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Publishing Language: Chinese | Open Access

Characteristics of Intestinal Flora in Egg-Allergic Population and Their Correlation with Serum Cytokines

Tong ZHAO1 , Shanping YANG2, Lingling CHEN3, Lianying ZHAO4, Dongqing LIU5, Weiwei MA1, Cui ZHOU1 ( )
School of Public Health, Capital Medical University, Beijing 100069, China
School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
Department of Nutriology, Handan First Hospital, Handan 056002, China
Department of Laser Cosmetology, Affiliated Hospital of Hebei Engineering University, Handan 056002, China
Department of Laboratory, Handan First Hospital, Handan 056002, China
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Abstract

Objective

The present study intended to analyze the characteristics of intestinal floral composition and the relationship with serum cytokines in individuals with egg allergy.

Methods

A total of 20 subjects were recruited in this study. The abundance and composition of intestinal flora were determined by 16S rRNA gene sequencing, and the serum levels of food allergy-related cytokines such as interleukin-4 (IL-4) and IL-5 were measured by enzyme immunoassay. The differences in the structure of intestinal flora and the levels of cytokines were compared between the egg allergy and control groups and the correlation between them was analyzed.

Results

The serum levels of IL-4 and IL-5 were significantly higher in the egg allergy group compared with the control group (P < 0.05). 16S rRNA gene sequencing showed that Betaproteobacteriales, Burkholderiaceae and Eubacterium_hallii group were significantly enriched in the allergy group (P < 0.05). Spearman’s correlation analysis revealed a negative correlation between the abundance of Weissella cibaria and Escherichia and the serum levels of IL-4 and IL-13. However, the abundance of Burkholderiaceae and uncultured_Parasutterella abundance was positively correlated with transforming growth factor beta1 (TGF-β1) and IL-13.

Conclusion

This study provides a scientific basis for determining the specific intestinal flora of egg-allergic individuals and for exploring the implication of intestinal flora in preventing or treating egg allergy.

Keywords

egg allergyintestinal floracytokinescorrelation
CLC number: R593.1 Document code: A Article ID: 1002-6630(2024)17-0080-08

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Food Science
Volume 45 Issue 17,
September 2024
Pages 80-87
DOI: 10.7506/spkx1002-6630-20231206-043

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Cite this article:
ZHAO T, YANG S, CHEN L, et al. Characteristics of Intestinal Flora in Egg-Allergic Population and Their Correlation with Serum Cytokines. Food Science, 2024, 45(17): 80-87. https://doi.org/10.7506/spkx1002-6630-20231206-043

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Received: 06 December 2023
Published: 15 September 2024
© Beijing Academy of Food Sciences 2024.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).