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Research Article | Open Access

Effect of Micro- and Nanoparticles of Ampicillin Trihydrate on Blood Medium: A Voltammetric Study

Muhammed Mizher Radhi1( ), Zuhair Numan Hamed2, Selda Sabah Ezzaldeen2, Emad Abbas Jaffar Al-Mulla3( )
Radiological Techniques Department, Health and Medical Technology College-Baghdad, Middle Technical University (MTU), Iraq
Lab. Techniques Department, Health and Medical Technology College-Baghdad, Middle Technical University (MTU), Iraq
College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, 54003 Al-Kufa, Iraq
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Abstract

For the first time, one of the antibiotic nanoparticles such as a classical form of ampicillin trihydrate compound was studied. The electrochemical behavior of ampicillin nanoparticles was investigated in blood medium using cyclic voltammetric technique by glassy carbon electrode. The results showed that the oxidation-reduction current peaks of ampicillin nanoparticles in blood medium were different from that of microparticles. The nanoparticles acted as anti-oxidative antibiotic by making the oxidation current peak at 1 V disappear, while the oxidation peak of microparticles still appeared in blood medium; hence, ampicillin at microform acted as oxidative reagent in blood medium. A good reliability and stability of glassy carbon electrode in blood medium was found with low values of RSD for oxidation-reduction current peaks at ±0.52% and ±0.038% respectively. Scanning electron microscopy for the characterization of ampicillin trihydrate nanoparticles was studied.

Keywords

Ampicillin trihydrateCyclic voltammetryNanoparticlesBlood mediumRedox process

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Nano Biomedicine and Engineering
Volume 9 Issue 3,
September 2017
Pages 185-190
DOI: 10.5101/nbe.v9i3.p185-190

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Cite this article:
Radhi MM, Hamed ZN, Ezzaldeen SS, et al. Effect of Micro- and Nanoparticles of Ampicillin Trihydrate on Blood Medium: A Voltammetric Study. Nano Biomedicine and Engineering, 2017, 9(3): 185-190. https://doi.org/10.5101/nbe.v9i3.p185-190

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Received: 27 June 2017
Accepted: 09 August 2017
Published: 11 August 2017
© 2017 Muhammed Mizher Radhi, Zuhair Numan Hamed, Selda Sabah Ezzaldeen, and Emad Abbas Jaffar Al-Mulla.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.