The Pharmacokinetic Profile of Freeze-dried Cyclosporine A-Eudragit S100 Nanoparticle Formulation in Dogs

Yang Liu; Zhigang Fang; Yagen Chen; Jiankang Zhang; Xuenong Zhang; Qiang Hong

doi:10.5101/nbe.v3i1.p53-56

Nano Biomedicine and Engineering 2011, 3(1): 53-56 https://doi.org/10.5101/nbe.v3i1.p53-56

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Open Access | Issue | Published: 31 March 2011

The Pharmacokinetic Profile of Freeze-dried Cyclosporine A-Eudragit S100 Nanoparticle Formulation in Dogs

Show Author's Information Hide Author's Information Yang Liu^¹, Zhigang Fang^¹, Yagen Chen^¹, Jiankang Zhang^¹, Xuenong Zhang^¹(

), Qiang Hong^²

College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China

Department of Pharmaceutics, School of Pharmaceutical Science, Peking University, Beijing 100083, People’s Republic of China

Keywords:

Nanoparticle, Pharmacokinetics, Bioavailability, HPLC, Cyclosporine A

Cite this article:

Liu Y, Fang Z, Chen Y, et al. The Pharmacokinetic Profile of Freeze-dried Cyclosporine A-Eudragit S100 Nanoparticle Formulation in Dogs. Nano Biomedicine and Engineering, 2011, 3(1): 53-56. https://doi.org/10.5101/nbe.v3i1.p53-56

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Abstract About this article

Abstract

The pharmacokinetic profile of freeze-dried cyclosporine A-Eudragit S100 nanoparticles (CyA-S100-NP)was studied with a random two-way crossover study in dogs. The drug blood concentration was determined by internal standard HPLC method after oral administration of CyA-S100-NP and Neoral. Pharmacokinetics parameters were calculated by 3P97 program. The concentration-time data were fitted as a two-compartment open model. The AUC of CyA-S100-NP was higher than that of Neoral(P<0.05), while the CL significantly decreased(P<0.05). The relative bioavailability of CyA-S100-NP were 135.9% compared with Neoral. The bioavailability of CyA was significantly improved. CyA-S100-NP was a potential drug for developing a new CyA nanoparticles solid formulation.

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Published: 31 March 2011

Issue date: March 2011

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Acknowledgements

This work was supported by the National Key Technology R&D Program in the 11th Five Year Plan of China (2006BAI09B00), National Basic Research Program of China (973 Program No. 2007CB935800), and National Key Program of New Drug innovation (No. 2009zx09310-001).

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.