Genes & Diseases Open Access Editors-in-Chief: Ailong Huang, Tong-Chuan He
Home Genes & Diseases All Issues Volume 12 Issue 6
Volume 12 Issue 6, November 2025
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COMMENTARY
Commentary | Open Access
Exploring the role of migrasomes in myocardial injury and repair: A novel mechanism of mitochondrial quality control
Chunnian Ren, Dawei He, Shulei Fan, Quan Wang
Published: 11 April 2025
2025, 12(6): 101639
LETTER
Letter | Open Access
The effect of sodium-glucose cotransporter 2 inhibition mediated by blood metabolites in lymphocytic leukemia
Diguang Wen, Kai Lei, Xiang Ma, Jianchuan Deng
Published: 02 May 2025
2025, 12(6): 101664
RAPID COMMUNICATION
Rapid Communication | Open Access
A novel method for the detection of Cas9 gRNAs using a fluorophore-labeled DNA oligo
Ranmal Avinash Bandara, Zhichang Peter Zhou, Ziyan Rachel Chen, [...], Rongqi Duan, Alan Richard Davidson, Amy P. Wong, Jim Hu << Fewer
Published: 14 April 2025
2025, 12(6): 101636
Rapid Communication | Open Access
Multi-omics approach reveals gene co-alterations and survival benefit in ovarian cancer patients under platinum-based adjuvant therapy
Ning Ding, Jiahui Chen, Xiaotian Zhao, [...], Minyi Zhu, Qiuxiang Ou, Jiaohui Pang, Luxi Ruan, Ying Zhang, Wei Sun, Xiaoxiang Chen << Fewer
Published: 04 April 2025
2025, 12(6): 101628
Rapid Communication | Open Access
Bone marrow mesenchymal stroma cell serves as a harbor anchoring acute B lymphoblastic leukemia cells
Kunpeng Wu, Fen Wang, Min Shen, [...], Xiaohui Liang, Dan Wei, Xi Zhu, Ying Qu, Xunbin Wei, Hua Jiang, Tong Chen << Fewer
Published: 12 April 2025
2025, 12(6): 101637
Rapid Communication | Open Access
Bulk RNA sequencing combined with single-cell RNA sequencing analysis revealed the ferroptosis immune target of osteoarthritis synovial fibroblasts
Qian Wu, Liang Zhou, Yuan Xue, Jiaqian Wang
Published: 04 March 2025
2025, 12(6): 101587
Rapid Communication | Open Access
The targeting of AKR1C1 synergizes with gefitinib via the STAT3 signaling pathway in EGFR-mutated NSCLC
Linlin Chang, Shuzhen Wei, Xiaotian Qi, [...], Yang Gao, Jinhua Chen, Yu Cui, Pengxing He, Wenzhou Zhang << Fewer
Published: 10 April 2025
2025, 12(6): 101633
Rapid Communication | Open Access
Restored phagocytic ability of RPE patches derived from gene-corrected retinitis pigmentosa-hiPSCs on a biodegradable scaffold via clinical-grade protocol: Implications for autologous therapy
Rodriguez-Jimenez Francisco Javier, Artero-Castro Ana, Studenovska Hana, [...], Selles Francisca, Arteaga Claramunt Alba Maria, Brymova Anna, Jendelova Pavla, Motlik Jan, Petrovski Goran, Lytvynchuk Lyubomyr, Ardan Taras, Tichotová Lucie, Drutovič Saskia, Sharma Ruchi, Lukovic Dunja, Bharti Kapil, Erceg Slaven << Fewer
Published: 22 March 2025
2025, 12(6): 101609
Rapid Communication | Open Access
A multi-omic integrative approach combining m6A-epitranscriptomic, transcriptomic, and splicing alternative events reveals potential candidates for colorectal cancer diagnosis
