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Publishing Language: Chinese | Open Access

Mapping of B Cell Epitopes of Major Allergens in Bovine Whey

Yongxin HU1,2 , Hongkai TAN1,2, Wei HU1,2, Ziyi XIONG1,2, Juanli YUAN1,3, Lina PAN4, Jiaqi WANG4, Xin LI1,2 ( )
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
School of Food Engineering, Nanchang University, Nanchang 330047, China
School of Pharmacy, Nanchang University, Nanchang 330047, China
Ausnutria Dairy (China) Co. Ltd., Changsha 410005, China
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Abstract

In this study, phage display technology combined with bioinformatics was used to identify the B cell epitopes of α-lactalbumin and β-lactoglobulin from bovine whey. The amino acid composition and spatial distribution of different types of epitopes was analyzed. The results showed that some linear epitopes were part of the conformational epitopes. IgE and IgG-binding epitopes shared some common sequences. At the same time, we identified a new linear IgE-binding epitope in β-lactoglobulin. The epitopes we obtained are candidate biomarkers for the diagnosis and prognosis of milk allergy, and can be used for guiding the development of hypoallergenic dairy products.

Keywords

α-lactalbuminβ-lactoglobulinlinear epitopeconformational epitopephage display technology
CLC number: TS252.1 Document code: A Article ID: 1002-6630(2022)20-0148-09

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Food Science
Volume 43 Issue 20,
October 2022
Pages 148-156
DOI: 10.7506/spkx1002-6630-20211111-143

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Cite this article:
HU Y, TAN H, HU W, et al. Mapping of B Cell Epitopes of Major Allergens in Bovine Whey. Food Science, 2022, 43(20): 148-156. https://doi.org/10.7506/spkx1002-6630-20211111-143

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Received: 11 November 2021
Published: 25 October 2022
© Beijing Academy of Food Sciences 2022.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).