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Review | Open Access

Surface Enhanced Raman Scattering (SERS): From Fundamental Mechanism to Bio-Analytics Tools

Xiao Zhi1, Li Lin1,2, Di Chen1( )
Institute of Nano Biomedicine and Engineering, Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
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Abstract

This review discusses the surface-enhanced Raman scattering (SERS) with efficiencies enhanced by as much as 1014-1015 fold as well as a SERS cross section on the order of 10-17-10-16 cm2/molecule. Despite the existing controversy on the origin of the enhancement, SERS effect offers new opportunities for spectroscopic detection of single molecules near or on the surface of metallic nanoparticles. There has been a considerable amount of research on explanation of the enhancement mechanism and on developing SERS labels as bio-analytics tools for either molecular multiplexed detection or bio-imaging at different levels.

Keywords

RamanSERSMachanismBio-analytics

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Nano Biomedicine and Engineering
Volume 8 Issue 4,
December 2016
Pages 297-305
DOI: 10.5101/nbe.v8i4.p297-305

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Cite this article:
Zhi X, Lin L, Chen D. Surface Enhanced Raman Scattering (SERS): From Fundamental Mechanism to Bio-Analytics Tools. Nano Biomedicine and Engineering, 2016, 8(4): 297-305. https://doi.org/10.5101/nbe.v8i4.p297-305

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Received: 09 December 2016
Accepted: 13 December 2016
Published: 26 December 2016
© 2016 Xiao Zhi, Li Lin, and Di Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.