Hatim Boughanem, Jesus Pilo, Alejandro Rego, [...], Libia Ajendra Garcia-Flores, Teresa Dawid-de Vera, Francisco J. Tinahones, Gracia Maria Martin-Nuñez, Manuel Macias-González << Fewer
Published: 22 January 2025
2025, 12(6): 101537
Rapid Communication | Open Access
Investigation of the temporal distribution of anti-VEGF drugs in the retina and the correlation with the distribution of FcR isoforms
Jicai He, Yanping Jiang, Rongqin Yang, [...], Ziwen Lu, Zhihuan Li, Zhigang Tu << Fewer
Published: 28 May 2025
2025, 12(6): 101698
Rapid Communication | Open Access
Population-based screening of CYP17A1 Y329fs mutation carriers in the Han Chinese population
Bing Han, Xiaoxi Zhang, Chang Liu, [...], Hui Zhu, Wenjiao Zhu, Yue Xu, Fengxue Zhang, Kaiwen Zhang, Shuhua Xu, Jie Qiao << Fewer
Published: 15 April 2025
2025, 12(6): 101647
Rapid Communication | Open Access
Genetic complexity underlies clinical heterogeneity: YWTD β-propeller mutations and second-hit modifier mutations in LRP6-related tooth agenesis and ectodermal dysplasia in human
Xinxin Dong, Miao Yu, Zhaoyang Jia, [...], Jinye Bai, Jing Zhang, Shengnan Ling, Limin Guan, Yi Lu, Dong Han, Xiwen Gu << Fewer
Published: 22 January 2025
2025, 12(6): 101541
Rapid Communication | Open Access
Transcriptomic analysis reveals the landscape of the shared gene network between ectopic pregnancy and early pregnancy loss
Mengyu Jing, Ying Zhou, Shuyue Zheng, [...], Yahui Xie, Xi Chen, Aixia Liu << Fewer
Published: 27 March 2025
2025, 12(6): 101616
Rapid Communication | Open Access
CMTM3 promotes adipocyte differentiation by regulating PPARγ in 3T3-L1 cells
Yanni Zhao, Meiyu Piao, Yuankuan Li, [...], Sung Ho Lee, Seung-Joo Nho, Yujian Jin, Chang-Yeol Yeo, Kwang Youl Lee << Fewer
Published: 30 May 2025
2025, 12(6): 101699
Rapid Communication | Open Access
X26nt-mediated recruitment of eIF4A2 facilitates CCND1 translation to drive endothelial cell cycle progression
Xinghe Zhao, Xiaocui Chen, Zheyi Chen, [...], Lisong Shen, Lingfang Zeng, Junyao Yang << Fewer
Published: 02 May 2025
2025, 12(6): 101667
Rapid Communication | Open Access
In vivo adeno-associated virus-mediated LDLR/PCSK9 intervention for familial hypercholesterolemia
Zeyu Han, Cheng Tan, Jianzhong Ai, Ye Zhu
Published: 10 April 2025
2025, 12(6): 101632
Rapid Communication | Open Access
Upregulated Krüppel-like factor 5 promotes hepatocellular carcinoma progression by activating Wnt3a signaling
Wenli Sai, Jie Yang, Liwei Qiu, [...], Min Xu, Min Yao, Dengfu Yao << Fewer
Published: 15 May 2025
2025, 12(6): 101685
Rapid Communication | Open Access
Role of angiogenesis-related lncRNAs in tumor microenvironment and prognosis of lung adenocarcinoma
Lifeng Li, Yaqi Yang, Mengle Peng, [...], Zhirui Fan, Xiaoran Duan, Ruyue Xue, Xuefeng Lv, Ming Cheng, Jie Zhao << Fewer
Published: 11 June 2025
2025, 12(6): 101700
Rapid Communication | Open Access
A novel variant of TFAP2A in a familial case of branchio-oculo-facial syndrome: Insights from structural bioinformatics and molecular dynamics simulation
Jingjing Zhao, Nuo Si, Ningbei Yin, Tao Song
Published: 15 April 2025
2025, 12(6): 101641
