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Nano Biomedicine and Engineering 2012, 4(2): 83-88 https://doi.org/10.5101/nbe.v4i2.p83-88
Article | Open Access | Issue | Published: 30 June 2012

Doxorubicin Loaded Polyurethanes Nanoparticles

Show Author's Information Alberto Dessy,†,  Anna Maria Piras,†,  Michele Alderighi,  Stefania Sandreschi,  Federica Chiellini( )
Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), Department of Chemistry & Industrial Chemistry, University of Pisa, Via Vecchia Livornese 1291, 56122 San Piero a Grado, Pisa (Italy)

†Alberto Dessy and Anna Maria Piras Contributed Equally to This Paper

Keywords:
Nanoparticles, Cancer, Drug Delivery Systems, Doxorubicin, Polyurethanes
Cite this article:
Dessy A, Piras AM, Alderighi M, et al. Doxorubicin Loaded Polyurethanes Nanoparticles. Nano Biomedicine and Engineering, 2012, 4(2): 83-88. https://doi.org/10.5101/nbe.v4i2.p83-88
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Abstract About this article

A poly(ether-ester-urethane) block copolymer based on poly(ε-caprolactone) and polyethylene glycol (PEGCL) was employed for the production of Doxorubicin loaded polymeric nanoparticles to be used as a drug delivery system. Nanoparticles were obtained by means of the nanoprecipitation/solvent evaporation technique, possessing a spherical shape and an average diameter of about 80 nm. The optimization of the formulation process led to high formulation yield and appreciable drug content. One of the main findings arising from the present study is represented by the protective activity played by nanoparticles in terms of preventing doxorubicin degradation in physiological conditions; moreover the observed time-delayed release of the drug was associated to PEGCL chemical structure.

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Published: 30 June 2012
Issue date: June 2012

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© 2012 Alberto Dessy, Anna Maria Piras, et al.

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Acknowledgements

The present research was performed within the framework of the European Commission funded project “Nanother” FP7-NMP Theme 2007-4.0-4

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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