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Publishing Language: Chinese | Open Access

Heterogeneity in association strength between psychological resilience and all-cause mortality among Chinese older adults: a prospective cohort study

Fangyi CHEN1,2Wei WANG3Xinru HU1,2Yingtian WANG4Qian YU5Manshu YU1Fan YANG6Xirui QIU7Haining QI4Ye DING4Xiqiao ZHOU1Meng JIANG3Xiaoxiao WANG1 ( )
Clinical Research Institute, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Hospital of Traditional Chinese Medicine), Nanjing 210029
School of Public Health, Nanjing University of Chinese Medicine, Nanjing 210023
GCP Center, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Hospital of Traditional Chinese Medicine), Nanjing 210029
School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023
Department of Science and Technology, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Hospital of Traditional Chinese Medicine), Nanjing 210029
School of Public Health, Nanjing Medical University, Nanjing 211166
Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Hospital of Traditional Chinese Medicine), Nanjing 210029, China
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Abstract

Objective

To explore potential heterogeneity in the association between psychological resilience and all-cause mortality across four obesity indices and to identify subpopulations warranting particular attention.

Methods

This cohort study included 7481 eligible participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) surveyed between 2011 and 2012. Cox proportional hazards model was employed to assess the associations between psychological resilience and all-cause mortality. Subpopulation treatment effect pattern plot (STEPP) analysis was further applied to investigate heterogeneity in this association strength among Chinese older adults.

Results

Higher psychological resilience was significantly associated with a lower risk of all-cause mortality among Chinese older adults (all P < 0.001). Significant heterogeneity in the association strength was observed across subpopulations defined by a body shape index (ABSI)(P < 0.001), body roundness index (BRI)(P < 0.001), waist-to-height ratio (WHtR)(P < 0.001), and body mass index (BMI)(P < 0.001).

Conclusion

The association strength between psychological resilience and all-cause mortality varies significantly among different subpopulations of Chinese older adults. Older adults classified as overweight by multiple indices are encouraged to maintain higher levels of psychological resilience to reduce all-cause mortality risk.

CLC number: R161.7 Document code: A Article ID: 1007-4368(2026)08-1197-14

References

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Journal of Nanjing Medical University (Natural Sciences)
Pages 1197-1210

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Cite this article:
CHEN F, WANG W, HU X, et al. Heterogeneity in association strength between psychological resilience and all-cause mortality among Chinese older adults: a prospective cohort study. Journal of Nanjing Medical University (Natural Sciences), 2026, 46(8): 1197-1210. https://doi.org/10.7655/NYDXBNSN251167

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Received: 23 October 2025
Revised: 24 March 2026
Accepted: 26 March 2026
Published: 01 August 2026
© 2026 Editorial Board of Journal of Nanjing Medical University(Natural Sciences)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).