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Chemotherapy is often hindered by issues associated with deficient drug selectivity and ineluctable toxic effects. The emerging realm of mechanochemistry has demonstrated significant promise in precise drug activation by using ultrasound-induced mechanical forces to regulate the chemical properties of compounds at the molecular level. Recently, we proved that the successful introduction of nanostructures to mechanochemistry could improve drug loading capacity and enhance their mechanical responsiveness. To further expand the application of the ultrasound-response drug activation strategy in nanosystems, in this context, we illustrate the preparation of a mechano-nanoswitch for spatiotemporal control of drug activation.
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