: 3 | Views: 12 |

PDF (7.7 MB)

Open Access Full Length Article

Transcriptomic analysis identifies the neuropeptide cortistatin (CORT) as an inhibitor of temozolomide (TMZ) resistance by suppressing the NF-κB-MGMT signaling axis in human glioma

Zongze He, Bo Peng, Qi Wang, [...], Jie Tian, Ping Liu, Jie Feng, Yiwei Liao, Longyi Chen, Ping Jia, Jian Tang << Fewer

https://doi.org/10.1016/j.gendis.2023.04.017

Published: 19 June 2023

2024, 11 (3): 100977

Downloads: 2 | Views: 6 |

PDF (5.6 MB)

Open Access Full Length Article

Colony-stimulating factor-1 receptor inhibition combined with paclitaxel exerts effective antitumor effects in the treatment of ovarian cancer

Meijia Yu, Yiming Wu, Qingfang Li, [...], Weiqi Hong, Yang Yang, Xiaoyi Hu, Yanfei Yang, Tianqi Lu, Xia Zhao, Xiawei Wei << Fewer

https://doi.org/10.1016/j.gendis.2023.04.023

Published: 22 June 2023

2024, 11 (3): 100989

Downloads: 2 | Views: 16 |

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LKB1 depletion-mediated epithelial–mesenchymal transition induces fibroblast activation in lung fibrosis

Zijian Xu, Elizabeth R. Davies, Liudi Yao, [...], Yilu Zhou, Juanjuan Li, Aiman Alzetani, Ben G. Marshall, David Hancock, Tim Wallis, Julian Downward, Rob M. Ewing, Donna E. Davies, Mark G. Jones, Yihua Wang << Fewer

https://doi.org/10.1016/j.gendis.2023.06.034

Published: 02 August 2023

2024, 11 (3): 101065

Downloads: 2 | Views: 19 |

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Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of breast capsular contracture

Yukun Mao, Xueying Hou, Su Fu, Jie Luan

https://doi.org/10.1016/j.gendis.2023.101087

Published: 09 September 2023

2024, 11 (3): 101087

Downloads: 2 | Views: 8 |

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Cerebral furin deficiency causes hydrocephalus in mice

Shiqi Xie, Xiaoyong Xie, Jing Tang, [...], Biao Luo, Jian Chen, Qixin Wen, Jianrong Zhou, Guojun Chen << Fewer

https://doi.org/10.1016/j.gendis.2023.04.037

Published: 08 July 2023

2024, 11 (3): 101009

Downloads: 2 | Views: 5 |

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The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1

Min Wang, Yixue Gu, Qiubo Li, [...], Bangzhe Feng, Xinke Lv, Hao Zhang, Qingxia Kong, Zhifang Dong, Xin Tian, Yanke Zhang << Fewer

https://doi.org/10.1016/j.gendis.2023.03.036

Published: 24 June 2023

2024, 11 (3): 100997

Downloads: 2 | Views: 14 |

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BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells

Jie Zhang, Jinhai Jiang, Hang Liu, [...], Shiyu Wang, Kaixin Ke, Siyuan Liu, Yue Jiang, Lu Liu, Xiang Gao, Baicheng He, Yuxi Su << Fewer

https://doi.org/10.1016/j.gendis.2023.101075

Published: 07 September 2023

2024, 11 (3): 101075

Downloads: 2 | Views: 10 |

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CORRIGENDA

Open Access Corrigenda

Corrigendum to “Crystal structure of RNA helicase from Saint Louis encephalitis virus and discovery of its inhibitors” [Genes Dis 10 (2023) 389–392]

De-Ping Wang, Fang-Ying Jiang, Xian-Yan Zeng, [...], Yu-Jie Liu, Rong Zhao, Mei-Yue Wang, Jing Luo, Chen Chen, Yong Zhu, Ji-Min Cao << Fewer

https://doi.org/10.1016/j.gendis.2023.101113

Published: 18 September 2023

2024, 11 (3): 101113

Downloads: 2 | Views: 9 |

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Open Access Corrigenda

Corrigendum to “A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis” [Genes & Diseases 11 (2024) 479–494]

Yanran Bi, Ruiling Zheng, Jiahao Hu, [...], Ruiqing Shi, Junfeng Shi, Yutao Wang, Peng Wang, Wenyi Jiang, Gyudong Kim, Zhiguo Liu, Xiaokun Li, Li Lin << Fewer

https://doi.org/10.1016/j.gendis.2023.101168

Published: 15 November 2023

2024, 11 (3): 101168

Downloads: 1 | Views: 9 |

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Open Access Corrigenda

Corrigendum to “Cellular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression” [Genes & Diseases 11 (2024) 952–963]

Zhenhao Zhang, Doudou Jing, Baijun Xuan, [...], Zhicai Zhang, Wei Wu, Zengwu Shao << Fewer

https://doi.org/10.1016/j.gendis.2023.101177

Published: 28 November 2023

2024, 11 (3): 101177

Downloads: 1 | Views: 42 |

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