Research progress in roles of clock gene BMAL1 in regulating muscle endurance

Flight fatigue can impact the ability of pilots to complete long endurance cross-domain flight missions, and skeletal muscle fatigue caused by insufficient muscle endurance is an important cause of flight fatigue. Circadian rhythm and clock genes reportedly play an important role in regulating muscle endurance, and BMAL1 is one of the core clock genes that affect muscle endurance by regulating muscle metabolism, energy production, and muscle fiber-type switching. Disturbance of circadian rhythm or abnormal expressions of BMAL1 can lead to decreased muscle endurance, resulting in body fatigue. In this paper, the research progress in the role of clock gene BMAL1 in regulating muscle endurance is reviewed, which is expected to provide insights and methods for improving muscle endurance and anti-fatigue ability of pilots in long-endurance cross-domain flights.