Rapid Communication | Open Access
Evolutionary characteristics, biochemical structure, and function impact of MSTN gene
Rui Zhang, Yunpeng Wu, Tianqi Sun, [...], Zhengxing Lian, Jingqing Chen, Yefeng Qiu << Fewer
Published: 02 May 2025
2025, 12(6): 101668
Rapid Communication | Open Access
Tryptophan attenuates acute hypoxic stress-induced intestinal injury through the modulation of intestinal barrier integrity and gut microbiota homeostasis
Jianhua Zheng, Jingqing Chen, Wensheng Zhang, [...], Yunpeng Wu, Tongtong Qin, Yunzhi Fa, Qianyan Dong, Rui Zhang, Yefeng Qiu << Fewer
Published: 04 April 2025
2025, 12(6): 101627
Rapid Communication | Open Access
Identification of POLQ as a chromosomal instability-associated biomarker for hepatocellular carcinoma
Ying Cai, Na Wang, Qiang Liu, [...], Yidi Wang, Dina Liu, Jing Liu, Hengyu Zhou << Fewer
Published: 04 February 2025
2025, 12(6): 101553
Rapid Communication | Open Access
The same genomic variants in the first three exons of KANSL1 can be either benign or causative of Koolen-de Vries syndrome: Definition of a validation procedure
Federica Francesca L’Erario, Giuseppe Marangi, Anna Gloria Renzi, [...], Marina Carapelle, Paolo Niccolò Doronzio, Domizia Pasquetti, Sabrina Maietta, Elena Sonnini, Annalisa Gazzellone, Marcella Zollino << Fewer
Published: 27 January 2025
2025, 12(6): 101546
Rapid Communication | Open Access
Welander distal myopathy-associated TIA1 mutation exacerbates P-body and stress granule dynamics concomitant with nucleolar stress under oxidative stress
Beatriz Ramos Velasco, José Alcalde, José M. Izquierdo
Published: 23 January 2025
2025, 12(6): 101543
Rapid Communication | Open Access
Single-cell transcriptome analysis of in vivo and in vitro human pancreas development
Xiaofei Zhang, Hongyan Yi, Zhuo Ma, [...], Yinsuo Zhao, Yanlin Ma, Eli Song, Tao Xu << Fewer
Published: 25 February 2025
2025, 12(6): 101573
Rapid Communication | Open Access
Investigation of long-term epigenetic changes in the Nr3c1 gene by neonatal valproate exposure in juvenile rats
Eun Hye Jang, Soon Ae Kim
Published: 08 March 2025
2025, 12(6): 101588
Rapid Communication | Open Access
iPSC-based merlin-deficient Schwann cell-like spheroids as an in vitro system for studying NF2 pathogenesis
Núria Catasús, Gemma Casals-Sendra, Miguel Torres-Martin, [...], Inma Rosas, Bernd Kuebler, Helena Mazuelas, Emilio Amilibia, Begoña Aran, Anna Veiga, Ángel Raya, Bernat Gel, Ignacio Blanco, Eduard Serra, Meritxell Carrió, Elisabeth Castellanos << Fewer
Published: 27 March 2025
2025, 12(6): 101615
Rapid Communication | Open Access
circ-miR-524 accelerates the growth of liver cancer cells by inducing DNA damage repair through K-RAS
Yanan Lu, Dongdong Lu
Published: 08 May 2025
2025, 12(6): 101675
Rapid Communication | Open Access
The lack of homozygotes with a large deletion encompassing SPAG1 and POLR2K in primary ciliary dyskinesia patients suggests the lethal effect of the loss of POLR2K protein
Alicja Rabiasz, Monika Drobna-Śledzińska, Patrycja Kaźmierczak, [...], Michał Witt, Ewa Ziętkiewicz << Fewer
Published: 20 January 2025
2025, 12(6): 101535
REVIEW ARTICLE
Review Article | Open Access
Emerging role of SETD2 in the development and function of immune cells
Longmin Chen, Yuan Zou, Yan Dong, [...], Tian Hong, Qianqian Xu, Jing Zhang << Fewer
Published: 03 April 2025
2025, 12(6): 101622
Review Article | Open Access
Genetics, epidemiology and management of clubfoot and related disorders
Muhammad Umar, Liping Tong, Hongting Jin, [...], Tamas Terebessy, Di Chen << Fewer
Published: 17 May 2025
2025, 12(6): 101690
Review Article | Open Access
Crosstalk between the circadian clock, intestinal stem cell niche, and epithelial cell fate decision
Ji Liu, Zhihui Jiang, Juanmin Zha, [...], Qiong Lin, Weiqi He << Fewer
Published: 18 April 2025
2025, 12(6): 101650
Review Article | Open Access
Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment
Luyao Wang, Ye Zhu, Chengying Huang, [...], Qiuming Pan, Junxi Wang, Hongrui Li, Yudi Huang, Guozhong Yi, Zhiyong Li, Songtao Qi, Guanglong Huang, Shanqiang Qu << Fewer
Published: 09 May 2025
2025, 12(6): 101678
Review Article | Open Access
Natural medicines target tumor vascular microenvironment to inhibit tumor
Yirui Lu, Zhiliang Guo, Hong Li, [...], Jiao Wen, Xiaoyun Zhang, Xiumei Guan, Xiaodong Cui, Min Cheng << Fewer
Published: 08 April 2025
2025, 12(6): 101623
Review Article | Open Access
The regulatory role and mechanism of energy metabolism and immune response in head and neck cancer
Haofan Li, Qiu Peng, Linda Oyang, [...], Wenjuan Yang, Shizhen Li, Yaqian Han, Mingjing Peng, Shiming Tan, Longzheng Xia, Jinguan Lin, Xuemeng Xu, Nayiyuan Wu, Yanyan Tang, Xia Luo, Xianjie Jiang, Qianjin Liao, Yujuan Zhou << Fewer
Published: 19 March 2025
2025, 12(6): 101607
Review Article | Open Access
Decoding the impact of gut microbiota on heart failure
Shuhong Zhao, Lingxuan Dan, Rong Huang, [...], Zhuoyu Shen, Dan Huang, Pan Wu, Zhenguo Ma << Fewer
Published: 06 March 2025
2025, 12(6): 101592
Review Article | Open Access
Unveiling the regulatory potential of the non-coding genome: Insights from the human genome project to precision medicine
Paola Ruffo, Bryan J. Traynor, Francesca Luisa Conforti
Published: 22 April 2025
2025, 12(6): 101652
Review Article | Open Access
Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation
Caihan Duan, Junhao Wu, Zhe Wang, [...], Xiaohua Hou, Chaoqun Han << Fewer
Published: 22 February 2025
2025, 12(6): 101570
Review Article | Open Access
ADAMTS2: More than a procollagen N-proteinase
Ruben Vanlerberghe, Alain Colige, Anne-Marie Malfait, [...], Delfien Syx, Fransiska Malfait << Fewer
Published: 13 May 2025
2025, 12(6): 101686
Review Article | Open Access
Harnessing mitochondrial biogenesis to combat acute kidney injury: Current insights and futuredirections
Yajie Hao, Fahui Chen, Xiya Ren, [...], Xiu Huang, Xiaoshuang Zhou << Fewer
Published: 15 April 2025
2025, 12(6): 101645
Review Article | Open Access
Role of chitinase-3-like protein 1 in liver diseases: A comprehensive review
Chao Tian, Shizhou Deng, Ming Yang, [...], Baochen Bai, Lai Wei << Fewer
Published: 24 April 2025
2025, 12(6): 101653
Review Article | Open Access
The role of SOX transcription factors in prostate cancer: Focusing on SOX2
Guotu Du, Xiang Huang, Peng Su, [...], Ying Yang, Shicheng Chen, Tianyu Huang, Neng Zhang << Fewer
Published: 21 May 2025
2025, 12(6): 101692
Review Article | Open Access
Recent advances in oncolytic virus combined immunotherapy in tumor treatment
Xiaoli Zhou, Shunfeng Hu, Xin Wang
Published: 12 March 2025
2025, 12(6): 101599
Review Article | Open Access
In vivo production of CAR T cell: Opportunities and challenges
Zhiqiang Song, Yi Zhou, Binbin Wang, [...], Yuke Geng, Gusheng Tang, Yang Wang, Jianmin Yang << Fewer
Published: 25 March 2025
2025, 12(6): 101612
Review Article | Open Access
Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication
Yulong Han, Binqiang Zhu, Shu Meng
Published: 24 March 2025
2025, 12(6): 101611
FULL LENGTH ARTICLE
Full Length Article | Open Access
RAB26 promotes prostate cancer progression via the MAPK/ERK-TWIST1 signaling axis
Hexi Wang, Simin Liang, Xiaoyi Du, [...], Guozhi Zhao, Yuanyuan Bai, Junwu Li, Haoyu Xu, Senlin Peng, Ye Yuan, Wei Tang << Fewer
Published: 22 May 2025
2025, 12(6): 101689
Full Length Article | Open Access
Unraveling the role of the WIPF1/ACTN4 complex in podosome formation of human placental EVTs: Insights into recurrent spontaneous abortion
Cong Li, Shengya Wang, Jing Tang, [...], Xin Luo, Luxing Ge, Youlong Xie, Lijuan Fu, Lingling Ruan, Enoch Appiah Adu-Gyamfi, Fangfang Li, Yingxiong Wang, Hongbo Qi, Yubin Ding << Fewer
Published: 02 May 2025
2025, 12(6): 101665
Full Length Article | Open Access
Selectively targeting BCL6 using a small-molecule inhibitor is a potential therapeutic strategy for glioblastoma
Min Wu, Lin Zhang, Weikai Guo, [...], Shiyi Lv, Wangrui Jin, Shuangshuang Zhu, Huang Chen, Shuyi Jian, Layang Liu, Yajing Xing, Shihong Peng, Mingyao Liu, Yihua Chen, Zhengfang Yi << Fewer
Published: 15 April 2025
2025, 12(6): 101644
Full Length Article | Open Access
Targeting STARD4/EGFR axis inhibits growth and overcomes lenvatinib resistance in hepatocellular carcinoma
Mengting Liu, Yixin Liu, Jiahui Zheng, [...], Xiangping An, Jiayong Wen, Fengchi Zhu, Jin Jia, Dan Guo, Nana Chen << Fewer
Published: 15 February 2025
2025, 12(6): 101556
Full Length Article | Open Access
Microglial NFAT5 aggravates neuroinflammation via mediating NLRP6 inflammasome in experimental ischemic stroke
Hui Gan, Mi Zhang, Yuhao Duan, [...], Ailiyaer Palahati, Qi He, Junyi Tan, Yong Li, Xuan Zhai, Jing Zhao << Fewer
Published: 01 April 2025
2025, 12(6): 101614
Full Length Article | Open Access
Exploring CISD1 as a multifaceted biomarker in cancer: Implications for diagnosis, prognosis, and immunotherapeutic response
Caiyue Li, Zhipin Liang, Gabrielle Vontz, [...], Connor Kent, Wenbo Ma, Lei Liu, Riya Dahal, Jovanny Zabaleta, Guoshuai Cai, Jia Zhou, Huangen Ding, Qiang Shen << Fewer
Published: 08 May 2025
2025, 12(6): 101677
Full Length Article | Open Access
lncRNA ADAMTS9-AS2/let-7a-5p axis regulates metabolic reprogramming by targeting HK2 in oral submucous fibrosis-associated oral squamous cell carcinoma
Shanghui Zhou, Jingyu Zhan, Jia Wang, [...], Jingang Yang, Dahe Zhang, Zhenming Li, Yue He << Fewer
Published: 05 May 2025
2025, 12(6): 101670
Full Length Article | Open Access
GTSE1-expressed osteoblastic cells facilitate formation of pro-metastatic tumor microenvironment in osteosarcoma
Linzhu Wang, Wenyue Li, Weihang Ji, [...], Danyang Bing, Mingyue Liu, Kaidong Liu, Bo Chen, Zhangxiang Zhao, Yunyan Gu, Xuelian Li, Xiaoqiang E, Lei Yang << Fewer
Published: 07 March 2025
2025, 12(6): 101591
Full Length Article | Open Access
Diagnosis of early-stage non-small cell lung cancer using DNA methylation in tissue and plasma
Lei Li, Kai Fu, Xuyu Cai, [...], Dan Liu, Yingying Zhu, Weiwen Wang, Panwen Tian, Ye Wang, Hui Xue, Michael P. Snyder, Weimin Li << Fewer
Published: 28 January 2025
2025, 12(6): 101548
Full Length Article | Open Access
Human retinal organoids for modelling dry age-related macular degeneration and screening drugs
Xiaolu Hao, Lu Du, Guang Liu, [...], Zhaohui Li, Shaojun Wang << Fewer
Published: 07 March 2025
2025, 12(6): 101593
Full Length Article | Open Access
Menin facilitates the cell proliferation of bladder cancer via modulating the TFAP2C/β-catenin axis
Qing Shi, Xiang Pan, Shiheng Zhang, [...], Mengyuan Wu, Meiqi Xu, Yun-Qi Li, Li Zhong, Zi-Qi Wang, Wanhai Xu, Yakun Luo << Fewer
Published: 20 February 2025
2025, 12(6): 101565
Full Length Article | Open Access
CCDC86-BHLHE40-ATF3 axis promotes aerobic glycolysis and tumor development in glioma
Jinping Liu, Dingyu Du, Yukai Huang, [...], Jie Tian, Xuhui Wang, Longyi Chen, Feng Wang << Fewer
Published: 12 April 2025
2025, 12(6): 101643
Full Length Article | Open Access
Integrated analysis of single-cell RNA-seq and ATAC-seq in lens epithelial cells: Unveiling the role of ATF6 as a key transcription factor
Huiping Lu, Xianyang Liu, Qian Zhou, [...], Ruonan Li, Hangjia Zuo, Ke Hu, Meng Tian, Hong Wang, Jianqiao Li, Na Li, Shengping Hou << Fewer
Published: 22 March 2025
2025, 12(6): 101610
Full Length Article | Open Access
Elevated miR-34a induced by lipotoxicity and inflammation mediates pathophysiological communication between hepatocytes and hepatic stellate cells in liver fibrosis
Qihua Duan, Ruixiang Hu, Yan Chen, [...], Henry Wade, Szczepan Kaluzny, Bingrui Zhang, Rongxue Wu, Guangnan Liu, Cunchuan Wang, Edward N. Harris, Qiaozhu Su << Fewer
Published: 18 April 2025
2025, 12(6): 101648
Full Length Article | Open Access
Tirzepatide, a dual GIP/GLP-1 receptor agonist, alleviates metabolic dysfunction-associated steatotic liver disease by reducing the expression of CD36 and OBP2A
Yun Li, Wencong Sun, Hong Liu, Xiong Z. Ruan
Published: 03 July 2025
2025, 12(6): 101761
CORRIGENDUM
Erratum | Open Access
Corrigendum to “Pan-cancer analysis of MET mutation and its association with the efficacy of immune checkpoint blockade” [Genes & Dis 12 (2025) 101450]
Lijin Chen, Yingying Li, Hong Zhao, [...], Jinyuan Huang, Huimeng Yan, Xiaoyan Lin, Bin Zhao << Fewer
Published: 01 November 2025
2025, 12(6): 101726